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Protein

CKLF-like MARVEL transmembrane domain-containing protein 6

Gene

CMTM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000091317-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 6
Alternative name(s):
Chemokine-like factor superfamily member 6
Gene namesi
Name:CMTM6
Synonyms:CKLFSF6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:19177. CMTM6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000091317.
PharmGKBiPA38816.

Polymorphism and mutation databases

BioMutaiCMTM6.
DMDMi34922183.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861071 – 183CKLF-like MARVEL transmembrane domain-containing protein 6Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei8PhosphoserineCombined sources1
Modified residuei171PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NX76.
MaxQBiQ9NX76.
PaxDbiQ9NX76.
PeptideAtlasiQ9NX76.
PRIDEiQ9NX76.
TopDownProteomicsiQ9NX76.

PTM databases

iPTMnetiQ9NX76.
PhosphoSitePlusiQ9NX76.
SwissPalmiQ9NX76.

Expressioni

Tissue specificityi

Expressed in the leukocytes, placenta and testis.1 Publication

Gene expression databases

BgeeiENSG00000091317.
CleanExiHS_CMTM6.
GenevisibleiQ9NX76. HS.

Organism-specific databases

HPAiHPA026980.

Interactioni

Protein-protein interaction databases

BioGridi120259. 16 interactors.
IntActiQ9NX76. 9 interactors.
MINTiMINT-8247417.
STRINGi9606.ENSP00000205636.

Structurei

3D structure databases

ProteinModelPortaliQ9NX76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 160MARVELPROSITE-ProRule annotationAdd BLAST128

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00530000063578.
HOGENOMiHOG000261609.
HOVERGENiHBG050980.
InParanoidiQ9NX76.
OMAiHDRTSAE.
OrthoDBiEOG091G0KPO.
PhylomeDBiQ9NX76.
TreeFamiTF317387.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NX76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENGAVYSPT TEEDPGPARG PRSGLAAYFF MGRLPLLRRV LKGLQLLLSL
60 70 80 90 100
LAFICEEVVS QCTLCGGLYF FEFVSCSAFL LSLLILIVYC TPFYERVDTT
110 120 130 140 150
KVKSSDFYIT LGTGCVFLLA SIIFVSTHDR TSAEIAAIVF GFIASFMFLL
160 170 180
DFITMLYEKR QESQLRKPEN TTRAEALTEP LNA
Length:183
Mass (Da):20,419
Last modified:October 1, 2000 - v1
Checksum:i43DAEB652A6B50B4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06199891T → A.Corresponds to variant rs35574803dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479261 mRNA. Translation: AAN73039.1.
AK000403 mRNA. Translation: BAA91141.1.
CR457231 mRNA. Translation: CAG33512.1.
CH471055 Genomic DNA. Translation: EAW64429.1.
BC002797 mRNA. Translation: AAH02797.1.
CCDSiCCDS2653.1.
RefSeqiNP_060271.1. NM_017801.2.
UniGeneiHs.380627.
Hs.731820.

Genome annotation databases

EnsembliENST00000205636; ENSP00000205636; ENSG00000091317.
GeneIDi54918.
KEGGihsa:54918.
UCSCiuc003cfa.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479261 mRNA. Translation: AAN73039.1.
AK000403 mRNA. Translation: BAA91141.1.
CR457231 mRNA. Translation: CAG33512.1.
CH471055 Genomic DNA. Translation: EAW64429.1.
BC002797 mRNA. Translation: AAH02797.1.
CCDSiCCDS2653.1.
RefSeqiNP_060271.1. NM_017801.2.
UniGeneiHs.380627.
Hs.731820.

3D structure databases

ProteinModelPortaliQ9NX76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120259. 16 interactors.
IntActiQ9NX76. 9 interactors.
MINTiMINT-8247417.
STRINGi9606.ENSP00000205636.

PTM databases

iPTMnetiQ9NX76.
PhosphoSitePlusiQ9NX76.
SwissPalmiQ9NX76.

Polymorphism and mutation databases

BioMutaiCMTM6.
DMDMi34922183.

Proteomic databases

EPDiQ9NX76.
MaxQBiQ9NX76.
PaxDbiQ9NX76.
PeptideAtlasiQ9NX76.
PRIDEiQ9NX76.
TopDownProteomicsiQ9NX76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000205636; ENSP00000205636; ENSG00000091317.
GeneIDi54918.
KEGGihsa:54918.
UCSCiuc003cfa.2. human.

Organism-specific databases

CTDi54918.
GeneCardsiCMTM6.
HGNCiHGNC:19177. CMTM6.
HPAiHPA026980.
MIMi607889. gene.
neXtProtiNX_Q9NX76.
OpenTargetsiENSG00000091317.
PharmGKBiPA38816.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00530000063578.
HOGENOMiHOG000261609.
HOVERGENiHBG050980.
InParanoidiQ9NX76.
OMAiHDRTSAE.
OrthoDBiEOG091G0KPO.
PhylomeDBiQ9NX76.
TreeFamiTF317387.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000091317-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiCMTM6. human.
GenomeRNAii54918.
PROiQ9NX76.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091317.
CleanExiHS_CMTM6.
GenevisibleiQ9NX76. HS.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCKLF6_HUMAN
AccessioniPrimary (citable) accession number: Q9NX76
Secondary accession number(s): Q6IAC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.