Reviewed,
UniProtKB/Swiss-Prot Q9NX47 (MARH5_HUMAN)
Last modified
June 15, 2010.
Version 87.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and originHide
| Protein names | Recommended name: E3 ubiquitin-protein ligase MARCH5 EC=6.3.2.- Alternative name(s): Membrane-associated RING finger protein 5 Membrane-associated RING-CH protein V Short name=MARCH-V RING finger protein 153 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributesHide
| Sequence length | 278 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)Hide
| Function | Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology. Promotes ubiquitination of DRP1. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. |
| Pathway | |
| Subunit structure | Interacts with MTFN2 and ubiquitinated forms of DRP1. Ref.1 |
| Subcellular location | Mitochondrion outer membrane; Multi-pass membrane protein Ref.1. |
| Domain | The RING-CH-type zinc finger domain is required for E3 ligase activity By similarity. |
| Sequence similarities | Contains 1 RING-CH-type zinc finger. |
OntologiesHide
| Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Cellular component | Membrane Mitochondrion Mitochondrion outer membrane |
| Domain | Transmembrane Zinc-finger |
| Ligand | Metal-binding Zinc |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ligase activity Inferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)Hide
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 278 | 278 | E3 ubiquitin-protein ligase MARCH5 | PRO_0000271769 | |||||
Regions | |||||||||
| Transmembrane | 99 – 119 | 21 | Helical; Potential | ||||||
| Transmembrane | 139 – 159 | 21 | Helical; Potential | ||||||
| Transmembrane | 209 – 229 | 21 | Helical; Potential | ||||||
| Transmembrane | 238 – 258 | 21 | Helical; Potential | ||||||
| Zinc finger | 6 – 75 | 70 | RING-CH-type | ||||||
SequencesHide
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ReferencesHide
| « Hide 'large scale' references | |
| [1] | "MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology." Nakamura N., Kimura Y., Tokuda M., Honda S., Hirose S. EMBO Rep. 7:1019-1022(2006) [PubMed: 16936636] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH MTFN2 AND DRP1, SUBCELLULAR LOCATION. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. Rogers J.Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus. |
| [5] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-referencesHide
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB191202 mRNA. Translation: BAF02285.1. AK000452 mRNA. Translation: BAA91173.1. AL158040, AL161652 Genomic DNA. Translation: CAI13639.1. AL161652, AL158040 Genomic DNA. Translation: CAI15361.1. BC015480 mRNA. Translation: AAH15480.1. |
| IPI | IPI00414168. |
| RefSeq | NP_060294.1. |
| UniGene | Hs.573490 |
3D structure databases | |
| SMR | Q9NX47. Positions 10-76. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9NX47. 5 interactions. |
| MINT | MINT-2844053. |
| STRING | Q9NX47. |
Proteomic databases | |
| PeptideAtlas | Q9NX47. |
| PRIDE | Q9NX47. |
Genome annotation databases | |
| Ensembl | ENST00000358935; ENSP00000351813; ENSG00000198060; Homo sapiens. [Genome view] |
| GeneID | 54708. |
| KEGG | hsa:54708. |
| UCSC | uc001khx.1. human. |
Organism-specific databases | |
| CTD | 54708. |
| GeneCards | GC10P094041. |
| H-InvDB | HIX0009041. |
| HGNC | HGNC:26025. MARCH5. |
| MIM | 610637. gene. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG05126. |
| HOGENOM | HBG715518. |
| HOVERGEN | HBG059795. |
| InParanoid | Q9NX47. |
| OMA | SCLQRWI. |
| PhylomeDB | Q9NX47. |
Gene expression databases | |
| ArrayExpress | Q9NX47. |
| Bgee | Q9NX47. |
| CleanEx | HS_MARCH5. |
| Genevestigator | Q9NX47. |
Family and domain databases | |
| InterPro | IPR018957. Znf_C3HC4_RING-type. IPR011016. Znf_RING-CH. [Graphical view] |
| Pfam | PF00097. zf-C3HC4. 1 hit. [Graphical view] |
| SMART | SM00744. RINGv. 1 hit. [Graphical view] |
| PROSITE | PS51292. ZF_RING_CH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 57269. |
| SOURCE | Search... |
Entry informationHide
| Entry name | MARH5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NX47 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documentsHide
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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