Q9NX61 (T161A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 161A

Gene names

Name:	TMEM161A
ORF Names:	UNQ582/PRO1152

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TMEM161 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to UV Inferred from direct assay PubMed 16551573. Source: BHF-UCL cellular response to oxidative stress Inferred from direct assay PubMed 16551573. Source: BHF-UCL negative regulation of apoptotic process Inferred from mutant phenotype PubMed 16551573. Source: BHF-UCL positive regulation of DNA repair Inferred from mutant phenotype PubMed 16551573. Source: BHF-UCL response to retinoic acid Inferred from direct assay PubMed 16551573. Source: BHF-UCL
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NX61-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NX61-2)

The sequence of this isoform differs from the canonical sequence as follows:
     96-198: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 479	451	Transmembrane protein 161A		PRO_0000288084
Regions
	Topological domain	29 – 98	70	Extracellular Potential
	Transmembrane	99 – 119	21	Helical; Potential
	Topological domain	120 – 134	15	Cytoplasmic Potential
	Transmembrane	135 – 155	21	Helical; Potential
	Topological domain	156 – 166	11	Extracellular Potential
	Transmembrane	167 – 187	21	Helical; Potential
	Topological domain	188 – 224	37	Cytoplasmic Potential
	Transmembrane	225 – 245	21	Helical; Potential
	Topological domain	246 – 263	18	Extracellular Potential
	Transmembrane	264 – 284	21	Helical; Potential
	Topological domain	285 – 304	20	Cytoplasmic Potential
	Transmembrane	305 – 325	21	Helical; Potential
	Topological domain	326 – 370	45	Extracellular Potential
	Transmembrane	371 – 391	21	Helical; Potential
	Topological domain	392 – 449	58	Cytoplasmic Potential
	Transmembrane	450 – 470	21	Helical; Potential
	Topological domain	471 – 479	9	Extracellular Potential
Amino acid modifications
	Glycosylation	34	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	96 – 198	103	Missing in isoform 2.		VSP_046042
	Natural variant	85	1	E → V in a breast cancer sample; somatic mutation. Ref.6		VAR_036537
Experimental info
	Sequence conflict	455	1	I → V in BAG53402. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 4DEA8A1C04CCA33D	FASTA	479	53,602
	10 20 30 40 50 60 MAVLGVQLVV TLLTATLMHR LAPHCSFARW LLCNGSLFRY KHPSEEELRA LAGKPRPRGR 70 80 90 100 110 120 KERWANGLSE EKPLSVPRDA PFQLETCPLT TVDALVLRFF LEYQWFVDFA VYSGGVYLFT 130 140 150 160 170 180 EAYYYMLGPA KETNIAVFWC LLTVTFSIKM FLTVTRLYFS AEEGGERSVC LTFAFLFLLL 190 200 210 220 230 240 AMLVQVVREE TLELGLEPGL ASMTQNLEPL LKKQGWDWAL PVAKLAIRVG LAVVGSVLGA 250 260 270 280 290 300 FLTFPGLRLA QTHRDALTMS EDRPMLQFLL HTSFLSPLFI LWLWTKPIAR DFLHQPPFGE 310 320 330 340 350 360 TRFSLLSDSA FDSGRLWLLV VLCLLRLAVT RPHLQAYLCL AKARVEQLRR EAGRIEAREI 370 380 390 400 410 420 QQRVVRVYCY VTVVSLQYLT PLILTLNCTL LLKTLGGYSW GLGPAPLLSP DPSSASAAPI 430 440 450 460 470 GSGEDEVQQT AARIAGALGG LLTPLFLRGV LAYLIWWTAA CQLLASLFGL YFHQHLAGS
	Isoform 2 [UniParc]. Checksum: 9533773B30DD4DF5	FASTA	376	41,632
	10 20 30 40 50 60 MAVLGVQLVV TLLTATLMHR LAPHCSFARW LLCNGSLFRY KHPSEEELRA LAGKPRPRGR 70 80 90 100 110 120 KERWANGLSE EKPLSVPRDA PFQLETCPLT TVDALGLASM TQNLEPLLKK QGWDWALPVA 130 140 150 160 170 180 KLAIRVGLAV VGSVLGAFLT FPGLRLAQTH RDALTMSEDR PMLQFLLHTS FLSPLFILWL 190 200 210 220 230 240 WTKPIARDFL HQPPFGETRF SLLSDSAFDS GRLWLLVVLC LLRLAVTRPH LQAYLCLAKA 250 260 270 280 290 300 RVEQLRREAG RIEAREIQQR VVRVYCYVTV VSLQYLTPLI LTLNCTLLLK TLGGYSWGLG 310 320 330 340 350 360 PAPLLSPDPS SASAAPIGSG EDEVQQTAAR IAGALGGLLT PLFLRGVLAY LIWWTAACQL 370 LASLFGLYFH QHLAGS

References

[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Signet-ring cell carcinoma and Small intestine.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney and Skin.
[6]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-85.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358088 mRNA. Translation: AAQ88455.1. AK000429 mRNA. Translation: BAA91159.1. AK096964 mRNA. Translation: BAG53402.1. AC002126 Genomic DNA. No translation available. CH471106 Genomic DNA. Translation: EAW84787.1. BC005210 mRNA. Translation: AAH05210.1. BC016478 mRNA. Translation: AAH16478.2.
IPI	IPI00301841. IPI00640585.
RefSeq	NP_001243695.1. NM_001256766.1. NP_060284.1. NM_017814.2.
UniGene	Hs.631629.
3D structure databases
ProteinModelPortal	Q9NX61.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NX61. 1 interaction.
PTM databases
PhosphoSite	Q9NX61.
Polymorphism databases
DMDM	74734686.
Proteomic databases
PaxDb	Q9NX61.
PRIDE	Q9NX61.
Protocols and materials databases
DNASU	54929.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000162044; ENSP00000162044; ENSG00000064545. ENST00000450333; ENSP00000404208; ENSG00000064545.
GeneID	54929.
KEGG	hsa:54929.
UCSC	uc002nlg.3. human.
Organism-specific databases
CTD	54929.
GeneCards	GC19M019231.
HGNC	HGNC:26020. TMEM161A.
HPA	HPA043365.
neXtProt	NX_Q9NX61.
PharmGKB	PA145147959.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG319472.
HOGENOM	HOG000273873.
HOVERGEN	HBG063501.
InParanoid	Q9NX61.
OMA	MLVLVVR.
PhylomeDB	Q9NX61.
Gene expression databases
ArrayExpress	Q9NX61.
Bgee	Q9NX61.
CleanEx	HS_TMEM161A.
Genevestigator	Q9NX61.
Family and domain databases
InterPro	IPR019395. Transmembrane_161A/B. [Graphical view]
Pfam	PF10268. Tmemb_161AB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TMEM161A. human.
GenomeRNAi	54929.
NextBio	58027.

Entry information

Entry name

T161A_HUMAN

Accession

Primary (citable) accession number: Q9NX61
Secondary accession number(s): B3KUE0, G5E9M6, Q7L2Y1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.