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Protein

Transmembrane protein 161A

Gene

TMEM161A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.1 Publication

Caution

GO - Biological processi

  • cellular response to oxidative stress Source: BHF-UCL
  • cellular response to UV Source: BHF-UCL
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
  • positive regulation of DNA repair Source: BHF-UCL
  • response to retinoic acid Source: BHF-UCL

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 161A
Alternative name(s):
Adaptive response to oxidative stress protein 29
Short name:
AROS-29
Gene namesi
ORF Names:UNQ582/PRO1152
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000064545.14
HGNCiHGNC:26020 TMEM161A
neXtProtiNX_Q9NX61

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 98ExtracellularSequence analysisAdd BLAST70
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 134CytoplasmicSequence analysisAdd BLAST15
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 166ExtracellularSequence analysisAdd BLAST11
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 224CytoplasmicSequence analysisAdd BLAST37
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 263ExtracellularSequence analysisAdd BLAST18
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 304CytoplasmicSequence analysisAdd BLAST20
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 370ExtracellularSequence analysisAdd BLAST45
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Topological domaini392 – 449CytoplasmicSequence analysisAdd BLAST58
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471 – 479ExtracellularSequence analysis9

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000064545
PharmGKBiPA145147959

Polymorphism and mutation databases

BioMutaiTMEM161A
DMDMi74734686

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000028808429 – 479Transmembrane protein 161AAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei69PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NX61
MaxQBiQ9NX61
PaxDbiQ9NX61
PeptideAtlasiQ9NX61
PRIDEiQ9NX61

PTM databases

iPTMnetiQ9NX61
PhosphoSitePlusiQ9NX61

Expressioni

Inductioni

Up-regulated in cells which display transient adaptation to mild oxidative stress by treatment with diethylmaleate, a glutathione-depleting agent. Also induced by retinoic acid.1 Publication

Gene expression databases

BgeeiENSG00000064545
CleanExiHS_TMEM161A
ExpressionAtlasiQ9NX61 baseline and differential
GenevisibleiQ9NX61 HS

Organism-specific databases

HPAiHPA043365

Interactioni

Protein-protein interaction databases

BioGridi12026917 interactors.
IntActiQ9NX61 18 interactors.
MINTiQ9NX61
STRINGi9606.ENSP00000162044

Structurei

3D structure databases

ProteinModelPortaliQ9NX61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM161 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3978 Eukaryota
ENOG410XPZC LUCA
GeneTreeiENSGT00390000000672
HOGENOMiHOG000273873
HOVERGENiHBG063501
InParanoidiQ9NX61
OMAiILWLWTK
OrthoDBiEOG091G0725
PhylomeDBiQ9NX61
TreeFamiTF314570

Family and domain databases

InterProiView protein in InterPro
IPR019395 Transmembrane_161A/B
PANTHERiPTHR13624 PTHR13624, 1 hit
PfamiView protein in Pfam
PF10268 Tmemb_161AB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX61-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVLGVQLVV TLLTATLMHR LAPHCSFARW LLCNGSLFRY KHPSEEELRA
60 70 80 90 100
LAGKPRPRGR KERWANGLSE EKPLSVPRDA PFQLETCPLT TVDALVLRFF
110 120 130 140 150
LEYQWFVDFA VYSGGVYLFT EAYYYMLGPA KETNIAVFWC LLTVTFSIKM
160 170 180 190 200
FLTVTRLYFS AEEGGERSVC LTFAFLFLLL AMLVQVVREE TLELGLEPGL
210 220 230 240 250
ASMTQNLEPL LKKQGWDWAL PVAKLAIRVG LAVVGSVLGA FLTFPGLRLA
260 270 280 290 300
QTHRDALTMS EDRPMLQFLL HTSFLSPLFI LWLWTKPIAR DFLHQPPFGE
310 320 330 340 350
TRFSLLSDSA FDSGRLWLLV VLCLLRLAVT RPHLQAYLCL AKARVEQLRR
360 370 380 390 400
EAGRIEAREI QQRVVRVYCY VTVVSLQYLT PLILTLNCTL LLKTLGGYSW
410 420 430 440 450
GLGPAPLLSP DPSSASAAPI GSGEDEVQQT AARIAGALGG LLTPLFLRGV
460 470
LAYLIWWTAA CQLLASLFGL YFHQHLAGS
Length:479
Mass (Da):53,602
Last modified:October 1, 2000 - v1
Checksum:i4DEA8A1C04CCA33D
GO
Isoform 2 (identifier: Q9NX61-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-198: Missing.

Note: No experimental confirmation available.
Show »
Length:376
Mass (Da):41,632
Checksum:i9533773B30DD4DF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti455I → V in BAG53402 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03653785E → V in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04604296 – 198Missing in isoform 2. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358088 mRNA Translation: AAQ88455.1
AK000429 mRNA Translation: BAA91159.1
AK096964 mRNA Translation: BAG53402.1
AC002126 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84787.1
BC005210 mRNA Translation: AAH05210.1
BC016478 mRNA Translation: AAH16478.2
CCDSiCCDS12393.1 [Q9NX61-1]
CCDS58656.1 [Q9NX61-2]
RefSeqiNP_001243695.1, NM_001256766.1 [Q9NX61-2]
NP_060284.1, NM_017814.2 [Q9NX61-1]
UniGeneiHs.631629

Genome annotation databases

EnsembliENST00000162044; ENSP00000162044; ENSG00000064545 [Q9NX61-1]
ENST00000450333; ENSP00000404208; ENSG00000064545 [Q9NX61-2]
GeneIDi54929
KEGGihsa:54929
UCSCiuc002nlg.5 human [Q9NX61-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiT161A_HUMAN
AccessioniPrimary (citable) accession number: Q9NX61
Secondary accession number(s): B3KUE0, G5E9M6, Q7L2Y1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome