Reviewed,
UniProtKB/Swiss-Prot Q9NX08 (COMD8_HUMAN)
Last modified
November 24, 2009.
Version 58.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: COMM domain-containing protein 8 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 183 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Tissue specificity | Widely expressed with highest expression in thyroid. Ref.1 |
| Sequence similarities | Contains 1 COMM domain. |
| Sequence caution | The sequence AAG14957.1 differs from that shown. Reason: Frameshift at position 11. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | protein binding Ref.1 Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 183 | 183 | COMM domain-containing protein 8 | PRO_0000077401 | |||||
Regions | |||||||||
| Domain | 116 – 183 | 68 | COMM | ||||||
Natural variations | |||||||||
| Natural variant | 17 | 1 | A → P: dbSNP rs35444219. | VAR_048814 | |||||
Experimental info | |||||||||
| Sequence conflict | 127 | 1 | A → L in AAH19826. Ref.4 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "COMMD proteins, a novel family of structural and functional homologs of MURR1." Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S. J. Biol. Chem. 280:22222-22232(2005) [PubMed: 15799966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
| [2] | "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients." Huang C., Qian B., Tu Y., Gu W., Wang Y., Han Z., Chen Z. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hematopoietic stem cell. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Placenta. |
| [5] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AY542163 mRNA. Translation: AAS22245.1. AF182421 mRNA. Translation: AAG14957.1. Frameshift. AK000509 mRNA. Translation: BAA91216.1. BC015145 mRNA. Translation: AAH15145.1. BC008371 mRNA. Translation: AAH08371.1. BC019826 mRNA. Translation: AAH19826.1. | |
| IPI | IPI00016447. |
| RefSeq | NP_060315.1. |
| UniGene | Hs.23956 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9NX08. 5 interactions. |
| STRING | Q9NX08. |
Proteomic databases | |
| PRIDE | Q9NX08. |
Genome annotation databases | |
| Ensembl | ENST00000381571; ENSP00000370984; ENSG00000169019; Homo sapiens. [Genome view] |
| GeneID | 54951. |
| KEGG | hsa:54951. |
| UCSC | uc003gxi.1. human. |
Organism-specific databases | |
| CTD | 54951. |
| GeneCards | GC04M047147. |
| HGNC | HGNC:26036. COMMD8. |
| PharmGKB | PA134876825. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9NX08. |
| HOVERGEN | Q9NX08. |
| OMA | WMHVLED |
Gene expression databases | |
| ArrayExpress | Q9NX08. |
| Bgee | Q9NX08. |
| CleanEx | HS_COMMD8. |
| Genevestigator | Q9NX08. |
| GermOnline | ENSG00000169019. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR017920. COMM. IPR009886. HCaRG. [Graphical view] |
| Pfam | PF07258. HCaRG. 1 hit. [Graphical view] |
| PROSITE | PS51269. COMM. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 58123. |
Entry information
| Entry name | COMD8_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NX08 Secondary accession number(s): Q8WUR4, Q9HC15 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

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