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Q9NX94

- WBP1L_HUMAN

UniProt

Q9NX94 - WBP1L_HUMAN

Protein

WW domain binding protein 1-like

Gene

WBP1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (27 Jun 2006)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WW domain binding protein 1-like
    Alternative name(s):
    Outcome predictor in acute leukemia 1
    Gene namesi
    Name:WBP1L
    Synonyms:C10orf26, OPA1L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23510. WBP1L.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394674.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342WW domain binding protein 1-likePRO_0000241450Add
    BLAST

    Proteomic databases

    PaxDbiQ9NX94.
    PRIDEiQ9NX94.

    PTM databases

    PhosphoSiteiQ9NX94.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NX94.
    BgeeiQ9NX94.
    CleanExiHS_C10orf26.
    GenevestigatoriQ9NX94.

    Organism-specific databases

    HPAiHPA037635.
    HPA038371.

    Interactioni

    Protein-protein interaction databases

    BioGridi120189. 2 interactions.
    STRINGi9606.ENSP00000414721.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NX94.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi101 – 18383Pro-richAdd
    BLAST
    Compositional biasi335 – 3428Poly-Ser

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47171.
    HOVERGENiHBG106189.
    InParanoidiQ9NX94.
    OMAiDKETCVG.
    OrthoDBiEOG7WMCJZ.
    PhylomeDBiQ9NX94.
    TreeFamiTF330726.

    Family and domain databases

    InterProiIPR021684. Uncharacterised_WW-bd.
    [Graphical view]
    PfamiPF11669. WBP-1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NX94-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPFLLGLRQD KEACVGTNNQ SYICDTGHCC GQSQCCNYYY ELWWFWLVWT    50
    IIIILSCCCV CHHRRAKHRL QAQQRQHEIN LIAYREAHNY SALPFYFRFL 100
    PNYLLPPYEE VVNRPPTPPP PYSAFQLQQQ QLLPPQCGPA GGSPPGIDPT 150
    RGSQGAQSSP LSEPSRSSTR PPSIADPDPS DLPVDRAATK APGMEPSGSV 200
    AGLGELDPGA FLDKDAECRE ELLKDDSSEH GAPDSKEKTP GRHRRFTGDS 250
    GIEVCVCNRG HHDDDLKEFN TLIDDALDGP LDFCDSCHVR PPGDEEEGLC 300
    QSSEEQAREP GHPHLPRPPA CLLLNTINEQ DSPNSQSSSS PS 342
    Length:342
    Mass (Da):37,828
    Last modified:June 27, 2006 - v2
    Checksum:iB8D73B065A2A222B
    GO
    Isoform 2 (identifier: Q9NX94-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-8: MPFLLGLR → MERRRLLGGMALLLLQALPSPLSARAEPP

    Show »
    Length:363
    Mass (Da):40,040
    Checksum:i79F4968D538645F7
    GO

    Sequence cautioni

    The sequence BAA91122.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti90 – 901Y → H in AAI13858. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti302 – 3021S → P.1 Publication
    Corresponds to variant rs284860 [ dbSNP | Ensembl ].
    VAR_026839
    Natural varianti320 – 3201A → S.1 Publication
    Corresponds to variant rs284859 [ dbSNP | Ensembl ].
    VAR_026840

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 88MPFLLGLR → MERRRLLGGMALLLLQALPS PLSARAEPP in isoform 2. 1 PublicationVSP_041670

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY656171 mRNA. Translation: AAV68559.1.
    AK000374 mRNA. Translation: BAA91122.1. Different initiation.
    AK316452 mRNA. Translation: BAH14823.1.
    AK056285 mRNA. Translation: BAG51666.1.
    AK300871 mRNA. Translation: BAH13363.1.
    AL358790 Genomic DNA. Translation: CAI52496.1.
    CH471066 Genomic DNA. Translation: EAW49673.1.
    CH471066 Genomic DNA. Translation: EAW49674.1.
    BC113857 mRNA. Translation: AAI13858.1.
    BC114465 mRNA. Translation: AAI14466.1.
    CCDSiCCDS44473.1. [Q9NX94-2]
    CCDS7540.1. [Q9NX94-1]
    RefSeqiNP_001077382.1. NM_001083913.1. [Q9NX94-2]
    NP_060257.4. NM_017787.4. [Q9NX94-1]
    UniGeneiHs.500897.
    Hs.693257.
    Hs.707763.

    Genome annotation databases

    EnsembliENST00000369889; ENSP00000358905; ENSG00000166272. [Q9NX94-1]
    ENST00000448841; ENSP00000414721; ENSG00000166272. [Q9NX94-2]
    GeneIDi54838.
    KEGGihsa:54838.
    UCSCiuc001kwe.4. human. [Q9NX94-1]
    uc001kwf.4. human. [Q9NX94-2]

    Polymorphism databases

    DMDMi109820639.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY656171 mRNA. Translation: AAV68559.1 .
    AK000374 mRNA. Translation: BAA91122.1 . Different initiation.
    AK316452 mRNA. Translation: BAH14823.1 .
    AK056285 mRNA. Translation: BAG51666.1 .
    AK300871 mRNA. Translation: BAH13363.1 .
    AL358790 Genomic DNA. Translation: CAI52496.1 .
    CH471066 Genomic DNA. Translation: EAW49673.1 .
    CH471066 Genomic DNA. Translation: EAW49674.1 .
    BC113857 mRNA. Translation: AAI13858.1 .
    BC114465 mRNA. Translation: AAI14466.1 .
    CCDSi CCDS44473.1. [Q9NX94-2 ]
    CCDS7540.1. [Q9NX94-1 ]
    RefSeqi NP_001077382.1. NM_001083913.1. [Q9NX94-2 ]
    NP_060257.4. NM_017787.4. [Q9NX94-1 ]
    UniGenei Hs.500897.
    Hs.693257.
    Hs.707763.

    3D structure databases

    ProteinModelPortali Q9NX94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120189. 2 interactions.
    STRINGi 9606.ENSP00000414721.

    PTM databases

    PhosphoSitei Q9NX94.

    Polymorphism databases

    DMDMi 109820639.

    Proteomic databases

    PaxDbi Q9NX94.
    PRIDEi Q9NX94.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369889 ; ENSP00000358905 ; ENSG00000166272 . [Q9NX94-1 ]
    ENST00000448841 ; ENSP00000414721 ; ENSG00000166272 . [Q9NX94-2 ]
    GeneIDi 54838.
    KEGGi hsa:54838.
    UCSCi uc001kwe.4. human. [Q9NX94-1 ]
    uc001kwf.4. human. [Q9NX94-2 ]

    Organism-specific databases

    CTDi 54838.
    GeneCardsi GC10P104504.
    HGNCi HGNC:23510. WBP1L.
    HPAi HPA037635.
    HPA038371.
    MIMi 611129. gene.
    neXtProti NX_Q9NX94.
    PharmGKBi PA128394674.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47171.
    HOVERGENi HBG106189.
    InParanoidi Q9NX94.
    OMAi DKETCVG.
    OrthoDBi EOG7WMCJZ.
    PhylomeDBi Q9NX94.
    TreeFami TF330726.

    Miscellaneous databases

    GeneWikii C10orf26.
    GenomeRNAii 54838.
    NextBioi 57634.
    PROi Q9NX94.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NX94.
    Bgeei Q9NX94.
    CleanExi HS_C10orf26.
    Genevestigatori Q9NX94.

    Family and domain databases

    InterProi IPR021684. Uncharacterised_WW-bd.
    [Graphical view ]
    Pfami PF11669. WBP-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene expression profiling reveals novel genes for improved risk classification and outcome prediction in pediatric acute lymphoblastic leukemia: identification, validation, and cloning of OPAL1."
      Helman P., Veroff R.L., Shuster J., Kang H., Mosquera-Caro M.P., Potter J.W., Harvey R.C., Martin S.B., Davidson G.S., Andries E., Atlas S.W., Chen I.-M., Wilson C.S., Ar K., Xu Y., Murphy M., Schultz F.A., Bedrick E.
      , Carroll A.J., Camitta B., Willman C.L.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: B-cell lymphoma.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS PRO-302 AND SER-320.
      Tissue: Hepatoma.
    3. "NEDO human cDNA sequencing project focused on splicing variants."
      Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
      , Sugano S., Nomura N., Isogai T.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Small intestine.
    4. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

    Entry informationi

    Entry nameiWBP1L_HUMAN
    AccessioniPrimary (citable) accession number: Q9NX94
    Secondary accession number(s): B3KPF4
    , B7Z6S7, D3DR90, Q1EG70, Q2HIY7, Q5F2G6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3