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Q9NX94

- WBP1L_HUMAN

UniProt

Q9NX94 - WBP1L_HUMAN

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Protein
WW domain binding protein 1-like
Gene
WBP1L, C10orf26, OPA1L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain binding protein 1-like
Alternative name(s):
Outcome predictor in acute leukemia 1
Gene namesi
Name:WBP1L
Synonyms:C10orf26, OPA1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23510. WBP1L.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei42 – 6221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394674.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342WW domain binding protein 1-like
PRO_0000241450Add
BLAST

Proteomic databases

PaxDbiQ9NX94.
PRIDEiQ9NX94.

PTM databases

PhosphoSiteiQ9NX94.

Expressioni

Gene expression databases

ArrayExpressiQ9NX94.
BgeeiQ9NX94.
CleanExiHS_C10orf26.
GenevestigatoriQ9NX94.

Organism-specific databases

HPAiHPA037635.
HPA038371.

Interactioni

Protein-protein interaction databases

BioGridi120189. 2 interactions.
STRINGi9606.ENSP00000414721.

Structurei

3D structure databases

ProteinModelPortaliQ9NX94.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi101 – 18383Pro-rich
Add
BLAST
Compositional biasi335 – 3428Poly-Ser

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47171.
HOVERGENiHBG106189.
InParanoidiQ9NX94.
OMAiDKETCVG.
OrthoDBiEOG7WMCJZ.
PhylomeDBiQ9NX94.
TreeFamiTF330726.

Family and domain databases

InterProiIPR021684. Uncharacterised_WW-bd.
[Graphical view]
PfamiPF11669. WBP-1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NX94-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPFLLGLRQD KEACVGTNNQ SYICDTGHCC GQSQCCNYYY ELWWFWLVWT    50
IIIILSCCCV CHHRRAKHRL QAQQRQHEIN LIAYREAHNY SALPFYFRFL 100
PNYLLPPYEE VVNRPPTPPP PYSAFQLQQQ QLLPPQCGPA GGSPPGIDPT 150
RGSQGAQSSP LSEPSRSSTR PPSIADPDPS DLPVDRAATK APGMEPSGSV 200
AGLGELDPGA FLDKDAECRE ELLKDDSSEH GAPDSKEKTP GRHRRFTGDS 250
GIEVCVCNRG HHDDDLKEFN TLIDDALDGP LDFCDSCHVR PPGDEEEGLC 300
QSSEEQAREP GHPHLPRPPA CLLLNTINEQ DSPNSQSSSS PS 342
Length:342
Mass (Da):37,828
Last modified:June 27, 2006 - v2
Checksum:iB8D73B065A2A222B
GO
Isoform 2 (identifier: Q9NX94-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MPFLLGLR → MERRRLLGGMALLLLQALPSPLSARAEPP

Show »
Length:363
Mass (Da):40,040
Checksum:i79F4968D538645F7
GO

Sequence cautioni

The sequence BAA91122.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti302 – 3021S → P.1 Publication
Corresponds to variant rs284860 [ dbSNP | Ensembl ].
VAR_026839
Natural varianti320 – 3201A → S.1 Publication
Corresponds to variant rs284859 [ dbSNP | Ensembl ].
VAR_026840

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 88MPFLLGLR → MERRRLLGGMALLLLQALPS PLSARAEPP in isoform 2.
VSP_041670

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 901Y → H in AAI13858. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY656171 mRNA. Translation: AAV68559.1.
AK000374 mRNA. Translation: BAA91122.1. Different initiation.
AK316452 mRNA. Translation: BAH14823.1.
AK056285 mRNA. Translation: BAG51666.1.
AK300871 mRNA. Translation: BAH13363.1.
AL358790 Genomic DNA. Translation: CAI52496.1.
CH471066 Genomic DNA. Translation: EAW49673.1.
CH471066 Genomic DNA. Translation: EAW49674.1.
BC113857 mRNA. Translation: AAI13858.1.
BC114465 mRNA. Translation: AAI14466.1.
CCDSiCCDS44473.1. [Q9NX94-2]
CCDS7540.1. [Q9NX94-1]
RefSeqiNP_001077382.1. NM_001083913.1. [Q9NX94-2]
NP_060257.4. NM_017787.4. [Q9NX94-1]
UniGeneiHs.500897.
Hs.693257.
Hs.707763.

Genome annotation databases

EnsembliENST00000369889; ENSP00000358905; ENSG00000166272. [Q9NX94-1]
ENST00000448841; ENSP00000414721; ENSG00000166272. [Q9NX94-2]
GeneIDi54838.
KEGGihsa:54838.
UCSCiuc001kwe.4. human. [Q9NX94-1]
uc001kwf.4. human. [Q9NX94-2]

Polymorphism databases

DMDMi109820639.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY656171 mRNA. Translation: AAV68559.1 .
AK000374 mRNA. Translation: BAA91122.1 . Different initiation.
AK316452 mRNA. Translation: BAH14823.1 .
AK056285 mRNA. Translation: BAG51666.1 .
AK300871 mRNA. Translation: BAH13363.1 .
AL358790 Genomic DNA. Translation: CAI52496.1 .
CH471066 Genomic DNA. Translation: EAW49673.1 .
CH471066 Genomic DNA. Translation: EAW49674.1 .
BC113857 mRNA. Translation: AAI13858.1 .
BC114465 mRNA. Translation: AAI14466.1 .
CCDSi CCDS44473.1. [Q9NX94-2 ]
CCDS7540.1. [Q9NX94-1 ]
RefSeqi NP_001077382.1. NM_001083913.1. [Q9NX94-2 ]
NP_060257.4. NM_017787.4. [Q9NX94-1 ]
UniGenei Hs.500897.
Hs.693257.
Hs.707763.

3D structure databases

ProteinModelPortali Q9NX94.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120189. 2 interactions.
STRINGi 9606.ENSP00000414721.

PTM databases

PhosphoSitei Q9NX94.

Polymorphism databases

DMDMi 109820639.

Proteomic databases

PaxDbi Q9NX94.
PRIDEi Q9NX94.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369889 ; ENSP00000358905 ; ENSG00000166272 . [Q9NX94-1 ]
ENST00000448841 ; ENSP00000414721 ; ENSG00000166272 . [Q9NX94-2 ]
GeneIDi 54838.
KEGGi hsa:54838.
UCSCi uc001kwe.4. human. [Q9NX94-1 ]
uc001kwf.4. human. [Q9NX94-2 ]

Organism-specific databases

CTDi 54838.
GeneCardsi GC10P104504.
HGNCi HGNC:23510. WBP1L.
HPAi HPA037635.
HPA038371.
MIMi 611129. gene.
neXtProti NX_Q9NX94.
PharmGKBi PA128394674.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47171.
HOVERGENi HBG106189.
InParanoidi Q9NX94.
OMAi DKETCVG.
OrthoDBi EOG7WMCJZ.
PhylomeDBi Q9NX94.
TreeFami TF330726.

Miscellaneous databases

GeneWikii C10orf26.
GenomeRNAii 54838.
NextBioi 57634.
PROi Q9NX94.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NX94.
Bgeei Q9NX94.
CleanExi HS_C10orf26.
Genevestigatori Q9NX94.

Family and domain databases

InterProi IPR021684. Uncharacterised_WW-bd.
[Graphical view ]
Pfami PF11669. WBP-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene expression profiling reveals novel genes for improved risk classification and outcome prediction in pediatric acute lymphoblastic leukemia: identification, validation, and cloning of OPAL1."
    Helman P., Veroff R.L., Shuster J., Kang H., Mosquera-Caro M.P., Potter J.W., Harvey R.C., Martin S.B., Davidson G.S., Andries E., Atlas S.W., Chen I.-M., Wilson C.S., Ar K., Xu Y., Murphy M., Schultz F.A., Bedrick E.
    , Carroll A.J., Camitta B., Willman C.L.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: B-cell lymphoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS PRO-302 AND SER-320.
    Tissue: Hepatoma.
  3. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Small intestine.
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiWBP1L_HUMAN
AccessioniPrimary (citable) accession number: Q9NX94
Secondary accession number(s): B3KPF4
, B7Z6S7, D3DR90, Q1EG70, Q2HIY7, Q5F2G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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