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Q9NX20

- RM16_HUMAN

UniProt

Q9NX20 - RM16_HUMAN

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Protein
39S ribosomal protein L16, mitochondrial
Gene
MRPL16, PNAS-111
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the large subunit of mitochondrial ribosome.

GO - Molecular functioni

  1. rRNA binding Source: InterPro
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L16, mitochondrial
Short name:
L16mt
Short name:
MRP-L16
Gene namesi
Name:MRPL16
ORF Names:PNAS-111
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14476. MRPL16.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30945.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3636Mitochondrion Reviewed prediction
Add
BLAST
Chaini37 – 25121539S ribosomal protein L16, mitochondrial
PRO_0000239841Add
BLAST

Proteomic databases

MaxQBiQ9NX20.
PaxDbiQ9NX20.
PeptideAtlasiQ9NX20.
PRIDEiQ9NX20.

PTM databases

PhosphoSiteiQ9NX20.

Expressioni

Gene expression databases

ArrayExpressiQ9NX20.
BgeeiQ9NX20.
CleanExiHS_MRPL16.
GenevestigatoriQ9NX20.

Organism-specific databases

HPAiHPA054133.

Interactioni

Protein-protein interaction databases

BioGridi120287. 17 interactions.
IntActiQ9NX20. 4 interactions.
MINTiMINT-3064053.
STRINGi9606.ENSP00000300151.

Structurei

3D structure databases

ProteinModelPortaliQ9NX20.
SMRiQ9NX20. Positions 85-192.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0197.
HOGENOMiHOG000021349.
HOVERGENiHBG056553.
InParanoidiQ9NX20.
KOiK02878.
OMAiPITRKGM.
OrthoDBiEOG7HQN8X.
PhylomeDBiQ9NX20.
TreeFamiTF312969.

Family and domain databases

Gene3Di3.90.1170.10. 1 hit.
InterProiIPR016180. Ribosomal_L10e/L16.
IPR000114. Ribosomal_L16.
[Graphical view]
PANTHERiPTHR12220. PTHR12220. 1 hit.
PfamiPF00252. Ribosomal_L16. 1 hit.
[Graphical view]
PRINTSiPR00060. RIBOSOMALL16.
SUPFAMiSSF54686. SSF54686. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NX20-1 [UniParc]FASTAAdd to Basket

« Hide

MWRLLARASA PLLRVPLSDS WALLPASAGV KTLLPVPSFE DVSIPEKPKL    50
RFIERAPLVP KVRREPKNLS DIRGPSTEAT EFTEGNFAIL ALGGGYLHWG 100
HFEMMRLTIN RSMDPKNMFA IWRVPAPFKP ITRKSVGHRM GGGKGAIDHY 150
VTPVKAGRLV VEMGGRCEFE EVQGFLDQVA HKLPFAAKAV SRGTLEKMRK 200
DQEERERNNQ NPWTFERIAT ANMLGIRKVL SPYDLTHKGK YWGKFYMPKR 250
V 251
Length:251
Mass (Da):28,449
Last modified:October 1, 2000 - v1
Checksum:i8A42A67DA80A6FEF
GO

Sequence cautioni

The sequence AAG23818.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291G → S.
Corresponds to variant rs7122468 [ dbSNP | Ensembl ].
VAR_052006
Natural varianti199 – 1991R → Q.
Corresponds to variant rs12787462 [ dbSNP | Ensembl ].
VAR_052007
Natural varianti207 – 2071R → C.
Corresponds to variant rs491671 [ dbSNP | Ensembl ].
VAR_052008

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151V → L in BAB40847. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049642 mRNA. Translation: BAB40847.1.
AF183428 mRNA. Translation: AAG09697.1.
AK000491 mRNA. Translation: BAA91202.1.
CR457117 mRNA. Translation: CAG33398.1.
BC001040 mRNA. Translation: AAH01040.1.
BC019269 mRNA. Translation: AAH19269.1.
AF275806 mRNA. Translation: AAG23818.1. Different initiation.
CCDSiCCDS7976.1.
RefSeqiNP_060310.1. NM_017840.3.
UniGeneiHs.530734.

Genome annotation databases

EnsembliENST00000300151; ENSP00000300151; ENSG00000166902.
GeneIDi54948.
KEGGihsa:54948.
UCSCiuc001noh.2. human.

Polymorphism databases

DMDMi74734684.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049642 mRNA. Translation: BAB40847.1 .
AF183428 mRNA. Translation: AAG09697.1 .
AK000491 mRNA. Translation: BAA91202.1 .
CR457117 mRNA. Translation: CAG33398.1 .
BC001040 mRNA. Translation: AAH01040.1 .
BC019269 mRNA. Translation: AAH19269.1 .
AF275806 mRNA. Translation: AAG23818.1 . Different initiation.
CCDSi CCDS7976.1.
RefSeqi NP_060310.1. NM_017840.3.
UniGenei Hs.530734.

3D structure databases

ProteinModelPortali Q9NX20.
SMRi Q9NX20. Positions 85-192.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120287. 17 interactions.
IntActi Q9NX20. 4 interactions.
MINTi MINT-3064053.
STRINGi 9606.ENSP00000300151.

PTM databases

PhosphoSitei Q9NX20.

Polymorphism databases

DMDMi 74734684.

Proteomic databases

MaxQBi Q9NX20.
PaxDbi Q9NX20.
PeptideAtlasi Q9NX20.
PRIDEi Q9NX20.

Protocols and materials databases

DNASUi 54948.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300151 ; ENSP00000300151 ; ENSG00000166902 .
GeneIDi 54948.
KEGGi hsa:54948.
UCSCi uc001noh.2. human.

Organism-specific databases

CTDi 54948.
GeneCardsi GC11M059573.
HGNCi HGNC:14476. MRPL16.
HPAi HPA054133.
MIMi 611829. gene.
neXtProti NX_Q9NX20.
PharmGKBi PA30945.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0197.
HOGENOMi HOG000021349.
HOVERGENi HBG056553.
InParanoidi Q9NX20.
KOi K02878.
OMAi PITRKGM.
OrthoDBi EOG7HQN8X.
PhylomeDBi Q9NX20.
TreeFami TF312969.

Miscellaneous databases

ChiTaRSi MRPL16. human.
GenomeRNAii 54948.
NextBioi 58115.
PROi Q9NX20.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NX20.
Bgeei Q9NX20.
CleanExi HS_MRPL16.
Genevestigatori Q9NX20.

Family and domain databases

Gene3Di 3.90.1170.10. 1 hit.
InterProi IPR016180. Ribosomal_L10e/L16.
IPR000114. Ribosomal_L16.
[Graphical view ]
PANTHERi PTHR12220. PTHR12220. 1 hit.
Pfami PF00252. Ribosomal_L16. 1 hit.
[Graphical view ]
PRINTSi PR00060. RIBOSOMALL16.
SUPFAMi SSF54686. SSF54686. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "A novel gene expressed in human pheochromocytoma."
    Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pheochromocytoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
    Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 194-251.
    Tissue: Promyelocytic leukemia.
  7. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM16_HUMAN
AccessioniPrimary (citable) accession number: Q9NX20
Secondary accession number(s): Q9BYD0, Q9HB70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi