Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NX58 (LYAR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell growth-regulating nucleolar protein
Gene names
Name:LYAR
ORF Names:PNAS-5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleusnucleolus Ref.7.

Sequence similarities

Contains 2 C2HC-type zinc fingers.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainCoiled coil
Repeat
Zinc-finger
   LigandMetal-binding
Zinc
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleolus

Inferred from direct assay. Source: LIFEdb

nucleus

Inferred from direct assay. Source: HPA

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

poly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Cell growth-regulating nucleolar protein
PRO_0000084528

Regions

Zinc finger6 – 2520C2HC-type 1
Zinc finger33 – 5119C2HC-type 2
Coiled coil175 – 21945 Potential
Compositional bias168 – 379212Lys-rich

Sites

Metal binding61Zinc 1 By similarity
Metal binding91Zinc 1 By similarity
Metal binding211Zinc 1 By similarity
Metal binding251Zinc 1 By similarity
Metal binding331Zinc 2 By similarity
Metal binding361Zinc 2 By similarity
Metal binding481Zinc 2 By similarity
Metal binding511Zinc 2 By similarity

Amino acid modifications

Modified residue2151Phosphoserine Ref.9
Modified residue2441Phosphoserine Ref.9

Natural variations

Natural variant1511D → Y.
Corresponds to variant rs2272739 [ dbSNP | Ensembl ].
VAR_023080
Natural variant2651H → R. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5
Corresponds to variant rs7376390 [ dbSNP | Ensembl ].
VAR_023081

Experimental info

Sequence conflict211H → R in CAG38579. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9NX58 [UniParc].

Last modified July 19, 2005. Version 2.
Checksum: 45159F44C22537DB

FASTA37943,615
        10         20         30         40         50         60 
MVFFTCNACG ESVKKIQVEK HVSVCRNCEC LSCIDCGKDF WGDDYKNHVK CISEDQKYGG 

        70         80         90        100        110        120 
KGYEGKTHKG DIKQQAWIQK ISELIKRPNV SPKVRELLEQ ISAFDNVPRK KAKFQNWMKN 

       130        140        150        160        170        180 
SLKVHNESIL DQVWNIFSEA SNSEPVNKEQ DQRPLHPVAN PHAEISTKVP ASKVKDAVEQ 

       190        200        210        220        230        240 
QGEVKKNKRE RKEERQKKRK REKKELKLEN HQENSRNQKP KKRKKGQEAD LEAGGEEVPE 

       250        260        270        280        290        300 
ANGSAGKRSK KKKQRKDSAS EEEAHVGAGK RKRRHSEVET DSKKKKMKLP EHPEGGEPED 

       310        320        330        340        350        360 
DEAPAKGKFN WKGTIKAILK QAPDNEITIK KLRKKVLAQY YTVTDEHHRS EEELLVIFNK 

       370 
KISKNPTFKL LKDKVKLVK 

« Hide

References

[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265.
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-265.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-265.
Tissue: Uterus.
[6]"Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 270-379.
Tissue: Promyelocytic leukemia.
[7]"Functional proteomic analysis of human nucleolus."
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215 AND SER-244, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL136750 mRNA. Translation: CAB66684.1.
AK000432 mRNA. Translation: BAA91162.1.
CR533548 mRNA. Translation: CAG38579.1.
CH471131 Genomic DNA. Translation: EAW82437.1.
CH471131 Genomic DNA. Translation: EAW82438.1.
CH471131 Genomic DNA. Translation: EAW82439.1.
BC015796 mRNA. Translation: AAH15796.1.
AF229835 mRNA. Translation: AAF42870.1.
RefSeqNP_001139197.1. NM_001145725.1.
NP_060286.1. NM_017816.2.
UniGeneHs.425427.

3D structure databases

ProteinModelPortalQ9NX58.
SMRQ9NX58. Positions 1-67.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120780. 50 interactions.
IntActQ9NX58. 18 interactions.
MINTMINT-1391739.
STRING9606.ENSP00000345917.

PTM databases

PhosphoSiteQ9NX58.

Polymorphism databases

DMDM71153817.

2D gel databases

SWISS-2DPAGEQ9NX58.

Proteomic databases

PaxDbQ9NX58.
PeptideAtlasQ9NX58.
PRIDEQ9NX58.

Protocols and materials databases

DNASU55646.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000343470; ENSP00000345917; ENSG00000145220.
ENST00000452476; ENSP00000397367; ENSG00000145220.
GeneID55646.
KEGGhsa:55646.
UCSCuc003ght.3. human.

Organism-specific databases

CTD55646.
GeneCardsGC04M004269.
H-InvDBHIX0017656.
HGNCHGNC:26021. LYAR.
HPAHPA035881.
neXtProtNX_Q9NX58.
PharmGKBPA162394697.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG253936.
HOGENOMHOG000006633.
HOVERGENHBG006298.
InParanoidQ9NX58.
KOK15263.
OMAGYEGKTH.
OrthoDBEOG7PP58C.
PhylomeDBQ9NX58.
TreeFamTF314925.

Gene expression databases

ArrayExpressQ9NX58.
BgeeQ9NX58.
CleanExHS_LYAR.
GenevestigatorQ9NX58.

Family and domain databases

InterProIPR014898. Znf_C2H2_LYAR.
[Graphical view]
PfamPF08790. zf-LYAR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLYAR. human.
GeneWikiLYAR.
GenomeRNAi55646.
NextBio60338.
PROQ9NX58.

Entry information

Entry nameLYAR_HUMAN
AccessionPrimary (citable) accession number: Q9NX58
Secondary accession number(s): D3DVS4, Q6FI78, Q9NYS1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM