ID   WBP1L_HUMAN             Reviewed;         342 AA.
AC   Q9NX94; B3KPF4; B7Z6S7; D3DR90; Q1EG70; Q2HIY7; Q5F2G6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 2.
DT   27-MAR-2024, entry version 149.
DE   RecName: Full=WW domain binding protein 1-like;
DE   AltName: Full=Outcome predictor in acute leukemia 1;
GN   Name=WBP1L; Synonyms=C10orf26, OPA1L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=B-cell lymphoma;
RA   Helman P., Veroff R.L., Shuster J., Kang H., Mosquera-Caro M.P.,
RA   Potter J.W., Harvey R.C., Martin S.B., Davidson G.S., Andries E.,
RA   Atlas S.W., Chen I.-M., Wilson C.S., Ar K., Xu Y., Murphy M., Schultz F.A.,
RA   Bedrick E., Carroll A.J., Camitta B., Willman C.L.;
RT   "Gene expression profiling reveals novel genes for improved risk
RT   classification and outcome prediction in pediatric acute lymphoblastic
RT   leukemia: identification, validation, and cloning of OPAL1.";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
RP   PRO-302 AND SER-320.
RC   TISSUE=Hepatoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Small intestine;
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- INTERACTION:
CC       Q9NX94; O95870: ABHD16A; NbExp=3; IntAct=EBI-10316321, EBI-348517;
CC       Q9NX94; P55212: CASP6; NbExp=3; IntAct=EBI-10316321, EBI-718729;
CC       Q9NX94; P06307: CCK; NbExp=3; IntAct=EBI-10316321, EBI-6624398;
CC       Q9NX94; P02489: CRYAA; NbExp=3; IntAct=EBI-10316321, EBI-6875961;
CC       Q9NX94; Q14204: DYNC1H1; NbExp=3; IntAct=EBI-10316321, EBI-356015;
CC       Q9NX94; P41091: EIF2S3; NbExp=3; IntAct=EBI-10316321, EBI-1054228;
CC       Q9NX94; O95208-2: EPN2; NbExp=3; IntAct=EBI-10316321, EBI-12135243;
CC       Q9NX94; O75460-2: ERN1; NbExp=3; IntAct=EBI-10316321, EBI-25852368;
CC       Q9NX94; P22607: FGFR3; NbExp=3; IntAct=EBI-10316321, EBI-348399;
CC       Q9NX94; Q0VDC6: FKBP1A; NbExp=3; IntAct=EBI-10316321, EBI-10226858;
CC       Q9NX94; P21333-2: FLNA; NbExp=3; IntAct=EBI-10316321, EBI-9641086;
CC       Q9NX94; Q14957: GRIN2C; NbExp=3; IntAct=EBI-10316321, EBI-8285963;
CC       Q9NX94; P06396: GSN; NbExp=3; IntAct=EBI-10316321, EBI-351506;
CC       Q9NX94; P54652: HSPA2; NbExp=3; IntAct=EBI-10316321, EBI-356991;
CC       Q9NX94; P13473-2: LAMP2; NbExp=3; IntAct=EBI-10316321, EBI-21591415;
CC       Q9NX94; Q8N2W9: PIAS4; NbExp=3; IntAct=EBI-10316321, EBI-473160;
CC       Q9NX94; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-10316321, EBI-5280197;
CC       Q9NX94; P62826: RAN; NbExp=3; IntAct=EBI-10316321, EBI-286642;
CC       Q9NX94; P49591: SARS1; NbExp=3; IntAct=EBI-10316321, EBI-1053431;
CC       Q9NX94; O43765: SGTA; NbExp=3; IntAct=EBI-10316321, EBI-347996;
CC       Q9NX94; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-10316321, EBI-741480;
CC       Q9NX94; Q9Y649; NbExp=3; IntAct=EBI-10316321, EBI-25900580;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9NX94-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9NX94-2; Sequence=VSP_041670;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA91122.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AY656171; AAV68559.1; -; mRNA.
DR   EMBL; AK000374; BAA91122.1; ALT_INIT; mRNA.
DR   EMBL; AK316452; BAH14823.1; -; mRNA.
DR   EMBL; AK056285; BAG51666.1; -; mRNA.
DR   EMBL; AK300871; BAH13363.1; -; mRNA.
DR   EMBL; AL358790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471066; EAW49673.1; -; Genomic_DNA.
DR   EMBL; CH471066; EAW49674.1; -; Genomic_DNA.
DR   EMBL; BC113857; AAI13858.1; -; mRNA.
DR   EMBL; BC114465; AAI14466.1; -; mRNA.
DR   CCDS; CCDS44473.1; -. [Q9NX94-2]
DR   CCDS; CCDS7540.1; -. [Q9NX94-1]
DR   RefSeq; NP_001077382.1; NM_001083913.1. [Q9NX94-2]
DR   RefSeq; NP_060257.4; NM_017787.4. [Q9NX94-1]
DR   AlphaFoldDB; Q9NX94; -.
DR   BioGRID; 120189; 8.
DR   IntAct; Q9NX94; 22.
DR   STRING; 9606.ENSP00000414721; -.
DR   iPTMnet; Q9NX94; -.
DR   PhosphoSitePlus; Q9NX94; -.
DR   SwissPalm; Q9NX94; -.
DR   BioMuta; WBP1L; -.
DR   DMDM; 109820639; -.
DR   EPD; Q9NX94; -.
DR   jPOST; Q9NX94; -.
DR   MassIVE; Q9NX94; -.
DR   PaxDb; 9606-ENSP00000414721; -.
DR   PeptideAtlas; Q9NX94; -.
DR   ProteomicsDB; 83057; -. [Q9NX94-1]
DR   ProteomicsDB; 83058; -. [Q9NX94-2]
DR   Antibodypedia; 48471; 88 antibodies from 16 providers.
DR   DNASU; 54838; -.
DR   Ensembl; ENST00000369889.5; ENSP00000358905.4; ENSG00000166272.18. [Q9NX94-1]
DR   Ensembl; ENST00000448841.7; ENSP00000414721.1; ENSG00000166272.18. [Q9NX94-2]
DR   GeneID; 54838; -.
DR   KEGG; hsa:54838; -.
DR   MANE-Select; ENST00000448841.7; ENSP00000414721.1; NM_001083913.2; NP_001077382.1. [Q9NX94-2]
DR   UCSC; uc001kwe.5; human. [Q9NX94-1]
DR   AGR; HGNC:23510; -.
DR   CTD; 54838; -.
DR   DisGeNET; 54838; -.
DR   GeneCards; WBP1L; -.
DR   HGNC; HGNC:23510; WBP1L.
DR   HPA; ENSG00000166272; Low tissue specificity.
DR   MIM; 611129; gene.
DR   neXtProt; NX_Q9NX94; -.
DR   OpenTargets; ENSG00000166272; -.
DR   PharmGKB; PA128394674; -.
DR   VEuPathDB; HostDB:ENSG00000166272; -.
DR   eggNOG; ENOG502QQBJ; Eukaryota.
DR   GeneTree; ENSGT00950000183109; -.
DR   HOGENOM; CLU_046863_0_0_1; -.
DR   InParanoid; Q9NX94; -.
DR   OMA; CSGLKMG; -.
DR   OrthoDB; 5401012at2759; -.
DR   PhylomeDB; Q9NX94; -.
DR   TreeFam; TF330726; -.
DR   PathwayCommons; Q9NX94; -.
DR   SignaLink; Q9NX94; -.
DR   BioGRID-ORCS; 54838; 184 hits in 1168 CRISPR screens.
DR   ChiTaRS; WBP1L; human.
DR   GeneWiki; C10orf26; -.
DR   GenomeRNAi; 54838; -.
DR   Pharos; Q9NX94; Tdark.
DR   PRO; PR:Q9NX94; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q9NX94; Protein.
DR   Bgee; ENSG00000166272; Expressed in tendon of biceps brachii and 202 other cell types or tissues.
DR   ExpressionAtlas; Q9NX94; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR   GO; GO:0038160; P:CXCL12-activated CXCR4 signaling pathway; IEA:Ensembl.
DR   GO; GO:0030097; P:hemopoiesis; IEA:Ensembl.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR   InterPro; IPR021684; WBP1-like.
DR   PANTHER; PTHR16209; VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1; 1.
DR   PANTHER; PTHR16209:SF4; WW DOMAIN BINDING PROTEIN 1-LIKE; 1.
DR   Pfam; PF11669; WBP-1; 1.
DR   Genevisible; Q9NX94; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..342
FT                   /note="WW domain binding protein 1-like"
FT                   /id="PRO_0000241450"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          133..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          292..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        150..174
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..247
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        292..312
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         173
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VAR_SEQ         1..8
FT                   /note="MPFLLGLR -> MERRRLLGGMALLLLQALPSPLSARAEPP (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_041670"
FT   VARIANT         302
FT                   /note="S -> P (in dbSNP:rs284860)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_026839"
FT   VARIANT         320
FT                   /note="A -> S (in dbSNP:rs284859)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_026840"
FT   CONFLICT        90
FT                   /note="Y -> H (in Ref. 6; AAI13858)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   342 AA;  37828 MW;  B8D73B065A2A222B CRC64;
     MPFLLGLRQD KEACVGTNNQ SYICDTGHCC GQSQCCNYYY ELWWFWLVWT IIIILSCCCV
     CHHRRAKHRL QAQQRQHEIN LIAYREAHNY SALPFYFRFL PNYLLPPYEE VVNRPPTPPP
     PYSAFQLQQQ QLLPPQCGPA GGSPPGIDPT RGSQGAQSSP LSEPSRSSTR PPSIADPDPS
     DLPVDRAATK APGMEPSGSV AGLGELDPGA FLDKDAECRE ELLKDDSSEH GAPDSKEKTP
     GRHRRFTGDS GIEVCVCNRG HHDDDLKEFN TLIDDALDGP LDFCDSCHVR PPGDEEEGLC
     QSSEEQAREP GHPHLPRPPA CLLLNTINEQ DSPNSQSSSS PS
//