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Protein

Cell growth-regulating nucleolar protein

Gene

LYAR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Zinc 1By similarity1
Metal bindingi9Zinc 1By similarity1
Metal bindingi21Zinc 1By similarity1
Metal bindingi25Zinc 1By similarity1
Metal bindingi33Zinc 2By similarity1
Metal bindingi36Zinc 2By similarity1
Metal bindingi48Zinc 2By similarity1
Metal bindingi51Zinc 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 26C2HC LYAR-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri28 – 52C2HC LYAR-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180039-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell growth-regulating nucleolar protein
Gene namesi
Name:LYAR
ORF Names:PNAS-5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26021. LYAR.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: LIFEdb
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394697.

Polymorphism and mutation databases

BioMutaiLYAR.
DMDMi71153817.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000845281 – 379Cell growth-regulating nucleolar proteinAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki207Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei215PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NX58.
MaxQBiQ9NX58.
PaxDbiQ9NX58.
PeptideAtlasiQ9NX58.
PRIDEiQ9NX58.

2D gel databases

SWISS-2DPAGEQ9NX58.

PTM databases

iPTMnetiQ9NX58.
PhosphoSitePlusiQ9NX58.
SwissPalmiQ9NX58.

Expressioni

Gene expression databases

BgeeiENSG00000145220.
CleanExiHS_LYAR.
ExpressionAtlasiQ9NX58. baseline and differential.
GenevisibleiQ9NX58. HS.

Organism-specific databases

HPAiHPA035881.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BEND7Q8N7W2-23EBI-713507,EBI-10181188
PRKRAO755694EBI-713507,EBI-713955
SDCBP2Q9H1905EBI-713507,EBI-742426

Protein-protein interaction databases

BioGridi120780. 71 interactors.
IntActiQ9NX58. 36 interactors.
MINTiMINT-1391739.
STRINGi9606.ENSP00000345917.

Structurei

3D structure databases

ProteinModelPortaliQ9NX58.
SMRiQ9NX58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili175 – 219Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi168 – 379Lys-richAdd BLAST212

Sequence similaritiesi

Contains 2 C2HC LYAR-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 26C2HC LYAR-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri28 – 52C2HC LYAR-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2186. Eukaryota.
ENOG411081U. LUCA.
HOGENOMiHOG000006633.
HOVERGENiHBG006298.
InParanoidiQ9NX58.
KOiK15263.
OrthoDBiEOG091G0L4Z.
PhylomeDBiQ9NX58.
TreeFamiTF314925.

Family and domain databases

InterProiIPR014898. Znf_C2H2_LYAR.
[Graphical view]
PfamiPF08790. zf-LYAR. 1 hit.
[Graphical view]
PROSITEiPS51804. ZF_C2HC_LYAR. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NX58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFFTCNACG ESVKKIQVEK HVSVCRNCEC LSCIDCGKDF WGDDYKNHVK
60 70 80 90 100
CISEDQKYGG KGYEGKTHKG DIKQQAWIQK ISELIKRPNV SPKVRELLEQ
110 120 130 140 150
ISAFDNVPRK KAKFQNWMKN SLKVHNESIL DQVWNIFSEA SNSEPVNKEQ
160 170 180 190 200
DQRPLHPVAN PHAEISTKVP ASKVKDAVEQ QGEVKKNKRE RKEERQKKRK
210 220 230 240 250
REKKELKLEN HQENSRNQKP KKRKKGQEAD LEAGGEEVPE ANGSAGKRSK
260 270 280 290 300
KKKQRKDSAS EEEAHVGAGK RKRRHSEVET DSKKKKMKLP EHPEGGEPED
310 320 330 340 350
DEAPAKGKFN WKGTIKAILK QAPDNEITIK KLRKKVLAQY YTVTDEHHRS
360 370
EEELLVIFNK KISKNPTFKL LKDKVKLVK
Length:379
Mass (Da):43,615
Last modified:July 19, 2005 - v2
Checksum:i45159F44C22537DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21H → R in CAG38579 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023080151D → Y.Corresponds to variant rs2272739dbSNPEnsembl.1
Natural variantiVAR_023081265H → R.5 PublicationsCorresponds to variant rs7376390dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136750 mRNA. Translation: CAB66684.1.
AK000432 mRNA. Translation: BAA91162.1.
CR533548 mRNA. Translation: CAG38579.1.
CH471131 Genomic DNA. Translation: EAW82437.1.
CH471131 Genomic DNA. Translation: EAW82438.1.
CH471131 Genomic DNA. Translation: EAW82439.1.
BC015796 mRNA. Translation: AAH15796.1.
AF229835 mRNA. Translation: AAF42870.1.
CCDSiCCDS3374.1.
RefSeqiNP_001139197.1. NM_001145725.1.
NP_060286.1. NM_017816.2.
XP_011511807.1. XM_011513505.1.
XP_011511808.1. XM_011513506.2.
UniGeneiHs.425427.

Genome annotation databases

EnsembliENST00000343470; ENSP00000345917; ENSG00000145220.
ENST00000452476; ENSP00000397367; ENSG00000145220.
GeneIDi55646.
KEGGihsa:55646.
UCSCiuc003ght.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136750 mRNA. Translation: CAB66684.1.
AK000432 mRNA. Translation: BAA91162.1.
CR533548 mRNA. Translation: CAG38579.1.
CH471131 Genomic DNA. Translation: EAW82437.1.
CH471131 Genomic DNA. Translation: EAW82438.1.
CH471131 Genomic DNA. Translation: EAW82439.1.
BC015796 mRNA. Translation: AAH15796.1.
AF229835 mRNA. Translation: AAF42870.1.
CCDSiCCDS3374.1.
RefSeqiNP_001139197.1. NM_001145725.1.
NP_060286.1. NM_017816.2.
XP_011511807.1. XM_011513505.1.
XP_011511808.1. XM_011513506.2.
UniGeneiHs.425427.

3D structure databases

ProteinModelPortaliQ9NX58.
SMRiQ9NX58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120780. 71 interactors.
IntActiQ9NX58. 36 interactors.
MINTiMINT-1391739.
STRINGi9606.ENSP00000345917.

PTM databases

iPTMnetiQ9NX58.
PhosphoSitePlusiQ9NX58.
SwissPalmiQ9NX58.

Polymorphism and mutation databases

BioMutaiLYAR.
DMDMi71153817.

2D gel databases

SWISS-2DPAGEQ9NX58.

Proteomic databases

EPDiQ9NX58.
MaxQBiQ9NX58.
PaxDbiQ9NX58.
PeptideAtlasiQ9NX58.
PRIDEiQ9NX58.

Protocols and materials databases

DNASUi55646.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343470; ENSP00000345917; ENSG00000145220.
ENST00000452476; ENSP00000397367; ENSG00000145220.
GeneIDi55646.
KEGGihsa:55646.
UCSCiuc003ght.4. human.

Organism-specific databases

CTDi55646.
GeneCardsiLYAR.
H-InvDBHIX0017656.
HGNCiHGNC:26021. LYAR.
HPAiHPA035881.
neXtProtiNX_Q9NX58.
PharmGKBiPA162394697.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2186. Eukaryota.
ENOG411081U. LUCA.
HOGENOMiHOG000006633.
HOVERGENiHBG006298.
InParanoidiQ9NX58.
KOiK15263.
OrthoDBiEOG091G0L4Z.
PhylomeDBiQ9NX58.
TreeFamiTF314925.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180039-MONOMER.

Miscellaneous databases

ChiTaRSiLYAR. human.
GeneWikiiLYAR.
GenomeRNAii55646.
PROiQ9NX58.

Gene expression databases

BgeeiENSG00000145220.
CleanExiHS_LYAR.
ExpressionAtlasiQ9NX58. baseline and differential.
GenevisibleiQ9NX58. HS.

Family and domain databases

InterProiIPR014898. Znf_C2H2_LYAR.
[Graphical view]
PfamiPF08790. zf-LYAR. 1 hit.
[Graphical view]
PROSITEiPS51804. ZF_C2HC_LYAR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYAR_HUMAN
AccessioniPrimary (citable) accession number: Q9NX58
Secondary accession number(s): D3DVS4, Q6FI78, Q9NYS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.