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Protein

COMM domain-containing protein 8

Gene

COMMD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).1 Publication1 Publication

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-8951664. Neddylation.

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 8
Gene namesi
Name:COMMD8
ORF Names:MDS022
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000169019.10.
HGNCiHGNC:26036. COMMD8.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54951.
OpenTargetsiENSG00000169019.
PharmGKBiPA134876825.

Polymorphism and mutation databases

BioMutaiCOMMD8.
DMDMi51316105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000774011 – 183COMM domain-containing protein 8Add BLAST183

Proteomic databases

EPDiQ9NX08.
MaxQBiQ9NX08.
PaxDbiQ9NX08.
PeptideAtlasiQ9NX08.
PRIDEiQ9NX08.
TopDownProteomicsiQ9NX08.

PTM databases

iPTMnetiQ9NX08.
PhosphoSitePlusiQ9NX08.

Expressioni

Tissue specificityi

Widely expressed with highest expression in thyroid.1 Publication

Gene expression databases

BgeeiENSG00000169019.
CleanExiHS_COMMD8.
GenevisibleiQ9NX08. HS.

Organism-specific databases

HPAiHPA035887.

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5.5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120289. 49 interactors.
CORUMiQ9NX08.
IntActiQ9NX08. 17 interactors.
STRINGi9606.ENSP00000370984.

Structurei

3D structure databases

ProteinModelPortaliQ9NX08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 183COMMPROSITE-ProRule annotationAdd BLAST68

Phylogenomic databases

eggNOGiENOG410IHDB. Eukaryota.
ENOG4111JYC. LUCA.
GeneTreeiENSGT00390000018121.
HOGENOMiHOG000007080.
HOVERGENiHBG051073.
InParanoidiQ9NX08.
OMAiVWDSTEW.
OrthoDBiEOG091G18T9.
PhylomeDBiQ9NX08.
TreeFamiTF328403.

Family and domain databases

InterProiView protein in InterPro
IPR017920. COMM.
PfamiView protein in Pfam
PF07258. COMM_domain. 1 hit.
PROSITEiView protein in PROSITE
PS51269. COMM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NX08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPEEGTPLW RLQKLPAELG PQLLHKIIDG ICGRAYPVYQ DYHTVWESEE
60 70 80 90 100
WMHVLEDIAK FFKAIVGKNL PDEEIFQQLN QLNSLHQETI MKCVKSRKDE
110 120 130 140 150
IKQALSREIV AISSAQLQDF DWQVKLALSS DKIAALRMPL LSLHLDVKEN
160 170 180
GEVKPYSIEM SREELQNLIQ SLEAANKVVL QLK
Length:183
Mass (Da):21,090
Last modified:October 1, 2000 - v1
Checksum:i59B48D6D7CECCCC7
GO

Sequence cautioni

The sequence AAG14957 differs from that shown. Reason: Frameshift at position 11.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127A → L in AAH19826 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04881417A → P. Corresponds to variant dbSNP:rs35444219Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542163 mRNA. Translation: AAS22245.1.
AF182421 mRNA. Translation: AAG14957.1. Frameshift.
AK000509 mRNA. Translation: BAA91216.1.
BC015145 mRNA. Translation: AAH15145.1.
BC008371 mRNA. Translation: AAH08371.1.
BC019826 mRNA. Translation: AAH19826.1.
CCDSiCCDS3475.1.
RefSeqiNP_001316597.1. NM_001329668.1.
NP_060315.1. NM_017845.4.
UniGeneiHs.23956.

Genome annotation databases

EnsembliENST00000381571; ENSP00000370984; ENSG00000169019.
GeneIDi54951.
KEGGihsa:54951.
UCSCiuc003gxi.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOMD8_HUMAN
AccessioniPrimary (citable) accession number: Q9NX08
Secondary accession number(s): Q8WUR4, Q9HC15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot