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Protein

Constitutive coactivator of PPAR-gamma-like protein 2

Gene

FAM120C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32649-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Constitutive coactivator of PPAR-gamma-like protein 2
Alternative name(s):
Protein FAM120C
Tumor antigen BJ-HCC-21
Gene namesi
Name:FAM120C
Synonyms:CXorf17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:16949. FAM120C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi54954.
PharmGKBiPA134932227.

Polymorphism and mutation databases

BioMutaiFAM120C.
DMDMi311033453.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002216281 – 1096Constitutive coactivator of PPAR-gamma-like protein 2Add BLAST1096

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58Omega-N-methylarginineBy similarity1
Modified residuei977Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ9NX05.
MaxQBiQ9NX05.
PaxDbiQ9NX05.
PeptideAtlasiQ9NX05.
PRIDEiQ9NX05.

PTM databases

iPTMnetiQ9NX05.
PhosphoSitePlusiQ9NX05.

Expressioni

Tissue specificityi

Expressed at low levels in a number of tissues.1 Publication

Gene expression databases

BgeeiENSG00000184083.
CleanExiHS_FAM120C.
ExpressionAtlasiQ9NX05. baseline and differential.
GenevisibleiQ9NX05. HS.

Organism-specific databases

HPAiHPA047677.

Interactioni

Protein-protein interaction databases

BioGridi120292. 9 interactors.
IntActiQ9NX05. 6 interactors.
STRINGi9606.ENSP00000364324.

Structurei

3D structure databases

ProteinModelPortaliQ9NX05.
SMRiQ9NX05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IE6R. Eukaryota.
ENOG410XPY7. LUCA.
HOGENOMiHOG000112430.
HOVERGENiHBG050957.
InParanoidiQ9NX05.
OrthoDBiEOG091G030W.
PhylomeDBiQ9NX05.
TreeFamiTF328642.

Family and domain databases

InterProiIPR026784. Coact_PPARg.
IPR026785. Coact_PPARg-like_2.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERiPTHR15976. PTHR15976. 2 hits.
PTHR15976:SF15. PTHR15976:SF15. 2 hits.
SUPFAMiSSF88723. SSF88723. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVQGFQEFL EKRCPGAVVP VDLLKLARTV SRQQQQQHLH RQLPPTAALA
60 70 80 90 100
PGAPRAARGS VPLQPPLPPA ALGAYSGGAG PIRHHHPAHH FHHHGQAQPG
110 120 130 140 150
LHPPLPPPPP PQLPGARVLV DAGSALPRLY GGYQTDWVCG GQWNAMLGYL
160 170 180 190 200
SALCQACAYP GGDGLELVVM FPGGLGKDRL AEWGRRCQAE RQTAQLIVGH
210 220 230 240 250
VGNKGTPPPR AWFLPPACLS HCVRLALIRF RVKVFQSLED HHLEVVAFFR
260 270 280 290 300
ENGFHGLLAH DSEYALYNIP SYYSSHALKL SWNGKNLTTN QFLMQEVAKQ
310 320 330 340 350
LGLKRMNFPI FAALLGNHIL PDEDLAAFHW SLLGPEHPLA SLKVRAHQLV
360 370 380 390 400
LPPCDVVIKA VSEYVSSIKD PSNLDVVGKD VFKQSQSRTE DKIERFKKAV
410 420 430 440 450
EYYSVTTKLS SLPVGPSFLG FRNNRLGNPP LPRNQVGTIS AGKPMFSHQV
460 470 480 490 500
PQKVKYPPPF PVGPNSSLLF SSHALGESHA FSEDPMLQNS PFANWAVSYD
510 520 530 540 550
SSASQFPNYL PSKASPPLGP DSSHSSSSDG DEPNGASSDH ITEAFHHQPE
560 570 580 590 600
WGNPNRDRGS WAQPVDTGVS EASLGDGEPH IPSLLSMSTR NHMDITIPPL
610 620 630 640 650
PPVAPEVLRV AEHRHRRGLM YPYIYHVLTK GEIKIPVCIE DECNMELPPA
660 670 680 690 700
ALLFRSARQY VYGVLFSLAE TQRKMERLAM RRRLPVEVPS VILKEWSAYK
710 720 730 740 750
GKSPQTPELV SALTFREWTC PNLKKLWLGK AVEDKNRRMR AFLACMKSDT
760 770 780 790 800
PSMLNPANVP THLLLMCCVL RYMVQWPGGR ILHRHELDTF LAQAVSTQLY
810 820 830 840 850
EPDRLQELKI EKLDARGIQL AALFMSGVDT ALFANDACGQ PVPWEHCCPW
860 870 880 890 900
IYFDGKLFQS KLIKAGRERV SLVELCDGQA DLATKVEKMR QSILEGVNMN
910 920 930 940 950
HPPPSALLPS PTFVPPMVPS LYPVSLYSRA MGSMPLPPQG RSRGFAGLHP
960 970 980 990 1000
IPPQGGKLEI AGMVVGQWAG SRSSRGRGSF GMQVVSVGGP GKGHGKEQTG
1010 1020 1030 1040 1050
RGSKGHKKGN KQGSSDGVSK SLELHQGRSR SQVNGNSGAL IKEEKSDHRL
1060 1070 1080 1090
PAPSQCALSR DSNECNNGNR YLPMNNREKN HLQEQKLETV AQRKED
Length:1,096
Mass (Da):120,588
Last modified:November 2, 2010 - v3
Checksum:i0BF2647EF9BFE1F1
GO
Isoform 2 (identifier: Q9NX05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-238: VFQSL → QAAML
     239-1096: Missing.

Show »
Length:238
Mass (Da):25,477
Checksum:iB4BCB860C18784D9
GO

Sequence cautioni

The sequence AAM82751 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAA91219 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04753882I → T.4 PublicationsCorresponds to variant rs2495783dbSNPEnsembl.1
Natural variantiVAR_062001934M → I.Corresponds to variant rs41304786dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010519234 – 238VFQSL → QAAML in isoform 2. 3 Publications5
Alternative sequenceiVSP_010520239 – 1096Missing in isoform 2. 3 PublicationsAdd BLAST858

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150025 mRNA. Translation: AAO24121.1.
AY121803 mRNA. Translation: AAM82751.1. Sequence problems.
AK000513 mRNA. Translation: BAA91219.1. Sequence problems.
AL589872 Genomic DNA. No translation available.
Z84469 Genomic DNA. No translation available.
BC016138 mRNA. Translation: AAH16138.2.
BC136413 mRNA. Translation: AAI36414.1.
CCDSiCCDS14356.1. [Q9NX05-1]
CCDS55421.1. [Q9NX05-2]
RefSeqiNP_060318.4. NM_017848.5.
NP_940858.2. NM_198456.2.
UniGeneiHs.86045.

Genome annotation databases

EnsembliENST00000375180; ENSP00000364324; ENSG00000184083.
ENST00000477084; ENSP00000420718; ENSG00000184083.
GeneIDi54954.
KEGGihsa:54954.
UCSCiuc004dsz.5. human. [Q9NX05-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150025 mRNA. Translation: AAO24121.1.
AY121803 mRNA. Translation: AAM82751.1. Sequence problems.
AK000513 mRNA. Translation: BAA91219.1. Sequence problems.
AL589872 Genomic DNA. No translation available.
Z84469 Genomic DNA. No translation available.
BC016138 mRNA. Translation: AAH16138.2.
BC136413 mRNA. Translation: AAI36414.1.
CCDSiCCDS14356.1. [Q9NX05-1]
CCDS55421.1. [Q9NX05-2]
RefSeqiNP_060318.4. NM_017848.5.
NP_940858.2. NM_198456.2.
UniGeneiHs.86045.

3D structure databases

ProteinModelPortaliQ9NX05.
SMRiQ9NX05.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120292. 9 interactors.
IntActiQ9NX05. 6 interactors.
STRINGi9606.ENSP00000364324.

PTM databases

iPTMnetiQ9NX05.
PhosphoSitePlusiQ9NX05.

Polymorphism and mutation databases

BioMutaiFAM120C.
DMDMi311033453.

Proteomic databases

EPDiQ9NX05.
MaxQBiQ9NX05.
PaxDbiQ9NX05.
PeptideAtlasiQ9NX05.
PRIDEiQ9NX05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375180; ENSP00000364324; ENSG00000184083.
ENST00000477084; ENSP00000420718; ENSG00000184083.
GeneIDi54954.
KEGGihsa:54954.
UCSCiuc004dsz.5. human. [Q9NX05-1]

Organism-specific databases

CTDi54954.
DisGeNETi54954.
GeneCardsiFAM120C.
H-InvDBHIX0020105.
HGNCiHGNC:16949. FAM120C.
HPAiHPA047677.
MIMi300741. gene.
neXtProtiNX_Q9NX05.
PharmGKBiPA134932227.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE6R. Eukaryota.
ENOG410XPY7. LUCA.
HOGENOMiHOG000112430.
HOVERGENiHBG050957.
InParanoidiQ9NX05.
OrthoDBiEOG091G030W.
PhylomeDBiQ9NX05.
TreeFamiTF328642.

Enzyme and pathway databases

BioCyciZFISH:G66-32649-MONOMER.

Miscellaneous databases

GeneWikiiFAM120C_(gene).
GenomeRNAii54954.
PROiQ9NX05.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184083.
CleanExiHS_FAM120C.
ExpressionAtlasiQ9NX05. baseline and differential.
GenevisibleiQ9NX05. HS.

Family and domain databases

InterProiIPR026784. Coact_PPARg.
IPR026785. Coact_PPARg-like_2.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERiPTHR15976. PTHR15976. 2 hits.
PTHR15976:SF15. PTHR15976:SF15. 2 hits.
SUPFAMiSSF88723. SSF88723. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF120C_HUMAN
AccessioniPrimary (citable) accession number: Q9NX05
Secondary accession number(s): B2RMT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.