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Protein

OCIA domain-containing protein 1

Gene

OCIAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
OCIA domain-containing protein 1
Alternative name(s):
Ovarian carcinoma immunoreactive antigen
Gene namesi
Name:OCIAD1
Synonyms:OCIA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:16074. OCIAD1.

Subcellular locationi

GO - Cellular componenti

  • endosome Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134898158.

Polymorphism and mutation databases

BioMutaiOCIAD1.
DMDMi74734685.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245OCIA domain-containing protein 1PRO_0000299382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei108 – 1081PhosphoserineCombined sources
Modified residuei123 – 1231PhosphoserineCombined sources
Modified residuei191 – 1911PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NX40.
MaxQBiQ9NX40.
PaxDbiQ9NX40.
PeptideAtlasiQ9NX40.
PRIDEiQ9NX40.
TopDownProteomicsiQ9NX40-1. [Q9NX40-1]
Q9NX40-2. [Q9NX40-2]
Q9NX40-3. [Q9NX40-3]

PTM databases

iPTMnetiQ9NX40.
PhosphoSiteiQ9NX40.
SwissPalmiQ9NX40.

Expressioni

Tissue specificityi

Isoform 1 is highly expressed in many tissues, including testis, brain, placenta, ovary, prostate and mammary gland. Isoform 2 expression is restricted to the central nervous system including brain, cerebellum and spinal cord.1 Publication

Gene expression databases

BgeeiQ9NX40.
CleanExiHS_OCIAD1.
ExpressionAtlasiQ9NX40. baseline and differential.
GenevisibleiQ9NX40. HS.

Organism-specific databases

HPAiHPA044803.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATF7P175442EBI-2683029,EBI-765623

Protein-protein interaction databases

BioGridi120280. 31 interactions.
IntActiQ9NX40. 8 interactions.
STRINGi9606.ENSP00000264312.

Structurei

3D structure databases

ProteinModelPortaliQ9NX40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 112112OCIAAdd
BLAST

Sequence similaritiesi

Belongs to the OCIAD1 family.Curated
Contains 1 OCIA domain.Curated

Phylogenomic databases

eggNOGiENOG410IZC9. Eukaryota.
ENOG4111R9S. LUCA.
GeneTreeiENSGT00530000063690.
HOGENOMiHOG000047933.
HOVERGENiHBG108207.
InParanoidiQ9NX40.
OMAiSQKSKYD.
PhylomeDBiQ9NX40.
TreeFamiTF327106.

Family and domain databases

InterProiIPR009764. OCIA.
[Graphical view]
PfamiPF07051. OCIA. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX40-1) [UniParc]FASTAAdd to basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGRADFREP NAEVPRPIPH IGPDYIPTEE ERRVFAECND ESFWFRSVPL
60 70 80 90 100
AATSMLITQG LISKGILSSH PKYGSIPKLI LACIMGYFAG KLSYVKTCQE
110 120 130 140 150
KFKKLENSPL GEALRSGQAR RSSPPGHYYQ KSKYDSSVSG QSSFVTSPAA
160 170 180 190 200
DNIEMLPHYE PIPFSSSMNE SAPTGITDHI VQGPDPNLEE SPKRKNITYE
210 220 230 240
ELRNKNRESY EVSLTQKTDP SVRPMHERVP KKEVKVNKYG DTWDE
Length:245
Mass (Da):27,626
Last modified:October 1, 2000 - v1
Checksum:iB4CD4F4B5483884D
GO
Isoform 2 (identifier: Q9NX40-2) [UniParc]FASTAAdd to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     184-187: PDPN → RNFS
     188-245: Missing.

Show »
Length:187
Mass (Da):20,718
Checksum:iA9AB24D04DC62410
GO
Isoform 3 (identifier: Q9NX40-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-245: Missing.

Show »
Length:187
Mass (Da):20,637
Checksum:iB8458A332DC62410
GO
Isoform 4 (identifier: Q9NX40-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     183-233: Missing.

Note: No experimental confirmation available.
Show »
Length:194
Mass (Da):21,592
Checksum:i584CBB2FFE38B08F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei183 – 23351Missing in isoform 4. 1 PublicationVSP_046212Add
BLAST
Alternative sequencei184 – 1874PDPN → RNFS in isoform 2. 1 PublicationVSP_027621
Alternative sequencei188 – 24558Missing in isoform 2 and isoform 3. 1 PublicationVSP_027622Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323665 mRNA. Translation: AAG45220.1.
AF324350 mRNA. Translation: AAK12121.1.
AF251296 mRNA. Translation: AAG44596.1.
AL539411 mRNA. No translation available.
AK000462 mRNA. Translation: BAA91181.1.
AC079927 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW93070.1.
BC003409 mRNA. Translation: AAH03409.1.
BC088361 mRNA. Translation: AAH88361.1.
CCDSiCCDS3484.1. [Q9NX40-1]
CCDS43228.1. [Q9NX40-2]
CCDS47052.1. [Q9NX40-4]
PIRiJC7586.
RefSeqiNP_001073308.1. NM_001079839.2. [Q9NX40-1]
NP_001073309.1. NM_001079840.2. [Q9NX40-4]
NP_001073310.1. NM_001079841.2. [Q9NX40-2]
NP_001073311.2. NM_001079842.2. [Q9NX40-4]
NP_060300.1. NM_017830.3. [Q9NX40-1]
UniGeneiHs.518750.

Genome annotation databases

EnsembliENST00000264312; ENSP00000264312; ENSG00000109180. [Q9NX40-1]
ENST00000381473; ENSP00000370882; ENSG00000109180. [Q9NX40-1]
ENST00000396448; ENSP00000379725; ENSG00000109180. [Q9NX40-2]
ENST00000425583; ENSP00000416943; ENSG00000109180. [Q9NX40-4]
ENST00000444354; ENSP00000399656; ENSG00000109180. [Q9NX40-4]
ENST00000508293; ENSP00000423002; ENSG00000109180. [Q9NX40-1]
ENST00000513391; ENSP00000423909; ENSG00000109180. [Q9NX40-1]
GeneIDi54940.
KEGGihsa:54940.
UCSCiuc003gyo.4. human. [Q9NX40-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323665 mRNA. Translation: AAG45220.1.
AF324350 mRNA. Translation: AAK12121.1.
AF251296 mRNA. Translation: AAG44596.1.
AL539411 mRNA. No translation available.
AK000462 mRNA. Translation: BAA91181.1.
AC079927 Genomic DNA. No translation available.
CH471069 Genomic DNA. Translation: EAW93070.1.
BC003409 mRNA. Translation: AAH03409.1.
BC088361 mRNA. Translation: AAH88361.1.
CCDSiCCDS3484.1. [Q9NX40-1]
CCDS43228.1. [Q9NX40-2]
CCDS47052.1. [Q9NX40-4]
PIRiJC7586.
RefSeqiNP_001073308.1. NM_001079839.2. [Q9NX40-1]
NP_001073309.1. NM_001079840.2. [Q9NX40-4]
NP_001073310.1. NM_001079841.2. [Q9NX40-2]
NP_001073311.2. NM_001079842.2. [Q9NX40-4]
NP_060300.1. NM_017830.3. [Q9NX40-1]
UniGeneiHs.518750.

3D structure databases

ProteinModelPortaliQ9NX40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120280. 31 interactions.
IntActiQ9NX40. 8 interactions.
STRINGi9606.ENSP00000264312.

PTM databases

iPTMnetiQ9NX40.
PhosphoSiteiQ9NX40.
SwissPalmiQ9NX40.

Polymorphism and mutation databases

BioMutaiOCIAD1.
DMDMi74734685.

Proteomic databases

EPDiQ9NX40.
MaxQBiQ9NX40.
PaxDbiQ9NX40.
PeptideAtlasiQ9NX40.
PRIDEiQ9NX40.
TopDownProteomicsiQ9NX40-1. [Q9NX40-1]
Q9NX40-2. [Q9NX40-2]
Q9NX40-3. [Q9NX40-3]

Protocols and materials databases

DNASUi54940.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264312; ENSP00000264312; ENSG00000109180. [Q9NX40-1]
ENST00000381473; ENSP00000370882; ENSG00000109180. [Q9NX40-1]
ENST00000396448; ENSP00000379725; ENSG00000109180. [Q9NX40-2]
ENST00000425583; ENSP00000416943; ENSG00000109180. [Q9NX40-4]
ENST00000444354; ENSP00000399656; ENSG00000109180. [Q9NX40-4]
ENST00000508293; ENSP00000423002; ENSG00000109180. [Q9NX40-1]
ENST00000513391; ENSP00000423909; ENSG00000109180. [Q9NX40-1]
GeneIDi54940.
KEGGihsa:54940.
UCSCiuc003gyo.4. human. [Q9NX40-1]

Organism-specific databases

CTDi54940.
GeneCardsiOCIAD1.
HGNCiHGNC:16074. OCIAD1.
HPAiHPA044803.
neXtProtiNX_Q9NX40.
PharmGKBiPA134898158.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZC9. Eukaryota.
ENOG4111R9S. LUCA.
GeneTreeiENSGT00530000063690.
HOGENOMiHOG000047933.
HOVERGENiHBG108207.
InParanoidiQ9NX40.
OMAiSQKSKYD.
PhylomeDBiQ9NX40.
TreeFamiTF327106.

Miscellaneous databases

ChiTaRSiOCIAD1. human.
GenomeRNAii54940.
PROiQ9NX40.

Gene expression databases

BgeeiQ9NX40.
CleanExiHS_OCIAD1.
ExpressionAtlasiQ9NX40. baseline and differential.
GenevisibleiQ9NX40. HS.

Family and domain databases

InterProiIPR009764. OCIA.
[Graphical view]
PfamiPF07051. OCIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel human gene on chromosome 4p11 by immunoscreening of an ovarian carcinoma cDNA library."
    Luo L.Y., Soosaipillai A., Diamandis E.P.
    Biochem. Biophys. Res. Commun. 280:401-406(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Tissue: Ovarian carcinoma.
  2. Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pituitary tumor.
  3. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Fetal brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108 AND SER-191, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108; SER-123 AND SER-191, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123 AND SER-191, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiOCAD1_HUMAN
AccessioniPrimary (citable) accession number: Q9NX40
Secondary accession number(s): C9K030, G8JLN7, Q9BZE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.