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Q9NX08

- COMD8_HUMAN

UniProt

Q9NX08 - COMD8_HUMAN

Protein

COMM domain-containing protein 8

Gene

COMMD8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    COMM domain-containing protein 8
    Gene namesi
    Name:COMMD8
    ORF Names:MDS022
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:26036. COMMD8.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134876825.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 183183COMM domain-containing protein 8PRO_0000077401Add
    BLAST

    Proteomic databases

    MaxQBiQ9NX08.
    PaxDbiQ9NX08.
    PRIDEiQ9NX08.

    PTM databases

    PhosphoSiteiQ9NX08.

    Expressioni

    Tissue specificityi

    Widely expressed with highest expression in thyroid.1 Publication

    Gene expression databases

    BgeeiQ9NX08.
    CleanExiHS_COMMD8.
    GenevestigatoriQ9NX08.

    Organism-specific databases

    HPAiHPA035887.

    Interactioni

    Subunit structurei

    Interacts (via COMM domain) with COMMD1 (via COMM domain).1 Publication

    Protein-protein interaction databases

    BioGridi120289. 13 interactions.
    IntActiQ9NX08. 8 interactions.
    STRINGi9606.ENSP00000370984.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NX08.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini116 – 18368COMMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 COMM domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG40782.
    HOGENOMiHOG000007080.
    HOVERGENiHBG051073.
    OMAiVWDSTEW.
    OrthoDBiEOG7FZ00T.
    PhylomeDBiQ9NX08.
    TreeFamiTF328403.

    Family and domain databases

    InterProiIPR017920. COMM.
    IPR009886. HCaRG.
    [Graphical view]
    PfamiPF07258. HCaRG. 1 hit.
    [Graphical view]
    PROSITEiPS51269. COMM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NX08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPEEGTPLW RLQKLPAELG PQLLHKIIDG ICGRAYPVYQ DYHTVWESEE    50
    WMHVLEDIAK FFKAIVGKNL PDEEIFQQLN QLNSLHQETI MKCVKSRKDE 100
    IKQALSREIV AISSAQLQDF DWQVKLALSS DKIAALRMPL LSLHLDVKEN 150
    GEVKPYSIEM SREELQNLIQ SLEAANKVVL QLK 183
    Length:183
    Mass (Da):21,090
    Last modified:October 1, 2000 - v1
    Checksum:i59B48D6D7CECCCC7
    GO

    Sequence cautioni

    The sequence AAG14957.1 differs from that shown. Reason: Frameshift at position 11.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti127 – 1271A → L in AAH19826. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171A → P.
    Corresponds to variant rs35444219 [ dbSNP | Ensembl ].
    VAR_048814

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY542163 mRNA. Translation: AAS22245.1.
    AF182421 mRNA. Translation: AAG14957.1. Frameshift.
    AK000509 mRNA. Translation: BAA91216.1.
    BC015145 mRNA. Translation: AAH15145.1.
    BC008371 mRNA. Translation: AAH08371.1.
    BC019826 mRNA. Translation: AAH19826.1.
    CCDSiCCDS3475.1.
    RefSeqiNP_060315.1. NM_017845.3.
    UniGeneiHs.23956.

    Genome annotation databases

    EnsembliENST00000381571; ENSP00000370984; ENSG00000169019.
    GeneIDi54951.
    KEGGihsa:54951.
    UCSCiuc003gxi.3. human.

    Polymorphism databases

    DMDMi51316105.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY542163 mRNA. Translation: AAS22245.1 .
    AF182421 mRNA. Translation: AAG14957.1 . Frameshift.
    AK000509 mRNA. Translation: BAA91216.1 .
    BC015145 mRNA. Translation: AAH15145.1 .
    BC008371 mRNA. Translation: AAH08371.1 .
    BC019826 mRNA. Translation: AAH19826.1 .
    CCDSi CCDS3475.1.
    RefSeqi NP_060315.1. NM_017845.3.
    UniGenei Hs.23956.

    3D structure databases

    ProteinModelPortali Q9NX08.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120289. 13 interactions.
    IntActi Q9NX08. 8 interactions.
    STRINGi 9606.ENSP00000370984.

    PTM databases

    PhosphoSitei Q9NX08.

    Polymorphism databases

    DMDMi 51316105.

    Proteomic databases

    MaxQBi Q9NX08.
    PaxDbi Q9NX08.
    PRIDEi Q9NX08.

    Protocols and materials databases

    DNASUi 54951.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000381571 ; ENSP00000370984 ; ENSG00000169019 .
    GeneIDi 54951.
    KEGGi hsa:54951.
    UCSCi uc003gxi.3. human.

    Organism-specific databases

    CTDi 54951.
    GeneCardsi GC04M047369.
    HGNCi HGNC:26036. COMMD8.
    HPAi HPA035887.
    neXtProti NX_Q9NX08.
    PharmGKBi PA134876825.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40782.
    HOGENOMi HOG000007080.
    HOVERGENi HBG051073.
    OMAi VWDSTEW.
    OrthoDBi EOG7FZ00T.
    PhylomeDBi Q9NX08.
    TreeFami TF328403.

    Miscellaneous databases

    GenomeRNAii 54951.
    NextBioi 58123.
    PROi Q9NX08.

    Gene expression databases

    Bgeei Q9NX08.
    CleanExi HS_COMMD8.
    Genevestigatori Q9NX08.

    Family and domain databases

    InterProi IPR017920. COMM.
    IPR009886. HCaRG.
    [Graphical view ]
    Pfami PF07258. HCaRG. 1 hit.
    [Graphical view ]
    PROSITEi PS51269. COMM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH COMMD1, TISSUE SPECIFICITY.
    2. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
      Huang C., Qian B., Tu Y., Gu W., Wang Y., Han Z., Chen Z.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hematopoietic stem cell.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney and Placenta.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOMD8_HUMAN
    AccessioniPrimary (citable) accession number: Q9NX08
    Secondary accession number(s): Q8WUR4, Q9HC15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3