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Protein

Ras-related protein Rab-20

Gene

RAB20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19GTPBy similarity8
Nucleotide bindingi55 – 59GTPBy similarity5
Nucleotide bindingi113 – 116GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • phagosome acidification Source: UniProtKB
  • phagosome-lysosome fusion Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of endocytosis Source: GO_Central

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719. RAB geranylgeranylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-20
Gene namesi
Name:RAB20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:18260. RAB20.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55647.
OpenTargetsiENSG00000139832.
PharmGKBiPA34110.

Polymorphism and mutation databases

BioMutaiRAB20.
DMDMi20139805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212021 – 234Ras-related protein Rab-20Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi232S-geranylgeranyl cysteineBy similarity1
Lipidationi233S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

EPDiQ9NX57.
MaxQBiQ9NX57.
PaxDbiQ9NX57.
PeptideAtlasiQ9NX57.
PRIDEiQ9NX57.

PTM databases

iPTMnetiQ9NX57.
PhosphoSitePlusiQ9NX57.

Expressioni

Tissue specificityi

Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000139832.
CleanExiHS_RAB20.
GenevisibleiQ9NX57. HS.

Organism-specific databases

HPAiHPA052111.
HPA068647.

Interactioni

Protein-protein interaction databases

BioGridi120781. 14 interactors.
STRINGi9606.ENSP00000267328.

Structurei

3D structure databases

ProteinModelPortaliQ9NX57.
SMRiQ9NX57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 41Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
GeneTreeiENSGT00760000119101.
HOGENOMiHOG000233968.
HOVERGENiHBG097927.
InParanoidiQ9NX57.
KOiK07911.
OMAiHRYMERR.
OrthoDBiEOG091G0XVL.
PhylomeDBiQ9NX57.
TreeFamiTF331574.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NX57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKPDSKIVL LGDMNVGKTS LLQRYMERRF PDTVSTVGGA FYLKQWRSYN
60 70 80 90 100
ISIWDTAGRE QFHGLGSMYC RGAAAIILTY DVNHRQSLVE LEDRFLGLTD
110 120 130 140 150
TASKDCLFAI VGNKVDLTEE GALAGQEKEE CSPNMDAGDR VSPRAPKQVQ
160 170 180 190 200
LEDAVALYKK ILKYKMLDEQ DVPAAEQMCF ETSAKTGYNV DLLFETLFDL
210 220 230
VVPMILQQRA ERPSHTVDIS SHKPPKRTRS GCCA
Length:234
Mass (Da):26,277
Last modified:October 1, 2000 - v1
Checksum:iA0201E23BBF75DC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62F → I in BAA91171 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_017158134N → S. Corresponds to variant dbSNP:rs426453Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272065 mRNA. Translation: CAC81247.1.
AK000436 mRNA. Translation: BAA91163.1.
AK000446 mRNA. Translation: BAA91171.1.
AL139385 Genomic DNA. No translation available.
CH471085 Genomic DNA. Translation: EAX09113.1.
BC026025 mRNA. Translation: AAH26025.1.
CCDSiCCDS9512.1.
RefSeqiNP_060287.1. NM_017817.2.
UniGeneiHs.743563.

Genome annotation databases

EnsembliENST00000267328; ENSP00000267328; ENSG00000139832.
GeneIDi55647.
KEGGihsa:55647.
UCSCiuc001vqy.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRAB20_HUMAN
AccessioniPrimary (citable) accession number: Q9NX57
Secondary accession number(s): Q5T9X5, Q9NX49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families