Q9NX58 (LYAR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell growth-regulating nucleolar protein

Gene names

Name:	LYAR
ORF Names:	PNAS-5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus › nucleolus Ref.7.
Sequence similarities	Contains 2 C2HC-type zinc fingers.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Coiled coil Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleolus Inferred from direct assay. Source: LIFEdb
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 379	379	Cell growth-regulating nucleolar protein		PRO_0000084528
Regions
	Zinc finger	6 – 25	20	C2HC-type 1
	Zinc finger	33 – 51	19	C2HC-type 2
	Coiled coil	175 – 219	45	Potential
	Compositional bias	168 – 379	212	Lys-rich
Sites
	Metal binding	6	1	Zinc 1 By similarity
	Metal binding	9	1	Zinc 1 By similarity
	Metal binding	21	1	Zinc 1 By similarity
	Metal binding	25	1	Zinc 1 By similarity
	Metal binding	33	1	Zinc 2 By similarity
	Metal binding	36	1	Zinc 2 By similarity
	Metal binding	48	1	Zinc 2 By similarity
	Metal binding	51	1	Zinc 2 By similarity
Amino acid modifications
	Modified residue	215	1	Phosphoserine Ref.9
	Modified residue	244	1	Phosphoserine Ref.9
Natural variations
	Natural variant	151	1	D → Y. Corresponds to variant rs2272739 [ dbSNP | Ensembl ].		VAR_023080
	Natural variant	265	1	H → R. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Corresponds to variant rs7376390 [ dbSNP | Ensembl ].		VAR_023081
Experimental info
	Sequence conflict	21	1	H → R in CAG38579. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9NX58 [UniParc]. Last modified July 19, 2005. Version 2. Checksum: 45159F44C22537DB	FASTA	379	43,615
	10 20 30 40 50 60 MVFFTCNACG ESVKKIQVEK HVSVCRNCEC LSCIDCGKDF WGDDYKNHVK CISEDQKYGG 70 80 90 100 110 120 KGYEGKTHKG DIKQQAWIQK ISELIKRPNV SPKVRELLEQ ISAFDNVPRK KAKFQNWMKN 130 140 150 160 170 180 SLKVHNESIL DQVWNIFSEA SNSEPVNKEQ DQRPLHPVAN PHAEISTKVP ASKVKDAVEQ 190 200 210 220 230 240 QGEVKKNKRE RKEERQKKRK REKKELKLEN HQENSRNQKP KKRKKGQEAD LEAGGEEVPE 250 260 270 280 290 300 ANGSAGKRSK KKKQRKDSAS EEEAHVGAGK RKRRHSEVET DSKKKKMKLP EHPEGGEPED 310 320 330 340 350 360 DEAPAKGKFN WKGTIKAILK QAPDNEITIK KLRKKVLAQY YTVTDEHHRS EEELLVIFNK 370 KISKNPTFKL LKDKVKLVK

References

[1]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265. Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-265.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265. Tissue: Uterus.
[6]	"Human acute promyelocytic leukemia cell line NB4's apoptosis related genes." Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 270-379. Tissue: Promyelocytic leukemia.
[7]	"Functional proteomic analysis of human nucleolus." Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215 AND SER-244, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136750 mRNA. Translation: CAB66684.1. AK000432 mRNA. Translation: BAA91162.1. CR533548 mRNA. Translation: CAG38579.1. CH471131 Genomic DNA. Translation: EAW82437.1. CH471131 Genomic DNA. Translation: EAW82438.1. CH471131 Genomic DNA. Translation: EAW82439.1. BC015796 mRNA. Translation: AAH15796.1. AF229835 mRNA. Translation: AAF42870.1.
IPI	IPI00015838.
RefSeq	NP_001139197.1. NM_001145725.1. NP_060286.1. NM_017816.2.
UniGene	Hs.425427.
3D structure databases
ProteinModelPortal	Q9NX58.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NX58. 13 interactions.
MINT	MINT-1391739.
STRING	9606.ENSP00000345917.
PTM databases
PhosphoSite	Q9NX58.
Polymorphism databases
DMDM	71153817.
2D gel databases
SWISS-2DPAGE	Q9NX58.
Proteomic databases
PaxDb	Q9NX58.
PeptideAtlas	Q9NX58.
PRIDE	Q9NX58.
Protocols and materials databases
DNASU	55646.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000343470; ENSP00000345917; ENSG00000145220. ENST00000452476; ENSP00000397367; ENSG00000145220.
GeneID	55646.
KEGG	hsa:55646.
UCSC	uc003ght.3. human.
Organism-specific databases
CTD	55646.
GeneCards	GC04M004269.
H-InvDB	HIX0017656.
HGNC	HGNC:26021. LYAR.
HPA	HPA035881.
neXtProt	NX_Q9NX58.
PharmGKB	PA162394697.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG253936.
HOGENOM	HOG000006633.
HOVERGEN	HBG006298.
InParanoid	Q9NX58.
KO	K15263.
OMA	GYEGKTH.
OrthoDB	EOG4STS57.
PhylomeDB	Q9NX58.
Gene expression databases
ArrayExpress	Q9NX58.
Bgee	Q9NX58.
CleanEx	HS_LYAR.
Genevestigator	Q9NX58.
GermOnline	ENSG00000145220. Homo sapiens.
Family and domain databases
InterPro	IPR014898. Znf_C2H2_LYAR. [Graphical view]
Pfam	PF08790. zf-LYAR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	LYAR. human.
GenomeRNAi	55646.
NextBio	60338.

Entry information

Entry name

LYAR_HUMAN

Accession

Primary (citable) accession number: Q9NX58
Secondary accession number(s): D3DVS4, Q6FI78, Q9NYS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	July 19, 2005
Last modified:	May 1, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.