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Protein

COMM domain-containing protein 8

Gene

COMMD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).1 Publication1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 8
Gene namesi
Name:COMMD8
ORF Names:MDS022
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26036. COMMD8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54951.
OpenTargetsiENSG00000169019.
PharmGKBiPA134876825.

Polymorphism and mutation databases

BioMutaiCOMMD8.
DMDMi51316105.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000774011 – 183COMM domain-containing protein 8Add BLAST183

Proteomic databases

EPDiQ9NX08.
MaxQBiQ9NX08.
PaxDbiQ9NX08.
PeptideAtlasiQ9NX08.
PRIDEiQ9NX08.
TopDownProteomicsiQ9NX08.

PTM databases

iPTMnetiQ9NX08.
PhosphoSitePlusiQ9NX08.

Expressioni

Tissue specificityi

Widely expressed with highest expression in thyroid.1 Publication

Gene expression databases

BgeeiENSG00000169019.
CleanExiHS_COMMD8.
GenevisibleiQ9NX08. HS.

Organism-specific databases

HPAiHPA035887.

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC22O608265EBI-725694,EBI-3943153
COMMD1Q8N6682EBI-725694,EBI-1550112

Protein-protein interaction databases

BioGridi120289. 45 interactors.
IntActiQ9NX08. 17 interactors.
STRINGi9606.ENSP00000370984.

Structurei

3D structure databases

ProteinModelPortaliQ9NX08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 183COMMPROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Contains 1 COMM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IHDB. Eukaryota.
ENOG4111JYC. LUCA.
GeneTreeiENSGT00390000018121.
HOGENOMiHOG000007080.
HOVERGENiHBG051073.
InParanoidiQ9NX08.
OMAiVWDSTEW.
OrthoDBiEOG091G18T9.
PhylomeDBiQ9NX08.
TreeFamiTF328403.

Family and domain databases

InterProiIPR017920. COMM.
[Graphical view]
PfamiPF07258. COMM_domain. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NX08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPEEGTPLW RLQKLPAELG PQLLHKIIDG ICGRAYPVYQ DYHTVWESEE
60 70 80 90 100
WMHVLEDIAK FFKAIVGKNL PDEEIFQQLN QLNSLHQETI MKCVKSRKDE
110 120 130 140 150
IKQALSREIV AISSAQLQDF DWQVKLALSS DKIAALRMPL LSLHLDVKEN
160 170 180
GEVKPYSIEM SREELQNLIQ SLEAANKVVL QLK
Length:183
Mass (Da):21,090
Last modified:October 1, 2000 - v1
Checksum:i59B48D6D7CECCCC7
GO

Sequence cautioni

The sequence AAG14957 differs from that shown. Reason: Frameshift at position 11.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127A → L in AAH19826 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04881417A → P.Corresponds to variant rs35444219dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542163 mRNA. Translation: AAS22245.1.
AF182421 mRNA. Translation: AAG14957.1. Frameshift.
AK000509 mRNA. Translation: BAA91216.1.
BC015145 mRNA. Translation: AAH15145.1.
BC008371 mRNA. Translation: AAH08371.1.
BC019826 mRNA. Translation: AAH19826.1.
CCDSiCCDS3475.1.
RefSeqiNP_001316597.1. NM_001329668.1.
NP_060315.1. NM_017845.4.
UniGeneiHs.23956.

Genome annotation databases

EnsembliENST00000381571; ENSP00000370984; ENSG00000169019.
GeneIDi54951.
KEGGihsa:54951.
UCSCiuc003gxi.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542163 mRNA. Translation: AAS22245.1.
AF182421 mRNA. Translation: AAG14957.1. Frameshift.
AK000509 mRNA. Translation: BAA91216.1.
BC015145 mRNA. Translation: AAH15145.1.
BC008371 mRNA. Translation: AAH08371.1.
BC019826 mRNA. Translation: AAH19826.1.
CCDSiCCDS3475.1.
RefSeqiNP_001316597.1. NM_001329668.1.
NP_060315.1. NM_017845.4.
UniGeneiHs.23956.

3D structure databases

ProteinModelPortaliQ9NX08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120289. 45 interactors.
IntActiQ9NX08. 17 interactors.
STRINGi9606.ENSP00000370984.

PTM databases

iPTMnetiQ9NX08.
PhosphoSitePlusiQ9NX08.

Polymorphism and mutation databases

BioMutaiCOMMD8.
DMDMi51316105.

Proteomic databases

EPDiQ9NX08.
MaxQBiQ9NX08.
PaxDbiQ9NX08.
PeptideAtlasiQ9NX08.
PRIDEiQ9NX08.
TopDownProteomicsiQ9NX08.

Protocols and materials databases

DNASUi54951.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381571; ENSP00000370984; ENSG00000169019.
GeneIDi54951.
KEGGihsa:54951.
UCSCiuc003gxi.4. human.

Organism-specific databases

CTDi54951.
DisGeNETi54951.
GeneCardsiCOMMD8.
HGNCiHGNC:26036. COMMD8.
HPAiHPA035887.
MIMi616656. gene.
neXtProtiNX_Q9NX08.
OpenTargetsiENSG00000169019.
PharmGKBiPA134876825.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHDB. Eukaryota.
ENOG4111JYC. LUCA.
GeneTreeiENSGT00390000018121.
HOGENOMiHOG000007080.
HOVERGENiHBG051073.
InParanoidiQ9NX08.
OMAiVWDSTEW.
OrthoDBiEOG091G18T9.
PhylomeDBiQ9NX08.
TreeFamiTF328403.

Miscellaneous databases

GenomeRNAii54951.
PROiQ9NX08.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169019.
CleanExiHS_COMMD8.
GenevisibleiQ9NX08. HS.

Family and domain databases

InterProiIPR017920. COMM.
[Graphical view]
PfamiPF07258. COMM_domain. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOMD8_HUMAN
AccessioniPrimary (citable) accession number: Q9NX08
Secondary accession number(s): Q8WUR4, Q9HC15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.