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Q9NX07

- TSAP1_HUMAN

UniProt

Q9NX07 - TSAP1_HUMAN

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Protein

tRNA selenocysteine 1-associated protein 1

Gene
TRNAU1AP, SECP43, TRSPAP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis By similarity.1 Publication

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. selenocysteine incorporation Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA selenocysteine 1-associated protein 1
Alternative name(s):
SECp43
tRNA selenocysteine-associated protein 1
Gene namesi
Synonyms:SECP43, TRSPAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:30813. TRNAU1AP.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity
Note: Abundant in the nucleus By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164727240.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287tRNA selenocysteine 1-associated protein 1PRO_0000304917Add
BLAST

Proteomic databases

MaxQBiQ9NX07.
PaxDbiQ9NX07.
PRIDEiQ9NX07.

PTM databases

PhosphoSiteiQ9NX07.

Expressioni

Gene expression databases

BgeeiQ9NX07.
CleanExiHS_TRNAU1AP.
GenevestigatoriQ9NX07.

Organism-specific databases

HPAiHPA032069.

Interactioni

Subunit structurei

Component of the tRNA(Sec) complex composed at least of EEFSEC, SECISBP2, SEPHS1, SEPSECS, TRNAU1AP and tRNA(Sec). Found in a complex with tRNA(Sec). Interacts with SEPSECS. Associates with mRNP and/or polysomes By similarity. Found in a complex with EEFSEC, SECISBP2, TRNAU1AP and tRNA(Sec).1 Publication

Protein-protein interaction databases

BioGridi120290. 3 interactions.
STRINGi9606.ENSP00000362936.

Structurei

Secondary structure

287
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi1 – 77
Helixi16 – 2510
Beta strandi32 – 376
Beta strandi39 – 413
Beta strandi44 – 518
Helixi55 – 639
Turni64 – 674
Beta strandi68 – 725
Beta strandi81 – 833
Beta strandi98 – 1014
Helixi109 – 11911
Beta strandi123 – 1308
Beta strandi136 – 14510
Helixi147 – 15610
Turni157 – 1593
Beta strandi162 – 1665

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DHGNMR-A94-184[»]
2DIVNMR-A1-86[»]
ProteinModelPortaliQ9NX07.
SMRiQ9NX07. Positions 1-184.

Miscellaneous databases

EvolutionaryTraceiQ9NX07.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8684RRM 1Add
BLAST
Domaini96 – 17580RRM 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi185 – 22541Tyr-richAdd
BLAST

Sequence similaritiesi

Belongs to the RRM TRSPAP family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0724.
HOGENOMiHOG000234338.
HOVERGENiHBG056959.
InParanoidiQ9NX07.
OMAiPEVDDGM.
OrthoDBiEOG76473F.
PhylomeDBiQ9NX07.
TreeFamiTF313275.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NX07-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAASLWMGDL EPYMDENFIS RAFATMGETV MSVKIIRNRL TGIPAGYCFV    50
EFADLATAEK CLHKINGKPL PGATPAKRFK LNYATYGKQP DNSPEYSLFV 100
GDLTPDVDDG MLYEFFVKVY PSCRGGKVVL DQTGVSKGYG FVKFTDELEQ 150
KRALTECQGA VGLGSKPVRL SVAIPKASRV KPVEYSQMYS YSYNQYYQQY 200
QNYYAQWGYD QNTGSYSYSY PQYGYTQSTM QTYEEVGDDA LEDPMPQLDV 250
TEANKEFMEQ SEELYDALMD CHWQPLDTVS SEIPAMM 287
Length:287
Mass (Da):32,499
Last modified:October 1, 2000 - v1
Checksum:i4F85AA839FF256F5
GO
Isoform 2 (identifier: Q9NX07-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:177
Mass (Da):20,403
Checksum:i5E08BFD70AA68A7C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 110110Missing in isoform 2. VSP_028130Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000510 mRNA. Translation: BAA91217.1.
AL513497 Genomic DNA. Translation: CAI22288.1.
CH471059 Genomic DNA. Translation: EAX07689.1.
BC000680 mRNA. Translation: AAH00680.1.
BC039879 mRNA. Translation: AAH39879.1.
CCDSiCCDS324.1. [Q9NX07-1]
RefSeqiNP_060316.1. NM_017846.4. [Q9NX07-1]
UniGeneiHs.533626.

Genome annotation databases

EnsembliENST00000373830; ENSP00000362936; ENSG00000180098. [Q9NX07-1]
GeneIDi54952.
KEGGihsa:54952.
UCSCiuc001bqi.3. human. [Q9NX07-1]

Polymorphism databases

DMDMi74761781.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000510 mRNA. Translation: BAA91217.1 .
AL513497 Genomic DNA. Translation: CAI22288.1 .
CH471059 Genomic DNA. Translation: EAX07689.1 .
BC000680 mRNA. Translation: AAH00680.1 .
BC039879 mRNA. Translation: AAH39879.1 .
CCDSi CCDS324.1. [Q9NX07-1 ]
RefSeqi NP_060316.1. NM_017846.4. [Q9NX07-1 ]
UniGenei Hs.533626.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DHG NMR - A 94-184 [» ]
2DIV NMR - A 1-86 [» ]
ProteinModelPortali Q9NX07.
SMRi Q9NX07. Positions 1-184.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120290. 3 interactions.
STRINGi 9606.ENSP00000362936.

PTM databases

PhosphoSitei Q9NX07.

Polymorphism databases

DMDMi 74761781.

Proteomic databases

MaxQBi Q9NX07.
PaxDbi Q9NX07.
PRIDEi Q9NX07.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373830 ; ENSP00000362936 ; ENSG00000180098 . [Q9NX07-1 ]
GeneIDi 54952.
KEGGi hsa:54952.
UCSCi uc001bqi.3. human. [Q9NX07-1 ]

Organism-specific databases

CTDi 54952.
GeneCardsi GC01P028879.
H-InvDB HIX0000337.
HGNCi HGNC:30813. TRNAU1AP.
HPAi HPA032069.
neXtProti NX_Q9NX07.
PharmGKBi PA164727240.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0724.
HOGENOMi HOG000234338.
HOVERGENi HBG056959.
InParanoidi Q9NX07.
OMAi PEVDDGM.
OrthoDBi EOG76473F.
PhylomeDBi Q9NX07.
TreeFami TF313275.

Miscellaneous databases

ChiTaRSi TRNAU1AP. human.
EvolutionaryTracei Q9NX07.
GenomeRNAii 54952.
NextBioi 58127.
PROi Q9NX07.

Gene expression databases

Bgeei Q9NX07.
CleanExi HS_TRNAU1AP.
Genevestigatori Q9NX07.

Family and domain databases

Gene3Di 3.30.70.330. 2 hits.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 2 hits.
[Graphical view ]
SMARTi SM00360. RRM. 2 hits.
[Graphical view ]
PROSITEi PS50102. RRM. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Colon.
  5. Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH EEFSEC; SECISBP2 AND TRNA(SEC).
  6. "Solution structure of the RRM domain and of the C-terminal RNA recognition motif of tRNA selenocysteine associated protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (SEP-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1-184.

Entry informationi

Entry nameiTSAP1_HUMAN
AccessioniPrimary (citable) accession number: Q9NX07
Secondary accession number(s): Q86SU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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