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Q9NX78 (TM260_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 260
Gene names
Name:TMEM260
Synonyms:C14orf101
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length707 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMEM260 family.

Sequence caution

The sequence BAA91139.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BC045556 differs from that shown. Reason: Frameshift at position 212.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NX78-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NX78-2)

The sequence of this isoform differs from the canonical sequence as follows:
     287-707: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 707707Transmembrane protein 260
PRO_0000089905

Regions

Transmembrane28 – 4821Helical; Potential
Transmembrane71 – 9121Helical; Potential
Transmembrane94 – 11421Helical; Potential
Transmembrane141 – 16121Helical; Potential
Transmembrane189 – 20921Helical; Potential
Transmembrane222 – 24221Helical; Potential
Transmembrane318 – 33821Helical; Potential
Transmembrane356 – 37621Helical; Potential

Natural variations

Alternative sequence287 – 707421Missing in isoform 2.
VSP_008621
Natural variant2451A → S. Ref.3
Corresponds to variant rs17776256 [ dbSNP | Ensembl ].
VAR_057823
Natural variant5651S → N.
Corresponds to variant rs1041316 [ dbSNP | Ensembl ].
VAR_057824

Experimental info

Sequence conflict31P → H in BC045556. Ref.3
Sequence conflict571I → T in BAF85788. Ref.1
Sequence conflict3351F → V in BAA91139. Ref.1
Sequence conflict6801N → S in BAF85788. Ref.1
Sequence conflict6801N → S in BAG51667. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: F3EAB7ED42B77489

FASTA70779,536
        10         20         30         40         50         60 
MSPHGDGRGQ AQGRAVRVGL RRSGGIRGGV AVFAAVAAVF TFTLPPSVPG GDSGELITAA 

        70         80         90        100        110        120 
HELGVAHPPG YPLFTLVAKL AITLFPFGSI AYRVNLLCGL FGAVAASLLF FTVFRLSGSS 

       130        140        150        160        170        180 
AGGILAAGVF SFSRLTWQWS IAAEVFSLNN LFVGLLMALT VHFEEAATAK ERSKVAKIGA 

       190        200        210        220        230        240 
FCCGLSLCNQ HTIILYVLCI IPWILFQLLK KKELSLGSLL KLSLYFSAGL LPYVHLPISS 

       250        260        270        280        290        300 
YLNHARWTWG DQTTLQGFLT HFLREEYGTF SLAKSEIGSS MSEILLSQVT NMRTELSFNI 

       310        320        330        340        350        360 
QALAVCANIC LATKDRQNPS LVWLFTGMFC IYSLFFAWRA NLDISKPLFM GVVERFWMQS 

       370        380        390        400        410        420 
NAVVAVLAGI GLAAVVSETN RVLNSNGLQC LEWLSATLFV VYQIYSNYSV CDQRTNYVID 

       430        440        450        460        470        480 
KFAKNLLTSM PHDAIILLRG DLPGNSLRYM HYCEGLRPDI SLVDQEMMTY EWYLPKMAKH 

       490        500        510        520        530        540 
LPGVNFPGNR WNPVEGILPS GMVTFNLYHF LEVNKQKETF VCIGIHEGDP TWKKNYSLWP 

       550        560        570        580        590        600 
WGSCDKLVPL EIVFNPEEWI KLTKSIYNWT EEYGRFDPSS WESVANEEMW QARMKTPFFI 

       610        620        630        640        650        660 
FNLAETAHMP SKVKAQLYAQ AYDLYKEIVY LQKEHPVNWH KNYAIACERM LRLQARDADP 

       670        680        690        700 
EVLLSETIRH FRLYSQKAPN DPQQADILGA LKHLRKELQS LRNRKNV 

« Hide

Isoform 2 [UniParc].

Checksum: C8F4DC3BB7A8F640
Show »

FASTA28630,702

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Ileal mucosa and Uterus.
[2]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-245.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK000399 mRNA. Translation: BAA91139.1. Different initiation.
AK293099 mRNA. Translation: BAF85788.1.
AK056291 mRNA. Translation: BAG51667.1.
AL161757 Genomic DNA. No translation available.
AL355103 Genomic DNA. No translation available.
BC045556 mRNA. No translation available.
RefSeqNP_060269.3. NM_017799.3.
UniGeneHs.497253.

3D structure databases

ProteinModelPortalQ9NX78.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9NX78.

Polymorphism databases

DMDM296439393.

Proteomic databases

PaxDbQ9NX78.
PRIDEQ9NX78.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261556; ENSP00000261556; ENSG00000070269. [Q9NX78-1]
GeneID54916.
KEGGhsa:54916.
UCSCuc001xck.3. human. [Q9NX78-2]
uc001xcm.3. human. [Q9NX78-1]

Organism-specific databases

CTD54916.
GeneCardsGC14P056956.
H-InvDBHIX0011691.
HGNCHGNC:20185. TMEM260.
HPAHPA003502.
neXtProtNX_Q9NX78.
PharmGKBPA134894829.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG26635.
HOGENOMHOG000031293.
HOVERGENHBG051017.
InParanoidQ9NX78.
OMADQEMMTY.
OrthoDBEOG7V1FQ0.
PhylomeDBQ9NX78.
TreeFamTF329604.

Gene expression databases

ArrayExpressQ9NX78.
BgeeQ9NX78.
CleanExHS_C14orf101.
GenevestigatorQ9NX78.

Family and domain databases

InterProIPR021280. DUF2723.
[Graphical view]
PfamPF11028. DUF2723. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi54916.
NextBio57978.

Entry information

Entry nameTM260_HUMAN
AccessionPrimary (citable) accession number: Q9NX78
Secondary accession number(s): A8KAN4, B3KPF5, Q86XE1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 18, 2010
Last modified: March 19, 2014
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM