UniProtKB - Q9NX76 (CKLF6_HUMAN)
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Protein
CKLF-like MARVEL transmembrane domain-containing protein 6
Gene
CMTM6
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
GO - Biological processi
- chemotaxis Source: UniProtKB-KW
- neutrophil degranulation Source: Reactome
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis |
Enzyme and pathway databases
Reactomei | R-HSA-6798695. Neutrophil degranulation. |
Names & Taxonomyi
Protein namesi | Recommended name: CKLF-like MARVEL transmembrane domain-containing protein 6Alternative name(s): Chemokine-like factor superfamily member 6 |
Gene namesi | Name:CMTM6 Synonyms:CKLFSF6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000091317.7. |
HGNCi | HGNC:19177. CMTM6. |
MIMi | 607889. gene. |
neXtProti | NX_Q9NX76. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 68 – 88 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 107 – 127 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 135 – 155 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000091317. |
PharmGKBi | PA38816. |
Polymorphism and mutation databases
BioMutai | CMTM6. |
DMDMi | 34922183. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186107 | 1 – 183 | CKLF-like MARVEL transmembrane domain-containing protein 6Add BLAST | 183 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources1 Publication | 1 | |
Modified residuei | 8 | PhosphoserineCombined sources | 1 | |
Modified residuei | 171 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9NX76. |
MaxQBi | Q9NX76. |
PaxDbi | Q9NX76. |
PeptideAtlasi | Q9NX76. |
PRIDEi | Q9NX76. |
TopDownProteomicsi | Q9NX76. |
PTM databases
iPTMneti | Q9NX76. |
PhosphoSitePlusi | Q9NX76. |
SwissPalmi | Q9NX76. |
Expressioni
Tissue specificityi
Expressed in the leukocytes, placenta and testis.1 Publication
Gene expression databases
Bgeei | ENSG00000091317. |
CleanExi | HS_CMTM6. |
Genevisiblei | Q9NX76. HS. |
Organism-specific databases
HPAi | HPA026980. |
Interactioni
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
CD274 | Q9NZQ7 | 11 | EBI-1054315,EBI-4314282 |
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
Protein-protein interaction databases
BioGridi | 120259. 20 interactors. |
IntActi | Q9NX76. 12 interactors. |
MINTi | Q9NX76. |
STRINGi | 9606.ENSP00000205636. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 160 | MARVELPROSITE-ProRule annotationAdd BLAST | 128 |
Sequence similaritiesi
Belongs to the chemokine-like factor family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4788. Eukaryota. ENOG4111IAF. LUCA. |
GeneTreei | ENSGT00530000063578. |
HOGENOMi | HOG000261609. |
HOVERGENi | HBG050980. |
InParanoidi | Q9NX76. |
OMAi | HDRTSAE. |
OrthoDBi | EOG091G0KPO. |
PhylomeDBi | Q9NX76. |
TreeFami | TF317387. |
Family and domain databases
InterProi | View protein in InterPro IPR008253. Marvel. |
Pfami | View protein in Pfam PF01284. MARVEL. 1 hit. |
PROSITEi | View protein in PROSITE PS51225. MARVEL. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9NX76-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENGAVYSPT TEEDPGPARG PRSGLAAYFF MGRLPLLRRV LKGLQLLLSL
60 70 80 90 100
LAFICEEVVS QCTLCGGLYF FEFVSCSAFL LSLLILIVYC TPFYERVDTT
110 120 130 140 150
KVKSSDFYIT LGTGCVFLLA SIIFVSTHDR TSAEIAAIVF GFIASFMFLL
160 170 180
DFITMLYEKR QESQLRKPEN TTRAEALTEP LNA
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061998 | 91 | T → A. Corresponds to variant dbSNP:rs35574803Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF479261 mRNA. Translation: AAN73039.1. AK000403 mRNA. Translation: BAA91141.1. CR457231 mRNA. Translation: CAG33512.1. CH471055 Genomic DNA. Translation: EAW64429.1. BC002797 mRNA. Translation: AAH02797.1. |
CCDSi | CCDS2653.1. |
RefSeqi | NP_060271.1. NM_017801.2. |
UniGenei | Hs.380627. Hs.731820. |
Genome annotation databases
Ensembli | ENST00000205636; ENSP00000205636; ENSG00000091317. |
GeneIDi | 54918. |
KEGGi | hsa:54918. |
UCSCi | uc003cfa.2. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | CKLF6_HUMAN | |
Accessioni | Q9NX76Primary (citable) accession number: Q9NX76 Secondary accession number(s): Q6IAC4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |