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Protein

Zinc finger and SCAN domain-containing protein 32

Gene

ZSCAN32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri521 – 543C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140987-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 32
Alternative name(s):
Human cervical cancer suppressor gene 5 protein
Short name:
HCCS-5
Zinc finger protein 434
Gene namesi
Name:ZSCAN32
Synonyms:ZNF434
ORF Names:HCCS5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:20812. ZSCAN32.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140987.
PharmGKBiPA134902932.

Polymorphism and mutation databases

DMDMi519668684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475821 – 697Zinc finger and SCAN domain-containing protein 32Add BLAST697

Proteomic databases

MaxQBiQ9NX65.
PaxDbiQ9NX65.
PeptideAtlasiQ9NX65.
PRIDEiQ9NX65.

PTM databases

iPTMnetiQ9NX65.
PhosphoSitePlusiQ9NX65.

Expressioni

Gene expression databases

BgeeiENSG00000140987.
CleanExiHS_ZNF434.
ExpressionAtlasiQ9NX65. baseline and differential.
GenevisibleiQ9NX65. HS.

Organism-specific databases

HPAiHPA005758.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZNF24P170283EBI-739949,EBI-707773

Protein-protein interaction databases

BioGridi120265. 37 interactors.
IntActiQ9NX65. 4 interactors.
STRINGi9606.ENSP00000302502.

Structurei

3D structure databases

ProteinModelPortaliQ9NX65.
SMRiQ9NX65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 119SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini212 – 296KRABAdd BLAST85

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.Curated
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri521 – 543C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri549 – 571C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri577 – 599C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri605 – 627C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri633 – 655C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri661 – 683C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063287.
HOGENOMiHOG000234618.
HOVERGENiHBG018163.
InParanoidiQ9NX65.
KOiK09228.
OMAiHFSAHRK.
OrthoDBiEOG091G09O3.
PhylomeDBiQ9NX65.
TreeFamiTF336839.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAAVKSTEA HPSSNKDPTQ GQKSALQGNS PDSEASRQRF RQFCYQEVTG
60 70 80 90 100
PHEAFSKLWE LCCQWLRPKT HSKEEILELL VLEQFLTILP EEIQTWVREQ
110 120 130 140 150
HPENGEEAVA LVEDVQRAPG QQVLDSEKDL KVLMKEMAPL GATRESLRSQ
160 170 180 190 200
WKQEVQPEEP TFKGSQSSHQ RPGEQSEAWL APQAPRNLPQ NTGLHDQETG
210 220 230 240 250
AVVWTAGSQG PAMRDNRAVS LCQQEWMCPG PAQRALYRGA TQRKDSHVSL
260 270 280 290 300
ATGVPWGYEE TKTLLAILSS SQFYGKLQTC QQNSQIYRAM AEGLWEQGFL
310 320 330 340 350
RTPEQCRTKF KSLQLSYRKV RRGRVPEPCI FYEEMNALSG SWASAPPMAS
360 370 380 390 400
DAVPGQEGSD IEAGELNHQN GEPTEVEDGT VDGADRDEKD FRNPGQEVRK
410 420 430 440 450
LDLPVLFPNR LGFEFKNEIK KENLKWDDSE EVEINKALQR KSRGVYWHSE
460 470 480 490 500
LQKGLESEPT SRRQCRNSPG ESEEKTPSQE KMSHQSFCAR DKACTHILCG
510 520 530 540 550
KNCSQSVHSP HKPALKLEKV SQCPECGKTF SRSSYLVRHQ RIHTGEKPHK
560 570 580 590 600
CSECGKGFSE RSNLTAHLRT HTGERPYQCG QCGKSFNQSS SLIVHQRTHT
610 620 630 640 650
GEKPYQCIVC GKRFNNSSQF SAHRRIHTGE SPYKCAVCGK IFNNSSHFSA
660 670 680 690
HRKTHTGEKP YRCSHCERGF TKNSALTRHQ TVHMKAVLSS QEGRDAL
Length:697
Mass (Da):78,728
Last modified:June 26, 2013 - v3
Checksum:iAAD779F62506FBCB
GO
Isoform 2 (identifier: Q9NX65-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-212: Missing.

Show »
Length:485
Mass (Da):54,929
Checksum:i7746A7684DC96631
GO
Isoform 3 (identifier: Q9NX65-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-289: Missing.

Note: No experimental confirmation available.
Show »
Length:408
Mass (Da):46,222
Checksum:i0B8440212CC12810
GO

Sequence cautioni

The sequence AAH02859 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 426.Curated
The sequence AAH02859 differs from that shown. Reason: Frameshift at position 254.Curated
The sequence AAM73658 differs from that shown. The cDNA sequence has been translated in the reverse direction.Curated
The sequence BAA91155 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052826266A → V.Corresponds to variant rs17136369dbSNPEnsembl.1
Natural variantiVAR_024215332Y → H.Corresponds to variant rs27230dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559881 – 289Missing in isoform 3. 1 PublicationAdd BLAST289
Alternative sequenceiVSP_0465711 – 212Missing in isoform 2. 3 PublicationsAdd BLAST212

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY261676 mRNA. Translation: AAP57398.1.
AF390550 mRNA. Translation: AAM73658.1. Sequence problems.
AY279347 mRNA. Translation: AAQ62844.1.
AK000424 mRNA. Translation: BAA91155.1. Different initiation.
AK291213 mRNA. Translation: BAF83902.1.
AK301586 mRNA. Translation: BAG63077.1.
AC025283 Genomic DNA. No translation available.
BC002859 mRNA. Translation: AAH02859.1. Sequence problems.
CCDSiCCDS10503.1. [Q9NX65-2]
CCDS66920.1. [Q9NX65-3]
CCDS66921.1. [Q9NX65-1]
RefSeqiNP_001271456.1. NM_001284527.1. [Q9NX65-1]
NP_001271457.1. NM_001284528.1. [Q9NX65-3]
NP_001271458.1. NM_001284529.1. [Q9NX65-3]
NP_001311269.1. NM_001324340.1. [Q9NX65-2]
NP_001311270.1. NM_001324341.1. [Q9NX65-2]
NP_001311271.1. NM_001324342.1. [Q9NX65-2]
NP_001311273.1. NM_001324344.1. [Q9NX65-2]
NP_001311274.1. NM_001324345.1. [Q9NX65-2]
NP_060280.2. NM_017810.3. [Q9NX65-2]
XP_011520857.1. XM_011522555.2. [Q9NX65-1]
XP_016878860.1. XM_017023371.1. [Q9NX65-1]
UniGeneiHs.592078.

Genome annotation databases

EnsembliENST00000304926; ENSP00000302502; ENSG00000140987. [Q9NX65-2]
ENST00000396846; ENSP00000380057; ENSG00000140987. [Q9NX65-1]
ENST00000396852; ENSP00000380061; ENSG00000140987. [Q9NX65-1]
ENST00000439568; ENSP00000391787; ENSG00000140987. [Q9NX65-3]
ENST00000618425; ENSP00000483210; ENSG00000140987. [Q9NX65-3]
GeneIDi54925.
KEGGihsa:54925.
UCSCiuc002cux.5. human. [Q9NX65-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY261676 mRNA. Translation: AAP57398.1.
AF390550 mRNA. Translation: AAM73658.1. Sequence problems.
AY279347 mRNA. Translation: AAQ62844.1.
AK000424 mRNA. Translation: BAA91155.1. Different initiation.
AK291213 mRNA. Translation: BAF83902.1.
AK301586 mRNA. Translation: BAG63077.1.
AC025283 Genomic DNA. No translation available.
BC002859 mRNA. Translation: AAH02859.1. Sequence problems.
CCDSiCCDS10503.1. [Q9NX65-2]
CCDS66920.1. [Q9NX65-3]
CCDS66921.1. [Q9NX65-1]
RefSeqiNP_001271456.1. NM_001284527.1. [Q9NX65-1]
NP_001271457.1. NM_001284528.1. [Q9NX65-3]
NP_001271458.1. NM_001284529.1. [Q9NX65-3]
NP_001311269.1. NM_001324340.1. [Q9NX65-2]
NP_001311270.1. NM_001324341.1. [Q9NX65-2]
NP_001311271.1. NM_001324342.1. [Q9NX65-2]
NP_001311273.1. NM_001324344.1. [Q9NX65-2]
NP_001311274.1. NM_001324345.1. [Q9NX65-2]
NP_060280.2. NM_017810.3. [Q9NX65-2]
XP_011520857.1. XM_011522555.2. [Q9NX65-1]
XP_016878860.1. XM_017023371.1. [Q9NX65-1]
UniGeneiHs.592078.

3D structure databases

ProteinModelPortaliQ9NX65.
SMRiQ9NX65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120265. 37 interactors.
IntActiQ9NX65. 4 interactors.
STRINGi9606.ENSP00000302502.

PTM databases

iPTMnetiQ9NX65.
PhosphoSitePlusiQ9NX65.

Polymorphism and mutation databases

DMDMi519668684.

Proteomic databases

MaxQBiQ9NX65.
PaxDbiQ9NX65.
PeptideAtlasiQ9NX65.
PRIDEiQ9NX65.

Protocols and materials databases

DNASUi54925.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304926; ENSP00000302502; ENSG00000140987. [Q9NX65-2]
ENST00000396846; ENSP00000380057; ENSG00000140987. [Q9NX65-1]
ENST00000396852; ENSP00000380061; ENSG00000140987. [Q9NX65-1]
ENST00000439568; ENSP00000391787; ENSG00000140987. [Q9NX65-3]
ENST00000618425; ENSP00000483210; ENSG00000140987. [Q9NX65-3]
GeneIDi54925.
KEGGihsa:54925.
UCSCiuc002cux.5. human. [Q9NX65-1]

Organism-specific databases

CTDi54925.
GeneCardsiZSCAN32.
HGNCiHGNC:20812. ZSCAN32.
HPAiHPA005758.
neXtProtiNX_Q9NX65.
OpenTargetsiENSG00000140987.
PharmGKBiPA134902932.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063287.
HOGENOMiHOG000234618.
HOVERGENiHBG018163.
InParanoidiQ9NX65.
KOiK09228.
OMAiHFSAHRK.
OrthoDBiEOG091G09O3.
PhylomeDBiQ9NX65.
TreeFamiTF336839.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140987-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii54925.
PROiQ9NX65.

Gene expression databases

BgeeiENSG00000140987.
CleanExiHS_ZNF434.
ExpressionAtlasiQ9NX65. baseline and differential.
GenevisibleiQ9NX65. HS.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZSC32_HUMAN
AccessioniPrimary (citable) accession number: Q9NX65
Secondary accession number(s): B4DWL5
, C9JB03, Q6WMU8, Q7Z6G2, Q8NFX8, Q9BU74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 26, 2013
Last modified: November 2, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.