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Protein

Exonuclease mut-7 homolog, isoform 5

Gene

EXD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Exonuclease mut-7 homolog, isoform 5
Gene namesi
Name:EXD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:26023. EXD3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Exonuclease mut-7 homolog, isoform 5PRO_0000378332Add
BLAST

Proteomic databases

PRIDEiQ9NX53.

PTM databases

iPTMnetiQ9NX53.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DAZAP2Q150383EBI-750745,EBI-724310

Protein-protein interaction databases

IntActiQ9NX53. 2 interactions.
MINTiMINT-1469933.

Structurei

3D structure databases

ProteinModelPortaliQ9NX53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 128121Pro-richAdd
BLAST

Phylogenomic databases

PhylomeDBiQ9NX53.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 5 (identifier: Q9NX53-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSKCNTPAS RAPGTASAPP GTLMALPGTD TAPPPRTASV PPGTASAPPG
60 70 80 90 100
TLMALPGTDT APPPRTASVP PGTASAPPGT LMALPGTDTA PRQNRHGARW
110 120 130 140 150
NTNGPPWNSL GAPWNTNGPP WNRHGAPPQN SLDAPWNSLG APWNSLGAPW
160 170 180 190 200
NSLVLLEQTQ PPQNRHSTPW NSLALPGMAT SPHPFCAALG ICPYMVRVQL
210 220 230 240 250
CQQGQLHKRP QLSPPQWAPL LRLWVSFFPG GVLAPVLAPP RCLDTCPCHP

GH
Length:252
Mass (Da):26,357
Last modified:June 16, 2009 - v2
Checksum:i5391735376352097
GO
Isoform 1 (identifier: Q8N9H8-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q8N9H8.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:876
Mass (Da):96,598
GO
Isoform 2 (identifier: Q8N9H8-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q8N9H8.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:599
Mass (Da):65,379
GO
Isoform 3 (identifier: Q8N9H8-3) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q8N9H8.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: No experimental confirmation available.
Length:514
Mass (Da):56,574
GO
Isoform 4 (identifier: Q8N9H8-4) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q8N9H8.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:246
Mass (Da):26,852
GO

Sequence cautioni

The sequence AAH39252 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti195 – 1951M → V in BAA91167 (PubMed:14702039).Curated
Sequence conflicti195 – 1951M → V in EAW88381 (Ref. 2) Curated
Sequence conflicti195 – 1951M → V in AAH65002 (PubMed:15489334).Curated
Sequence conflicti235 – 2351P → H in AAH39252 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000440 mRNA. Translation: BAA91167.1.
CH471090 Genomic DNA. Translation: EAW88381.1.
BC039252 mRNA. Translation: AAH39252.2. Different initiation.
BC065002 mRNA. Translation: AAH65002.1.
UniGeneiHs.495553.
Hs.721419.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000440 mRNA. Translation: BAA91167.1.
CH471090 Genomic DNA. Translation: EAW88381.1.
BC039252 mRNA. Translation: AAH39252.2. Different initiation.
BC065002 mRNA. Translation: AAH65002.1.
UniGeneiHs.495553.
Hs.721419.

3D structure databases

ProteinModelPortaliQ9NX53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9NX53. 2 interactions.
MINTiMINT-1469933.

PTM databases

iPTMnetiQ9NX53.

Proteomic databases

PRIDEiQ9NX53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiEXD3.
HGNCiHGNC:26023. EXD3.
neXtProtiNX_Q9NX53.
GenAtlasiSearch...

Phylogenomic databases

PhylomeDBiQ9NX53.

Miscellaneous databases

ChiTaRSiEXD3. human.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiMUT7B_HUMAN
AccessioniPrimary (citable) accession number: Q9NX53
Secondary accession number(s): Q6P1M1, Q8IXT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: June 8, 2016
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.