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Protein

39S ribosomal protein L16, mitochondrial

Gene

MRPL16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the large subunit of mitochondrial ribosome.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L16, mitochondrial
Short name:
L16mt
Short name:
MRP-L16
Gene namesi
Name:MRPL16
ORF Names:PNAS-111
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14476. MRPL16.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30945.

Polymorphism and mutation databases

BioMutaiMRPL16.
DMDMi74734684.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3636MitochondrionSequence AnalysisAdd
BLAST
Chaini37 – 25121539S ribosomal protein L16, mitochondrialPRO_0000239841Add
BLAST

Proteomic databases

MaxQBiQ9NX20.
PaxDbiQ9NX20.
PeptideAtlasiQ9NX20.
PRIDEiQ9NX20.

PTM databases

PhosphoSiteiQ9NX20.

Expressioni

Gene expression databases

BgeeiQ9NX20.
CleanExiHS_MRPL16.
ExpressionAtlasiQ9NX20. baseline and differential.
GenevisibleiQ9NX20. HS.

Organism-specific databases

HPAiHPA054133.

Interactioni

Protein-protein interaction databases

BioGridi120287. 25 interactions.
IntActiQ9NX20. 4 interactions.
MINTiMINT-3064053.
STRINGi9606.ENSP00000300151.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40N1-251[»]
3J9Melectron microscopy3.50N1-251[»]
ProteinModelPortaliQ9NX20.
SMRiQ9NX20. Positions 47-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L16P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0197.
GeneTreeiENSGT00390000002038.
HOGENOMiHOG000021349.
HOVERGENiHBG056553.
InParanoidiQ9NX20.
KOiK02878.
OMAiPITRKGM.
OrthoDBiEOG7HQN8X.
PhylomeDBiQ9NX20.
TreeFamiTF312969.

Family and domain databases

Gene3Di3.90.1170.10. 1 hit.
InterProiIPR016180. Ribosomal_L10e/L16.
IPR000114. Ribosomal_L16.
[Graphical view]
PANTHERiPTHR12220. PTHR12220. 1 hit.
PfamiPF00252. Ribosomal_L16. 1 hit.
[Graphical view]
PRINTSiPR00060. RIBOSOMALL16.
SUPFAMiSSF54686. SSF54686. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NX20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLLARASA PLLRVPLSDS WALLPASAGV KTLLPVPSFE DVSIPEKPKL
60 70 80 90 100
RFIERAPLVP KVRREPKNLS DIRGPSTEAT EFTEGNFAIL ALGGGYLHWG
110 120 130 140 150
HFEMMRLTIN RSMDPKNMFA IWRVPAPFKP ITRKSVGHRM GGGKGAIDHY
160 170 180 190 200
VTPVKAGRLV VEMGGRCEFE EVQGFLDQVA HKLPFAAKAV SRGTLEKMRK
210 220 230 240 250
DQEERERNNQ NPWTFERIAT ANMLGIRKVL SPYDLTHKGK YWGKFYMPKR

V
Length:251
Mass (Da):28,449
Last modified:October 1, 2000 - v1
Checksum:i8A42A67DA80A6FEF
GO

Sequence cautioni

The sequence AAG23818.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151V → L in BAB40847 (PubMed:11279069).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291G → S.
Corresponds to variant rs7122468 [ dbSNP | Ensembl ].
VAR_052006
Natural varianti199 – 1991R → Q.
Corresponds to variant rs12787462 [ dbSNP | Ensembl ].
VAR_052007
Natural varianti207 – 2071R → C.
Corresponds to variant rs491671 [ dbSNP | Ensembl ].
VAR_052008

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049642 mRNA. Translation: BAB40847.1.
AF183428 mRNA. Translation: AAG09697.1.
AK000491 mRNA. Translation: BAA91202.1.
CR457117 mRNA. Translation: CAG33398.1.
BC001040 mRNA. Translation: AAH01040.1.
BC019269 mRNA. Translation: AAH19269.1.
AF275806 mRNA. Translation: AAG23818.1. Different initiation.
CCDSiCCDS7976.1.
RefSeqiNP_060310.1. NM_017840.3.
UniGeneiHs.530734.

Genome annotation databases

EnsembliENST00000300151; ENSP00000300151; ENSG00000166902.
GeneIDi54948.
KEGGihsa:54948.
UCSCiuc001noh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049642 mRNA. Translation: BAB40847.1.
AF183428 mRNA. Translation: AAG09697.1.
AK000491 mRNA. Translation: BAA91202.1.
CR457117 mRNA. Translation: CAG33398.1.
BC001040 mRNA. Translation: AAH01040.1.
BC019269 mRNA. Translation: AAH19269.1.
AF275806 mRNA. Translation: AAG23818.1. Different initiation.
CCDSiCCDS7976.1.
RefSeqiNP_060310.1. NM_017840.3.
UniGeneiHs.530734.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40N1-251[»]
3J9Melectron microscopy3.50N1-251[»]
ProteinModelPortaliQ9NX20.
SMRiQ9NX20. Positions 47-251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120287. 25 interactions.
IntActiQ9NX20. 4 interactions.
MINTiMINT-3064053.
STRINGi9606.ENSP00000300151.

PTM databases

PhosphoSiteiQ9NX20.

Polymorphism and mutation databases

BioMutaiMRPL16.
DMDMi74734684.

Proteomic databases

MaxQBiQ9NX20.
PaxDbiQ9NX20.
PeptideAtlasiQ9NX20.
PRIDEiQ9NX20.

Protocols and materials databases

DNASUi54948.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300151; ENSP00000300151; ENSG00000166902.
GeneIDi54948.
KEGGihsa:54948.
UCSCiuc001noh.2. human.

Organism-specific databases

CTDi54948.
GeneCardsiGC11M059573.
HGNCiHGNC:14476. MRPL16.
HPAiHPA054133.
MIMi611829. gene.
neXtProtiNX_Q9NX20.
PharmGKBiPA30945.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0197.
GeneTreeiENSGT00390000002038.
HOGENOMiHOG000021349.
HOVERGENiHBG056553.
InParanoidiQ9NX20.
KOiK02878.
OMAiPITRKGM.
OrthoDBiEOG7HQN8X.
PhylomeDBiQ9NX20.
TreeFamiTF312969.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL16. human.
GenomeRNAii54948.
NextBioi58115.
PROiQ9NX20.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NX20.
CleanExiHS_MRPL16.
ExpressionAtlasiQ9NX20. baseline and differential.
GenevisibleiQ9NX20. HS.

Family and domain databases

Gene3Di3.90.1170.10. 1 hit.
InterProiIPR016180. Ribosomal_L10e/L16.
IPR000114. Ribosomal_L16.
[Graphical view]
PANTHERiPTHR12220. PTHR12220. 1 hit.
PfamiPF00252. Ribosomal_L16. 1 hit.
[Graphical view]
PRINTSiPR00060. RIBOSOMALL16.
SUPFAMiSSF54686. SSF54686. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "A novel gene expressed in human pheochromocytoma."
    Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pheochromocytoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
    Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 194-251.
    Tissue: Promyelocytic leukemia.
  7. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM16_HUMAN
AccessioniPrimary (citable) accession number: Q9NX20
Secondary accession number(s): Q9BYD0, Q9HB70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.