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Q9NX58

- LYAR_HUMAN

UniProt

Q9NX58 - LYAR_HUMAN

Protein

Cell growth-regulating nucleolar protein

Gene

LYAR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi6 – 61Zinc 1By similarity
    Metal bindingi9 – 91Zinc 1By similarity
    Metal bindingi21 – 211Zinc 1By similarity
    Metal bindingi25 – 251Zinc 1By similarity
    Metal bindingi33 – 331Zinc 2By similarity
    Metal bindingi36 – 361Zinc 2By similarity
    Metal bindingi48 – 481Zinc 2By similarity
    Metal bindingi51 – 511Zinc 2By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri6 – 2520C2HC-type 1Add
    BLAST
    Zinc fingeri33 – 5119C2HC-type 2Add
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: UniProt

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell growth-regulating nucleolar protein
    Gene namesi
    Name:LYAR
    ORF Names:PNAS-5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:26021. LYAR.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: LIFEdb
    2. nucleus Source: UniProt

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162394697.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 379379Cell growth-regulating nucleolar proteinPRO_0000084528Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei215 – 2151Phosphoserine1 Publication
    Modified residuei244 – 2441Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NX58.
    PaxDbiQ9NX58.
    PeptideAtlasiQ9NX58.
    PRIDEiQ9NX58.

    2D gel databases

    SWISS-2DPAGEQ9NX58.

    PTM databases

    PhosphoSiteiQ9NX58.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NX58.
    BgeeiQ9NX58.
    CleanExiHS_LYAR.
    GenevestigatoriQ9NX58.

    Organism-specific databases

    HPAiHPA035881.

    Interactioni

    Protein-protein interaction databases

    BioGridi120780. 51 interactions.
    IntActiQ9NX58. 18 interactions.
    MINTiMINT-1391739.
    STRINGi9606.ENSP00000345917.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NX58.
    SMRiQ9NX58. Positions 1-67.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili175 – 21945Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi168 – 379212Lys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 C2HC-type zinc fingers.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri6 – 2520C2HC-type 1Add
    BLAST
    Zinc fingeri33 – 5119C2HC-type 2Add
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG253936.
    HOGENOMiHOG000006633.
    HOVERGENiHBG006298.
    InParanoidiQ9NX58.
    KOiK15263.
    OMAiAPAKGKF.
    OrthoDBiEOG7PP58C.
    PhylomeDBiQ9NX58.
    TreeFamiTF314925.

    Family and domain databases

    InterProiIPR014898. Znf_C2H2_LYAR.
    [Graphical view]
    PfamiPF08790. zf-LYAR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NX58-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVFFTCNACG ESVKKIQVEK HVSVCRNCEC LSCIDCGKDF WGDDYKNHVK    50
    CISEDQKYGG KGYEGKTHKG DIKQQAWIQK ISELIKRPNV SPKVRELLEQ 100
    ISAFDNVPRK KAKFQNWMKN SLKVHNESIL DQVWNIFSEA SNSEPVNKEQ 150
    DQRPLHPVAN PHAEISTKVP ASKVKDAVEQ QGEVKKNKRE RKEERQKKRK 200
    REKKELKLEN HQENSRNQKP KKRKKGQEAD LEAGGEEVPE ANGSAGKRSK 250
    KKKQRKDSAS EEEAHVGAGK RKRRHSEVET DSKKKKMKLP EHPEGGEPED 300
    DEAPAKGKFN WKGTIKAILK QAPDNEITIK KLRKKVLAQY YTVTDEHHRS 350
    EEELLVIFNK KISKNPTFKL LKDKVKLVK 379
    Length:379
    Mass (Da):43,615
    Last modified:July 19, 2005 - v2
    Checksum:i45159F44C22537DB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211H → R in CAG38579. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti151 – 1511D → Y.
    Corresponds to variant rs2272739 [ dbSNP | Ensembl ].
    VAR_023080
    Natural varianti265 – 2651H → R.5 Publications
    Corresponds to variant rs7376390 [ dbSNP | Ensembl ].
    VAR_023081

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136750 mRNA. Translation: CAB66684.1.
    AK000432 mRNA. Translation: BAA91162.1.
    CR533548 mRNA. Translation: CAG38579.1.
    CH471131 Genomic DNA. Translation: EAW82437.1.
    CH471131 Genomic DNA. Translation: EAW82438.1.
    CH471131 Genomic DNA. Translation: EAW82439.1.
    BC015796 mRNA. Translation: AAH15796.1.
    AF229835 mRNA. Translation: AAF42870.1.
    CCDSiCCDS3374.1.
    RefSeqiNP_001139197.1. NM_001145725.1.
    NP_060286.1. NM_017816.2.
    UniGeneiHs.425427.

    Genome annotation databases

    EnsembliENST00000343470; ENSP00000345917; ENSG00000145220.
    ENST00000452476; ENSP00000397367; ENSG00000145220.
    GeneIDi55646.
    KEGGihsa:55646.
    UCSCiuc003ght.3. human.

    Polymorphism databases

    DMDMi71153817.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136750 mRNA. Translation: CAB66684.1 .
    AK000432 mRNA. Translation: BAA91162.1 .
    CR533548 mRNA. Translation: CAG38579.1 .
    CH471131 Genomic DNA. Translation: EAW82437.1 .
    CH471131 Genomic DNA. Translation: EAW82438.1 .
    CH471131 Genomic DNA. Translation: EAW82439.1 .
    BC015796 mRNA. Translation: AAH15796.1 .
    AF229835 mRNA. Translation: AAF42870.1 .
    CCDSi CCDS3374.1.
    RefSeqi NP_001139197.1. NM_001145725.1.
    NP_060286.1. NM_017816.2.
    UniGenei Hs.425427.

    3D structure databases

    ProteinModelPortali Q9NX58.
    SMRi Q9NX58. Positions 1-67.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120780. 51 interactions.
    IntActi Q9NX58. 18 interactions.
    MINTi MINT-1391739.
    STRINGi 9606.ENSP00000345917.

    PTM databases

    PhosphoSitei Q9NX58.

    Polymorphism databases

    DMDMi 71153817.

    2D gel databases

    SWISS-2DPAGE Q9NX58.

    Proteomic databases

    MaxQBi Q9NX58.
    PaxDbi Q9NX58.
    PeptideAtlasi Q9NX58.
    PRIDEi Q9NX58.

    Protocols and materials databases

    DNASUi 55646.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000343470 ; ENSP00000345917 ; ENSG00000145220 .
    ENST00000452476 ; ENSP00000397367 ; ENSG00000145220 .
    GeneIDi 55646.
    KEGGi hsa:55646.
    UCSCi uc003ght.3. human.

    Organism-specific databases

    CTDi 55646.
    GeneCardsi GC04M004269.
    H-InvDB HIX0017656.
    HGNCi HGNC:26021. LYAR.
    HPAi HPA035881.
    neXtProti NX_Q9NX58.
    PharmGKBi PA162394697.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253936.
    HOGENOMi HOG000006633.
    HOVERGENi HBG006298.
    InParanoidi Q9NX58.
    KOi K15263.
    OMAi APAKGKF.
    OrthoDBi EOG7PP58C.
    PhylomeDBi Q9NX58.
    TreeFami TF314925.

    Miscellaneous databases

    ChiTaRSi LYAR. human.
    GeneWikii LYAR.
    GenomeRNAii 55646.
    NextBioi 60338.
    PROi Q9NX58.

    Gene expression databases

    ArrayExpressi Q9NX58.
    Bgeei Q9NX58.
    CleanExi HS_LYAR.
    Genevestigatori Q9NX58.

    Family and domain databases

    InterProi IPR014898. Znf_C2H2_LYAR.
    [Graphical view ]
    Pfami PF08790. zf-LYAR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265.
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-265.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265.
      Tissue: Uterus.
    6. "Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
      Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 270-379.
      Tissue: Promyelocytic leukemia.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215 AND SER-244, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLYAR_HUMAN
    AccessioniPrimary (citable) accession number: Q9NX58
    Secondary accession number(s): D3DVS4, Q6FI78, Q9NYS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3