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Q9NX20 (RM16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L16, mitochondrial

Short name=L16mt
Short name=MRP-L16
Gene names
Name:MRPL16
ORF Names:PNAS-111
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the large subunit of mitochondrial ribosome.

Subcellular location

Mitochondrion Ref.1.

Sequence similarities

Belongs to the ribosomal protein L16P family.

Sequence caution

The sequence AAG23818.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityPolymorphism
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

ribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionrRNA binding

Inferred from electronic annotation. Source: InterPro

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3636Mitochondrion Potential
Chain37 – 25121539S ribosomal protein L16, mitochondrial
PRO_0000239841

Natural variations

Natural variant291G → S.
Corresponds to variant rs7122468 [ dbSNP | Ensembl ].
VAR_052006
Natural variant1991R → Q.
Corresponds to variant rs12787462 [ dbSNP | Ensembl ].
VAR_052007
Natural variant2071R → C.
Corresponds to variant rs491671 [ dbSNP | Ensembl ].
VAR_052008

Experimental info

Sequence conflict151V → L in BAB40847. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9NX20 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 8A42A67DA80A6FEF

FASTA25128,449
        10         20         30         40         50         60 
MWRLLARASA PLLRVPLSDS WALLPASAGV KTLLPVPSFE DVSIPEKPKL RFIERAPLVP 

        70         80         90        100        110        120 
KVRREPKNLS DIRGPSTEAT EFTEGNFAIL ALGGGYLHWG HFEMMRLTIN RSMDPKNMFA 

       130        140        150        160        170        180 
IWRVPAPFKP ITRKSVGHRM GGGKGAIDHY VTPVKAGRLV VEMGGRCEFE EVQGFLDQVA 

       190        200        210        220        230        240 
HKLPFAAKAV SRGTLEKMRK DQEERERNNQ NPWTFERIAT ANMLGIRKVL SPYDLTHKGK 

       250 
YWGKFYMPKR V 

« Hide

References

« Hide 'large scale' references
[1]"Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
[2]"A novel gene expressed in human pheochromocytoma."
Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pheochromocytoma.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[6]"Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 194-251.
Tissue: Promyelocytic leukemia.
[7]"The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB049642 mRNA. Translation: BAB40847.1.
AF183428 mRNA. Translation: AAG09697.1.
AK000491 mRNA. Translation: BAA91202.1.
CR457117 mRNA. Translation: CAG33398.1.
BC001040 mRNA. Translation: AAH01040.1.
BC019269 mRNA. Translation: AAH19269.1.
AF275806 mRNA. Translation: AAG23818.1. Different initiation.
RefSeqNP_060310.1. NM_017840.3.
UniGeneHs.530734.

3D structure databases

ProteinModelPortalQ9NX20.
SMRQ9NX20. Positions 56-192.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120287. 17 interactions.
IntActQ9NX20. 4 interactions.
MINTMINT-3064053.
STRING9606.ENSP00000300151.

PTM databases

PhosphoSiteQ9NX20.

Polymorphism databases

DMDM74734684.

Proteomic databases

PaxDbQ9NX20.
PeptideAtlasQ9NX20.
PRIDEQ9NX20.

Protocols and materials databases

DNASU54948.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300151; ENSP00000300151; ENSG00000166902.
GeneID54948.
KEGGhsa:54948.
UCSCuc001noh.2. human.

Organism-specific databases

CTD54948.
GeneCardsGC11M059573.
HGNCHGNC:14476. MRPL16.
HPAHPA054133.
MIM611829. gene.
neXtProtNX_Q9NX20.
PharmGKBPA30945.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0197.
HOGENOMHOG000021349.
HOVERGENHBG056553.
InParanoidQ9NX20.
KOK02878.
OMASPYDLTH.
OrthoDBEOG7HQN8X.
PhylomeDBQ9NX20.
TreeFamTF312969.

Gene expression databases

ArrayExpressQ9NX20.
BgeeQ9NX20.
CleanExHS_MRPL16.
GenevestigatorQ9NX20.

Family and domain databases

Gene3D3.90.1170.10. 1 hit.
InterProIPR016180. Ribosomal_L10e/L16.
IPR000114. Ribosomal_L16.
[Graphical view]
PANTHERPTHR12220. PTHR12220. 1 hit.
PfamPF00252. Ribosomal_L16. 1 hit.
[Graphical view]
PRINTSPR00060. RIBOSOMALL16.
SUPFAMSSF54686. SSF54686. 1 hit.
ProtoNetSearch...

Other

ChiTaRSMRPL16. human.
GenomeRNAi54948.
NextBio58115.
PROQ9NX20.
SOURCESearch...

Entry information

Entry nameRM16_HUMAN
AccessionPrimary (citable) accession number: Q9NX20
Secondary accession number(s): Q9BYD0, Q9HB70
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2000
Last modified: March 19, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM