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Q9NX78

- TM260_HUMAN

UniProt

Q9NX78 - TM260_HUMAN

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Protein

Transmembrane protein 260

Gene

TMEM260

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 260
Gene namesi
Name:TMEM260
Synonyms:C14orf101
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20185. TMEM260.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821HelicalSequence AnalysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence AnalysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence AnalysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence AnalysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence AnalysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence AnalysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence AnalysisAdd
BLAST
Transmembranei356 – 37621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134894829.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707Transmembrane protein 260PRO_0000089905Add
BLAST

Proteomic databases

MaxQBiQ9NX78.
PaxDbiQ9NX78.
PRIDEiQ9NX78.

PTM databases

PhosphoSiteiQ9NX78.

Expressioni

Gene expression databases

BgeeiQ9NX78.
CleanExiHS_C14orf101.
ExpressionAtlasiQ9NX78. baseline and differential.
GenevestigatoriQ9NX78.

Organism-specific databases

HPAiHPA003502.

Interactioni

Protein-protein interaction databases

BioGridi120258. 7 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9NX78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM260 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26635.
GeneTreeiENSGT00390000013544.
HOGENOMiHOG000031293.
HOVERGENiHBG051017.
InParanoidiQ9NX78.
OMAiLWPWGSC.
OrthoDBiEOG7V1FQ0.
PhylomeDBiQ9NX78.
TreeFamiTF329604.

Family and domain databases

InterProiIPR021280. DUF2723.
[Graphical view]
PfamiPF11028. DUF2723. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NX78-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPHGDGRGQ AQGRAVRVGL RRSGGIRGGV AVFAAVAAVF TFTLPPSVPG
60 70 80 90 100
GDSGELITAA HELGVAHPPG YPLFTLVAKL AITLFPFGSI AYRVNLLCGL
110 120 130 140 150
FGAVAASLLF FTVFRLSGSS AGGILAAGVF SFSRLTWQWS IAAEVFSLNN
160 170 180 190 200
LFVGLLMALT VHFEEAATAK ERSKVAKIGA FCCGLSLCNQ HTIILYVLCI
210 220 230 240 250
IPWILFQLLK KKELSLGSLL KLSLYFSAGL LPYVHLPISS YLNHARWTWG
260 270 280 290 300
DQTTLQGFLT HFLREEYGTF SLAKSEIGSS MSEILLSQVT NMRTELSFNI
310 320 330 340 350
QALAVCANIC LATKDRQNPS LVWLFTGMFC IYSLFFAWRA NLDISKPLFM
360 370 380 390 400
GVVERFWMQS NAVVAVLAGI GLAAVVSETN RVLNSNGLQC LEWLSATLFV
410 420 430 440 450
VYQIYSNYSV CDQRTNYVID KFAKNLLTSM PHDAIILLRG DLPGNSLRYM
460 470 480 490 500
HYCEGLRPDI SLVDQEMMTY EWYLPKMAKH LPGVNFPGNR WNPVEGILPS
510 520 530 540 550
GMVTFNLYHF LEVNKQKETF VCIGIHEGDP TWKKNYSLWP WGSCDKLVPL
560 570 580 590 600
EIVFNPEEWI KLTKSIYNWT EEYGRFDPSS WESVANEEMW QARMKTPFFI
610 620 630 640 650
FNLAETAHMP SKVKAQLYAQ AYDLYKEIVY LQKEHPVNWH KNYAIACERM
660 670 680 690 700
LRLQARDADP EVLLSETIRH FRLYSQKAPN DPQQADILGA LKHLRKELQS

LRNRKNV
Length:707
Mass (Da):79,536
Last modified:May 18, 2010 - v3
Checksum:iF3EAB7ED42B77489
GO
Isoform 2 (identifier: Q9NX78-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-707: Missing.

Note: No experimental confirmation available.

Show »
Length:286
Mass (Da):30,702
Checksum:iC8F4DC3BB7A8F640
GO

Sequence cautioni

The sequence BAA91139.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BC045556 differs from that shown. Reason: Frameshift at position 212. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31P → H in BC045556. (PubMed:15489334)Curated
Sequence conflicti57 – 571I → T in BAF85788. (PubMed:14702039)Curated
Sequence conflicti335 – 3351F → V in BAA91139. (PubMed:14702039)Curated
Sequence conflicti680 – 6801N → S in BAF85788. (PubMed:14702039)Curated
Sequence conflicti680 – 6801N → S in BAG51667. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti245 – 2451A → S.1 Publication
Corresponds to variant rs17776256 [ dbSNP | Ensembl ].
VAR_057823
Natural varianti565 – 5651S → N.
Corresponds to variant rs1041316 [ dbSNP | Ensembl ].
VAR_057824

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei287 – 707421Missing in isoform 2. 1 PublicationVSP_008621Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000399 mRNA. Translation: BAA91139.1. Different initiation.
AK293099 mRNA. Translation: BAF85788.1.
AK056291 mRNA. Translation: BAG51667.1.
AL161757 Genomic DNA. No translation available.
AL355103 Genomic DNA. No translation available.
BC045556 mRNA. No translation available.
CCDSiCCDS9727.2. [Q9NX78-1]
RefSeqiNP_060269.3. NM_017799.3. [Q9NX78-1]
UniGeneiHs.497253.

Genome annotation databases

EnsembliENST00000261556; ENSP00000261556; ENSG00000070269. [Q9NX78-1]
GeneIDi54916.
KEGGihsa:54916.
UCSCiuc001xck.3. human. [Q9NX78-2]
uc001xcm.3. human. [Q9NX78-1]

Polymorphism databases

DMDMi296439393.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000399 mRNA. Translation: BAA91139.1 . Different initiation.
AK293099 mRNA. Translation: BAF85788.1 .
AK056291 mRNA. Translation: BAG51667.1 .
AL161757 Genomic DNA. No translation available.
AL355103 Genomic DNA. No translation available.
BC045556 mRNA. No translation available.
CCDSi CCDS9727.2. [Q9NX78-1 ]
RefSeqi NP_060269.3. NM_017799.3. [Q9NX78-1 ]
UniGenei Hs.497253.

3D structure databases

ProteinModelPortali Q9NX78.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120258. 7 interactions.

PTM databases

PhosphoSitei Q9NX78.

Polymorphism databases

DMDMi 296439393.

Proteomic databases

MaxQBi Q9NX78.
PaxDbi Q9NX78.
PRIDEi Q9NX78.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261556 ; ENSP00000261556 ; ENSG00000070269 . [Q9NX78-1 ]
GeneIDi 54916.
KEGGi hsa:54916.
UCSCi uc001xck.3. human. [Q9NX78-2 ]
uc001xcm.3. human. [Q9NX78-1 ]

Organism-specific databases

CTDi 54916.
GeneCardsi GC14P056956.
H-InvDB HIX0011691.
HGNCi HGNC:20185. TMEM260.
HPAi HPA003502.
neXtProti NX_Q9NX78.
PharmGKBi PA134894829.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26635.
GeneTreei ENSGT00390000013544.
HOGENOMi HOG000031293.
HOVERGENi HBG051017.
InParanoidi Q9NX78.
OMAi LWPWGSC.
OrthoDBi EOG7V1FQ0.
PhylomeDBi Q9NX78.
TreeFami TF329604.

Miscellaneous databases

ChiTaRSi TMEM260. human.
GenomeRNAii 54916.
NextBioi 57978.

Gene expression databases

Bgeei Q9NX78.
CleanExi HS_C14orf101.
ExpressionAtlasi Q9NX78. baseline and differential.
Genevestigatori Q9NX78.

Family and domain databases

InterProi IPR021280. DUF2723.
[Graphical view ]
Pfami PF11028. DUF2723. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ileal mucosa and Uterus.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-245.
    Tissue: Brain.

Entry informationi

Entry nameiTM260_HUMAN
AccessioniPrimary (citable) accession number: Q9NX78
Secondary accession number(s): A8KAN4, B3KPF5, Q86XE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3