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Q9NX08

- COMD8_HUMAN

UniProt

Q9NX08 - COMD8_HUMAN

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Protein

COMM domain-containing protein 8

Gene

COMMD8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 8
Gene namesi
Name:COMMD8
ORF Names:MDS022
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:26036. COMMD8.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183COMM domain-containing protein 8PRO_0000077401Add
BLAST

Proteomic databases

MaxQBiQ9NX08.
PaxDbiQ9NX08.
PRIDEiQ9NX08.

PTM databases

PhosphoSiteiQ9NX08.

Expressioni

Tissue specificityi

Widely expressed with highest expression in thyroid.1 Publication

Gene expression databases

BgeeiQ9NX08.
CleanExiHS_COMMD8.
GenevestigatoriQ9NX08.

Organism-specific databases

HPAiHPA035887.

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain).1 Publication

Protein-protein interaction databases

BioGridi120289. 15 interactions.
IntActiQ9NX08. 8 interactions.
STRINGi9606.ENSP00000370984.

Structurei

3D structure databases

ProteinModelPortaliQ9NX08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 18368COMMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 COMM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG40782.
GeneTreeiENSGT00390000018121.
HOGENOMiHOG000007080.
HOVERGENiHBG051073.
InParanoidiQ9NX08.
OMAiVWDSTEW.
OrthoDBiEOG7FZ00T.
PhylomeDBiQ9NX08.
TreeFamiTF328403.

Family and domain databases

InterProiIPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NX08 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPEEGTPLW RLQKLPAELG PQLLHKIIDG ICGRAYPVYQ DYHTVWESEE
60 70 80 90 100
WMHVLEDIAK FFKAIVGKNL PDEEIFQQLN QLNSLHQETI MKCVKSRKDE
110 120 130 140 150
IKQALSREIV AISSAQLQDF DWQVKLALSS DKIAALRMPL LSLHLDVKEN
160 170 180
GEVKPYSIEM SREELQNLIQ SLEAANKVVL QLK
Length:183
Mass (Da):21,090
Last modified:October 1, 2000 - v1
Checksum:i59B48D6D7CECCCC7
GO

Sequence cautioni

The sequence AAG14957.1 differs from that shown. Reason: Frameshift at position 11.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271A → L in AAH19826. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171A → P.
Corresponds to variant rs35444219 [ dbSNP | Ensembl ].
VAR_048814

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY542163 mRNA. Translation: AAS22245.1.
AF182421 mRNA. Translation: AAG14957.1. Frameshift.
AK000509 mRNA. Translation: BAA91216.1.
BC015145 mRNA. Translation: AAH15145.1.
BC008371 mRNA. Translation: AAH08371.1.
BC019826 mRNA. Translation: AAH19826.1.
CCDSiCCDS3475.1.
RefSeqiNP_060315.1. NM_017845.3.
UniGeneiHs.23956.

Genome annotation databases

EnsembliENST00000381571; ENSP00000370984; ENSG00000169019.
GeneIDi54951.
KEGGihsa:54951.
UCSCiuc003gxi.3. human.

Polymorphism databases

DMDMi51316105.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY542163 mRNA. Translation: AAS22245.1 .
AF182421 mRNA. Translation: AAG14957.1 . Frameshift.
AK000509 mRNA. Translation: BAA91216.1 .
BC015145 mRNA. Translation: AAH15145.1 .
BC008371 mRNA. Translation: AAH08371.1 .
BC019826 mRNA. Translation: AAH19826.1 .
CCDSi CCDS3475.1.
RefSeqi NP_060315.1. NM_017845.3.
UniGenei Hs.23956.

3D structure databases

ProteinModelPortali Q9NX08.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120289. 15 interactions.
IntActi Q9NX08. 8 interactions.
STRINGi 9606.ENSP00000370984.

PTM databases

PhosphoSitei Q9NX08.

Polymorphism databases

DMDMi 51316105.

Proteomic databases

MaxQBi Q9NX08.
PaxDbi Q9NX08.
PRIDEi Q9NX08.

Protocols and materials databases

DNASUi 54951.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000381571 ; ENSP00000370984 ; ENSG00000169019 .
GeneIDi 54951.
KEGGi hsa:54951.
UCSCi uc003gxi.3. human.

Organism-specific databases

CTDi 54951.
GeneCardsi GC04M047369.
HGNCi HGNC:26036. COMMD8.
HPAi HPA035887.
neXtProti NX_Q9NX08.
PharmGKBi PA134876825.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40782.
GeneTreei ENSGT00390000018121.
HOGENOMi HOG000007080.
HOVERGENi HBG051073.
InParanoidi Q9NX08.
OMAi VWDSTEW.
OrthoDBi EOG7FZ00T.
PhylomeDBi Q9NX08.
TreeFami TF328403.

Miscellaneous databases

GenomeRNAii 54951.
NextBioi 58123.
PROi Q9NX08.

Gene expression databases

Bgeei Q9NX08.
CleanExi HS_COMMD8.
Genevestigatori Q9NX08.

Family and domain databases

InterProi IPR017920. COMM.
IPR009886. HCaRG.
[Graphical view ]
Pfami PF07258. HCaRG. 1 hit.
[Graphical view ]
PROSITEi PS51269. COMM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH COMMD1, TISSUE SPECIFICITY.
  2. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
    Huang C., Qian B., Tu Y., Gu W., Wang Y., Han Z., Chen Z.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hematopoietic stem cell.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Placenta.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOMD8_HUMAN
AccessioniPrimary (citable) accession number: Q9NX08
Secondary accession number(s): Q8WUR4, Q9HC15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3