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Q9NX05

- F120C_HUMAN

UniProt

Q9NX05 - F120C_HUMAN

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Protein
Constitutive coactivator of PPAR-gamma-like protein 2
Gene
FAM120C, CXorf17
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Constitutive coactivator of PPAR-gamma-like protein 2
Alternative name(s):
Protein FAM120C
Tumor antigen BJ-HCC-21
Gene namesi
Name:FAM120C
Synonyms:CXorf17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:16949. FAM120C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134932227.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10961096Constitutive coactivator of PPAR-gamma-like protein 2
PRO_0000221628Add
BLAST

Proteomic databases

MaxQBiQ9NX05.
PaxDbiQ9NX05.
PRIDEiQ9NX05.

PTM databases

PhosphoSiteiQ9NX05.

Expressioni

Tissue specificityi

Expressed at low levels in a number of tissues.1 Publication

Gene expression databases

ArrayExpressiQ9NX05.
BgeeiQ9NX05.
CleanExiHS_FAM120C.
GenevestigatoriQ9NX05.

Organism-specific databases

HPAiHPA047677.

Interactioni

Protein-protein interaction databases

BioGridi120292. 3 interactions.
IntActiQ9NX05. 2 interactions.
STRINGi9606.ENSP00000364324.

Structurei

3D structure databases

ProteinModelPortaliQ9NX05.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG40155.
HOGENOMiHOG000112430.
HOVERGENiHBG050957.
InParanoidiQ9NX05.
OMAiQACAYPG.
PhylomeDBiQ9NX05.
TreeFamiTF328642.

Family and domain databases

InterProiIPR026785. Coact_PPARg-like_2.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERiPTHR15976:SF15. PTHR15976:SF15. 1 hit.
SUPFAMiSSF88723. SSF88723. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NX05-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGVQGFQEFL EKRCPGAVVP VDLLKLARTV SRQQQQQHLH RQLPPTAALA     50
PGAPRAARGS VPLQPPLPPA ALGAYSGGAG PIRHHHPAHH FHHHGQAQPG 100
LHPPLPPPPP PQLPGARVLV DAGSALPRLY GGYQTDWVCG GQWNAMLGYL 150
SALCQACAYP GGDGLELVVM FPGGLGKDRL AEWGRRCQAE RQTAQLIVGH 200
VGNKGTPPPR AWFLPPACLS HCVRLALIRF RVKVFQSLED HHLEVVAFFR 250
ENGFHGLLAH DSEYALYNIP SYYSSHALKL SWNGKNLTTN QFLMQEVAKQ 300
LGLKRMNFPI FAALLGNHIL PDEDLAAFHW SLLGPEHPLA SLKVRAHQLV 350
LPPCDVVIKA VSEYVSSIKD PSNLDVVGKD VFKQSQSRTE DKIERFKKAV 400
EYYSVTTKLS SLPVGPSFLG FRNNRLGNPP LPRNQVGTIS AGKPMFSHQV 450
PQKVKYPPPF PVGPNSSLLF SSHALGESHA FSEDPMLQNS PFANWAVSYD 500
SSASQFPNYL PSKASPPLGP DSSHSSSSDG DEPNGASSDH ITEAFHHQPE 550
WGNPNRDRGS WAQPVDTGVS EASLGDGEPH IPSLLSMSTR NHMDITIPPL 600
PPVAPEVLRV AEHRHRRGLM YPYIYHVLTK GEIKIPVCIE DECNMELPPA 650
ALLFRSARQY VYGVLFSLAE TQRKMERLAM RRRLPVEVPS VILKEWSAYK 700
GKSPQTPELV SALTFREWTC PNLKKLWLGK AVEDKNRRMR AFLACMKSDT 750
PSMLNPANVP THLLLMCCVL RYMVQWPGGR ILHRHELDTF LAQAVSTQLY 800
EPDRLQELKI EKLDARGIQL AALFMSGVDT ALFANDACGQ PVPWEHCCPW 850
IYFDGKLFQS KLIKAGRERV SLVELCDGQA DLATKVEKMR QSILEGVNMN 900
HPPPSALLPS PTFVPPMVPS LYPVSLYSRA MGSMPLPPQG RSRGFAGLHP 950
IPPQGGKLEI AGMVVGQWAG SRSSRGRGSF GMQVVSVGGP GKGHGKEQTG 1000
RGSKGHKKGN KQGSSDGVSK SLELHQGRSR SQVNGNSGAL IKEEKSDHRL 1050
PAPSQCALSR DSNECNNGNR YLPMNNREKN HLQEQKLETV AQRKED 1096
Length:1,096
Mass (Da):120,588
Last modified:November 2, 2010 - v3
Checksum:i0BF2647EF9BFE1F1
GO
Isoform 2 (identifier: Q9NX05-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-238: VFQSL → QAAML
     239-1096: Missing.

Show »
Length:238
Mass (Da):25,477
Checksum:iB4BCB860C18784D9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821I → T.4 Publications
Corresponds to variant rs2495783 [ dbSNP | Ensembl ].
VAR_047538
Natural varianti934 – 9341M → I.
Corresponds to variant rs41304786 [ dbSNP | Ensembl ].
VAR_062001

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei234 – 2385VFQSL → QAAML in isoform 2.
VSP_010519
Alternative sequencei239 – 1096858Missing in isoform 2.
VSP_010520Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY150025 mRNA. Translation: AAO24121.1.
AY121803 mRNA. Translation: AAM82751.1. Sequence problems.
AK000513 mRNA. Translation: BAA91219.1. Sequence problems.
AL589872 Genomic DNA. No translation available.
Z84469 Genomic DNA. No translation available.
BC016138 mRNA. Translation: AAH16138.2.
BC136413 mRNA. Translation: AAI36414.1.
CCDSiCCDS14356.1. [Q9NX05-1]
CCDS55421.1. [Q9NX05-2]
RefSeqiNP_060318.4. NM_017848.5.
NP_940858.2. NM_198456.2.
UniGeneiHs.86045.

Genome annotation databases

EnsembliENST00000375180; ENSP00000364324; ENSG00000184083. [Q9NX05-1]
ENST00000477084; ENSP00000420718; ENSG00000184083. [Q9NX05-2]
ENST00000594687; ENSP00000470416; ENSG00000268158. [Q9NX05-1]
ENST00000601479; ENSP00000469117; ENSG00000268158. [Q9NX05-2]
GeneIDi54954.
KEGGihsa:54954.
UCSCiuc004dsz.4. human. [Q9NX05-1]
uc004dta.2. human. [Q9NX05-2]

Polymorphism databases

DMDMi311033453.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY150025 mRNA. Translation: AAO24121.1 .
AY121803 mRNA. Translation: AAM82751.1 . Sequence problems.
AK000513 mRNA. Translation: BAA91219.1 . Sequence problems.
AL589872 Genomic DNA. No translation available.
Z84469 Genomic DNA. No translation available.
BC016138 mRNA. Translation: AAH16138.2 .
BC136413 mRNA. Translation: AAI36414.1 .
CCDSi CCDS14356.1. [Q9NX05-1 ]
CCDS55421.1. [Q9NX05-2 ]
RefSeqi NP_060318.4. NM_017848.5.
NP_940858.2. NM_198456.2.
UniGenei Hs.86045.

3D structure databases

ProteinModelPortali Q9NX05.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120292. 3 interactions.
IntActi Q9NX05. 2 interactions.
STRINGi 9606.ENSP00000364324.

PTM databases

PhosphoSitei Q9NX05.

Polymorphism databases

DMDMi 311033453.

Proteomic databases

MaxQBi Q9NX05.
PaxDbi Q9NX05.
PRIDEi Q9NX05.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375180 ; ENSP00000364324 ; ENSG00000184083 . [Q9NX05-1 ]
ENST00000477084 ; ENSP00000420718 ; ENSG00000184083 . [Q9NX05-2 ]
ENST00000594687 ; ENSP00000470416 ; ENSG00000268158 . [Q9NX05-1 ]
ENST00000601479 ; ENSP00000469117 ; ENSG00000268158 . [Q9NX05-2 ]
GeneIDi 54954.
KEGGi hsa:54954.
UCSCi uc004dsz.4. human. [Q9NX05-1 ]
uc004dta.2. human. [Q9NX05-2 ]

Organism-specific databases

CTDi 54954.
GeneCardsi GC0XM054097.
H-InvDB HIX0020105.
HGNCi HGNC:16949. FAM120C.
HPAi HPA047677.
MIMi 300741. gene.
neXtProti NX_Q9NX05.
PharmGKBi PA134932227.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40155.
HOGENOMi HOG000112430.
HOVERGENi HBG050957.
InParanoidi Q9NX05.
OMAi QACAYPG.
PhylomeDBi Q9NX05.
TreeFami TF328642.

Miscellaneous databases

GeneWikii FAM120C_(gene).
GenomeRNAii 54954.
NextBioi 58136.
PROi Q9NX05.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NX05.
Bgeei Q9NX05.
CleanExi HS_FAM120C.
Genevestigatori Q9NX05.

Family and domain databases

InterProi IPR026785. Coact_PPARg-like_2.
IPR029060. PIN_domain-like.
[Graphical view ]
PANTHERi PTHR15976:SF15. PTHR15976:SF15. 1 hit.
SUPFAMi SSF88723. SSF88723. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34."
    Holden S., Raymond F.L.
    Gene 318:149-161(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT THR-82.
    Tissue: Brain.
  2. "Cloning and identification of genes which are differentially expressed in carcinoma."
    Dong X.-Y., Chen W.-F.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT THR-82.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-82.
    Tissue: Signet-ring cell carcinoma.
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-82.
    Tissue: Brain and Skin.

Entry informationi

Entry nameiF120C_HUMAN
AccessioniPrimary (citable) accession number: Q9NX05
Secondary accession number(s): B2RMT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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