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Q9NX24

- NHP2_HUMAN

UniProt

Q9NX24 - NHP2_HUMAN

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Protein
H/ACA ribonucleoprotein complex subunit 2
Gene
NHP2, NOLA2, HSPC286
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.1 Publication

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. snoRNA binding Source: UniProtKB

GO - Biological processi

  1. rRNA pseudouridine synthesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_7974. Telomere Extension By Telomerase.

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex subunit 2
Alternative name(s):
Nucleolar protein family A member 2
snoRNP protein NHP2
Gene namesi
Name:NHP2
Synonyms:NOLA2
ORF Names:HSPC286
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:14377. NHP2.

Subcellular locationi

Nucleusnucleolus. NucleusCajal body
Note: Also localized to Cajal bodies (coiled bodies).3 Publications

GO - Cellular componenti

  1. Cajal body Source: UniProtKB-SubCell
  2. cytoplasm Source: HPA
  3. nucleus Source: HPA
  4. small nucleolar ribonucleoprotein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Dyskeratosis congenita, autosomal recessive, 2 (DKCB2) [MIM:613987]: A rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti126 – 1261V → M in DKCB2. 1 Publication
Corresponds to variant rs121908090 [ dbSNP | Ensembl ].
VAR_065871
Natural varianti139 – 1391Y → H in DKCB2. 1 Publication
Corresponds to variant rs121908089 [ dbSNP | Ensembl ].
VAR_065872

Keywords - Diseasei

Disease mutation, Dyskeratosis congenita

Organism-specific databases

MIMi613987. phenotype.
Orphaneti1775. Dyskeratosis congenita.
PharmGKBiPA164723898.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153H/ACA ribonucleoprotein complex subunit 2
PRO_0000136763Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki5 – 5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei19 – 191Phosphoserine1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9NX24.
PaxDbiQ9NX24.
PeptideAtlasiQ9NX24.
PRIDEiQ9NX24.

2D gel databases

SWISS-2DPAGEQ9NX24.

PTM databases

PhosphoSiteiQ9NX24.

Expressioni

Tissue specificityi

Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver.1 Publication

Developmental stagei

Transcript peaks at G1/S transition.1 Publication

Gene expression databases

ArrayExpressiQ9NX24.
BgeeiQ9NX24.
CleanExiHS_NHP2.
GenevestigatoriQ9NX24.

Organism-specific databases

HPAiHPA044171.
HPA050400.

Interactioni

Subunit structurei

Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains NHP2/NOLA2, GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic subunit. The complex contains a stable core formed by binding of one or two NOP10-DKC1 heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1. The complex binds a box H/ACA small nucleolar RNA (snoRNA), which may target the specific site of modification within the RNA substrate. During assembly, the complex contains NAF1 instead of GAR1/NOLA1. The complex also interacts with TERC, which contains a 3'-terminal domain related to the box H/ACA snoRNAs. Specific interactions with snoRNAs or TERC are mediated by GAR1 and NHP2. Associates with NOLC1/NOPP140. H/ACA snoRNPs interact with the SMN complex, consisting of SMN1 or SMN2, GEMIN2/SIP1, DDX20/GEMIN3, and GEMIN4. This is mediated by interaction between GAR1 and SMN1 or SMN2. The SMN complex may be required for correct assembly of the H/ACA snoRNP complex. Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC).2 Publications

Protein-protein interaction databases

BioGridi120783. 24 interactions.
IntActiQ9NX24. 9 interactions.
MINTiMINT-3077751.
STRINGi9606.ENSP00000274606.

Structurei

3D structure databases

ProteinModelPortaliQ9NX24.
SMRiQ9NX24. Positions 40-149.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1358.
HOGENOMiHOG000055227.
HOVERGENiHBG000328.
InParanoidiQ9NX24.
KOiK11129.
OMAiPVDIMCH.
OrthoDBiEOG7288T8.
PhylomeDBiQ9NX24.
TreeFamiTF105839.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR002415. H/ACA_rnp_Nhp2_euk.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00881. L7ARS6FAMILY.
PR00883. NUCLEARHMG.
SUPFAMiSSF55315. SSF55315. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NX24-1 [UniParc]FASTAAdd to Basket

« Hide

MTKIKADPDG PEAQAEACSG ERTYQELLVN QNPIAQPLAS RRLTRKLYKC    50
IKKAVKQKQI RRGVKEVQKF VNKGEKGIMV LAGDTLPIEV YCHLPVMCED 100
RNLPYVYIPS KTDLGAAAGS KRPTCVIMVK PHEEYQEAYD ECLEEVQSLP 150
LPL 153
Length:153
Mass (Da):17,201
Last modified:October 1, 2000 - v1
Checksum:i7658FDFF88AF3178
GO

Sequence cautioni

The sequence AAF28964.1 differs from that shown. Reason: Frameshift at positions 37, 119 and 120.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti118 – 1181A → T.1 Publication
Corresponds to variant rs139588879 [ dbSNP | Ensembl ].
VAR_065870
Natural varianti126 – 1261V → M in DKCB2. 1 Publication
Corresponds to variant rs121908090 [ dbSNP | Ensembl ].
VAR_065871
Natural varianti139 – 1391Y → H in DKCB2. 1 Publication
Corresponds to variant rs121908089 [ dbSNP | Ensembl ].
VAR_065872

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ293309 mRNA. Translation: CAC08452.1.
AF401219 mRNA. Translation: AAL02175.1.
AF161404 mRNA. Translation: AAF28964.1. Frameshift.
AK000486 mRNA. Translation: BAA91198.1.
CR457238 mRNA. Translation: CAG33519.1.
AC136632 Genomic DNA. No translation available.
BC000009 mRNA. Translation: AAH00009.1.
BC006387 mRNA. Translation: AAH06387.1.
CCDSiCCDS4432.1.
RefSeqiNP_001030005.1. NM_001034833.1.
NP_060308.1. NM_017838.3.
UniGeneiHs.744074.

Genome annotation databases

EnsembliENST00000274606; ENSP00000274606; ENSG00000145912.
GeneIDi55651.
KEGGihsa:55651.
UCSCiuc003mir.2. human.

Polymorphism databases

DMDMi68565945.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ293309 mRNA. Translation: CAC08452.1 .
AF401219 mRNA. Translation: AAL02175.1 .
AF161404 mRNA. Translation: AAF28964.1 . Frameshift.
AK000486 mRNA. Translation: BAA91198.1 .
CR457238 mRNA. Translation: CAG33519.1 .
AC136632 Genomic DNA. No translation available.
BC000009 mRNA. Translation: AAH00009.1 .
BC006387 mRNA. Translation: AAH06387.1 .
CCDSi CCDS4432.1.
RefSeqi NP_001030005.1. NM_001034833.1.
NP_060308.1. NM_017838.3.
UniGenei Hs.744074.

3D structure databases

ProteinModelPortali Q9NX24.
SMRi Q9NX24. Positions 40-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120783. 24 interactions.
IntActi Q9NX24. 9 interactions.
MINTi MINT-3077751.
STRINGi 9606.ENSP00000274606.

PTM databases

PhosphoSitei Q9NX24.

Polymorphism databases

DMDMi 68565945.

2D gel databases

SWISS-2DPAGE Q9NX24.

Proteomic databases

MaxQBi Q9NX24.
PaxDbi Q9NX24.
PeptideAtlasi Q9NX24.
PRIDEi Q9NX24.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274606 ; ENSP00000274606 ; ENSG00000145912 .
GeneIDi 55651.
KEGGi hsa:55651.
UCSCi uc003mir.2. human.

Organism-specific databases

CTDi 55651.
GeneCardsi GC05M177510.
GeneReviewsi NHP2.
HGNCi HGNC:14377. NHP2.
HPAi HPA044171.
HPA050400.
MIMi 606470. gene.
613987. phenotype.
neXtProti NX_Q9NX24.
Orphaneti 1775. Dyskeratosis congenita.
PharmGKBi PA164723898.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1358.
HOGENOMi HOG000055227.
HOVERGENi HBG000328.
InParanoidi Q9NX24.
KOi K11129.
OMAi PVDIMCH.
OrthoDBi EOG7288T8.
PhylomeDBi Q9NX24.
TreeFami TF105839.

Enzyme and pathway databases

Reactomei REACT_7974. Telomere Extension By Telomerase.

Miscellaneous databases

ChiTaRSi NHP2. human.
GeneWikii NOLA2.
GenomeRNAii 55651.
NextBioi 60350.
PROi Q9NX24.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NX24.
Bgeei Q9NX24.
CleanExi HS_NHP2.
Genevestigatori Q9NX24.

Family and domain databases

Gene3Di 3.30.1330.30. 1 hit.
InterProi IPR002415. H/ACA_rnp_Nhp2_euk.
IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
[Graphical view ]
Pfami PF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view ]
PRINTSi PR00881. L7ARS6FAMILY.
PR00883. NUCLEARHMG.
SUPFAMi SSF55315. SSF55315. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10."
    Pogacic V., Dragon F., Filipowicz W.
    Mol. Cell. Biol. 20:9028-9040(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH GAR1; SMALL NUCLEOLAR RNAS AND TERC, SUBCELLULAR LOCATION.
  2. "Expression of the human homologue of the small nucleolar RNA-binding protein NHP2 gene during monocytic differentiation of U937 cells."
    Kang H.S., Jung H.M., Jun D., Huh T.L., Kim Y.H.
    Biochim. Biophys. Acta 1575:31-39(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle and Placenta.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins."
    Wang C., Meier U.T.
    EMBO J. 23:1857-1867(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CHARACTERIZATION OF THE H/ACA SNORNP COMPLEX.
  11. "A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis."
    Venteicher A.S., Abreu E.B., Meng Z., McCann K.E., Terns R.M., Veenstra T.D., Terns M.P., Artandi S.E.
    Science 323:644-648(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE TELOMERASE HOLOENZYME COMPLEX.
  12. "A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58."
    Westman B.J., Verheggen C., Hutten S., Lam Y.W., Bertrand E., Lamond A.I.
    Mol. Cell 39:618-631(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION AT LYS-5.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita."
    Vulliamy T., Beswick R., Kirwan M., Marrone A., Digweed M., Walne A., Dokal I.
    Proc. Natl. Acad. Sci. U.S.A. 105:8073-8078(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS DKCB2 MET-126 AND HIS-139, VARIANT THR-118.

Entry informationi

Entry nameiNHP2_HUMAN
AccessioniPrimary (citable) accession number: Q9NX24
Secondary accession number(s): A6NKY8, Q9P095
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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