Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NX05

- F120C_HUMAN

UniProt

Q9NX05 - F120C_HUMAN

Protein

Constitutive coactivator of PPAR-gamma-like protein 2

Gene

FAM120C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Constitutive coactivator of PPAR-gamma-like protein 2
    Alternative name(s):
    Protein FAM120C
    Tumor antigen BJ-HCC-21
    Gene namesi
    Name:FAM120C
    Synonyms:CXorf17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:16949. FAM120C.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134932227.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10961096Constitutive coactivator of PPAR-gamma-like protein 2PRO_0000221628Add
    BLAST

    Proteomic databases

    MaxQBiQ9NX05.
    PaxDbiQ9NX05.
    PRIDEiQ9NX05.

    PTM databases

    PhosphoSiteiQ9NX05.

    Expressioni

    Tissue specificityi

    Expressed at low levels in a number of tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ9NX05.
    BgeeiQ9NX05.
    CleanExiHS_FAM120C.
    GenevestigatoriQ9NX05.

    Organism-specific databases

    HPAiHPA047677.

    Interactioni

    Protein-protein interaction databases

    BioGridi120292. 3 interactions.
    IntActiQ9NX05. 2 interactions.
    STRINGi9606.ENSP00000364324.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NX05.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG40155.
    HOGENOMiHOG000112430.
    HOVERGENiHBG050957.
    InParanoidiQ9NX05.
    OMAiQACAYPG.
    PhylomeDBiQ9NX05.
    TreeFamiTF328642.

    Family and domain databases

    InterProiIPR026785. Coact_PPARg-like_2.
    IPR029060. PIN_domain-like.
    [Graphical view]
    PANTHERiPTHR15976:SF15. PTHR15976:SF15. 1 hit.
    SUPFAMiSSF88723. SSF88723. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NX05-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGVQGFQEFL EKRCPGAVVP VDLLKLARTV SRQQQQQHLH RQLPPTAALA     50
    PGAPRAARGS VPLQPPLPPA ALGAYSGGAG PIRHHHPAHH FHHHGQAQPG 100
    LHPPLPPPPP PQLPGARVLV DAGSALPRLY GGYQTDWVCG GQWNAMLGYL 150
    SALCQACAYP GGDGLELVVM FPGGLGKDRL AEWGRRCQAE RQTAQLIVGH 200
    VGNKGTPPPR AWFLPPACLS HCVRLALIRF RVKVFQSLED HHLEVVAFFR 250
    ENGFHGLLAH DSEYALYNIP SYYSSHALKL SWNGKNLTTN QFLMQEVAKQ 300
    LGLKRMNFPI FAALLGNHIL PDEDLAAFHW SLLGPEHPLA SLKVRAHQLV 350
    LPPCDVVIKA VSEYVSSIKD PSNLDVVGKD VFKQSQSRTE DKIERFKKAV 400
    EYYSVTTKLS SLPVGPSFLG FRNNRLGNPP LPRNQVGTIS AGKPMFSHQV 450
    PQKVKYPPPF PVGPNSSLLF SSHALGESHA FSEDPMLQNS PFANWAVSYD 500
    SSASQFPNYL PSKASPPLGP DSSHSSSSDG DEPNGASSDH ITEAFHHQPE 550
    WGNPNRDRGS WAQPVDTGVS EASLGDGEPH IPSLLSMSTR NHMDITIPPL 600
    PPVAPEVLRV AEHRHRRGLM YPYIYHVLTK GEIKIPVCIE DECNMELPPA 650
    ALLFRSARQY VYGVLFSLAE TQRKMERLAM RRRLPVEVPS VILKEWSAYK 700
    GKSPQTPELV SALTFREWTC PNLKKLWLGK AVEDKNRRMR AFLACMKSDT 750
    PSMLNPANVP THLLLMCCVL RYMVQWPGGR ILHRHELDTF LAQAVSTQLY 800
    EPDRLQELKI EKLDARGIQL AALFMSGVDT ALFANDACGQ PVPWEHCCPW 850
    IYFDGKLFQS KLIKAGRERV SLVELCDGQA DLATKVEKMR QSILEGVNMN 900
    HPPPSALLPS PTFVPPMVPS LYPVSLYSRA MGSMPLPPQG RSRGFAGLHP 950
    IPPQGGKLEI AGMVVGQWAG SRSSRGRGSF GMQVVSVGGP GKGHGKEQTG 1000
    RGSKGHKKGN KQGSSDGVSK SLELHQGRSR SQVNGNSGAL IKEEKSDHRL 1050
    PAPSQCALSR DSNECNNGNR YLPMNNREKN HLQEQKLETV AQRKED 1096
    Length:1,096
    Mass (Da):120,588
    Last modified:November 2, 2010 - v3
    Checksum:i0BF2647EF9BFE1F1
    GO
    Isoform 2 (identifier: Q9NX05-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         234-238: VFQSL → QAAML
         239-1096: Missing.

    Show »
    Length:238
    Mass (Da):25,477
    Checksum:iB4BCB860C18784D9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti82 – 821I → T.4 Publications
    Corresponds to variant rs2495783 [ dbSNP | Ensembl ].
    VAR_047538
    Natural varianti934 – 9341M → I.
    Corresponds to variant rs41304786 [ dbSNP | Ensembl ].
    VAR_062001

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei234 – 2385VFQSL → QAAML in isoform 2. 3 PublicationsVSP_010519
    Alternative sequencei239 – 1096858Missing in isoform 2. 3 PublicationsVSP_010520Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY150025 mRNA. Translation: AAO24121.1.
    AY121803 mRNA. Translation: AAM82751.1. Sequence problems.
    AK000513 mRNA. Translation: BAA91219.1. Sequence problems.
    AL589872 Genomic DNA. No translation available.
    Z84469 Genomic DNA. No translation available.
    BC016138 mRNA. Translation: AAH16138.2.
    BC136413 mRNA. Translation: AAI36414.1.
    CCDSiCCDS14356.1. [Q9NX05-1]
    CCDS55421.1. [Q9NX05-2]
    RefSeqiNP_060318.4. NM_017848.5.
    NP_940858.2. NM_198456.2.
    UniGeneiHs.86045.

    Genome annotation databases

    EnsembliENST00000375180; ENSP00000364324; ENSG00000184083. [Q9NX05-1]
    ENST00000477084; ENSP00000420718; ENSG00000184083. [Q9NX05-2]
    GeneIDi54954.
    KEGGihsa:54954.
    UCSCiuc004dsz.4. human. [Q9NX05-1]
    uc004dta.2. human. [Q9NX05-2]

    Polymorphism databases

    DMDMi311033453.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY150025 mRNA. Translation: AAO24121.1 .
    AY121803 mRNA. Translation: AAM82751.1 . Sequence problems.
    AK000513 mRNA. Translation: BAA91219.1 . Sequence problems.
    AL589872 Genomic DNA. No translation available.
    Z84469 Genomic DNA. No translation available.
    BC016138 mRNA. Translation: AAH16138.2 .
    BC136413 mRNA. Translation: AAI36414.1 .
    CCDSi CCDS14356.1. [Q9NX05-1 ]
    CCDS55421.1. [Q9NX05-2 ]
    RefSeqi NP_060318.4. NM_017848.5.
    NP_940858.2. NM_198456.2.
    UniGenei Hs.86045.

    3D structure databases

    ProteinModelPortali Q9NX05.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120292. 3 interactions.
    IntActi Q9NX05. 2 interactions.
    STRINGi 9606.ENSP00000364324.

    PTM databases

    PhosphoSitei Q9NX05.

    Polymorphism databases

    DMDMi 311033453.

    Proteomic databases

    MaxQBi Q9NX05.
    PaxDbi Q9NX05.
    PRIDEi Q9NX05.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375180 ; ENSP00000364324 ; ENSG00000184083 . [Q9NX05-1 ]
    ENST00000477084 ; ENSP00000420718 ; ENSG00000184083 . [Q9NX05-2 ]
    GeneIDi 54954.
    KEGGi hsa:54954.
    UCSCi uc004dsz.4. human. [Q9NX05-1 ]
    uc004dta.2. human. [Q9NX05-2 ]

    Organism-specific databases

    CTDi 54954.
    GeneCardsi GC0XM054097.
    H-InvDB HIX0020105.
    HGNCi HGNC:16949. FAM120C.
    HPAi HPA047677.
    MIMi 300741. gene.
    neXtProti NX_Q9NX05.
    PharmGKBi PA134932227.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40155.
    HOGENOMi HOG000112430.
    HOVERGENi HBG050957.
    InParanoidi Q9NX05.
    OMAi QACAYPG.
    PhylomeDBi Q9NX05.
    TreeFami TF328642.

    Miscellaneous databases

    GeneWikii FAM120C_(gene).
    GenomeRNAii 54954.
    NextBioi 58136.
    PROi Q9NX05.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NX05.
    Bgeei Q9NX05.
    CleanExi HS_FAM120C.
    Genevestigatori Q9NX05.

    Family and domain databases

    InterProi IPR026785. Coact_PPARg-like_2.
    IPR029060. PIN_domain-like.
    [Graphical view ]
    PANTHERi PTHR15976:SF15. PTHR15976:SF15. 1 hit.
    SUPFAMi SSF88723. SSF88723. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34."
      Holden S., Raymond F.L.
      Gene 318:149-161(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT THR-82.
      Tissue: Brain.
    2. "Cloning and identification of genes which are differentially expressed in carcinoma."
      Dong X.-Y., Chen W.-F.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT THR-82.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-82.
      Tissue: Signet-ring cell carcinoma.
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-82.
      Tissue: Brain and Skin.

    Entry informationi

    Entry nameiF120C_HUMAN
    AccessioniPrimary (citable) accession number: Q9NX05
    Secondary accession number(s): B2RMT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 94 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3