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Protein

OCIA domain-containing protein 1

Gene

OCIAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing STAT3 recruitment onto endosomes (By similarity). Involved in integrin-mediated cancer cell adhesion and colony formation in ovarian cancer (PubMed:20515946).By similarity1 Publication

Miscellaneous

'Asrij' stands for 'blood' in Sanskrit as this protein is strongly expressed in blood vessels.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
OCIA domain-containing protein 1
Alternative name(s):
Ovarian cancer immunoreactive antigen domain containing 11 Publication
Ovarian carcinoma immunoreactive antigen
Gene namesi
Name:OCIAD1Imported
Synonyms:ASRIJBy similarity, OCIA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109180.14
HGNCiHGNC:16074 OCIAD1
neXtProtiNX_Q9NX40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi54940
OpenTargetsiENSG00000109180
PharmGKBiPA134898158

Polymorphism and mutation databases

BioMutaiOCIAD1
DMDMi74734685

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002993821 – 245OCIA domain-containing protein 1Add BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei123PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NX40
MaxQBiQ9NX40
PaxDbiQ9NX40
PeptideAtlasiQ9NX40
PRIDEiQ9NX40
ProteomicsDBi83031
83032 [Q9NX40-2]
83033 [Q9NX40-3]
TopDownProteomicsiQ9NX40-1 [Q9NX40-1]
Q9NX40-2 [Q9NX40-2]
Q9NX40-3 [Q9NX40-3]

PTM databases

iPTMnetiQ9NX40
PhosphoSitePlusiQ9NX40
SwissPalmiQ9NX40

Expressioni

Tissue specificityi

Isoform 1 is highly expressed in many tissues, including testis, brain, placenta, ovary, prostate and mammary gland. Isoform 2 expression is restricted to the central nervous system including brain, cerebellum and spinal cord.1 Publication

Gene expression databases

BgeeiENSG00000109180
CleanExiHS_OCIAD1
ExpressionAtlasiQ9NX40 baseline and differential
GenevisibleiQ9NX40 HS

Organism-specific databases

HPAiHPA044803

Interactioni

Subunit structurei

Interacts with STAT3.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120280, 83 interactors
IntActiQ9NX40, 24 interactors
MINTiQ9NX40
STRINGi9606.ENSP00000264312

Structurei

3D structure databases

ProteinModelPortaliQ9NX40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 112OCIAAdd BLAST112

Domaini

The OCIA domain is necessary and sufficient for endosomal localization.By similarity

Sequence similaritiesi

Belongs to the OCIAD1 family.Curated

Phylogenomic databases

eggNOGiENOG410IZC9 Eukaryota
ENOG4111R9S LUCA
GeneTreeiENSGT00530000063690
HOGENOMiHOG000047933
HOVERGENiHBG108207
InParanoidiQ9NX40
OMAiYEVTLTH
OrthoDBiEOG091G0USR
PhylomeDBiQ9NX40
TreeFamiTF327106

Family and domain databases

InterProiView protein in InterPro
IPR009764 OCIA
PfamiView protein in Pfam
PF07051 OCIA, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX40-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGRADFREP NAEVPRPIPH IGPDYIPTEE ERRVFAECND ESFWFRSVPL
60 70 80 90 100
AATSMLITQG LISKGILSSH PKYGSIPKLI LACIMGYFAG KLSYVKTCQE
110 120 130 140 150
KFKKLENSPL GEALRSGQAR RSSPPGHYYQ KSKYDSSVSG QSSFVTSPAA
160 170 180 190 200
DNIEMLPHYE PIPFSSSMNE SAPTGITDHI VQGPDPNLEE SPKRKNITYE
210 220 230 240
ELRNKNRESY EVSLTQKTDP SVRPMHERVP KKEVKVNKYG DTWDE
Length:245
Mass (Da):27,626
Last modified:October 1, 2000 - v1
Checksum:iB4CD4F4B5483884D
GO
Isoform 2 (identifier: Q9NX40-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     184-187: PDPN → RNFS
     188-245: Missing.

Show »
Length:187
Mass (Da):20,718
Checksum:iA9AB24D04DC62410
GO
Isoform 3 (identifier: Q9NX40-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-245: Missing.

Show »
Length:187
Mass (Da):20,637
Checksum:iB8458A332DC62410
GO
Isoform 4 (identifier: Q9NX40-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-233: Missing.

Note: No experimental confirmation available.
Show »
Length:194
Mass (Da):21,592
Checksum:i584CBB2FFE38B08F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046212183 – 233Missing in isoform 4. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_027621184 – 187PDPN → RNFS in isoform 2. 1 Publication4
Alternative sequenceiVSP_027622188 – 245Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323665 mRNA Translation: AAG45220.1
AF324350 mRNA Translation: AAK12121.1
AF251296 mRNA Translation: AAG44596.1
AL539411 mRNA No translation available.
AK000462 mRNA Translation: BAA91181.1
AC079927 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW93070.1
BC003409 mRNA Translation: AAH03409.1
BC088361 mRNA Translation: AAH88361.1
CCDSiCCDS3484.1 [Q9NX40-1]
CCDS43228.1 [Q9NX40-2]
CCDS47052.1 [Q9NX40-4]
PIRiJC7586
RefSeqiNP_001073308.1, NM_001079839.2 [Q9NX40-1]
NP_001073309.1, NM_001079840.2 [Q9NX40-4]
NP_001073310.1, NM_001079841.2 [Q9NX40-2]
NP_001073311.2, NM_001079842.2 [Q9NX40-4]
NP_060300.1, NM_017830.3 [Q9NX40-1]
XP_016863818.1, XM_017008329.1 [Q9NX40-2]
UniGeneiHs.518750

Genome annotation databases

EnsembliENST00000264312; ENSP00000264312; ENSG00000109180 [Q9NX40-1]
ENST00000381473; ENSP00000370882; ENSG00000109180 [Q9NX40-1]
ENST00000396448; ENSP00000379725; ENSG00000109180 [Q9NX40-2]
ENST00000425583; ENSP00000416943; ENSG00000109180 [Q9NX40-4]
ENST00000444354; ENSP00000399656; ENSG00000109180 [Q9NX40-4]
ENST00000508293; ENSP00000423002; ENSG00000109180 [Q9NX40-1]
ENST00000513391; ENSP00000423909; ENSG00000109180 [Q9NX40-1]
GeneIDi54940
KEGGihsa:54940
UCSCiuc003gyo.4 human [Q9NX40-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiOCAD1_HUMAN
AccessioniPrimary (citable) accession number: Q9NX40
Secondary accession number(s): C9K030, G8JLN7, Q9BZE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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