SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9NX78

- TM260_HUMAN

UniProt

Q9NX78 - TM260_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Transmembrane protein 260

Gene
TMEM260, C14orf101
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 260
Gene namesi
Name:TMEM260
Synonyms:C14orf101
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20185. TMEM260.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821Helical; Reviewed predictionAdd
BLAST
Transmembranei71 – 9121Helical; Reviewed predictionAdd
BLAST
Transmembranei94 – 11421Helical; Reviewed predictionAdd
BLAST
Transmembranei141 – 16121Helical; Reviewed predictionAdd
BLAST
Transmembranei189 – 20921Helical; Reviewed predictionAdd
BLAST
Transmembranei222 – 24221Helical; Reviewed predictionAdd
BLAST
Transmembranei318 – 33821Helical; Reviewed predictionAdd
BLAST
Transmembranei356 – 37621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134894829.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707Transmembrane protein 260PRO_0000089905Add
BLAST

Proteomic databases

MaxQBiQ9NX78.
PaxDbiQ9NX78.
PRIDEiQ9NX78.

PTM databases

PhosphoSiteiQ9NX78.

Expressioni

Gene expression databases

ArrayExpressiQ9NX78.
BgeeiQ9NX78.
CleanExiHS_C14orf101.
GenevestigatoriQ9NX78.

Organism-specific databases

HPAiHPA003502.

Structurei

3D structure databases

ProteinModelPortaliQ9NX78.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM260 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26635.
HOGENOMiHOG000031293.
HOVERGENiHBG051017.
InParanoidiQ9NX78.
OMAiLWPWGSC.
OrthoDBiEOG7V1FQ0.
PhylomeDBiQ9NX78.
TreeFamiTF329604.

Family and domain databases

InterProiIPR021280. DUF2723.
[Graphical view]
PfamiPF11028. DUF2723. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NX78-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSPHGDGRGQ AQGRAVRVGL RRSGGIRGGV AVFAAVAAVF TFTLPPSVPG    50
GDSGELITAA HELGVAHPPG YPLFTLVAKL AITLFPFGSI AYRVNLLCGL 100
FGAVAASLLF FTVFRLSGSS AGGILAAGVF SFSRLTWQWS IAAEVFSLNN 150
LFVGLLMALT VHFEEAATAK ERSKVAKIGA FCCGLSLCNQ HTIILYVLCI 200
IPWILFQLLK KKELSLGSLL KLSLYFSAGL LPYVHLPISS YLNHARWTWG 250
DQTTLQGFLT HFLREEYGTF SLAKSEIGSS MSEILLSQVT NMRTELSFNI 300
QALAVCANIC LATKDRQNPS LVWLFTGMFC IYSLFFAWRA NLDISKPLFM 350
GVVERFWMQS NAVVAVLAGI GLAAVVSETN RVLNSNGLQC LEWLSATLFV 400
VYQIYSNYSV CDQRTNYVID KFAKNLLTSM PHDAIILLRG DLPGNSLRYM 450
HYCEGLRPDI SLVDQEMMTY EWYLPKMAKH LPGVNFPGNR WNPVEGILPS 500
GMVTFNLYHF LEVNKQKETF VCIGIHEGDP TWKKNYSLWP WGSCDKLVPL 550
EIVFNPEEWI KLTKSIYNWT EEYGRFDPSS WESVANEEMW QARMKTPFFI 600
FNLAETAHMP SKVKAQLYAQ AYDLYKEIVY LQKEHPVNWH KNYAIACERM 650
LRLQARDADP EVLLSETIRH FRLYSQKAPN DPQQADILGA LKHLRKELQS 700
LRNRKNV 707
Length:707
Mass (Da):79,536
Last modified:May 18, 2010 - v3
Checksum:iF3EAB7ED42B77489
GO
Isoform 2 (identifier: Q9NX78-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-707: Missing.

Note: No experimental confirmation available.

Show »
Length:286
Mass (Da):30,702
Checksum:iC8F4DC3BB7A8F640
GO

Sequence cautioni

The sequence BC045556 differs from that shown. Reason: Frameshift at position 212.
The sequence BAA91139.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti245 – 2451A → S.1 Publication
Corresponds to variant rs17776256 [ dbSNP | Ensembl ].
VAR_057823
Natural varianti565 – 5651S → N.
Corresponds to variant rs1041316 [ dbSNP | Ensembl ].
VAR_057824

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei287 – 707421Missing in isoform 2. VSP_008621Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31P → H in BC045556. 1 Publication
Sequence conflicti57 – 571I → T in BAF85788. 1 Publication
Sequence conflicti335 – 3351F → V in BAA91139. 1 Publication
Sequence conflicti680 – 6801N → S in BAF85788. 1 Publication
Sequence conflicti680 – 6801N → S in BAG51667. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000399 mRNA. Translation: BAA91139.1. Different initiation.
AK293099 mRNA. Translation: BAF85788.1.
AK056291 mRNA. Translation: BAG51667.1.
AL161757 Genomic DNA. No translation available.
AL355103 Genomic DNA. No translation available.
BC045556 mRNA. No translation available.
CCDSiCCDS9727.2. [Q9NX78-1]
RefSeqiNP_060269.3. NM_017799.3. [Q9NX78-1]
UniGeneiHs.497253.

Genome annotation databases

EnsembliENST00000261556; ENSP00000261556; ENSG00000070269. [Q9NX78-1]
GeneIDi54916.
KEGGihsa:54916.
UCSCiuc001xck.3. human. [Q9NX78-2]
uc001xcm.3. human. [Q9NX78-1]

Polymorphism databases

DMDMi296439393.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000399 mRNA. Translation: BAA91139.1 . Different initiation.
AK293099 mRNA. Translation: BAF85788.1 .
AK056291 mRNA. Translation: BAG51667.1 .
AL161757 Genomic DNA. No translation available.
AL355103 Genomic DNA. No translation available.
BC045556 mRNA. No translation available.
CCDSi CCDS9727.2. [Q9NX78-1 ]
RefSeqi NP_060269.3. NM_017799.3. [Q9NX78-1 ]
UniGenei Hs.497253.

3D structure databases

ProteinModelPortali Q9NX78.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9NX78.

Polymorphism databases

DMDMi 296439393.

Proteomic databases

MaxQBi Q9NX78.
PaxDbi Q9NX78.
PRIDEi Q9NX78.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261556 ; ENSP00000261556 ; ENSG00000070269 . [Q9NX78-1 ]
GeneIDi 54916.
KEGGi hsa:54916.
UCSCi uc001xck.3. human. [Q9NX78-2 ]
uc001xcm.3. human. [Q9NX78-1 ]

Organism-specific databases

CTDi 54916.
GeneCardsi GC14P056956.
H-InvDB HIX0011691.
HGNCi HGNC:20185. TMEM260.
HPAi HPA003502.
neXtProti NX_Q9NX78.
PharmGKBi PA134894829.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26635.
HOGENOMi HOG000031293.
HOVERGENi HBG051017.
InParanoidi Q9NX78.
OMAi LWPWGSC.
OrthoDBi EOG7V1FQ0.
PhylomeDBi Q9NX78.
TreeFami TF329604.

Miscellaneous databases

GenomeRNAii 54916.
NextBioi 57978.

Gene expression databases

ArrayExpressi Q9NX78.
Bgeei Q9NX78.
CleanExi HS_C14orf101.
Genevestigatori Q9NX78.

Family and domain databases

InterProi IPR021280. DUF2723.
[Graphical view ]
Pfami PF11028. DUF2723. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ileal mucosa and Uterus.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-245.
    Tissue: Brain.

Entry informationi

Entry nameiTM260_HUMAN
AccessioniPrimary (citable) accession number: Q9NX78
Secondary accession number(s): A8KAN4, B3KPF5, Q86XE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi