Reviewed, UniProtKB/Swiss-Prot Q9NX53 (MUT7B_HUMAN)

Names and origin

Protein names

Recommended name:
    Probable exonuclease mut-7 homolog, isoform 5

Gene names

Name:

EXD3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DAZAP2	Q15038	2	EBI-750745,EBI-724310

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 5 (identifier: Q9NX53-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q8N9H8-1)

The sequence of this isoform can be found in the external entry Q8N9H8-1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 2 (identifier: Q8N9H8-2)

The sequence of this isoform can be found in the external entry Q8N9H8-2.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 3 (identifier: Q8N9H8-3)

The sequence of this isoform can be found in the external entry Q8N9H8-3.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Isoform 4 (identifier: Q8N9H8-4)

The sequence of this isoform can be found in the external entry Q8N9H8-4.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Probable exonuclease mut-7 homolog, isoform 5		PRO_0000378332
Regions
	Compositional bias	8 – 128	121	Pro-rich
Experimental info
	Sequence conflict	195	1	M → V in BAA91167. Ref.1
	Sequence conflict	195	1	M → V in EAW88381. Ref.2
	Sequence conflict	195	1	M → V in AAH65002. Ref.3
	Sequence conflict	235	1	P → H in AAH39252. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 5 [UniParc]. Last modified June 16, 2009. Version 2. Checksum: 5391735376352097	FASTA	252	26,357
	10 20 30 40 50 60 MFSKCNTPAS RAPGTASAPP GTLMALPGTD TAPPPRTASV PPGTASAPPG TLMALPGTDT 70 80 90 100 110 120 APPPRTASVP PGTASAPPGT LMALPGTDTA PRQNRHGARW NTNGPPWNSL GAPWNTNGPP 130 140 150 160 170 180 WNRHGAPPQN SLDAPWNSLG APWNSLGAPW NSLVLLEQTQ PPQNRHSTPW NSLALPGMAT 190 200 210 220 230 240 SPHPFCAALG ICPYMVRVQL CQQGQLHKRP QLSPPQWAPL LRLWVSFFPG GVLAPVLAPP 250 RCLDTCPCHP GH
	Isoform 1. See Q8N9H8.	FASTA	–	–
	Isoform 2. See Q8N9H8.	FASTA	–	–
	Isoform 3. See Q8N9H8.	FASTA	–	–
	Isoform 4. See Q8N9H8.	FASTA	–	–

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK000440 mRNA. Translation: BAA91167.1. CH471090 Genomic DNA. Translation: EAW88381.1. BC039252 mRNA. Translation: AAH39252.2. Different initiation. BC065002 mRNA. Translation: AAH65002.1.
IPI	IPI00015857.
UniGene	Hs.694420
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NX53. 2 interactions.
Proteomic databases
PRIDE	Q9NX53.
Organism-specific databases
HGNC	HGNC:26023. EXD3.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9NX53.
Gene expression databases
Genevestigator	Q9NX53.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

MUT7B_HUMAN

Accession

Primary (citable) accession number: Q9NX53
Secondary accession number(s): Q6P1M1, Q8IXT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	June 16, 2009
Last modified:	November 24, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.