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Protein

COMM domain-containing protein 8

Gene

COMMD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).1 Publication1 Publication

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 8
Gene namesi
Name:COMMD8
ORF Names:MDS022
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26036. COMMD8.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183COMM domain-containing protein 8PRO_0000077401Add
BLAST

Proteomic databases

MaxQBiQ9NX08.
PaxDbiQ9NX08.
PRIDEiQ9NX08.

PTM databases

PhosphoSiteiQ9NX08.

Expressioni

Tissue specificityi

Widely expressed with highest expression in thyroid.1 Publication

Gene expression databases

BgeeiQ9NX08.
CleanExiHS_COMMD8.
GenevestigatoriQ9NX08.

Organism-specific databases

HPAiHPA035887.

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5.5 Publications

Protein-protein interaction databases

BioGridi120289. 14 interactions.
IntActiQ9NX08. 8 interactions.
STRINGi9606.ENSP00000370984.

Structurei

3D structure databases

ProteinModelPortaliQ9NX08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 18368COMMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 COMM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG40782.
GeneTreeiENSGT00390000018121.
HOGENOMiHOG000007080.
HOVERGENiHBG051073.
InParanoidiQ9NX08.
OMAiVWDSTEW.
OrthoDBiEOG7FZ00T.
PhylomeDBiQ9NX08.
TreeFamiTF328403.

Family and domain databases

InterProiIPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NX08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPEEGTPLW RLQKLPAELG PQLLHKIIDG ICGRAYPVYQ DYHTVWESEE
60 70 80 90 100
WMHVLEDIAK FFKAIVGKNL PDEEIFQQLN QLNSLHQETI MKCVKSRKDE
110 120 130 140 150
IKQALSREIV AISSAQLQDF DWQVKLALSS DKIAALRMPL LSLHLDVKEN
160 170 180
GEVKPYSIEM SREELQNLIQ SLEAANKVVL QLK
Length:183
Mass (Da):21,090
Last modified:September 30, 2000 - v1
Checksum:i59B48D6D7CECCCC7
GO

Sequence cautioni

The sequence AAG14957.1 differs from that shown. Reason: Frameshift at position 11. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271A → L in AAH19826 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171A → P.
Corresponds to variant rs35444219 [ dbSNP | Ensembl ].
VAR_048814

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542163 mRNA. Translation: AAS22245.1.
AF182421 mRNA. Translation: AAG14957.1. Frameshift.
AK000509 mRNA. Translation: BAA91216.1.
BC015145 mRNA. Translation: AAH15145.1.
BC008371 mRNA. Translation: AAH08371.1.
BC019826 mRNA. Translation: AAH19826.1.
CCDSiCCDS3475.1.
RefSeqiNP_060315.1. NM_017845.3.
UniGeneiHs.23956.

Genome annotation databases

EnsembliENST00000381571; ENSP00000370984; ENSG00000169019.
GeneIDi54951.
KEGGihsa:54951.
UCSCiuc003gxi.3. human.

Polymorphism databases

DMDMi51316105.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542163 mRNA. Translation: AAS22245.1.
AF182421 mRNA. Translation: AAG14957.1. Frameshift.
AK000509 mRNA. Translation: BAA91216.1.
BC015145 mRNA. Translation: AAH15145.1.
BC008371 mRNA. Translation: AAH08371.1.
BC019826 mRNA. Translation: AAH19826.1.
CCDSiCCDS3475.1.
RefSeqiNP_060315.1. NM_017845.3.
UniGeneiHs.23956.

3D structure databases

ProteinModelPortaliQ9NX08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120289. 14 interactions.
IntActiQ9NX08. 8 interactions.
STRINGi9606.ENSP00000370984.

PTM databases

PhosphoSiteiQ9NX08.

Polymorphism databases

DMDMi51316105.

Proteomic databases

MaxQBiQ9NX08.
PaxDbiQ9NX08.
PRIDEiQ9NX08.

Protocols and materials databases

DNASUi54951.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381571; ENSP00000370984; ENSG00000169019.
GeneIDi54951.
KEGGihsa:54951.
UCSCiuc003gxi.3. human.

Organism-specific databases

CTDi54951.
GeneCardsiGC04M047369.
HGNCiHGNC:26036. COMMD8.
HPAiHPA035887.
neXtProtiNX_Q9NX08.
PharmGKBiPA134876825.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40782.
GeneTreeiENSGT00390000018121.
HOGENOMiHOG000007080.
HOVERGENiHBG051073.
InParanoidiQ9NX08.
OMAiVWDSTEW.
OrthoDBiEOG7FZ00T.
PhylomeDBiQ9NX08.
TreeFamiTF328403.

Miscellaneous databases

GenomeRNAii54951.
NextBioi58123.
PROiQ9NX08.

Gene expression databases

BgeeiQ9NX08.
CleanExiHS_COMMD8.
GenevestigatoriQ9NX08.

Family and domain databases

InterProiIPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH COMMD1; RELA; RELB AND NFKB1, TISSUE SPECIFICITY.
  2. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
    Huang C., Qian B., Tu Y., Gu W., Wang Y., Han Z., Chen Z.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hematopoietic stem cell.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Placenta.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding."
    Mao X., Gluck N., Chen B., Starokadomskyy P., Li H., Maine G.N., Burstein E.
    J. Biol. Chem. 286:32355-32365(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CUL1; CUL2; CUL3; CUL4A; CUL4B AND CUL5, SUBCELLULAR LOCATION.
  7. "Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel."
    Liu Y.F., Swart M., Ke Y., Ly K., McDonald F.J.
    Am. J. Physiol. 305:F80-F89(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SCNN1B.
  8. Cited for: INTERACTION WITH CCDC22.
  9. Cited for: INTERACTION WITH CCDC93.

Entry informationi

Entry nameiCOMD8_HUMAN
AccessioniPrimary (citable) accession number: Q9NX08
Secondary accession number(s): Q8WUR4, Q9HC15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2004
Last sequence update: September 30, 2000
Last modified: March 31, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.