Q9NX94 (WBP1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WW domain binding protein 1-like

Alternative name(s):
Outcome predictor in acute leukemia 1

Gene names

Name:	WBP1L
Synonyms:	C10orf26, OPA1L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence caution	The sequence BAA91122.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NX94-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NX94-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MPFLLGLR → MERRRLLGGMALLLLQALPSPLSARAEPP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	WW domain binding protein 1-like		PRO_0000241450
Regions
	Transmembrane	42 – 62	21	Helical; Potential
	Compositional bias	101 – 183	83	Pro-rich
	Compositional bias	335 – 342	8	Poly-Ser
Natural variations
	Alternative sequence	1 – 8	8	MPFLLGLR → MERRRLLGGMALLLLQALPS PLSARAEPP in isoform 2.		VSP_041670
	Natural variant	302	1	S → P. Ref.2 Corresponds to variant rs284860 [ dbSNP | Ensembl ].		VAR_026839
	Natural variant	320	1	A → S. Ref.2 Corresponds to variant rs284859 [ dbSNP | Ensembl ].		VAR_026840
Experimental info
	Sequence conflict	90	1	Y → H in AAI13858. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: B8D73B065A2A222B	FASTA	342	37,828
	10 20 30 40 50 60 MPFLLGLRQD KEACVGTNNQ SYICDTGHCC GQSQCCNYYY ELWWFWLVWT IIIILSCCCV 70 80 90 100 110 120 CHHRRAKHRL QAQQRQHEIN LIAYREAHNY SALPFYFRFL PNYLLPPYEE VVNRPPTPPP 130 140 150 160 170 180 PYSAFQLQQQ QLLPPQCGPA GGSPPGIDPT RGSQGAQSSP LSEPSRSSTR PPSIADPDPS 190 200 210 220 230 240 DLPVDRAATK APGMEPSGSV AGLGELDPGA FLDKDAECRE ELLKDDSSEH GAPDSKEKTP 250 260 270 280 290 300 GRHRRFTGDS GIEVCVCNRG HHDDDLKEFN TLIDDALDGP LDFCDSCHVR PPGDEEEGLC 310 320 330 340 QSSEEQAREP GHPHLPRPPA CLLLNTINEQ DSPNSQSSSS PS
	Isoform 2 [UniParc]. Checksum: 79F4968D538645F7	FASTA	363	40,040
	10 20 30 40 50 60 MERRRLLGGM ALLLLQALPS PLSARAEPPQ DKEACVGTNN QSYICDTGHC CGQSQCCNYY 70 80 90 100 110 120 YELWWFWLVW TIIIILSCCC VCHHRRAKHR LQAQQRQHEI NLIAYREAHN YSALPFYFRF 130 140 150 160 170 180 LPNYLLPPYE EVVNRPPTPP PPYSAFQLQQ QQLLPPQCGP AGGSPPGIDP TRGSQGAQSS 190 200 210 220 230 240 PLSEPSRSST RPPSIADPDP SDLPVDRAAT KAPGMEPSGS VAGLGELDPG AFLDKDAECR 250 260 270 280 290 300 EELLKDDSSE HGAPDSKEKT PGRHRRFTGD SGIEVCVCNR GHHDDDLKEF NTLIDDALDG 310 320 330 340 350 360 PLDFCDSCHV RPPGDEEEGL CQSSEEQARE PGHPHLPRPP ACLLLNTINE QDSPNSQSSS SPS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gene expression profiling reveals novel genes for improved risk classification and outcome prediction in pediatric acute lymphoblastic leukemia: identification, validation, and cloning of OPAL1." Helman P., Veroff R.L., Shuster J., Kang H., Mosquera-Caro M.P., Potter J.W., Harvey R.C., Martin S.B., Davidson G.S., Andries E., Atlas S.W., Chen I.-M., Wilson C.S., Ar K., Xu Y., Murphy M., Schultz F.A., Bedrick E. , Carroll A.J., Camitta B., Willman C.L. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: B-cell lymphoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS PRO-302 AND SER-320. Tissue: Hepatoma.
[3]	"NEDO human cDNA sequencing project focused on splicing variants." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Small intestine.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY656171 mRNA. Translation: AAV68559.1. AK000374 mRNA. Translation: BAA91122.1. Different initiation. AK316452 mRNA. Translation: BAH14823.1. AK056285 mRNA. Translation: BAG51666.1. AK300871 mRNA. Translation: BAH13363.1. AL358790 Genomic DNA. Translation: CAI52496.1. CH471066 Genomic DNA. Translation: EAW49673.1. CH471066 Genomic DNA. Translation: EAW49674.1. BC113857 mRNA. Translation: AAI13858.1. BC114465 mRNA. Translation: AAI14466.1.
IPI	IPI00015758. IPI00815634.
RefSeq	NP_001077382.1. NM_001083913.1. NP_060257.4. NM_017787.4.
UniGene	Hs.500897. Hs.693257.
3D structure databases
ProteinModelPortal	Q9NX94.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000414721.
PTM databases
PhosphoSite	Q9NX94.
Polymorphism databases
DMDM	109820639.
Proteomic databases
PaxDb	Q9NX94.
PRIDE	Q9NX94.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000369889; ENSP00000358905; ENSG00000166272. ENST00000448841; ENSP00000414721; ENSG00000166272.
GeneID	54838.
KEGG	hsa:54838.
UCSC	uc001kwe.4. human. uc001kwf.4. human.
Organism-specific databases
CTD	54838.
GeneCards	GC10P104504.
HGNC	HGNC:23510. WBP1L.
HPA	HPA037635.
MIM	611129. gene.
neXtProt	NX_Q9NX94.
PharmGKB	PA128394674.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47171.
HOVERGEN	HBG106189.
InParanoid	Q9NX94.
OMA	QAQQRQH.
OrthoDB	EOG4N30P9.
PhylomeDB	Q9NX94.
Gene expression databases
ArrayExpress	Q9NX94.
Bgee	Q9NX94.
CleanEx	HS_C10orf26.
Genevestigator	Q9NX94.
Family and domain databases
InterPro	IPR021684. Uncharacterised_WW-bd. [Graphical view]
Pfam	PF11669. WBP-1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	54838.
NextBio	57634.
SOURCE	Search...

Entry information

Entry name

WBP1L_HUMAN

Accession

Primary (citable) accession number: Q9NX94
Secondary accession number(s): B3KPF4 , B7Z6S7, D3DR90, Q1EG70, Q2HIY7, Q5F2G6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	April 3, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.