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Q9NX61

- T161A_HUMAN

UniProt

Q9NX61 - T161A_HUMAN

Protein

Transmembrane protein 161A

Gene

TMEM161A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.1 Publication

    GO - Biological processi

    1. cellular response to oxidative stress Source: BHF-UCL
    2. cellular response to UV Source: BHF-UCL
    3. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
    4. positive regulation of DNA repair Source: BHF-UCL
    5. response to retinoic acid Source: BHF-UCL

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 161A
    Alternative name(s):
    Adaptive response to oxidative stress protein 29
    Short name:
    AROS-29
    Gene namesi
    ORF Names:UNQ582/PRO1152
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:26020. TMEM161A.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145147959.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 479451Transmembrane protein 161APRO_0000288084Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9NX61.
    PaxDbiQ9NX61.
    PRIDEiQ9NX61.

    PTM databases

    PhosphoSiteiQ9NX61.

    Expressioni

    Inductioni

    Up-regulated in cells which display transient adaptation to mild oxidative stress by treatment with diethylmaleate, a glutathione-depleting agent. Also induced by retinoic acid.1 Publication

    Gene expression databases

    ArrayExpressiQ9NX61.
    BgeeiQ9NX61.
    CleanExiHS_TMEM161A.
    GenevestigatoriQ9NX61.

    Organism-specific databases

    HPAiHPA043365.

    Interactioni

    Protein-protein interaction databases

    BioGridi120269. 3 interactions.
    IntActiQ9NX61. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NX61.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 9870ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13415CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini156 – 16611ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini188 – 22437CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini246 – 26318ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini285 – 30420CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini326 – 37045ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini392 – 44958CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini471 – 4799ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei99 – 11921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei135 – 15521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei371 – 39121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei450 – 47021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM161 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG319472.
    HOGENOMiHOG000273873.
    HOVERGENiHBG063501.
    InParanoidiQ9NX61.
    OMAiILWLWTK.
    OrthoDBiEOG7RFTHH.
    PhylomeDBiQ9NX61.
    TreeFamiTF314570.

    Family and domain databases

    InterProiIPR019395. Transmembrane_161A/B.
    [Graphical view]
    PfamiPF10268. Tmemb_161AB. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NX61-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVLGVQLVV TLLTATLMHR LAPHCSFARW LLCNGSLFRY KHPSEEELRA    50
    LAGKPRPRGR KERWANGLSE EKPLSVPRDA PFQLETCPLT TVDALVLRFF 100
    LEYQWFVDFA VYSGGVYLFT EAYYYMLGPA KETNIAVFWC LLTVTFSIKM 150
    FLTVTRLYFS AEEGGERSVC LTFAFLFLLL AMLVQVVREE TLELGLEPGL 200
    ASMTQNLEPL LKKQGWDWAL PVAKLAIRVG LAVVGSVLGA FLTFPGLRLA 250
    QTHRDALTMS EDRPMLQFLL HTSFLSPLFI LWLWTKPIAR DFLHQPPFGE 300
    TRFSLLSDSA FDSGRLWLLV VLCLLRLAVT RPHLQAYLCL AKARVEQLRR 350
    EAGRIEAREI QQRVVRVYCY VTVVSLQYLT PLILTLNCTL LLKTLGGYSW 400
    GLGPAPLLSP DPSSASAAPI GSGEDEVQQT AARIAGALGG LLTPLFLRGV 450
    LAYLIWWTAA CQLLASLFGL YFHQHLAGS 479
    Length:479
    Mass (Da):53,602
    Last modified:October 1, 2000 - v1
    Checksum:i4DEA8A1C04CCA33D
    GO
    Isoform 2 (identifier: Q9NX61-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         96-198: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:376
    Mass (Da):41,632
    Checksum:i9533773B30DD4DF5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti455 – 4551I → V in BAG53402. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti85 – 851E → V in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036537

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei96 – 198103Missing in isoform 2. 1 PublicationVSP_046042Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358088 mRNA. Translation: AAQ88455.1.
    AK000429 mRNA. Translation: BAA91159.1.
    AK096964 mRNA. Translation: BAG53402.1.
    AC002126 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84787.1.
    BC005210 mRNA. Translation: AAH05210.1.
    BC016478 mRNA. Translation: AAH16478.2.
    CCDSiCCDS12393.1. [Q9NX61-1]
    CCDS58656.1. [Q9NX61-2]
    RefSeqiNP_001243695.1. NM_001256766.1. [Q9NX61-2]
    NP_060284.1. NM_017814.2. [Q9NX61-1]
    UniGeneiHs.631629.

    Genome annotation databases

    EnsembliENST00000162044; ENSP00000162044; ENSG00000064545. [Q9NX61-1]
    ENST00000450333; ENSP00000404208; ENSG00000064545. [Q9NX61-2]
    GeneIDi54929.
    KEGGihsa:54929.
    UCSCiuc002nlg.4. human. [Q9NX61-1]
    uc002nli.4. human.

    Polymorphism databases

    DMDMi74734686.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358088 mRNA. Translation: AAQ88455.1 .
    AK000429 mRNA. Translation: BAA91159.1 .
    AK096964 mRNA. Translation: BAG53402.1 .
    AC002126 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84787.1 .
    BC005210 mRNA. Translation: AAH05210.1 .
    BC016478 mRNA. Translation: AAH16478.2 .
    CCDSi CCDS12393.1. [Q9NX61-1 ]
    CCDS58656.1. [Q9NX61-2 ]
    RefSeqi NP_001243695.1. NM_001256766.1. [Q9NX61-2 ]
    NP_060284.1. NM_017814.2. [Q9NX61-1 ]
    UniGenei Hs.631629.

    3D structure databases

    ProteinModelPortali Q9NX61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120269. 3 interactions.
    IntActi Q9NX61. 1 interaction.

    PTM databases

    PhosphoSitei Q9NX61.

    Polymorphism databases

    DMDMi 74734686.

    Proteomic databases

    MaxQBi Q9NX61.
    PaxDbi Q9NX61.
    PRIDEi Q9NX61.

    Protocols and materials databases

    DNASUi 54929.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000162044 ; ENSP00000162044 ; ENSG00000064545 . [Q9NX61-1 ]
    ENST00000450333 ; ENSP00000404208 ; ENSG00000064545 . [Q9NX61-2 ]
    GeneIDi 54929.
    KEGGi hsa:54929.
    UCSCi uc002nlg.4. human. [Q9NX61-1 ]
    uc002nli.4. human.

    Organism-specific databases

    CTDi 54929.
    GeneCardsi GC19M019231.
    HGNCi HGNC:26020. TMEM161A.
    HPAi HPA043365.
    neXtProti NX_Q9NX61.
    PharmGKBi PA145147959.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG319472.
    HOGENOMi HOG000273873.
    HOVERGENi HBG063501.
    InParanoidi Q9NX61.
    OMAi ILWLWTK.
    OrthoDBi EOG7RFTHH.
    PhylomeDBi Q9NX61.
    TreeFami TF314570.

    Miscellaneous databases

    ChiTaRSi TMEM161A. human.
    GenomeRNAii 54929.
    NextBioi 58027.
    PROi Q9NX61.

    Gene expression databases

    ArrayExpressi Q9NX61.
    Bgeei Q9NX61.
    CleanExi HS_TMEM161A.
    Genevestigatori Q9NX61.

    Family and domain databases

    InterProi IPR019395. Transmembrane_161A/B.
    [Graphical view ]
    Pfami PF10268. Tmemb_161AB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Signet-ring cell carcinoma and Small intestine.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney and Skin.
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-85.
    7. Cited for: FUNCTION, INDUCTION.

    Entry informationi

    Entry nameiT161A_HUMAN
    AccessioniPrimary (citable) accession number: Q9NX61
    Secondary accession number(s): B3KUE0, G5E9M6, Q7L2Y1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3