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Protein

WW domain binding protein 1-like

Gene

WBP1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain binding protein 1-like
Alternative name(s):
Outcome predictor in acute leukemia 1
Gene namesi
Name:WBP1L
Synonyms:C10orf26, OPA1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000166272.16
HGNCiHGNC:23510 WBP1L
MIMi611129 gene
neXtProtiNX_Q9NX94

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54838
OpenTargetsiENSG00000166272
PharmGKBiPA128394674

Polymorphism and mutation databases

BioMutaiWBP1L
DMDMi109820639

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002414501 – 342WW domain binding protein 1-likeAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9NX94
PeptideAtlasiQ9NX94
PRIDEiQ9NX94
ProteomicsDBi83057
83058 [Q9NX94-2]

PTM databases

iPTMnetiQ9NX94
PhosphoSitePlusiQ9NX94

Expressioni

Gene expression databases

BgeeiENSG00000166272
CleanExiHS_C10orf26
GenevisibleiQ9NX94 HS

Organism-specific databases

HPAiHPA037635
HPA038371

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120189, 2 interactors
IntActiQ9NX94, 2 interactors
STRINGi9606.ENSP00000414721

Structurei

3D structure databases

ProteinModelPortaliQ9NX94
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi101 – 183Pro-richAdd BLAST83
Compositional biasi335 – 342Poly-Ser8

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHWG Eukaryota
ENOG410Y9CC LUCA
GeneTreeiENSGT00530000063663
HOVERGENiHBG106189
InParanoidiQ9NX94
OMAiYSAFQLQ
OrthoDBiEOG091G0SD3
PhylomeDBiQ9NX94
TreeFamiTF330726

Family and domain databases

InterProiView protein in InterPro
IPR021684 WBP1-like
PfamiView protein in Pfam
PF11669 WBP-1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX94-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPFLLGLRQD KEACVGTNNQ SYICDTGHCC GQSQCCNYYY ELWWFWLVWT
60 70 80 90 100
IIIILSCCCV CHHRRAKHRL QAQQRQHEIN LIAYREAHNY SALPFYFRFL
110 120 130 140 150
PNYLLPPYEE VVNRPPTPPP PYSAFQLQQQ QLLPPQCGPA GGSPPGIDPT
160 170 180 190 200
RGSQGAQSSP LSEPSRSSTR PPSIADPDPS DLPVDRAATK APGMEPSGSV
210 220 230 240 250
AGLGELDPGA FLDKDAECRE ELLKDDSSEH GAPDSKEKTP GRHRRFTGDS
260 270 280 290 300
GIEVCVCNRG HHDDDLKEFN TLIDDALDGP LDFCDSCHVR PPGDEEEGLC
310 320 330 340
QSSEEQAREP GHPHLPRPPA CLLLNTINEQ DSPNSQSSSS PS
Length:342
Mass (Da):37,828
Last modified:June 27, 2006 - v2
Checksum:iB8D73B065A2A222B
GO
Isoform 2 (identifier: Q9NX94-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MPFLLGLR → MERRRLLGGMALLLLQALPSPLSARAEPP

Show »
Length:363
Mass (Da):40,040
Checksum:i79F4968D538645F7
GO

Sequence cautioni

The sequence BAA91122 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90Y → H in AAI13858 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026839302S → P1 PublicationCorresponds to variant dbSNP:rs284860Ensembl.1
Natural variantiVAR_026840320A → S1 PublicationCorresponds to variant dbSNP:rs284859Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0416701 – 8MPFLLGLR → MERRRLLGGMALLLLQALPS PLSARAEPP in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY656171 mRNA Translation: AAV68559.1
AK000374 mRNA Translation: BAA91122.1 Different initiation.
AK316452 mRNA Translation: BAH14823.1
AK056285 mRNA Translation: BAG51666.1
AK300871 mRNA Translation: BAH13363.1
AL358790 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49673.1
CH471066 Genomic DNA Translation: EAW49674.1
BC113857 mRNA Translation: AAI13858.1
BC114465 mRNA Translation: AAI14466.1
CCDSiCCDS44473.1 [Q9NX94-2]
CCDS7540.1 [Q9NX94-1]
RefSeqiNP_001077382.1, NM_001083913.1 [Q9NX94-2]
NP_060257.4, NM_017787.4 [Q9NX94-1]
UniGeneiHs.500897
Hs.693257
Hs.707763

Genome annotation databases

EnsembliENST00000369889; ENSP00000358905; ENSG00000166272 [Q9NX94-1]
ENST00000448841; ENSP00000414721; ENSG00000166272 [Q9NX94-2]
GeneIDi54838
KEGGihsa:54838
UCSCiuc001kwe.5 human [Q9NX94-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWBP1L_HUMAN
AccessioniPrimary (citable) accession number: Q9NX94
Secondary accession number(s): B3KPF4
, B7Z6S7, D3DR90, Q1EG70, Q2HIY7, Q5F2G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: June 20, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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