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Protein

WW domain binding protein 1-like

Gene

WBP1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain binding protein 1-like
Alternative name(s):
Outcome predictor in acute leukemia 1
Gene namesi
Name:WBP1L
Synonyms:C10orf26, OPA1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23510. WBP1L.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342WW domain binding protein 1-likePRO_0000241450Add
BLAST

Proteomic databases

PaxDbiQ9NX94.
PRIDEiQ9NX94.

PTM databases

PhosphoSiteiQ9NX94.

Expressioni

Gene expression databases

BgeeiQ9NX94.
CleanExiHS_C10orf26.
ExpressionAtlasiQ9NX94. baseline and differential.
GenevestigatoriQ9NX94.

Organism-specific databases

HPAiHPA037635.
HPA038371.

Interactioni

Protein-protein interaction databases

BioGridi120189. 3 interactions.
STRINGi9606.ENSP00000414721.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi101 – 18383Pro-richAdd
BLAST
Compositional biasi335 – 3428Poly-Ser

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47171.
GeneTreeiENSGT00530000063663.
HOVERGENiHBG106189.
InParanoidiQ9NX94.
OMAiYSAFQLQ.
OrthoDBiEOG7WMCJZ.
PhylomeDBiQ9NX94.
TreeFamiTF330726.

Family and domain databases

InterProiIPR021684. Uncharacterised_WW-bd.
[Graphical view]
PfamiPF11669. WBP-1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX94-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPFLLGLRQD KEACVGTNNQ SYICDTGHCC GQSQCCNYYY ELWWFWLVWT
60 70 80 90 100
IIIILSCCCV CHHRRAKHRL QAQQRQHEIN LIAYREAHNY SALPFYFRFL
110 120 130 140 150
PNYLLPPYEE VVNRPPTPPP PYSAFQLQQQ QLLPPQCGPA GGSPPGIDPT
160 170 180 190 200
RGSQGAQSSP LSEPSRSSTR PPSIADPDPS DLPVDRAATK APGMEPSGSV
210 220 230 240 250
AGLGELDPGA FLDKDAECRE ELLKDDSSEH GAPDSKEKTP GRHRRFTGDS
260 270 280 290 300
GIEVCVCNRG HHDDDLKEFN TLIDDALDGP LDFCDSCHVR PPGDEEEGLC
310 320 330 340
QSSEEQAREP GHPHLPRPPA CLLLNTINEQ DSPNSQSSSS PS
Length:342
Mass (Da):37,828
Last modified:June 27, 2006 - v2
Checksum:iB8D73B065A2A222B
GO
Isoform 2 (identifier: Q9NX94-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MPFLLGLR → MERRRLLGGMALLLLQALPSPLSARAEPP

Show »
Length:363
Mass (Da):40,040
Checksum:i79F4968D538645F7
GO

Sequence cautioni

The sequence BAA91122.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901Y → H in AAI13858 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti302 – 3021S → P.1 Publication
Corresponds to variant rs284860 [ dbSNP | Ensembl ].
VAR_026839
Natural varianti320 – 3201A → S.1 Publication
Corresponds to variant rs284859 [ dbSNP | Ensembl ].
VAR_026840

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 88MPFLLGLR → MERRRLLGGMALLLLQALPS PLSARAEPP in isoform 2. 1 PublicationVSP_041670

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY656171 mRNA. Translation: AAV68559.1.
AK000374 mRNA. Translation: BAA91122.1. Different initiation.
AK316452 mRNA. Translation: BAH14823.1.
AK056285 mRNA. Translation: BAG51666.1.
AK300871 mRNA. Translation: BAH13363.1.
AL358790 Genomic DNA. Translation: CAI52496.1.
CH471066 Genomic DNA. Translation: EAW49673.1.
CH471066 Genomic DNA. Translation: EAW49674.1.
BC113857 mRNA. Translation: AAI13858.1.
BC114465 mRNA. Translation: AAI14466.1.
CCDSiCCDS44473.1. [Q9NX94-2]
CCDS7540.1. [Q9NX94-1]
RefSeqiNP_001077382.1. NM_001083913.1. [Q9NX94-2]
NP_060257.4. NM_017787.4. [Q9NX94-1]
UniGeneiHs.500897.
Hs.693257.
Hs.707763.

Genome annotation databases

EnsembliENST00000369889; ENSP00000358905; ENSG00000166272. [Q9NX94-1]
ENST00000448841; ENSP00000414721; ENSG00000166272. [Q9NX94-2]
GeneIDi54838.
KEGGihsa:54838.
UCSCiuc001kwe.4. human. [Q9NX94-1]
uc001kwf.4. human. [Q9NX94-2]

Polymorphism databases

DMDMi109820639.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY656171 mRNA. Translation: AAV68559.1.
AK000374 mRNA. Translation: BAA91122.1. Different initiation.
AK316452 mRNA. Translation: BAH14823.1.
AK056285 mRNA. Translation: BAG51666.1.
AK300871 mRNA. Translation: BAH13363.1.
AL358790 Genomic DNA. Translation: CAI52496.1.
CH471066 Genomic DNA. Translation: EAW49673.1.
CH471066 Genomic DNA. Translation: EAW49674.1.
BC113857 mRNA. Translation: AAI13858.1.
BC114465 mRNA. Translation: AAI14466.1.
CCDSiCCDS44473.1. [Q9NX94-2]
CCDS7540.1. [Q9NX94-1]
RefSeqiNP_001077382.1. NM_001083913.1. [Q9NX94-2]
NP_060257.4. NM_017787.4. [Q9NX94-1]
UniGeneiHs.500897.
Hs.693257.
Hs.707763.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120189. 3 interactions.
STRINGi9606.ENSP00000414721.

PTM databases

PhosphoSiteiQ9NX94.

Polymorphism databases

DMDMi109820639.

Proteomic databases

PaxDbiQ9NX94.
PRIDEiQ9NX94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369889; ENSP00000358905; ENSG00000166272. [Q9NX94-1]
ENST00000448841; ENSP00000414721; ENSG00000166272. [Q9NX94-2]
GeneIDi54838.
KEGGihsa:54838.
UCSCiuc001kwe.4. human. [Q9NX94-1]
uc001kwf.4. human. [Q9NX94-2]

Organism-specific databases

CTDi54838.
GeneCardsiGC10P104504.
HGNCiHGNC:23510. WBP1L.
HPAiHPA037635.
HPA038371.
MIMi611129. gene.
neXtProtiNX_Q9NX94.
PharmGKBiPA128394674.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47171.
GeneTreeiENSGT00530000063663.
HOVERGENiHBG106189.
InParanoidiQ9NX94.
OMAiYSAFQLQ.
OrthoDBiEOG7WMCJZ.
PhylomeDBiQ9NX94.
TreeFamiTF330726.

Miscellaneous databases

GeneWikiiC10orf26.
GenomeRNAii54838.
NextBioi57634.
PROiQ9NX94.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NX94.
CleanExiHS_C10orf26.
ExpressionAtlasiQ9NX94. baseline and differential.
GenevestigatoriQ9NX94.

Family and domain databases

InterProiIPR021684. Uncharacterised_WW-bd.
[Graphical view]
PfamiPF11669. WBP-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gene expression profiling reveals novel genes for improved risk classification and outcome prediction in pediatric acute lymphoblastic leukemia: identification, validation, and cloning of OPAL1."
    Helman P., Veroff R.L., Shuster J., Kang H., Mosquera-Caro M.P., Potter J.W., Harvey R.C., Martin S.B., Davidson G.S., Andries E., Atlas S.W., Chen I.-M., Wilson C.S., Ar K., Xu Y., Murphy M., Schultz F.A., Bedrick E.
    , Carroll A.J., Camitta B., Willman C.L.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: B-cell lymphoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS PRO-302 AND SER-320.
    Tissue: Hepatoma.
  3. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Small intestine.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiWBP1L_HUMAN
AccessioniPrimary (citable) accession number: Q9NX94
Secondary accession number(s): B3KPF4
, B7Z6S7, D3DR90, Q1EG70, Q2HIY7, Q5F2G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: April 1, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.