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Protein

DnaJ homolog subfamily C member 28

Gene

DNAJC28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May have a role in protein folding or as a chaperone.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177692-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 28
Gene namesi
Name:DNAJC28
Synonyms:C21orf55, C21orf78
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:1297. DNAJC28.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi54943.
OpenTargetsiENSG00000177692.
ENSG00000262911.
PharmGKBiPA162383922.

Polymorphism and mutation databases

DMDMi23396536.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000711391 – 388DnaJ homolog subfamily C member 28Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei347PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NX36.
MaxQBiQ9NX36.
PaxDbiQ9NX36.
PeptideAtlasiQ9NX36.
PRIDEiQ9NX36.

PTM databases

iPTMnetiQ9NX36.
PhosphoSitePlusiQ9NX36.

Expressioni

Tissue specificityi

Expressed in the fetal and adult brain, testis, uterus, spleen and liver.

Developmental stagei

Not expressed in 8 and 10 weeks old fetuses.

Gene expression databases

BgeeiENSG00000177692.
CleanExiHS_DNAJC28.
GenevisibleiQ9NX36. HS.

Organism-specific databases

HPAiHPA018003.
HPA030076.

Interactioni

Protein-protein interaction databases

BioGridi120283. 5 interactors.
IntActiQ9NX36. 2 interactors.
MINTiMINT-6782695.
STRINGi9606.ENSP00000320303.

Structurei

3D structure databases

ProteinModelPortaliQ9NX36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 115JPROSITE-ProRule annotationAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili261 – 349Sequence analysisAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi118 – 121Poly-Glu4

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0568. Eukaryota.
ENOG410ZU5V. LUCA.
GeneTreeiENSGT00390000008217.
HOGENOMiHOG000010237.
HOVERGENiHBG051232.
InParanoidiQ9NX36.
KOiK19373.
OMAiKFSGCSY.
OrthoDBiEOG091G0LRM.
PhylomeDBiQ9NX36.
TreeFamiTF323730.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018961. DnaJ_homolog_subfam-C_membr-28.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF09350. DUF1992. 1 hit.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NX36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTMYVMMAQ ILRSHLIKAT VIPNRVKMLP YFGIIRNRMM STHKSKKKIR
60 70 80 90 100
EYYRLLNVEE GCSADEVRES FHKLAKQYHP DSGSNTADSA TFIRIEKAYR
110 120 130 140 150
KVLSHVIEQT NASQSKGEEE EDVEKFKYKT PQHRHYLSFE GIGFGTPTQR
160 170 180 190 200
EKHYRQFRAD RAAEQVMEYQ KQKLQSQYFP DSVIVKNIRQ SKQQKITQAI
210 220 230 240 250
ERLVEDLIQE SMAKGDFDNL SGKGKPLKKF SDCSYIDPMT HNLNRILIDN
260 270 280 290 300
GYQPEWILKQ KEISDTIEQL REAILVSRKK LGNPMTPTEK KQWNHVCEQF
310 320 330 340 350
QENIRKLNKR INDFNLIVPI LTRQKVHFDA QKEIVRAQKI YETLIKTKEV
360 370 380
TDRNPNNLDQ GEGEKTPEIK KGFLNWMNLW KFIKIRSF
Length:388
Mass (Da):45,806
Last modified:September 19, 2002 - v2
Checksum:iCB19D9FD060031D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti316 – 388LIVPI…KIRSF → CSHPDQAKSPF in BAA91185 (PubMed:14702039).CuratedAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462153 mRNA. Translation: AAL59618.2.
AK000468 mRNA. Translation: BAA91185.1.
CH471079 Genomic DNA. Translation: EAX09830.1.
CH471079 Genomic DNA. Translation: EAX09831.1.
CCDSiCCDS13626.1.
RefSeqiNP_001035282.1. NM_001040192.2.
NP_001307675.1. NM_001320746.1.
NP_060303.2. NM_017833.4.
UniGeneiHs.458308.

Genome annotation databases

EnsembliENST00000314399; ENSP00000320303; ENSG00000177692.
ENST00000381947; ENSP00000371373; ENSG00000177692.
ENST00000402202; ENSP00000385777; ENSG00000177692.
ENST00000571432; ENSP00000461665; ENSG00000262911.
ENST00000572540; ENSP00000461737; ENSG00000262911.
ENST00000573306; ENSP00000461084; ENSG00000262911.
ENST00000615701; ENSP00000483670; ENSG00000262911.
ENST00000617313; ENSP00000479716; ENSG00000177692.
GeneIDi54943.
KEGGihsa:54943.
UCSCiuc002yrv.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462153 mRNA. Translation: AAL59618.2.
AK000468 mRNA. Translation: BAA91185.1.
CH471079 Genomic DNA. Translation: EAX09830.1.
CH471079 Genomic DNA. Translation: EAX09831.1.
CCDSiCCDS13626.1.
RefSeqiNP_001035282.1. NM_001040192.2.
NP_001307675.1. NM_001320746.1.
NP_060303.2. NM_017833.4.
UniGeneiHs.458308.

3D structure databases

ProteinModelPortaliQ9NX36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120283. 5 interactors.
IntActiQ9NX36. 2 interactors.
MINTiMINT-6782695.
STRINGi9606.ENSP00000320303.

PTM databases

iPTMnetiQ9NX36.
PhosphoSitePlusiQ9NX36.

Polymorphism and mutation databases

DMDMi23396536.

Proteomic databases

EPDiQ9NX36.
MaxQBiQ9NX36.
PaxDbiQ9NX36.
PeptideAtlasiQ9NX36.
PRIDEiQ9NX36.

Protocols and materials databases

DNASUi54943.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314399; ENSP00000320303; ENSG00000177692.
ENST00000381947; ENSP00000371373; ENSG00000177692.
ENST00000402202; ENSP00000385777; ENSG00000177692.
ENST00000571432; ENSP00000461665; ENSG00000262911.
ENST00000572540; ENSP00000461737; ENSG00000262911.
ENST00000573306; ENSP00000461084; ENSG00000262911.
ENST00000615701; ENSP00000483670; ENSG00000262911.
ENST00000617313; ENSP00000479716; ENSG00000177692.
GeneIDi54943.
KEGGihsa:54943.
UCSCiuc002yrv.5. human.

Organism-specific databases

CTDi54943.
DisGeNETi54943.
GeneCardsiDNAJC28.
H-InvDBHIX0016077.
HGNCiHGNC:1297. DNAJC28.
HPAiHPA018003.
HPA030076.
neXtProtiNX_Q9NX36.
OpenTargetsiENSG00000177692.
ENSG00000262911.
PharmGKBiPA162383922.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0568. Eukaryota.
ENOG410ZU5V. LUCA.
GeneTreeiENSGT00390000008217.
HOGENOMiHOG000010237.
HOVERGENiHBG051232.
InParanoidiQ9NX36.
KOiK19373.
OMAiKFSGCSY.
OrthoDBiEOG091G0LRM.
PhylomeDBiQ9NX36.
TreeFamiTF323730.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177692-MONOMER.

Miscellaneous databases

GeneWikiiC21orf55.
GenomeRNAii54943.
PROiQ9NX36.

Gene expression databases

BgeeiENSG00000177692.
CleanExiHS_DNAJC28.
GenevisibleiQ9NX36. HS.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018961. DnaJ_homolog_subfam-C_membr-28.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF09350. DUF1992. 1 hit.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDJC28_HUMAN
AccessioniPrimary (citable) accession number: Q9NX36
Secondary accession number(s): D3DSF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.