ID F120C_HUMAN Reviewed; 1096 AA. AC Q9NX05; B2RMT7; DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot. DT 28-JUN-2023, sequence version 4. DT 27-MAR-2024, entry version 151. DE RecName: Full=Constitutive coactivator of PPAR-gamma-like protein 2; DE AltName: Full=Protein FAM120C; DE AltName: Full=Tumor antigen BJ-HCC-21; GN Name=FAM120C; Synonyms=CXorf17; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY. RC TISSUE=Brain; RX PubMed=14585507; DOI=10.1016/s0378-1119(03)00770-4; RA Holden S., Raymond F.L.; RT "The human gene CXorf17 encodes a member of a novel family of putative RT transmembrane proteins: cDNA cloning and characterization of CXorf17 and RT its mouse ortholog orf34."; RL Gene 318:149-161(2003). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RA Dong X.-Y., Chen W.-F.; RT "Cloning and identification of genes which are differentially expressed in RT carcinoma."; RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Signet-ring cell carcinoma; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., RA Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Brain, and Skin; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-1042, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=28112733; DOI=10.1038/nsmb.3366; RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C., RA Nielsen M.L.; RT "Site-specific mapping of the human SUMO proteome reveals co-modification RT with phosphorylation."; RL Nat. Struct. Mol. Biol. 24:325-336(2017). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q9NX05-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9NX05-2; Sequence=VSP_010519, VSP_010520; CC -!- TISSUE SPECIFICITY: Expressed at low levels in a number of tissues. CC {ECO:0000269|PubMed:14585507}. CC -!- SIMILARITY: Belongs to the constitutive coactivator of PPAR-gamma CC family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAM82751.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; CC Sequence=BAA91219.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY150025; AAO24121.1; -; mRNA. DR EMBL; AY121803; AAM82751.1; ALT_SEQ; mRNA. DR EMBL; AK000513; BAA91219.1; ALT_SEQ; mRNA. DR EMBL; AL589872; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; Z84469; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC016138; AAH16138.2; -; mRNA. DR EMBL; BC136413; AAI36414.1; -; mRNA. DR CCDS; CCDS14356.1; -. [Q9NX05-1] DR CCDS; CCDS55421.1; -. [Q9NX05-2] DR RefSeq; NP_060318.4; NM_017848.5. [Q9NX05-1] DR RefSeq; NP_940858.2; NM_198456.2. [Q9NX05-2] DR AlphaFoldDB; Q9NX05; -. DR BioGRID; 120292; 181. DR IntAct; Q9NX05; 10. DR MINT; Q9NX05; -. DR STRING; 9606.ENSP00000364324; -. DR iPTMnet; Q9NX05; -. DR PhosphoSitePlus; Q9NX05; -. DR SwissPalm; Q9NX05; -. DR BioMuta; FAM120C; -. DR DMDM; 311033453; -. DR EPD; Q9NX05; -. DR jPOST; Q9NX05; -. DR MassIVE; Q9NX05; -. DR MaxQB; Q9NX05; -. DR PaxDb; 9606-ENSP00000364324; -. DR PeptideAtlas; Q9NX05; -. DR ProteomicsDB; 83015; -. [Q9NX05-1] DR ProteomicsDB; 83016; -. [Q9NX05-2] DR Pumba; Q9NX05; -. DR Antibodypedia; 26758; 79 antibodies from 16 providers. DR DNASU; 54954; -. DR Ensembl; ENST00000375180.7; ENSP00000364324.2; ENSG00000184083.12. [Q9NX05-1] DR Ensembl; ENST00000477084.1; ENSP00000420718.1; ENSG00000184083.12. [Q9NX05-2] DR GeneID; 54954; -. DR KEGG; hsa:54954; -. DR MANE-Select; ENST00000375180.7; ENSP00000364324.2; NM_017848.6; NP_060318.4. DR UCSC; uc004dsz.5; human. [Q9NX05-1] DR AGR; HGNC:16949; -. DR CTD; 54954; -. DR DisGeNET; 54954; -. DR GeneCards; FAM120C; -. DR HGNC; HGNC:16949; FAM120C. DR HPA; ENSG00000184083; Low tissue specificity. DR MIM; 300741; gene. DR neXtProt; NX_Q9NX05; -. DR OpenTargets; ENSG00000184083; -. DR PharmGKB; PA134932227; -. DR VEuPathDB; HostDB:ENSG00000184083; -. DR eggNOG; ENOG502QQNQ; Eukaryota. DR GeneTree; ENSGT00530000063168; -. DR HOGENOM; CLU_008339_0_0_1; -. DR InParanoid; Q9NX05; -. DR OMA; SRDSNVC; -. DR OrthoDB; 20093at2759; -. DR PhylomeDB; Q9NX05; -. DR TreeFam; TF328642; -. DR PathwayCommons; Q9NX05; -. DR SignaLink; Q9NX05; -. DR BioGRID-ORCS; 54954; 8 hits in 777 CRISPR screens. DR ChiTaRS; FAM120C; human. DR GeneWiki; FAM120C_(gene); -. DR GenomeRNAi; 54954; -. DR Pharos; Q9NX05; Tbio. DR PRO; PR:Q9NX05; -. DR Proteomes; UP000005640; Chromosome X. DR RNAct; Q9NX05; Protein. DR Bgee; ENSG00000184083; Expressed in inferior vagus X ganglion and 183 other cell types or tissues. DR ExpressionAtlas; Q9NX05; baseline and differential. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB. DR InterPro; IPR026784; Coact_PPARg. DR InterPro; IPR029060; PIN-like_dom_sf. DR PANTHER; PTHR15976; CONSTITUTIVE COACTIVATOR OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA; 1. DR PANTHER; PTHR15976:SF15; CONSTITUTIVE COACTIVATOR OF PPAR-GAMMA-LIKE PROTEIN 2; 1. DR SUPFAM; SSF88723; PIN domain-like; 1. DR Genevisible; Q9NX05; HS. PE 1: Evidence at protein level; KW Alternative splicing; Isopeptide bond; Methylation; Reference proteome; KW Ubl conjugation. FT CHAIN 1..1096 FT /note="Constitutive coactivator of PPAR-gamma-like protein FT 2" FT /id="PRO_0000221628" FT REGION 35..113 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 508..579 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 971..1096 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 518..535 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 997..1013 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1014..1039 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1056..1076 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1077..1096 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 58 FT /note="Omega-N-methylarginine" FT /evidence="ECO:0000250|UniProtKB:Q8C3F2" FT MOD_RES 977 FT /note="Omega-N-methylarginine" FT /evidence="ECO:0000250|UniProtKB:Q8C3F2" FT CROSSLNK 1042 FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with FT G-Cter in SUMO2)" FT /evidence="ECO:0007744|PubMed:28112733" FT VAR_SEQ 234..238 FT /note="VFQSL -> QAAML (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2" FT /id="VSP_010519" FT VAR_SEQ 239..1096 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.2" FT /id="VSP_010520" FT VARIANT 82 FT /note="T -> I (in dbSNP:rs2495783)" FT /id="VAR_047538" FT VARIANT 934 FT /note="M -> I (in dbSNP:rs41304786)" FT /id="VAR_062001" SQ SEQUENCE 1096 AA; 120576 MW; C356797EF9BFE0FB CRC64; MGVQGFQEFL EKRCPGAVVP VDLLKLARTV SRQQQQQHLH RQLPPTAALA PGAPRAARGS VPLQPPLPPA ALGAYSGGAG PTRHHHPAHH FHHHGQAQPG LHPPLPPPPP PQLPGARVLV DAGSALPRLY GGYQTDWVCG GQWNAMLGYL SALCQACAYP GGDGLELVVM FPGGLGKDRL AEWGRRCQAE RQTAQLIVGH VGNKGTPPPR AWFLPPACLS HCVRLALIRF RVKVFQSLED HHLEVVAFFR ENGFHGLLAH DSEYALYNIP SYYSSHALKL SWNGKNLTTN QFLMQEVAKQ LGLKRMNFPI FAALLGNHIL PDEDLAAFHW SLLGPEHPLA SLKVRAHQLV LPPCDVVIKA VSEYVSSIKD PSNLDVVGKD VFKQSQSRTE DKIERFKKAV EYYSVTTKLS SLPVGPSFLG FRNNRLGNPP LPRNQVGTIS AGKPMFSHQV PQKVKYPPPF PVGPNSSLLF SSHALGESHA FSEDPMLQNS PFANWAVSYD SSASQFPNYL PSKASPPLGP DSSHSSSSDG DEPNGASSDH ITEAFHHQPE WGNPNRDRGS WAQPVDTGVS EASLGDGEPH IPSLLSMSTR NHMDITIPPL PPVAPEVLRV AEHRHRRGLM YPYIYHVLTK GEIKIPVCIE DECNMELPPA ALLFRSARQY VYGVLFSLAE TQRKMERLAM RRRLPVEVPS VILKEWSAYK GKSPQTPELV SALTFREWTC PNLKKLWLGK AVEDKNRRMR AFLACMKSDT PSMLNPANVP THLLLMCCVL RYMVQWPGGR ILHRHELDTF LAQAVSTQLY EPDRLQELKI EKLDARGIQL AALFMSGVDT ALFANDACGQ PVPWEHCCPW IYFDGKLFQS KLIKAGRERV SLVELCDGQA DLATKVEKMR QSILEGVNMN HPPPSALLPS PTFVPPMVPS LYPVSLYSRA MGSMPLPPQG RSRGFAGLHP IPPQGGKLEI AGMVVGQWAG SRSSRGRGSF GMQVVSVGGP GKGHGKEQTG RGSKGHKKGN KQGSSDGVSK SLELHQGRSR SQVNGNSGAL IKEEKSDHRL PAPSQCALSR DSNECNNGNR YLPMNNREKN HLQEQKLETV AQRKED //