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Protein

Transmembrane protein 161A

Gene

TMEM161A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.1 Publication

GO - Biological processi

  • cellular response to oxidative stress Source: BHF-UCL
  • cellular response to UV Source: BHF-UCL
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
  • positive regulation of DNA repair Source: BHF-UCL
  • response to retinoic acid Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000064545-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 161A
Alternative name(s):
Adaptive response to oxidative stress protein 29
Short name:
AROS-29
Gene namesi
ORF Names:UNQ582/PRO1152
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26020. TMEM161A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 98ExtracellularSequence analysisAdd BLAST70
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 134CytoplasmicSequence analysisAdd BLAST15
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Topological domaini156 – 166ExtracellularSequence analysisAdd BLAST11
Transmembranei167 – 187HelicalSequence analysisAdd BLAST21
Topological domaini188 – 224CytoplasmicSequence analysisAdd BLAST37
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 263ExtracellularSequence analysisAdd BLAST18
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 304CytoplasmicSequence analysisAdd BLAST20
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 370ExtracellularSequence analysisAdd BLAST45
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Topological domaini392 – 449CytoplasmicSequence analysisAdd BLAST58
Transmembranei450 – 470HelicalSequence analysisAdd BLAST21
Topological domaini471 – 479ExtracellularSequence analysis9

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000064545.
PharmGKBiPA145147959.

Polymorphism and mutation databases

BioMutaiTMEM161A.
DMDMi74734686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000028808429 – 479Transmembrane protein 161AAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Modified residuei69PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NX61.
MaxQBiQ9NX61.
PaxDbiQ9NX61.
PeptideAtlasiQ9NX61.
PRIDEiQ9NX61.

PTM databases

iPTMnetiQ9NX61.
PhosphoSitePlusiQ9NX61.

Expressioni

Inductioni

Up-regulated in cells which display transient adaptation to mild oxidative stress by treatment with diethylmaleate, a glutathione-depleting agent. Also induced by retinoic acid.1 Publication

Gene expression databases

BgeeiENSG00000064545.
CleanExiHS_TMEM161A.
ExpressionAtlasiQ9NX61. baseline and differential.
GenevisibleiQ9NX61. HS.

Organism-specific databases

HPAiHPA043365.

Interactioni

Protein-protein interaction databases

BioGridi120269. 15 interactors.
IntActiQ9NX61. 18 interactors.
STRINGi9606.ENSP00000162044.

Structurei

3D structure databases

ProteinModelPortaliQ9NX61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM161 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3978. Eukaryota.
ENOG410XPZC. LUCA.
GeneTreeiENSGT00390000000672.
HOGENOMiHOG000273873.
HOVERGENiHBG063501.
InParanoidiQ9NX61.
OMAiEDYLEFG.
OrthoDBiEOG091G0725.
PhylomeDBiQ9NX61.
TreeFamiTF314570.

Family and domain databases

InterProiIPR019395. Transmembrane_161A/B.
[Graphical view]
PfamiPF10268. Tmemb_161AB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX61-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVLGVQLVV TLLTATLMHR LAPHCSFARW LLCNGSLFRY KHPSEEELRA
60 70 80 90 100
LAGKPRPRGR KERWANGLSE EKPLSVPRDA PFQLETCPLT TVDALVLRFF
110 120 130 140 150
LEYQWFVDFA VYSGGVYLFT EAYYYMLGPA KETNIAVFWC LLTVTFSIKM
160 170 180 190 200
FLTVTRLYFS AEEGGERSVC LTFAFLFLLL AMLVQVVREE TLELGLEPGL
210 220 230 240 250
ASMTQNLEPL LKKQGWDWAL PVAKLAIRVG LAVVGSVLGA FLTFPGLRLA
260 270 280 290 300
QTHRDALTMS EDRPMLQFLL HTSFLSPLFI LWLWTKPIAR DFLHQPPFGE
310 320 330 340 350
TRFSLLSDSA FDSGRLWLLV VLCLLRLAVT RPHLQAYLCL AKARVEQLRR
360 370 380 390 400
EAGRIEAREI QQRVVRVYCY VTVVSLQYLT PLILTLNCTL LLKTLGGYSW
410 420 430 440 450
GLGPAPLLSP DPSSASAAPI GSGEDEVQQT AARIAGALGG LLTPLFLRGV
460 470
LAYLIWWTAA CQLLASLFGL YFHQHLAGS
Length:479
Mass (Da):53,602
Last modified:October 1, 2000 - v1
Checksum:i4DEA8A1C04CCA33D
GO
Isoform 2 (identifier: Q9NX61-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-198: Missing.

Note: No experimental confirmation available.
Show »
Length:376
Mass (Da):41,632
Checksum:i9533773B30DD4DF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti455I → V in BAG53402 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03653785E → V in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04604296 – 198Missing in isoform 2. 1 PublicationAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358088 mRNA. Translation: AAQ88455.1.
AK000429 mRNA. Translation: BAA91159.1.
AK096964 mRNA. Translation: BAG53402.1.
AC002126 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84787.1.
BC005210 mRNA. Translation: AAH05210.1.
BC016478 mRNA. Translation: AAH16478.2.
CCDSiCCDS12393.1. [Q9NX61-1]
CCDS58656.1. [Q9NX61-2]
RefSeqiNP_001243695.1. NM_001256766.1. [Q9NX61-2]
NP_060284.1. NM_017814.2. [Q9NX61-1]
UniGeneiHs.631629.

Genome annotation databases

EnsembliENST00000162044; ENSP00000162044; ENSG00000064545. [Q9NX61-1]
ENST00000450333; ENSP00000404208; ENSG00000064545. [Q9NX61-2]
GeneIDi54929.
KEGGihsa:54929.
UCSCiuc002nlg.5. human. [Q9NX61-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358088 mRNA. Translation: AAQ88455.1.
AK000429 mRNA. Translation: BAA91159.1.
AK096964 mRNA. Translation: BAG53402.1.
AC002126 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84787.1.
BC005210 mRNA. Translation: AAH05210.1.
BC016478 mRNA. Translation: AAH16478.2.
CCDSiCCDS12393.1. [Q9NX61-1]
CCDS58656.1. [Q9NX61-2]
RefSeqiNP_001243695.1. NM_001256766.1. [Q9NX61-2]
NP_060284.1. NM_017814.2. [Q9NX61-1]
UniGeneiHs.631629.

3D structure databases

ProteinModelPortaliQ9NX61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120269. 15 interactors.
IntActiQ9NX61. 18 interactors.
STRINGi9606.ENSP00000162044.

PTM databases

iPTMnetiQ9NX61.
PhosphoSitePlusiQ9NX61.

Polymorphism and mutation databases

BioMutaiTMEM161A.
DMDMi74734686.

Proteomic databases

EPDiQ9NX61.
MaxQBiQ9NX61.
PaxDbiQ9NX61.
PeptideAtlasiQ9NX61.
PRIDEiQ9NX61.

Protocols and materials databases

DNASUi54929.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000162044; ENSP00000162044; ENSG00000064545. [Q9NX61-1]
ENST00000450333; ENSP00000404208; ENSG00000064545. [Q9NX61-2]
GeneIDi54929.
KEGGihsa:54929.
UCSCiuc002nlg.5. human. [Q9NX61-1]

Organism-specific databases

CTDi54929.
GeneCardsiTMEM161A.
HGNCiHGNC:26020. TMEM161A.
HPAiHPA043365.
neXtProtiNX_Q9NX61.
OpenTargetsiENSG00000064545.
PharmGKBiPA145147959.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3978. Eukaryota.
ENOG410XPZC. LUCA.
GeneTreeiENSGT00390000000672.
HOGENOMiHOG000273873.
HOVERGENiHBG063501.
InParanoidiQ9NX61.
OMAiEDYLEFG.
OrthoDBiEOG091G0725.
PhylomeDBiQ9NX61.
TreeFamiTF314570.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000064545-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM161A. human.
GenomeRNAii54929.
PROiQ9NX61.

Gene expression databases

BgeeiENSG00000064545.
CleanExiHS_TMEM161A.
ExpressionAtlasiQ9NX61. baseline and differential.
GenevisibleiQ9NX61. HS.

Family and domain databases

InterProiIPR019395. Transmembrane_161A/B.
[Graphical view]
PfamiPF10268. Tmemb_161AB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT161A_HUMAN
AccessioniPrimary (citable) accession number: Q9NX61
Secondary accession number(s): B3KUE0, G5E9M6, Q7L2Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.