Q9NX20 (RM16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L16, mitochondrial
Short name=L16mt
Short name=MRP-L16

Gene names

Name:	MRPL16
ORF Names:	PNAS-111

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the large subunit of mitochondrial ribosome.
Subcellular location	Mitochondrion Ref.1.
Sequence similarities	Belongs to the ribosomal protein L16P family.
Sequence caution	The sequence AAG23818.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	rRNA binding Inferred from electronic annotation. Source: InterPro structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 36	36	Mitochondrion Potential
	Chain	37 – 251	215	39S ribosomal protein L16, mitochondrial		PRO_0000239841
Natural variations
	Natural variant	29	1	G → S. Corresponds to variant rs7122468 [ dbSNP | Ensembl ].		VAR_052006
	Natural variant	199	1	R → Q. Corresponds to variant rs12787462 [ dbSNP | Ensembl ].		VAR_052007
	Natural variant	207	1	R → C. Corresponds to variant rs491671 [ dbSNP | Ensembl ].		VAR_052008
Experimental info
	Sequence conflict	15	1	V → L in BAB40847. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9NX20 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 8A42A67DA80A6FEF	FASTA	251	28,449
	10 20 30 40 50 60 MWRLLARASA PLLRVPLSDS WALLPASAGV KTLLPVPSFE DVSIPEKPKL RFIERAPLVP 70 80 90 100 110 120 KVRREPKNLS DIRGPSTEAT EFTEGNFAIL ALGGGYLHWG HFEMMRLTIN RSMDPKNMFA 130 140 150 160 170 180 IWRVPAPFKP ITRKSVGHRM GGGKGAIDHY VTPVKAGRLV VEMGGRCEFE EVQGFLDQVA 190 200 210 220 230 240 HKLPFAAKAV SRGTLEKMRK DQEERERNNQ NPWTFERIAT ANMLGIRKVL SPYDLTHKGK 250 YWGKFYMPKR V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria." Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K. J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
[2]	"A novel gene expressed in human pheochromocytoma." Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pheochromocytoma.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[6]	"Human acute promyelocytic leukemia cell line NB4's apoptosis related genes." Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 194-251. Tissue: Promyelocytic leukemia.
[7]	"The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L. J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB049642 mRNA. Translation: BAB40847.1. AF183428 mRNA. Translation: AAG09697.1. AK000491 mRNA. Translation: BAA91202.1. CR457117 mRNA. Translation: CAG33398.1. BC001040 mRNA. Translation: AAH01040.1. BC019269 mRNA. Translation: AAH19269.1. AF275806 mRNA. Translation: AAG23818.1. Different initiation.
IPI	IPI00000821.
RefSeq	NP_060310.1. NM_017840.3.
UniGene	Hs.530734.
3D structure databases
ProteinModelPortal	Q9NX20.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NX20. 3 interactions.
STRING	9606.ENSP00000300151.
PTM databases
PhosphoSite	Q9NX20.
Polymorphism databases
DMDM	74734684.
Proteomic databases
PaxDb	Q9NX20.
PeptideAtlas	Q9NX20.
PRIDE	Q9NX20.
Protocols and materials databases
DNASU	54948.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300151; ENSP00000300151; ENSG00000166902.
GeneID	54948.
KEGG	hsa:54948.
UCSC	uc001noh.2. human.
Organism-specific databases
CTD	54948.
GeneCards	GC11M059573.
HGNC	HGNC:14476. MRPL16.
HPA	HPA054133.
MIM	611829. gene.
neXtProt	NX_Q9NX20.
PharmGKB	PA30945.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0197.
HOGENOM	HOG000021349.
HOVERGEN	HBG056553.
InParanoid	Q9NX20.
KO	K02878.
OMA	SPYDLTH.
OrthoDB	EOG4K6G50.
PhylomeDB	Q9NX20.
Gene expression databases
ArrayExpress	Q9NX20.
Bgee	Q9NX20.
CleanEx	HS_MRPL16.
Genevestigator	Q9NX20.
GermOnline	ENSG00000166902. Homo sapiens.
Family and domain databases
InterPro	IPR016180. Ribosomal_L10e/L16. IPR000114. Ribosomal_L16. [Graphical view]
PANTHER	PTHR12220. PTHR12220. 1 hit.
Pfam	PF00252. Ribosomal_L16. 1 hit. [Graphical view]
PRINTS	PR00060. RIBOSOMALL16.
SUPFAM	SSF54686. Ribosomal_L10e/L16. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	MRPL16. human.
GenomeRNAi	54948.
NextBio	58115.
SOURCE	Search...

Entry information

Entry name

RM16_HUMAN

Accession

Primary (citable) accession number: Q9NX20
Secondary accession number(s): Q9BYD0, Q9HB70

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.