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Q9NX94 (WBP1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WW domain binding protein 1-like
Alternative name(s):
Outcome predictor in acute leukemia 1
Gene names
Name:WBP1L
Synonyms:C10orf26, OPA1L
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence caution

The sequence BAA91122.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NX94-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NX94-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MPFLLGLR → MERRRLLGGMALLLLQALPSPLSARAEPP

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342WW domain binding protein 1-like
PRO_0000241450

Regions

Transmembrane42 – 6221Helical; Potential
Compositional bias101 – 18383Pro-rich
Compositional bias335 – 3428Poly-Ser

Natural variations

Alternative sequence1 – 88MPFLLGLR → MERRRLLGGMALLLLQALPS PLSARAEPP in isoform 2.
VSP_041670
Natural variant3021S → P. Ref.2
Corresponds to variant rs284860 [ dbSNP | Ensembl ].
VAR_026839
Natural variant3201A → S. Ref.2
Corresponds to variant rs284859 [ dbSNP | Ensembl ].
VAR_026840

Experimental info

Sequence conflict901Y → H in AAI13858. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: B8D73B065A2A222B

FASTA34237,828
        10         20         30         40         50         60 
MPFLLGLRQD KEACVGTNNQ SYICDTGHCC GQSQCCNYYY ELWWFWLVWT IIIILSCCCV 

        70         80         90        100        110        120 
CHHRRAKHRL QAQQRQHEIN LIAYREAHNY SALPFYFRFL PNYLLPPYEE VVNRPPTPPP 

       130        140        150        160        170        180 
PYSAFQLQQQ QLLPPQCGPA GGSPPGIDPT RGSQGAQSSP LSEPSRSSTR PPSIADPDPS 

       190        200        210        220        230        240 
DLPVDRAATK APGMEPSGSV AGLGELDPGA FLDKDAECRE ELLKDDSSEH GAPDSKEKTP 

       250        260        270        280        290        300 
GRHRRFTGDS GIEVCVCNRG HHDDDLKEFN TLIDDALDGP LDFCDSCHVR PPGDEEEGLC 

       310        320        330        340 
QSSEEQAREP GHPHLPRPPA CLLLNTINEQ DSPNSQSSSS PS 

« Hide

Isoform 2 [UniParc].

Checksum: 79F4968D538645F7
Show »

FASTA36340,040

References

« Hide 'large scale' references
[1]"Gene expression profiling reveals novel genes for improved risk classification and outcome prediction in pediatric acute lymphoblastic leukemia: identification, validation, and cloning of OPAL1."
Helman P., Veroff R.L., Shuster J., Kang H., Mosquera-Caro M.P., Potter J.W., Harvey R.C., Martin S.B., Davidson G.S., Andries E., Atlas S.W., Chen I.-M., Wilson C.S., Ar K., Xu Y., Murphy M., Schultz F.A., Bedrick E. expand/collapse author list , Carroll A.J., Camitta B., Willman C.L.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: B-cell lymphoma.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS PRO-302 AND SER-320.
Tissue: Hepatoma.
[3]"NEDO human cDNA sequencing project focused on splicing variants."
Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. expand/collapse author list , Sugano S., Nomura N., Isogai T.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Small intestine.
[4]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY656171 mRNA. Translation: AAV68559.1.
AK000374 mRNA. Translation: BAA91122.1. Different initiation.
AK316452 mRNA. Translation: BAH14823.1.
AK056285 mRNA. Translation: BAG51666.1.
AK300871 mRNA. Translation: BAH13363.1.
AL358790 Genomic DNA. Translation: CAI52496.1.
CH471066 Genomic DNA. Translation: EAW49673.1.
CH471066 Genomic DNA. Translation: EAW49674.1.
BC113857 mRNA. Translation: AAI13858.1.
BC114465 mRNA. Translation: AAI14466.1.
CCDSCCDS44473.1. [Q9NX94-2]
CCDS7540.1. [Q9NX94-1]
RefSeqNP_001077382.1. NM_001083913.1. [Q9NX94-2]
NP_060257.4. NM_017787.4. [Q9NX94-1]
UniGeneHs.500897.
Hs.693257.
Hs.707763.

3D structure databases

ProteinModelPortalQ9NX94.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120189. 2 interactions.
STRING9606.ENSP00000414721.

PTM databases

PhosphoSiteQ9NX94.

Polymorphism databases

DMDM109820639.

Proteomic databases

PaxDbQ9NX94.
PRIDEQ9NX94.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369889; ENSP00000358905; ENSG00000166272. [Q9NX94-1]
ENST00000448841; ENSP00000414721; ENSG00000166272. [Q9NX94-2]
GeneID54838.
KEGGhsa:54838.
UCSCuc001kwe.4. human. [Q9NX94-1]
uc001kwf.4. human. [Q9NX94-2]

Organism-specific databases

CTD54838.
GeneCardsGC10P104504.
HGNCHGNC:23510. WBP1L.
HPAHPA037635.
HPA038371.
MIM611129. gene.
neXtProtNX_Q9NX94.
PharmGKBPA128394674.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47171.
HOVERGENHBG106189.
InParanoidQ9NX94.
OMADKETCVG.
OrthoDBEOG7WMCJZ.
PhylomeDBQ9NX94.
TreeFamTF330726.

Gene expression databases

ArrayExpressQ9NX94.
BgeeQ9NX94.
CleanExHS_C10orf26.
GenevestigatorQ9NX94.

Family and domain databases

InterProIPR021684. Uncharacterised_WW-bd.
[Graphical view]
PfamPF11669. WBP-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiC10orf26.
GenomeRNAi54838.
NextBio57634.
PROQ9NX94.
SOURCESearch...

Entry information

Entry nameWBP1L_HUMAN
AccessionPrimary (citable) accession number: Q9NX94
Secondary accession number(s): B3KPF4 expand/collapse secondary AC list , B7Z6S7, D3DR90, Q1EG70, Q2HIY7, Q5F2G6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM