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Protein

39S ribosomal protein L16, mitochondrial

Gene

MRPL16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L16, mitochondrial
Short name:
L16mt
Short name:
MRP-L16
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL16m1 Publication
Gene namesi
Name:MRPL16
ORF Names:PNAS-111
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14476. MRPL16.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial large ribosomal subunit Source: UniProtKB

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166902.
PharmGKBiPA30945.

Polymorphism and mutation databases

BioMutaiMRPL16.
DMDMi74734684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000023984130 – 25139S ribosomal protein L16, mitochondrialAdd BLAST222

Proteomic databases

EPDiQ9NX20.
MaxQBiQ9NX20.
PaxDbiQ9NX20.
PeptideAtlasiQ9NX20.
PRIDEiQ9NX20.
TopDownProteomicsiQ9NX20.

PTM databases

iPTMnetiQ9NX20.
PhosphoSitePlusiQ9NX20.
SwissPalmiQ9NX20.

Expressioni

Gene expression databases

BgeeiENSG00000166902.
CleanExiHS_MRPL16.
ExpressionAtlasiQ9NX20. baseline and differential.
GenevisibleiQ9NX20. HS.

Organism-specific databases

HPAiHPA054133.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Protein-protein interaction databases

BioGridi120287. 44 interactors.
IntActiQ9NX20. 11 interactors.
MINTiMINT-3064053.
STRINGi9606.ENSP00000300151.

Structurei

Secondary structure

1251
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi69 – 71Combined sources3
Beta strandi73 – 75Combined sources3
Beta strandi77 – 79Combined sources3
Beta strandi86 – 93Combined sources8
Beta strandi95 – 97Combined sources3
Helixi99 – 111Combined sources13
Turni115 – 117Combined sources3
Beta strandi118 – 122Combined sources5
Beta strandi129 – 133Combined sources5
Beta strandi146 – 154Combined sources9
Beta strandi159 – 166Combined sources8
Helixi169 – 182Combined sources14
Beta strandi183 – 185Combined sources3
Beta strandi187 – 191Combined sources5
Helixi192 – 208Combined sources17
Helixi215 – 220Combined sources6
Helixi226 – 228Combined sources3
Turni233 – 236Combined sources4
Beta strandi239 – 244Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40N1-251[»]
3J9Melectron microscopy3.50N1-251[»]
ProteinModelPortaliQ9NX20.
SMRiQ9NX20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3422. Eukaryota.
COG0197. LUCA.
GeneTreeiENSGT00390000002038.
HOGENOMiHOG000021349.
HOVERGENiHBG056553.
InParanoidiQ9NX20.
KOiK02878.
OMAiMFAIWRV.
OrthoDBiEOG091G0KF0.
PhylomeDBiQ9NX20.
TreeFamiTF312969.

Family and domain databases

CDDicd01433. Ribosomal_L16_L10e. 1 hit.
Gene3Di3.90.1170.10. 1 hit.
InterProiView protein in InterPro
IPR016180. Ribosomal_L10e/L16.
IPR000114. Ribosomal_L16.
PANTHERiPTHR12220. PTHR12220. 1 hit.
PfamiView protein in Pfam
PF00252. Ribosomal_L16. 1 hit.
PRINTSiPR00060. RIBOSOMALL16.
SUPFAMiSSF54686. SSF54686. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NX20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLLARASA PLLRVPLSDS WALLPASAGV KTLLPVPSFE DVSIPEKPKL
60 70 80 90 100
RFIERAPLVP KVRREPKNLS DIRGPSTEAT EFTEGNFAIL ALGGGYLHWG
110 120 130 140 150
HFEMMRLTIN RSMDPKNMFA IWRVPAPFKP ITRKSVGHRM GGGKGAIDHY
160 170 180 190 200
VTPVKAGRLV VEMGGRCEFE EVQGFLDQVA HKLPFAAKAV SRGTLEKMRK
210 220 230 240 250
DQEERERNNQ NPWTFERIAT ANMLGIRKVL SPYDLTHKGK YWGKFYMPKR

V
Length:251
Mass (Da):28,449
Last modified:October 1, 2000 - v1
Checksum:i8A42A67DA80A6FEF
GO

Sequence cautioni

The sequence AAG23818 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15V → L in BAB40847 (PubMed:11279069).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05200629G → S. Corresponds to variant dbSNP:rs7122468Ensembl.1
Natural variantiVAR_052007199R → Q. Corresponds to variant dbSNP:rs12787462Ensembl.1
Natural variantiVAR_052008207R → C. Corresponds to variant dbSNP:rs491671Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049642 mRNA. Translation: BAB40847.1.
AF183428 mRNA. Translation: AAG09697.1.
AK000491 mRNA. Translation: BAA91202.1.
CR457117 mRNA. Translation: CAG33398.1.
BC001040 mRNA. Translation: AAH01040.1.
BC019269 mRNA. Translation: AAH19269.1.
AF275806 mRNA. Translation: AAG23818.1. Different initiation.
CCDSiCCDS7976.1.
RefSeqiNP_060310.1. NM_017840.3.
UniGeneiHs.530734.

Genome annotation databases

EnsembliENST00000300151; ENSP00000300151; ENSG00000166902.
GeneIDi54948.
KEGGihsa:54948.
UCSCiuc001noh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049642 mRNA. Translation: BAB40847.1.
AF183428 mRNA. Translation: AAG09697.1.
AK000491 mRNA. Translation: BAA91202.1.
CR457117 mRNA. Translation: CAG33398.1.
BC001040 mRNA. Translation: AAH01040.1.
BC019269 mRNA. Translation: AAH19269.1.
AF275806 mRNA. Translation: AAG23818.1. Different initiation.
CCDSiCCDS7976.1.
RefSeqiNP_060310.1. NM_017840.3.
UniGeneiHs.530734.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40N1-251[»]
3J9Melectron microscopy3.50N1-251[»]
ProteinModelPortaliQ9NX20.
SMRiQ9NX20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120287. 44 interactors.
IntActiQ9NX20. 11 interactors.
MINTiMINT-3064053.
STRINGi9606.ENSP00000300151.

PTM databases

iPTMnetiQ9NX20.
PhosphoSitePlusiQ9NX20.
SwissPalmiQ9NX20.

Polymorphism and mutation databases

BioMutaiMRPL16.
DMDMi74734684.

Proteomic databases

EPDiQ9NX20.
MaxQBiQ9NX20.
PaxDbiQ9NX20.
PeptideAtlasiQ9NX20.
PRIDEiQ9NX20.
TopDownProteomicsiQ9NX20.

Protocols and materials databases

DNASUi54948.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300151; ENSP00000300151; ENSG00000166902.
GeneIDi54948.
KEGGihsa:54948.
UCSCiuc001noh.2. human.

Organism-specific databases

CTDi54948.
GeneCardsiMRPL16.
HGNCiHGNC:14476. MRPL16.
HPAiHPA054133.
MIMi611829. gene.
neXtProtiNX_Q9NX20.
OpenTargetsiENSG00000166902.
PharmGKBiPA30945.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3422. Eukaryota.
COG0197. LUCA.
GeneTreeiENSGT00390000002038.
HOGENOMiHOG000021349.
HOVERGENiHBG056553.
InParanoidiQ9NX20.
KOiK02878.
OMAiMFAIWRV.
OrthoDBiEOG091G0KF0.
PhylomeDBiQ9NX20.
TreeFamiTF312969.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL16. human.
GenomeRNAii54948.
PROiPR:Q9NX20.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166902.
CleanExiHS_MRPL16.
ExpressionAtlasiQ9NX20. baseline and differential.
GenevisibleiQ9NX20. HS.

Family and domain databases

CDDicd01433. Ribosomal_L16_L10e. 1 hit.
Gene3Di3.90.1170.10. 1 hit.
InterProiView protein in InterPro
IPR016180. Ribosomal_L10e/L16.
IPR000114. Ribosomal_L16.
PANTHERiPTHR12220. PTHR12220. 1 hit.
PfamiView protein in Pfam
PF00252. Ribosomal_L16. 1 hit.
PRINTSiPR00060. RIBOSOMALL16.
SUPFAMiSSF54686. SSF54686. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM16_HUMAN
AccessioniPrimary (citable) accession number: Q9NX20
Secondary accession number(s): Q9BYD0, Q9HB70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2000
Last modified: June 7, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.