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Q9NX78

- TM260_HUMAN

UniProt

Q9NX78 - TM260_HUMAN

Protein

Transmembrane protein 260

Gene

TMEM260

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 260
    Gene namesi
    Name:TMEM260
    Synonyms:C14orf101
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20185. TMEM260.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134894829.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 707707Transmembrane protein 260PRO_0000089905Add
    BLAST

    Proteomic databases

    MaxQBiQ9NX78.
    PaxDbiQ9NX78.
    PRIDEiQ9NX78.

    PTM databases

    PhosphoSiteiQ9NX78.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NX78.
    BgeeiQ9NX78.
    CleanExiHS_C14orf101.
    GenevestigatoriQ9NX78.

    Organism-specific databases

    HPAiHPA003502.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NX78.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei318 – 33821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei356 – 37621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM260 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26635.
    HOGENOMiHOG000031293.
    HOVERGENiHBG051017.
    InParanoidiQ9NX78.
    OMAiLWPWGSC.
    OrthoDBiEOG7V1FQ0.
    PhylomeDBiQ9NX78.
    TreeFamiTF329604.

    Family and domain databases

    InterProiIPR021280. DUF2723.
    [Graphical view]
    PfamiPF11028. DUF2723. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NX78-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSPHGDGRGQ AQGRAVRVGL RRSGGIRGGV AVFAAVAAVF TFTLPPSVPG    50
    GDSGELITAA HELGVAHPPG YPLFTLVAKL AITLFPFGSI AYRVNLLCGL 100
    FGAVAASLLF FTVFRLSGSS AGGILAAGVF SFSRLTWQWS IAAEVFSLNN 150
    LFVGLLMALT VHFEEAATAK ERSKVAKIGA FCCGLSLCNQ HTIILYVLCI 200
    IPWILFQLLK KKELSLGSLL KLSLYFSAGL LPYVHLPISS YLNHARWTWG 250
    DQTTLQGFLT HFLREEYGTF SLAKSEIGSS MSEILLSQVT NMRTELSFNI 300
    QALAVCANIC LATKDRQNPS LVWLFTGMFC IYSLFFAWRA NLDISKPLFM 350
    GVVERFWMQS NAVVAVLAGI GLAAVVSETN RVLNSNGLQC LEWLSATLFV 400
    VYQIYSNYSV CDQRTNYVID KFAKNLLTSM PHDAIILLRG DLPGNSLRYM 450
    HYCEGLRPDI SLVDQEMMTY EWYLPKMAKH LPGVNFPGNR WNPVEGILPS 500
    GMVTFNLYHF LEVNKQKETF VCIGIHEGDP TWKKNYSLWP WGSCDKLVPL 550
    EIVFNPEEWI KLTKSIYNWT EEYGRFDPSS WESVANEEMW QARMKTPFFI 600
    FNLAETAHMP SKVKAQLYAQ AYDLYKEIVY LQKEHPVNWH KNYAIACERM 650
    LRLQARDADP EVLLSETIRH FRLYSQKAPN DPQQADILGA LKHLRKELQS 700
    LRNRKNV 707
    Length:707
    Mass (Da):79,536
    Last modified:May 18, 2010 - v3
    Checksum:iF3EAB7ED42B77489
    GO
    Isoform 2 (identifier: Q9NX78-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         287-707: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:286
    Mass (Da):30,702
    Checksum:iC8F4DC3BB7A8F640
    GO

    Sequence cautioni

    The sequence BC045556 differs from that shown. Reason: Frameshift at position 212.
    The sequence BAA91139.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31P → H in BC045556. (PubMed:15489334)Curated
    Sequence conflicti57 – 571I → T in BAF85788. (PubMed:14702039)Curated
    Sequence conflicti335 – 3351F → V in BAA91139. (PubMed:14702039)Curated
    Sequence conflicti680 – 6801N → S in BAF85788. (PubMed:14702039)Curated
    Sequence conflicti680 – 6801N → S in BAG51667. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti245 – 2451A → S.1 Publication
    Corresponds to variant rs17776256 [ dbSNP | Ensembl ].
    VAR_057823
    Natural varianti565 – 5651S → N.
    Corresponds to variant rs1041316 [ dbSNP | Ensembl ].
    VAR_057824

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei287 – 707421Missing in isoform 2. 1 PublicationVSP_008621Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000399 mRNA. Translation: BAA91139.1. Different initiation.
    AK293099 mRNA. Translation: BAF85788.1.
    AK056291 mRNA. Translation: BAG51667.1.
    AL161757 Genomic DNA. No translation available.
    AL355103 Genomic DNA. No translation available.
    BC045556 mRNA. No translation available.
    CCDSiCCDS9727.2. [Q9NX78-1]
    RefSeqiNP_060269.3. NM_017799.3. [Q9NX78-1]
    UniGeneiHs.497253.

    Genome annotation databases

    EnsembliENST00000261556; ENSP00000261556; ENSG00000070269. [Q9NX78-1]
    GeneIDi54916.
    KEGGihsa:54916.
    UCSCiuc001xck.3. human. [Q9NX78-2]
    uc001xcm.3. human. [Q9NX78-1]

    Polymorphism databases

    DMDMi296439393.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000399 mRNA. Translation: BAA91139.1 . Different initiation.
    AK293099 mRNA. Translation: BAF85788.1 .
    AK056291 mRNA. Translation: BAG51667.1 .
    AL161757 Genomic DNA. No translation available.
    AL355103 Genomic DNA. No translation available.
    BC045556 mRNA. No translation available.
    CCDSi CCDS9727.2. [Q9NX78-1 ]
    RefSeqi NP_060269.3. NM_017799.3. [Q9NX78-1 ]
    UniGenei Hs.497253.

    3D structure databases

    ProteinModelPortali Q9NX78.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9NX78.

    Polymorphism databases

    DMDMi 296439393.

    Proteomic databases

    MaxQBi Q9NX78.
    PaxDbi Q9NX78.
    PRIDEi Q9NX78.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261556 ; ENSP00000261556 ; ENSG00000070269 . [Q9NX78-1 ]
    GeneIDi 54916.
    KEGGi hsa:54916.
    UCSCi uc001xck.3. human. [Q9NX78-2 ]
    uc001xcm.3. human. [Q9NX78-1 ]

    Organism-specific databases

    CTDi 54916.
    GeneCardsi GC14P056956.
    H-InvDB HIX0011691.
    HGNCi HGNC:20185. TMEM260.
    HPAi HPA003502.
    neXtProti NX_Q9NX78.
    PharmGKBi PA134894829.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG26635.
    HOGENOMi HOG000031293.
    HOVERGENi HBG051017.
    InParanoidi Q9NX78.
    OMAi LWPWGSC.
    OrthoDBi EOG7V1FQ0.
    PhylomeDBi Q9NX78.
    TreeFami TF329604.

    Miscellaneous databases

    GenomeRNAii 54916.
    NextBioi 57978.

    Gene expression databases

    ArrayExpressi Q9NX78.
    Bgeei Q9NX78.
    CleanExi HS_C14orf101.
    Genevestigatori Q9NX78.

    Family and domain databases

    InterProi IPR021280. DUF2723.
    [Graphical view ]
    Pfami PF11028. DUF2723. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Ileal mucosa and Uterus.
    2. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-245.
      Tissue: Brain.

    Entry informationi

    Entry nameiTM260_HUMAN
    AccessioniPrimary (citable) accession number: Q9NX78
    Secondary accession number(s): A8KAN4, B3KPF5, Q86XE1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 24, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 91 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3