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Q9NX57

- RAB20_HUMAN

UniProt

Q9NX57 - RAB20_HUMAN

Protein

Ras-related protein Rab-20

Gene

RAB20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 198GTPBy similarity
    Nucleotide bindingi55 – 595GTPBy similarity
    Nucleotide bindingi113 – 1164GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. phagosome acidification Source: UniProtKB
    2. phagosome-lysosome fusion Source: UniProtKB
    3. protein transport Source: UniProtKB-KW
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-20
    Gene namesi
    Name:RAB20
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:18260. RAB20.

    Subcellular locationi

    Golgi apparatus. Cytoplasmic vesiclephagosome. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
    Note: Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules By similarity. Recruited to phagosomes containing S.aureus or M.tuberculosis.By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: HPA
    2. intracellular membrane-bounded organelle Source: HPA
    3. phagocytic vesicle Source: UniProtKB
    4. phagocytic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34110.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 234234Ras-related protein Rab-20PRO_0000121202Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi232 – 2321S-geranylgeranyl cysteineBy similarity
    Lipidationi233 – 2331S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Prenylation

    Proteomic databases

    MaxQBiQ9NX57.
    PaxDbiQ9NX57.
    PRIDEiQ9NX57.

    PTM databases

    PhosphoSiteiQ9NX57.

    Expressioni

    Tissue specificityi

    Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level).1 Publication

    Gene expression databases

    BgeeiQ9NX57.
    CleanExiHS_RAB20.
    GenevestigatoriQ9NX57.

    Organism-specific databases

    HPAiHPA052111.

    Interactioni

    Protein-protein interaction databases

    BioGridi120781. 1 interaction.
    STRINGi9606.ENSP00000267328.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NX57.
    SMRiQ9NX57. Positions 7-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi33 – 419Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG097927.
    InParanoidiQ9NX57.
    KOiK07911.
    OMAiMRKPDGK.
    OrthoDBiEOG78D7MT.
    PhylomeDBiQ9NX57.
    TreeFamiTF331574.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SUPFAMiSSF52540. SSF52540. 2 hits.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NX57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKPDSKIVL LGDMNVGKTS LLQRYMERRF PDTVSTVGGA FYLKQWRSYN    50
    ISIWDTAGRE QFHGLGSMYC RGAAAIILTY DVNHRQSLVE LEDRFLGLTD 100
    TASKDCLFAI VGNKVDLTEE GALAGQEKEE CSPNMDAGDR VSPRAPKQVQ 150
    LEDAVALYKK ILKYKMLDEQ DVPAAEQMCF ETSAKTGYNV DLLFETLFDL 200
    VVPMILQQRA ERPSHTVDIS SHKPPKRTRS GCCA 234
    Length:234
    Mass (Da):26,277
    Last modified:October 1, 2000 - v1
    Checksum:iA0201E23BBF75DC8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti62 – 621F → I in BAA91171. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti134 – 1341N → S.
    Corresponds to variant rs426453 [ dbSNP | Ensembl ].
    VAR_017158

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272065 mRNA. Translation: CAC81247.1.
    AK000436 mRNA. Translation: BAA91163.1.
    AK000446 mRNA. Translation: BAA91171.1.
    AL139385 Genomic DNA. Translation: CAI17006.1.
    CH471085 Genomic DNA. Translation: EAX09113.1.
    BC026025 mRNA. Translation: AAH26025.1.
    CCDSiCCDS9512.1.
    RefSeqiNP_060287.1. NM_017817.1.
    UniGeneiHs.743563.

    Genome annotation databases

    EnsembliENST00000267328; ENSP00000267328; ENSG00000139832.
    GeneIDi55647.
    KEGGihsa:55647.
    UCSCiuc001vqy.3. human.

    Polymorphism databases

    DMDMi20139805.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ272065 mRNA. Translation: CAC81247.1 .
    AK000436 mRNA. Translation: BAA91163.1 .
    AK000446 mRNA. Translation: BAA91171.1 .
    AL139385 Genomic DNA. Translation: CAI17006.1 .
    CH471085 Genomic DNA. Translation: EAX09113.1 .
    BC026025 mRNA. Translation: AAH26025.1 .
    CCDSi CCDS9512.1.
    RefSeqi NP_060287.1. NM_017817.1.
    UniGenei Hs.743563.

    3D structure databases

    ProteinModelPortali Q9NX57.
    SMRi Q9NX57. Positions 7-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120781. 1 interaction.
    STRINGi 9606.ENSP00000267328.

    PTM databases

    PhosphoSitei Q9NX57.

    Polymorphism databases

    DMDMi 20139805.

    Proteomic databases

    MaxQBi Q9NX57.
    PaxDbi Q9NX57.
    PRIDEi Q9NX57.

    Protocols and materials databases

    DNASUi 55647.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000267328 ; ENSP00000267328 ; ENSG00000139832 .
    GeneIDi 55647.
    KEGGi hsa:55647.
    UCSCi uc001vqy.3. human.

    Organism-specific databases

    CTDi 55647.
    GeneCardsi GC13M111175.
    HGNCi HGNC:18260. RAB20.
    HPAi HPA052111.
    neXtProti NX_Q9NX57.
    PharmGKBi PA34110.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG097927.
    InParanoidi Q9NX57.
    KOi K07911.
    OMAi MRKPDGK.
    OrthoDBi EOG78D7MT.
    PhylomeDBi Q9NX57.
    TreeFami TF331574.

    Miscellaneous databases

    GenomeRNAii 55647.
    NextBioi 60342.
    PROi Q9NX57.

    Gene expression databases

    Bgeei Q9NX57.
    CleanExi HS_RAB20.
    Genevestigatori Q9NX57.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SUPFAMi SSF52540. SSF52540. 2 hits.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of human Rab20 overexpressed in exocrine pancreatic carcinoma."
      Amillet J.-M., Ferbus D., Real F.X., Antony C., Muleris M., Gress T.M., Goubin G.
      Hum. Pathol. 37:256-263(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    6. "Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes."
      Seto S., Tsujimura K., Koide Y.
      Traffic 12:407-420(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiRAB20_HUMAN
    AccessioniPrimary (citable) accession number: Q9NX57
    Secondary accession number(s): Q5T9X5, Q9NX49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3