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Q9NX61

- T161A_HUMAN

UniProt

Q9NX61 - T161A_HUMAN

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Protein

Transmembrane protein 161A

Gene

TMEM161A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.1 Publication

GO - Biological processi

  1. cellular response to oxidative stress Source: BHF-UCL
  2. cellular response to UV Source: BHF-UCL
  3. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
  4. positive regulation of DNA repair Source: BHF-UCL
  5. response to retinoic acid Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 161A
Alternative name(s):
Adaptive response to oxidative stress protein 29
Short name:
AROS-29
Gene namesi
ORF Names:UNQ582/PRO1152
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:26020. TMEM161A.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147959.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 479451Transmembrane protein 161APRO_0000288084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9NX61.
PaxDbiQ9NX61.
PRIDEiQ9NX61.

PTM databases

PhosphoSiteiQ9NX61.

Expressioni

Inductioni

Up-regulated in cells which display transient adaptation to mild oxidative stress by treatment with diethylmaleate, a glutathione-depleting agent. Also induced by retinoic acid.1 Publication

Gene expression databases

BgeeiQ9NX61.
CleanExiHS_TMEM161A.
ExpressionAtlasiQ9NX61. baseline.
GenevestigatoriQ9NX61.

Organism-specific databases

HPAiHPA043365.

Interactioni

Protein-protein interaction databases

BioGridi120269. 3 interactions.
IntActiQ9NX61. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9NX61.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 9870ExtracellularSequence AnalysisAdd
BLAST
Topological domaini120 – 13415CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini156 – 16611ExtracellularSequence AnalysisAdd
BLAST
Topological domaini188 – 22437CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini246 – 26318ExtracellularSequence AnalysisAdd
BLAST
Topological domaini285 – 30420CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini326 – 37045ExtracellularSequence AnalysisAdd
BLAST
Topological domaini392 – 44958CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini471 – 4799ExtracellularSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei99 – 11921HelicalSequence AnalysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence AnalysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence AnalysisAdd
BLAST
Transmembranei371 – 39121HelicalSequence AnalysisAdd
BLAST
Transmembranei450 – 47021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM161 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG319472.
GeneTreeiENSGT00390000000672.
HOGENOMiHOG000273873.
HOVERGENiHBG063501.
InParanoidiQ9NX61.
OMAiILWLWTK.
OrthoDBiEOG7RFTHH.
PhylomeDBiQ9NX61.
TreeFamiTF314570.

Family and domain databases

InterProiIPR019395. Transmembrane_161A/B.
[Graphical view]
PfamiPF10268. Tmemb_161AB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NX61-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVLGVQLVV TLLTATLMHR LAPHCSFARW LLCNGSLFRY KHPSEEELRA
60 70 80 90 100
LAGKPRPRGR KERWANGLSE EKPLSVPRDA PFQLETCPLT TVDALVLRFF
110 120 130 140 150
LEYQWFVDFA VYSGGVYLFT EAYYYMLGPA KETNIAVFWC LLTVTFSIKM
160 170 180 190 200
FLTVTRLYFS AEEGGERSVC LTFAFLFLLL AMLVQVVREE TLELGLEPGL
210 220 230 240 250
ASMTQNLEPL LKKQGWDWAL PVAKLAIRVG LAVVGSVLGA FLTFPGLRLA
260 270 280 290 300
QTHRDALTMS EDRPMLQFLL HTSFLSPLFI LWLWTKPIAR DFLHQPPFGE
310 320 330 340 350
TRFSLLSDSA FDSGRLWLLV VLCLLRLAVT RPHLQAYLCL AKARVEQLRR
360 370 380 390 400
EAGRIEAREI QQRVVRVYCY VTVVSLQYLT PLILTLNCTL LLKTLGGYSW
410 420 430 440 450
GLGPAPLLSP DPSSASAAPI GSGEDEVQQT AARIAGALGG LLTPLFLRGV
460 470
LAYLIWWTAA CQLLASLFGL YFHQHLAGS
Length:479
Mass (Da):53,602
Last modified:October 1, 2000 - v1
Checksum:i4DEA8A1C04CCA33D
GO
Isoform 2 (identifier: Q9NX61-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-198: Missing.

Note: No experimental confirmation available.

Show »
Length:376
Mass (Da):41,632
Checksum:i9533773B30DD4DF5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti455 – 4551I → V in BAG53402. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti85 – 851E → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_036537

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei96 – 198103Missing in isoform 2. 1 PublicationVSP_046042Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358088 mRNA. Translation: AAQ88455.1.
AK000429 mRNA. Translation: BAA91159.1.
AK096964 mRNA. Translation: BAG53402.1.
AC002126 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84787.1.
BC005210 mRNA. Translation: AAH05210.1.
BC016478 mRNA. Translation: AAH16478.2.
CCDSiCCDS12393.1. [Q9NX61-1]
CCDS58656.1. [Q9NX61-2]
RefSeqiNP_001243695.1. NM_001256766.1. [Q9NX61-2]
NP_060284.1. NM_017814.2. [Q9NX61-1]
UniGeneiHs.631629.

Genome annotation databases

EnsembliENST00000162044; ENSP00000162044; ENSG00000064545. [Q9NX61-1]
ENST00000450333; ENSP00000404208; ENSG00000064545. [Q9NX61-2]
GeneIDi54929.
KEGGihsa:54929.
UCSCiuc002nlg.4. human. [Q9NX61-1]
uc002nli.4. human.

Polymorphism databases

DMDMi74734686.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358088 mRNA. Translation: AAQ88455.1 .
AK000429 mRNA. Translation: BAA91159.1 .
AK096964 mRNA. Translation: BAG53402.1 .
AC002126 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84787.1 .
BC005210 mRNA. Translation: AAH05210.1 .
BC016478 mRNA. Translation: AAH16478.2 .
CCDSi CCDS12393.1. [Q9NX61-1 ]
CCDS58656.1. [Q9NX61-2 ]
RefSeqi NP_001243695.1. NM_001256766.1. [Q9NX61-2 ]
NP_060284.1. NM_017814.2. [Q9NX61-1 ]
UniGenei Hs.631629.

3D structure databases

ProteinModelPortali Q9NX61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120269. 3 interactions.
IntActi Q9NX61. 1 interaction.

PTM databases

PhosphoSitei Q9NX61.

Polymorphism databases

DMDMi 74734686.

Proteomic databases

MaxQBi Q9NX61.
PaxDbi Q9NX61.
PRIDEi Q9NX61.

Protocols and materials databases

DNASUi 54929.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000162044 ; ENSP00000162044 ; ENSG00000064545 . [Q9NX61-1 ]
ENST00000450333 ; ENSP00000404208 ; ENSG00000064545 . [Q9NX61-2 ]
GeneIDi 54929.
KEGGi hsa:54929.
UCSCi uc002nlg.4. human. [Q9NX61-1 ]
uc002nli.4. human.

Organism-specific databases

CTDi 54929.
GeneCardsi GC19M019231.
HGNCi HGNC:26020. TMEM161A.
HPAi HPA043365.
neXtProti NX_Q9NX61.
PharmGKBi PA145147959.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG319472.
GeneTreei ENSGT00390000000672.
HOGENOMi HOG000273873.
HOVERGENi HBG063501.
InParanoidi Q9NX61.
OMAi ILWLWTK.
OrthoDBi EOG7RFTHH.
PhylomeDBi Q9NX61.
TreeFami TF314570.

Miscellaneous databases

ChiTaRSi TMEM161A. human.
GenomeRNAii 54929.
NextBioi 58027.
PROi Q9NX61.

Gene expression databases

Bgeei Q9NX61.
CleanExi HS_TMEM161A.
ExpressionAtlasi Q9NX61. baseline.
Genevestigatori Q9NX61.

Family and domain databases

InterProi IPR019395. Transmembrane_161A/B.
[Graphical view ]
Pfami PF10268. Tmemb_161AB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Signet-ring cell carcinoma and Small intestine.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney and Skin.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-85.
  7. Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiT161A_HUMAN
AccessioniPrimary (citable) accession number: Q9NX61
Secondary accession number(s): B3KUE0, G5E9M6, Q7L2Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3