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Q9NX20

- RM16_HUMAN

UniProt

Q9NX20 - RM16_HUMAN

Protein

39S ribosomal protein L16, mitochondrial

Gene

MRPL16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Component of the large subunit of mitochondrial ribosome.

    GO - Molecular functioni

    1. rRNA binding Source: InterPro
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L16, mitochondrial
    Short name:
    L16mt
    Short name:
    MRP-L16
    Gene namesi
    Name:MRPL16
    ORF Names:PNAS-111
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14476. MRPL16.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell
    2. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30945.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3636MitochondrionSequence AnalysisAdd
    BLAST
    Chaini37 – 25121539S ribosomal protein L16, mitochondrialPRO_0000239841Add
    BLAST

    Proteomic databases

    MaxQBiQ9NX20.
    PaxDbiQ9NX20.
    PeptideAtlasiQ9NX20.
    PRIDEiQ9NX20.

    PTM databases

    PhosphoSiteiQ9NX20.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NX20.
    BgeeiQ9NX20.
    CleanExiHS_MRPL16.
    GenevestigatoriQ9NX20.

    Organism-specific databases

    HPAiHPA054133.

    Interactioni

    Protein-protein interaction databases

    BioGridi120287. 17 interactions.
    IntActiQ9NX20. 4 interactions.
    MINTiMINT-3064053.
    STRINGi9606.ENSP00000300151.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NX20.
    SMRiQ9NX20. Positions 85-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L16P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0197.
    HOGENOMiHOG000021349.
    HOVERGENiHBG056553.
    InParanoidiQ9NX20.
    KOiK02878.
    OMAiPITRKGM.
    OrthoDBiEOG7HQN8X.
    PhylomeDBiQ9NX20.
    TreeFamiTF312969.

    Family and domain databases

    Gene3Di3.90.1170.10. 1 hit.
    InterProiIPR016180. Ribosomal_L10e/L16.
    IPR000114. Ribosomal_L16.
    [Graphical view]
    PANTHERiPTHR12220. PTHR12220. 1 hit.
    PfamiPF00252. Ribosomal_L16. 1 hit.
    [Graphical view]
    PRINTSiPR00060. RIBOSOMALL16.
    SUPFAMiSSF54686. SSF54686. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NX20-1 [UniParc]FASTAAdd to Basket

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    MWRLLARASA PLLRVPLSDS WALLPASAGV KTLLPVPSFE DVSIPEKPKL    50
    RFIERAPLVP KVRREPKNLS DIRGPSTEAT EFTEGNFAIL ALGGGYLHWG 100
    HFEMMRLTIN RSMDPKNMFA IWRVPAPFKP ITRKSVGHRM GGGKGAIDHY 150
    VTPVKAGRLV VEMGGRCEFE EVQGFLDQVA HKLPFAAKAV SRGTLEKMRK 200
    DQEERERNNQ NPWTFERIAT ANMLGIRKVL SPYDLTHKGK YWGKFYMPKR 250
    V 251
    Length:251
    Mass (Da):28,449
    Last modified:October 1, 2000 - v1
    Checksum:i8A42A67DA80A6FEF
    GO

    Sequence cautioni

    The sequence AAG23818.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151V → L in BAB40847. (PubMed:11279069)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291G → S.
    Corresponds to variant rs7122468 [ dbSNP | Ensembl ].
    VAR_052006
    Natural varianti199 – 1991R → Q.
    Corresponds to variant rs12787462 [ dbSNP | Ensembl ].
    VAR_052007
    Natural varianti207 – 2071R → C.
    Corresponds to variant rs491671 [ dbSNP | Ensembl ].
    VAR_052008

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049642 mRNA. Translation: BAB40847.1.
    AF183428 mRNA. Translation: AAG09697.1.
    AK000491 mRNA. Translation: BAA91202.1.
    CR457117 mRNA. Translation: CAG33398.1.
    BC001040 mRNA. Translation: AAH01040.1.
    BC019269 mRNA. Translation: AAH19269.1.
    AF275806 mRNA. Translation: AAG23818.1. Different initiation.
    CCDSiCCDS7976.1.
    RefSeqiNP_060310.1. NM_017840.3.
    UniGeneiHs.530734.

    Genome annotation databases

    EnsembliENST00000300151; ENSP00000300151; ENSG00000166902.
    GeneIDi54948.
    KEGGihsa:54948.
    UCSCiuc001noh.2. human.

    Polymorphism databases

    DMDMi74734684.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049642 mRNA. Translation: BAB40847.1 .
    AF183428 mRNA. Translation: AAG09697.1 .
    AK000491 mRNA. Translation: BAA91202.1 .
    CR457117 mRNA. Translation: CAG33398.1 .
    BC001040 mRNA. Translation: AAH01040.1 .
    BC019269 mRNA. Translation: AAH19269.1 .
    AF275806 mRNA. Translation: AAG23818.1 . Different initiation.
    CCDSi CCDS7976.1.
    RefSeqi NP_060310.1. NM_017840.3.
    UniGenei Hs.530734.

    3D structure databases

    ProteinModelPortali Q9NX20.
    SMRi Q9NX20. Positions 85-192.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120287. 17 interactions.
    IntActi Q9NX20. 4 interactions.
    MINTi MINT-3064053.
    STRINGi 9606.ENSP00000300151.

    PTM databases

    PhosphoSitei Q9NX20.

    Polymorphism databases

    DMDMi 74734684.

    Proteomic databases

    MaxQBi Q9NX20.
    PaxDbi Q9NX20.
    PeptideAtlasi Q9NX20.
    PRIDEi Q9NX20.

    Protocols and materials databases

    DNASUi 54948.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300151 ; ENSP00000300151 ; ENSG00000166902 .
    GeneIDi 54948.
    KEGGi hsa:54948.
    UCSCi uc001noh.2. human.

    Organism-specific databases

    CTDi 54948.
    GeneCardsi GC11M059573.
    HGNCi HGNC:14476. MRPL16.
    HPAi HPA054133.
    MIMi 611829. gene.
    neXtProti NX_Q9NX20.
    PharmGKBi PA30945.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0197.
    HOGENOMi HOG000021349.
    HOVERGENi HBG056553.
    InParanoidi Q9NX20.
    KOi K02878.
    OMAi PITRKGM.
    OrthoDBi EOG7HQN8X.
    PhylomeDBi Q9NX20.
    TreeFami TF312969.

    Miscellaneous databases

    ChiTaRSi MRPL16. human.
    GenomeRNAii 54948.
    NextBioi 58115.
    PROi Q9NX20.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NX20.
    Bgeei Q9NX20.
    CleanExi HS_MRPL16.
    Genevestigatori Q9NX20.

    Family and domain databases

    Gene3Di 3.90.1170.10. 1 hit.
    InterProi IPR016180. Ribosomal_L10e/L16.
    IPR000114. Ribosomal_L16.
    [Graphical view ]
    PANTHERi PTHR12220. PTHR12220. 1 hit.
    Pfami PF00252. Ribosomal_L16. 1 hit.
    [Graphical view ]
    PRINTSi PR00060. RIBOSOMALL16.
    SUPFAMi SSF54686. SSF54686. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
      Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
      J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    2. "A novel gene expressed in human pheochromocytoma."
      Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pheochromocytoma.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    6. "Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
      Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 194-251.
      Tissue: Promyelocytic leukemia.
    7. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM16_HUMAN
    AccessioniPrimary (citable) accession number: Q9NX20
    Secondary accession number(s): Q9BYD0, Q9HB70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3