Q9NX78 (TM260_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 260

Gene names

Name:	TMEM260
Synonyms:	C14orf101

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	707 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TMEM260 family.
Sequence caution	The sequence BAA91139.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BC045556 differs from that shown. Reason: Frameshift at position 212.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NX78-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NX78-2)

The sequence of this isoform differs from the canonical sequence as follows:
     287-707: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 707	707	Transmembrane protein 260		PRO_0000089905
Regions
	Transmembrane	28 – 48	21	Helical; Potential
	Transmembrane	71 – 91	21	Helical; Potential
	Transmembrane	94 – 114	21	Helical; Potential
	Transmembrane	141 – 161	21	Helical; Potential
	Transmembrane	189 – 209	21	Helical; Potential
	Transmembrane	222 – 242	21	Helical; Potential
	Transmembrane	318 – 338	21	Helical; Potential
	Transmembrane	356 – 376	21	Helical; Potential
Natural variations
	Alternative sequence	287 – 707	421	Missing in isoform 2.		VSP_008621
	Natural variant	245	1	A → S. Ref.3 Corresponds to variant rs17776256 [ dbSNP | Ensembl ].		VAR_057823
	Natural variant	565	1	S → N. Corresponds to variant rs1041316 [ dbSNP | Ensembl ].		VAR_057824
Experimental info
	Sequence conflict	3	1	P → H in BC045556. Ref.3
	Sequence conflict	57	1	I → T in BAF85788. Ref.1
	Sequence conflict	335	1	F → V in BAA91139. Ref.1
	Sequence conflict	680	1	N → S in BAF85788. Ref.1
	Sequence conflict	680	1	N → S in BAG51667. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: F3EAB7ED42B77489	FASTA	707	79,536
	10 20 30 40 50 60 MSPHGDGRGQ AQGRAVRVGL RRSGGIRGGV AVFAAVAAVF TFTLPPSVPG GDSGELITAA 70 80 90 100 110 120 HELGVAHPPG YPLFTLVAKL AITLFPFGSI AYRVNLLCGL FGAVAASLLF FTVFRLSGSS 130 140 150 160 170 180 AGGILAAGVF SFSRLTWQWS IAAEVFSLNN LFVGLLMALT VHFEEAATAK ERSKVAKIGA 190 200 210 220 230 240 FCCGLSLCNQ HTIILYVLCI IPWILFQLLK KKELSLGSLL KLSLYFSAGL LPYVHLPISS 250 260 270 280 290 300 YLNHARWTWG DQTTLQGFLT HFLREEYGTF SLAKSEIGSS MSEILLSQVT NMRTELSFNI 310 320 330 340 350 360 QALAVCANIC LATKDRQNPS LVWLFTGMFC IYSLFFAWRA NLDISKPLFM GVVERFWMQS 370 380 390 400 410 420 NAVVAVLAGI GLAAVVSETN RVLNSNGLQC LEWLSATLFV VYQIYSNYSV CDQRTNYVID 430 440 450 460 470 480 KFAKNLLTSM PHDAIILLRG DLPGNSLRYM HYCEGLRPDI SLVDQEMMTY EWYLPKMAKH 490 500 510 520 530 540 LPGVNFPGNR WNPVEGILPS GMVTFNLYHF LEVNKQKETF VCIGIHEGDP TWKKNYSLWP 550 560 570 580 590 600 WGSCDKLVPL EIVFNPEEWI KLTKSIYNWT EEYGRFDPSS WESVANEEMW QARMKTPFFI 610 620 630 640 650 660 FNLAETAHMP SKVKAQLYAQ AYDLYKEIVY LQKEHPVNWH KNYAIACERM LRLQARDADP 670 680 690 700 EVLLSETIRH FRLYSQKAPN DPQQADILGA LKHLRKELQS LRNRKNV
	Isoform 2 [UniParc]. Checksum: C8F4DC3BB7A8F640	FASTA	286	30,702
	10 20 30 40 50 60 MSPHGDGRGQ AQGRAVRVGL RRSGGIRGGV AVFAAVAAVF TFTLPPSVPG GDSGELITAA 70 80 90 100 110 120 HELGVAHPPG YPLFTLVAKL AITLFPFGSI AYRVNLLCGL FGAVAASLLF FTVFRLSGSS 130 140 150 160 170 180 AGGILAAGVF SFSRLTWQWS IAAEVFSLNN LFVGLLMALT VHFEEAATAK ERSKVAKIGA 190 200 210 220 230 240 FCCGLSLCNQ HTIILYVLCI IPWILFQLLK KKELSLGSLL KLSLYFSAGL LPYVHLPISS 250 260 270 280 YLNHARWTWG DQTTLQGFLT HFLREEYGTF SLAKSEIGSS MSEILL

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Ileal mucosa and Uterus.
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-245. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000399 mRNA. Translation: BAA91139.1. Different initiation. AK293099 mRNA. Translation: BAF85788.1. AK056291 mRNA. Translation: BAG51667.1. AL161757 Genomic DNA. No translation available. AL355103 Genomic DNA. No translation available. BC045556 mRNA. No translation available.
IPI	IPI00375471. IPI01011354.
RefSeq	NP_060269.3. NM_017799.3.
UniGene	Hs.497253.
3D structure databases
ProteinModelPortal	Q9NX78.
ModBase	Search...
PTM databases
PhosphoSite	Q9NX78.
Polymorphism databases
DMDM	296439393.
Proteomic databases
PaxDb	Q9NX78.
PRIDE	Q9NX78.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261556; ENSP00000261556; ENSG00000070269.
GeneID	54916.
KEGG	hsa:54916.
UCSC	uc001xck.3. human. uc001xcm.3. human.
Organism-specific databases
CTD	54916.
GeneCards	GC14P056955.
H-InvDB	HIX0011691.
HGNC	HGNC:20185. TMEM260.
HPA	HPA003502.
neXtProt	NX_Q9NX78.
PharmGKB	PA134894829.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG26635.
HOGENOM	HOG000031293.
HOVERGEN	HBG051017.
InParanoid	Q9NX78.
OMA	RMKTAFF.
OrthoDB	EOG4ZPDTV.
PhylomeDB	Q9NX78.
Gene expression databases
ArrayExpress	Q9NX78.
Bgee	Q9NX78.
CleanEx	HS_C14orf101.
Genevestigator	Q9NX78.
GermOnline	ENSG00000070269. Homo sapiens.
Family and domain databases
InterPro	IPR021280. DUF2723. [Graphical view]
Pfam	PF11028. DUF2723. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	54916.
NextBio	57978.

Entry information

Entry name

TM260_HUMAN

Accession

Primary (citable) accession number: Q9NX78
Secondary accession number(s): A8KAN4, B3KPF5, Q86XE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 82 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.