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Q9NX58

- LYAR_HUMAN

UniProt

Q9NX58 - LYAR_HUMAN

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Protein
Cell growth-regulating nucleolar protein
Gene
LYAR, PNAS-5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Zinc 1 By similarity
Metal bindingi9 – 91Zinc 1 By similarity
Metal bindingi21 – 211Zinc 1 By similarity
Metal bindingi25 – 251Zinc 1 By similarity
Metal bindingi33 – 331Zinc 2 By similarity
Metal bindingi36 – 361Zinc 2 By similarity
Metal bindingi48 – 481Zinc 2 By similarity
Metal bindingi51 – 511Zinc 2 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri6 – 2520C2HC-type 1
Add
BLAST
Zinc fingeri33 – 5119C2HC-type 2
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. poly(A) RNA binding Source: UniProtKB
  3. protein binding Source: UniProt
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cell growth-regulating nucleolar protein
Gene namesi
Name:LYAR
ORF Names:PNAS-5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:26021. LYAR.

Subcellular locationi

Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. nucleolus Source: LIFEdb
  2. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394697.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Cell growth-regulating nucleolar protein
PRO_0000084528Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei215 – 2151Phosphoserine1 Publication
Modified residuei244 – 2441Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NX58.
PaxDbiQ9NX58.
PeptideAtlasiQ9NX58.
PRIDEiQ9NX58.

2D gel databases

SWISS-2DPAGEQ9NX58.

PTM databases

PhosphoSiteiQ9NX58.

Expressioni

Gene expression databases

ArrayExpressiQ9NX58.
BgeeiQ9NX58.
CleanExiHS_LYAR.
GenevestigatoriQ9NX58.

Organism-specific databases

HPAiHPA035881.

Interactioni

Protein-protein interaction databases

BioGridi120780. 51 interactions.
IntActiQ9NX58. 18 interactions.
MINTiMINT-1391739.
STRINGi9606.ENSP00000345917.

Structurei

3D structure databases

ProteinModelPortaliQ9NX58.
SMRiQ9NX58. Positions 1-67.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili175 – 21945 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi168 – 379212Lys-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG253936.
HOGENOMiHOG000006633.
HOVERGENiHBG006298.
InParanoidiQ9NX58.
KOiK15263.
OMAiAPAKGKF.
OrthoDBiEOG7PP58C.
PhylomeDBiQ9NX58.
TreeFamiTF314925.

Family and domain databases

InterProiIPR014898. Znf_C2H2_LYAR.
[Graphical view]
PfamiPF08790. zf-LYAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NX58-1 [UniParc]FASTAAdd to Basket

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MVFFTCNACG ESVKKIQVEK HVSVCRNCEC LSCIDCGKDF WGDDYKNHVK    50
CISEDQKYGG KGYEGKTHKG DIKQQAWIQK ISELIKRPNV SPKVRELLEQ 100
ISAFDNVPRK KAKFQNWMKN SLKVHNESIL DQVWNIFSEA SNSEPVNKEQ 150
DQRPLHPVAN PHAEISTKVP ASKVKDAVEQ QGEVKKNKRE RKEERQKKRK 200
REKKELKLEN HQENSRNQKP KKRKKGQEAD LEAGGEEVPE ANGSAGKRSK 250
KKKQRKDSAS EEEAHVGAGK RKRRHSEVET DSKKKKMKLP EHPEGGEPED 300
DEAPAKGKFN WKGTIKAILK QAPDNEITIK KLRKKVLAQY YTVTDEHHRS 350
EEELLVIFNK KISKNPTFKL LKDKVKLVK 379
Length:379
Mass (Da):43,615
Last modified:July 19, 2005 - v2
Checksum:i45159F44C22537DB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti151 – 1511D → Y.
Corresponds to variant rs2272739 [ dbSNP | Ensembl ].
VAR_023080
Natural varianti265 – 2651H → R.5 Publications
Corresponds to variant rs7376390 [ dbSNP | Ensembl ].
VAR_023081

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211H → R in CAG38579. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136750 mRNA. Translation: CAB66684.1.
AK000432 mRNA. Translation: BAA91162.1.
CR533548 mRNA. Translation: CAG38579.1.
CH471131 Genomic DNA. Translation: EAW82437.1.
CH471131 Genomic DNA. Translation: EAW82438.1.
CH471131 Genomic DNA. Translation: EAW82439.1.
BC015796 mRNA. Translation: AAH15796.1.
AF229835 mRNA. Translation: AAF42870.1.
CCDSiCCDS3374.1.
RefSeqiNP_001139197.1. NM_001145725.1.
NP_060286.1. NM_017816.2.
UniGeneiHs.425427.

Genome annotation databases

EnsembliENST00000343470; ENSP00000345917; ENSG00000145220.
ENST00000452476; ENSP00000397367; ENSG00000145220.
GeneIDi55646.
KEGGihsa:55646.
UCSCiuc003ght.3. human.

Polymorphism databases

DMDMi71153817.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136750 mRNA. Translation: CAB66684.1 .
AK000432 mRNA. Translation: BAA91162.1 .
CR533548 mRNA. Translation: CAG38579.1 .
CH471131 Genomic DNA. Translation: EAW82437.1 .
CH471131 Genomic DNA. Translation: EAW82438.1 .
CH471131 Genomic DNA. Translation: EAW82439.1 .
BC015796 mRNA. Translation: AAH15796.1 .
AF229835 mRNA. Translation: AAF42870.1 .
CCDSi CCDS3374.1.
RefSeqi NP_001139197.1. NM_001145725.1.
NP_060286.1. NM_017816.2.
UniGenei Hs.425427.

3D structure databases

ProteinModelPortali Q9NX58.
SMRi Q9NX58. Positions 1-67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120780. 51 interactions.
IntActi Q9NX58. 18 interactions.
MINTi MINT-1391739.
STRINGi 9606.ENSP00000345917.

PTM databases

PhosphoSitei Q9NX58.

Polymorphism databases

DMDMi 71153817.

2D gel databases

SWISS-2DPAGE Q9NX58.

Proteomic databases

MaxQBi Q9NX58.
PaxDbi Q9NX58.
PeptideAtlasi Q9NX58.
PRIDEi Q9NX58.

Protocols and materials databases

DNASUi 55646.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343470 ; ENSP00000345917 ; ENSG00000145220 .
ENST00000452476 ; ENSP00000397367 ; ENSG00000145220 .
GeneIDi 55646.
KEGGi hsa:55646.
UCSCi uc003ght.3. human.

Organism-specific databases

CTDi 55646.
GeneCardsi GC04M004269.
H-InvDB HIX0017656.
HGNCi HGNC:26021. LYAR.
HPAi HPA035881.
neXtProti NX_Q9NX58.
PharmGKBi PA162394697.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253936.
HOGENOMi HOG000006633.
HOVERGENi HBG006298.
InParanoidi Q9NX58.
KOi K15263.
OMAi APAKGKF.
OrthoDBi EOG7PP58C.
PhylomeDBi Q9NX58.
TreeFami TF314925.

Miscellaneous databases

ChiTaRSi LYAR. human.
GeneWikii LYAR.
GenomeRNAii 55646.
NextBioi 60338.
PROi Q9NX58.

Gene expression databases

ArrayExpressi Q9NX58.
Bgeei Q9NX58.
CleanExi HS_LYAR.
Genevestigatori Q9NX58.

Family and domain databases

InterProi IPR014898. Znf_C2H2_LYAR.
[Graphical view ]
Pfami PF08790. zf-LYAR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265.
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-265.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265.
    Tissue: Uterus.
  6. "Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
    Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 270-379.
    Tissue: Promyelocytic leukemia.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215 AND SER-244, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLYAR_HUMAN
AccessioniPrimary (citable) accession number: Q9NX58
Secondary accession number(s): D3DVS4, Q6FI78, Q9NYS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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