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Protein

Transmembrane protein 260

Gene

TMEM260

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000070269-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 260
Gene namesi
Name:TMEM260
Synonyms:C14orf101
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20185. TMEM260.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Transmembranei356 – 376HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000070269.
PharmGKBiPA134894829.

Polymorphism and mutation databases

BioMutaiTMEM260.
DMDMi296439393.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899051 – 707Transmembrane protein 260Add BLAST707

Proteomic databases

MaxQBiQ9NX78.
PaxDbiQ9NX78.
PeptideAtlasiQ9NX78.
PRIDEiQ9NX78.

PTM databases

iPTMnetiQ9NX78.
PhosphoSitePlusiQ9NX78.

Expressioni

Gene expression databases

BgeeiENSG00000070269.
CleanExiHS_C14orf101.
ExpressionAtlasiQ9NX78. baseline and differential.
GenevisibleiQ9NX78. HS.

Organism-specific databases

HPAiHPA003502.

Interactioni

Protein-protein interaction databases

BioGridi120258. 7 interactors.
STRINGi9606.ENSP00000261556.

Structurei

3D structure databases

ProteinModelPortaliQ9NX78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM260 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHX8. Eukaryota.
ENOG410XQTX. LUCA.
GeneTreeiENSGT00390000013544.
HOGENOMiHOG000031293.
HOVERGENiHBG051017.
InParanoidiQ9NX78.
OMAiLWPWGSC.
OrthoDBiEOG091G031D.
PhylomeDBiQ9NX78.
TreeFamiTF329604.

Family and domain databases

InterProiIPR021280. DUF2723.
[Graphical view]
PfamiPF11028. DUF2723. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX78-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPHGDGRGQ AQGRAVRVGL RRSGGIRGGV AVFAAVAAVF TFTLPPSVPG
60 70 80 90 100
GDSGELITAA HELGVAHPPG YPLFTLVAKL AITLFPFGSI AYRVNLLCGL
110 120 130 140 150
FGAVAASLLF FTVFRLSGSS AGGILAAGVF SFSRLTWQWS IAAEVFSLNN
160 170 180 190 200
LFVGLLMALT VHFEEAATAK ERSKVAKIGA FCCGLSLCNQ HTIILYVLCI
210 220 230 240 250
IPWILFQLLK KKELSLGSLL KLSLYFSAGL LPYVHLPISS YLNHARWTWG
260 270 280 290 300
DQTTLQGFLT HFLREEYGTF SLAKSEIGSS MSEILLSQVT NMRTELSFNI
310 320 330 340 350
QALAVCANIC LATKDRQNPS LVWLFTGMFC IYSLFFAWRA NLDISKPLFM
360 370 380 390 400
GVVERFWMQS NAVVAVLAGI GLAAVVSETN RVLNSNGLQC LEWLSATLFV
410 420 430 440 450
VYQIYSNYSV CDQRTNYVID KFAKNLLTSM PHDAIILLRG DLPGNSLRYM
460 470 480 490 500
HYCEGLRPDI SLVDQEMMTY EWYLPKMAKH LPGVNFPGNR WNPVEGILPS
510 520 530 540 550
GMVTFNLYHF LEVNKQKETF VCIGIHEGDP TWKKNYSLWP WGSCDKLVPL
560 570 580 590 600
EIVFNPEEWI KLTKSIYNWT EEYGRFDPSS WESVANEEMW QARMKTPFFI
610 620 630 640 650
FNLAETAHMP SKVKAQLYAQ AYDLYKEIVY LQKEHPVNWH KNYAIACERM
660 670 680 690 700
LRLQARDADP EVLLSETIRH FRLYSQKAPN DPQQADILGA LKHLRKELQS

LRNRKNV
Length:707
Mass (Da):79,536
Last modified:May 18, 2010 - v3
Checksum:iF3EAB7ED42B77489
GO
Isoform 2 (identifier: Q9NX78-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-707: Missing.

Note: No experimental confirmation available.
Show »
Length:286
Mass (Da):30,702
Checksum:iC8F4DC3BB7A8F640
GO

Sequence cautioni

The sequence BAA91139 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BC045556 differs from that shown. Reason: Frameshift at position 212.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3P → H in BC045556 (PubMed:15489334).Curated1
Sequence conflicti57I → T in BAF85788 (PubMed:14702039).Curated1
Sequence conflicti335F → V in BAA91139 (PubMed:14702039).Curated1
Sequence conflicti680N → S in BAF85788 (PubMed:14702039).Curated1
Sequence conflicti680N → S in BAG51667 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057823245A → S.1 PublicationCorresponds to variant rs17776256dbSNPEnsembl.1
Natural variantiVAR_057824565S → N.Corresponds to variant rs1041316dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008621287 – 707Missing in isoform 2. 1 PublicationAdd BLAST421

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000399 mRNA. Translation: BAA91139.1. Different initiation.
AK293099 mRNA. Translation: BAF85788.1.
AK056291 mRNA. Translation: BAG51667.1.
AL161757 Genomic DNA. No translation available.
AL355103 Genomic DNA. No translation available.
BC045556 mRNA. No translation available.
CCDSiCCDS9727.2. [Q9NX78-1]
RefSeqiNP_060269.3. NM_017799.3. [Q9NX78-1]
UniGeneiHs.497253.

Genome annotation databases

EnsembliENST00000261556; ENSP00000261556; ENSG00000070269. [Q9NX78-1]
GeneIDi54916.
KEGGihsa:54916.
UCSCiuc001xcm.4. human. [Q9NX78-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000399 mRNA. Translation: BAA91139.1. Different initiation.
AK293099 mRNA. Translation: BAF85788.1.
AK056291 mRNA. Translation: BAG51667.1.
AL161757 Genomic DNA. No translation available.
AL355103 Genomic DNA. No translation available.
BC045556 mRNA. No translation available.
CCDSiCCDS9727.2. [Q9NX78-1]
RefSeqiNP_060269.3. NM_017799.3. [Q9NX78-1]
UniGeneiHs.497253.

3D structure databases

ProteinModelPortaliQ9NX78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120258. 7 interactors.
STRINGi9606.ENSP00000261556.

PTM databases

iPTMnetiQ9NX78.
PhosphoSitePlusiQ9NX78.

Polymorphism and mutation databases

BioMutaiTMEM260.
DMDMi296439393.

Proteomic databases

MaxQBiQ9NX78.
PaxDbiQ9NX78.
PeptideAtlasiQ9NX78.
PRIDEiQ9NX78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261556; ENSP00000261556; ENSG00000070269. [Q9NX78-1]
GeneIDi54916.
KEGGihsa:54916.
UCSCiuc001xcm.4. human. [Q9NX78-1]

Organism-specific databases

CTDi54916.
GeneCardsiTMEM260.
H-InvDBHIX0011691.
HGNCiHGNC:20185. TMEM260.
HPAiHPA003502.
neXtProtiNX_Q9NX78.
OpenTargetsiENSG00000070269.
PharmGKBiPA134894829.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHX8. Eukaryota.
ENOG410XQTX. LUCA.
GeneTreeiENSGT00390000013544.
HOGENOMiHOG000031293.
HOVERGENiHBG051017.
InParanoidiQ9NX78.
OMAiLWPWGSC.
OrthoDBiEOG091G031D.
PhylomeDBiQ9NX78.
TreeFamiTF329604.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000070269-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM260. human.
GenomeRNAii54916.
PROiQ9NX78.

Gene expression databases

BgeeiENSG00000070269.
CleanExiHS_C14orf101.
ExpressionAtlasiQ9NX78. baseline and differential.
GenevisibleiQ9NX78. HS.

Family and domain databases

InterProiIPR021280. DUF2723.
[Graphical view]
PfamiPF11028. DUF2723. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM260_HUMAN
AccessioniPrimary (citable) accession number: Q9NX78
Secondary accession number(s): A8KAN4, B3KPF5, Q86XE1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.