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Q9NX76

- CKLF6_HUMAN

UniProt

Q9NX76 - CKLF6_HUMAN

Protein

CKLF-like MARVEL transmembrane domain-containing protein 6

Gene

CMTM6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. chemotaxis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CKLF-like MARVEL transmembrane domain-containing protein 6
    Alternative name(s):
    Chemokine-like factor superfamily member 6
    Gene namesi
    Name:CMTM6
    Synonyms:CKLFSF6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:19177. CMTM6.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38816.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 183183CKLF-like MARVEL transmembrane domain-containing protein 6PRO_0000186107Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine5 Publications
    Modified residuei8 – 81Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9NX76.
    PaxDbiQ9NX76.
    PRIDEiQ9NX76.

    PTM databases

    PhosphoSiteiQ9NX76.

    Expressioni

    Tissue specificityi

    Expressed in the leukocytes, placenta and testis.1 Publication

    Gene expression databases

    BgeeiQ9NX76.
    CleanExiHS_CMTM6.
    GenevestigatoriQ9NX76.

    Organism-specific databases

    HPAiHPA026980.

    Interactioni

    Protein-protein interaction databases

    BioGridi120259. 8 interactions.
    IntActiQ9NX76. 8 interactions.
    MINTiMINT-8247417.
    STRINGi9606.ENSP00000205636.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NX76.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei68 – 8821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei107 – 12721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei135 – 15521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 160128MARVELPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the chemokine-like factor family.Curated
    Contains 1 MARVEL domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238555.
    HOGENOMiHOG000261609.
    HOVERGENiHBG050980.
    InParanoidiQ9NX76.
    OMAiLIVYCTP.
    OrthoDBiEOG7FNC8Q.
    PhylomeDBiQ9NX76.
    TreeFamiTF317387.

    Family and domain databases

    InterProiIPR008253. Marvel.
    [Graphical view]
    PfamiPF01284. MARVEL. 1 hit.
    [Graphical view]
    PROSITEiPS51225. MARVEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NX76-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENGAVYSPT TEEDPGPARG PRSGLAAYFF MGRLPLLRRV LKGLQLLLSL    50
    LAFICEEVVS QCTLCGGLYF FEFVSCSAFL LSLLILIVYC TPFYERVDTT 100
    KVKSSDFYIT LGTGCVFLLA SIIFVSTHDR TSAEIAAIVF GFIASFMFLL 150
    DFITMLYEKR QESQLRKPEN TTRAEALTEP LNA 183
    Length:183
    Mass (Da):20,419
    Last modified:October 1, 2000 - v1
    Checksum:i43DAEB652A6B50B4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti91 – 911T → A.
    Corresponds to variant rs35574803 [ dbSNP | Ensembl ].
    VAR_061998

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF479261 mRNA. Translation: AAN73039.1.
    AK000403 mRNA. Translation: BAA91141.1.
    CR457231 mRNA. Translation: CAG33512.1.
    CH471055 Genomic DNA. Translation: EAW64429.1.
    BC002797 mRNA. Translation: AAH02797.1.
    CCDSiCCDS2653.1.
    RefSeqiNP_060271.1. NM_017801.2.
    UniGeneiHs.380627.
    Hs.731820.

    Genome annotation databases

    EnsembliENST00000205636; ENSP00000205636; ENSG00000091317.
    GeneIDi54918.
    KEGGihsa:54918.
    UCSCiuc003cfa.1. human.

    Polymorphism databases

    DMDMi34922183.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF479261 mRNA. Translation: AAN73039.1 .
    AK000403 mRNA. Translation: BAA91141.1 .
    CR457231 mRNA. Translation: CAG33512.1 .
    CH471055 Genomic DNA. Translation: EAW64429.1 .
    BC002797 mRNA. Translation: AAH02797.1 .
    CCDSi CCDS2653.1.
    RefSeqi NP_060271.1. NM_017801.2.
    UniGenei Hs.380627.
    Hs.731820.

    3D structure databases

    ProteinModelPortali Q9NX76.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120259. 8 interactions.
    IntActi Q9NX76. 8 interactions.
    MINTi MINT-8247417.
    STRINGi 9606.ENSP00000205636.

    PTM databases

    PhosphoSitei Q9NX76.

    Polymorphism databases

    DMDMi 34922183.

    Proteomic databases

    MaxQBi Q9NX76.
    PaxDbi Q9NX76.
    PRIDEi Q9NX76.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000205636 ; ENSP00000205636 ; ENSG00000091317 .
    GeneIDi 54918.
    KEGGi hsa:54918.
    UCSCi uc003cfa.1. human.

    Organism-specific databases

    CTDi 54918.
    GeneCardsi GC03M032499.
    HGNCi HGNC:19177. CMTM6.
    HPAi HPA026980.
    MIMi 607889. gene.
    neXtProti NX_Q9NX76.
    PharmGKBi PA38816.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238555.
    HOGENOMi HOG000261609.
    HOVERGENi HBG050980.
    InParanoidi Q9NX76.
    OMAi LIVYCTP.
    OrthoDBi EOG7FNC8Q.
    PhylomeDBi Q9NX76.
    TreeFami TF317387.

    Miscellaneous databases

    ChiTaRSi CMTM6. human.
    GenomeRNAii 54918.
    NextBioi 57982.
    PROi Q9NX76.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NX76.
    CleanExi HS_CMTM6.
    Genevestigatori Q9NX76.

    Family and domain databases

    InterProi IPR008253. Marvel.
    [Graphical view ]
    Pfami PF01284. MARVEL. 1 hit.
    [Graphical view ]
    PROSITEi PS51225. MARVEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation."
      Han W., Ding P., Xu M., Wang L., Rui M., Shi S., Liu Y., Zheng Y., Chen Y., Yang T., Ma D.
      Genomics 81:609-617(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Prostate.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    6. Bienvenut W.V., Claeys D.
      Submitted (NOV-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 1-19; 23-33 AND 160-166, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Platelet.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCKLF6_HUMAN
    AccessioniPrimary (citable) accession number: Q9NX76
    Secondary accession number(s): Q6IAC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3