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Protein

tRNA selenocysteine 1-associated protein 1

Gene

TRNAU1AP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA selenocysteine 1-associated protein 1
Alternative name(s):
SECp43
tRNA selenocysteine-associated protein 1
Gene namesi
Name:TRNAU1AP
Synonyms:SECP43, TRSPAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000180098.9
HGNCiHGNC:30813 TRNAU1AP
neXtProtiNX_Q9NX07

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180098
PharmGKBiPA164727240

Polymorphism and mutation databases

BioMutaiTRNAU1AP
DMDMi74761781

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049171 – 287tRNA selenocysteine 1-associated protein 1Add BLAST287

Proteomic databases

EPDiQ9NX07
MaxQBiQ9NX07
PaxDbiQ9NX07
PeptideAtlasiQ9NX07
PRIDEiQ9NX07

PTM databases

iPTMnetiQ9NX07
PhosphoSitePlusiQ9NX07

Expressioni

Gene expression databases

BgeeiENSG00000180098
CleanExiHS_TRNAU1AP
GenevisibleiQ9NX07 HS

Organism-specific databases

HPAiHPA032068
HPA032069

Interactioni

Subunit structurei

Component of the tRNA(Sec) complex composed at least of EEFSEC, SECISBP2, SEPHS1, SEPSECS, TRNAU1AP and tRNA(Sec). Found in a complex with tRNA(Sec). Interacts with SEPSECS. Associates with mRNP and/or polysomes (By similarity). Found in a complex with EEFSEC, SECISBP2, TRNAU1AP and tRNA(Sec).By similarity1 Publication

Protein-protein interaction databases

BioGridi1202905 interactors.
IntActiQ9NX07 1 interactor.
STRINGi9606.ENSP00000362936

Structurei

Secondary structure

1287
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 7Combined sources7
Helixi16 – 25Combined sources10
Beta strandi32 – 37Combined sources6
Beta strandi39 – 41Combined sources3
Beta strandi44 – 51Combined sources8
Helixi55 – 63Combined sources9
Turni64 – 67Combined sources4
Beta strandi68 – 72Combined sources5
Beta strandi81 – 83Combined sources3
Beta strandi98 – 101Combined sources4
Helixi109 – 119Combined sources11
Beta strandi123 – 130Combined sources8
Beta strandi136 – 145Combined sources10
Helixi147 – 156Combined sources10
Turni157 – 159Combined sources3
Beta strandi162 – 166Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DHGNMR-A94-184[»]
2DIVNMR-A1-86[»]
ProteinModelPortaliQ9NX07
SMRiQ9NX07
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NX07

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 86RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini96 – 175RRM 2PROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi185 – 225Tyr-richAdd BLAST41

Sequence similaritiesi

Belongs to the RRM TRSPAP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00510000047100
HOGENOMiHOG000234338
HOVERGENiHBG056959
InParanoidiQ9NX07
OMAiCQLWMGG
OrthoDBiEOG091G0CAW
PhylomeDBiQ9NX07
TreeFamiTF313275

Family and domain databases

CDDicd12612 RRM2_SECp43, 1 hit
Gene3Di3.30.70.3302 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034510 SECp43_RRM2
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX07-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASLWMGDL EPYMDENFIS RAFATMGETV MSVKIIRNRL TGIPAGYCFV
60 70 80 90 100
EFADLATAEK CLHKINGKPL PGATPAKRFK LNYATYGKQP DNSPEYSLFV
110 120 130 140 150
GDLTPDVDDG MLYEFFVKVY PSCRGGKVVL DQTGVSKGYG FVKFTDELEQ
160 170 180 190 200
KRALTECQGA VGLGSKPVRL SVAIPKASRV KPVEYSQMYS YSYNQYYQQY
210 220 230 240 250
QNYYAQWGYD QNTGSYSYSY PQYGYTQSTM QTYEEVGDDA LEDPMPQLDV
260 270 280
TEANKEFMEQ SEELYDALMD CHWQPLDTVS SEIPAMM
Length:287
Mass (Da):32,499
Last modified:October 1, 2000 - v1
Checksum:i4F85AA839FF256F5
GO
Isoform 2 (identifier: Q9NX07-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:177
Mass (Da):20,403
Checksum:i5E08BFD70AA68A7C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0281301 – 110Missing in isoform 2. 1 PublicationAdd BLAST110

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000510 mRNA Translation: BAA91217.1
AL513497 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07689.1
BC000680 mRNA Translation: AAH00680.1
BC039879 mRNA Translation: AAH39879.1
CCDSiCCDS324.1 [Q9NX07-1]
RefSeqiNP_060316.1, NM_017846.4 [Q9NX07-1]
XP_016857031.1, XM_017001542.1 [Q9NX07-2]
UniGeneiHs.533626

Genome annotation databases

EnsembliENST00000373830; ENSP00000362936; ENSG00000180098 [Q9NX07-1]
GeneIDi54952
KEGGihsa:54952
UCSCiuc001bqi.4 human [Q9NX07-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTSAP1_HUMAN
AccessioniPrimary (citable) accession number: Q9NX07
Secondary accession number(s): Q86SU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome