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Protein

Constitutive coactivator of PPAR-gamma-like protein 2

Gene

FAM120C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Constitutive coactivator of PPAR-gamma-like protein 2
Alternative name(s):
Protein FAM120C
Tumor antigen BJ-HCC-21
Gene namesi
Name:FAM120C
Synonyms:CXorf17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:16949. FAM120C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134932227.

Polymorphism and mutation databases

BioMutaiFAM120C.
DMDMi311033453.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10961096Constitutive coactivator of PPAR-gamma-like protein 2PRO_0000221628Add
BLAST

Proteomic databases

MaxQBiQ9NX05.
PaxDbiQ9NX05.
PRIDEiQ9NX05.

PTM databases

PhosphoSiteiQ9NX05.

Expressioni

Tissue specificityi

Expressed at low levels in a number of tissues.1 Publication

Gene expression databases

BgeeiQ9NX05.
CleanExiHS_FAM120C.
ExpressionAtlasiQ9NX05. baseline and differential.
GenevisibleiQ9NX05. HS.

Organism-specific databases

HPAiHPA047677.

Interactioni

Protein-protein interaction databases

BioGridi120292. 2 interactions.
IntActiQ9NX05. 3 interactions.
STRINGi9606.ENSP00000364324.

Structurei

3D structure databases

ProteinModelPortaliQ9NX05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG40155.
HOGENOMiHOG000112430.
HOVERGENiHBG050957.
InParanoidiQ9NX05.
PhylomeDBiQ9NX05.
TreeFamiTF328642.

Family and domain databases

InterProiIPR026785. Coact_PPARg-like_2.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERiPTHR15976:SF15. PTHR15976:SF15. 1 hit.
SUPFAMiSSF88723. SSF88723. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVQGFQEFL EKRCPGAVVP VDLLKLARTV SRQQQQQHLH RQLPPTAALA
60 70 80 90 100
PGAPRAARGS VPLQPPLPPA ALGAYSGGAG PIRHHHPAHH FHHHGQAQPG
110 120 130 140 150
LHPPLPPPPP PQLPGARVLV DAGSALPRLY GGYQTDWVCG GQWNAMLGYL
160 170 180 190 200
SALCQACAYP GGDGLELVVM FPGGLGKDRL AEWGRRCQAE RQTAQLIVGH
210 220 230 240 250
VGNKGTPPPR AWFLPPACLS HCVRLALIRF RVKVFQSLED HHLEVVAFFR
260 270 280 290 300
ENGFHGLLAH DSEYALYNIP SYYSSHALKL SWNGKNLTTN QFLMQEVAKQ
310 320 330 340 350
LGLKRMNFPI FAALLGNHIL PDEDLAAFHW SLLGPEHPLA SLKVRAHQLV
360 370 380 390 400
LPPCDVVIKA VSEYVSSIKD PSNLDVVGKD VFKQSQSRTE DKIERFKKAV
410 420 430 440 450
EYYSVTTKLS SLPVGPSFLG FRNNRLGNPP LPRNQVGTIS AGKPMFSHQV
460 470 480 490 500
PQKVKYPPPF PVGPNSSLLF SSHALGESHA FSEDPMLQNS PFANWAVSYD
510 520 530 540 550
SSASQFPNYL PSKASPPLGP DSSHSSSSDG DEPNGASSDH ITEAFHHQPE
560 570 580 590 600
WGNPNRDRGS WAQPVDTGVS EASLGDGEPH IPSLLSMSTR NHMDITIPPL
610 620 630 640 650
PPVAPEVLRV AEHRHRRGLM YPYIYHVLTK GEIKIPVCIE DECNMELPPA
660 670 680 690 700
ALLFRSARQY VYGVLFSLAE TQRKMERLAM RRRLPVEVPS VILKEWSAYK
710 720 730 740 750
GKSPQTPELV SALTFREWTC PNLKKLWLGK AVEDKNRRMR AFLACMKSDT
760 770 780 790 800
PSMLNPANVP THLLLMCCVL RYMVQWPGGR ILHRHELDTF LAQAVSTQLY
810 820 830 840 850
EPDRLQELKI EKLDARGIQL AALFMSGVDT ALFANDACGQ PVPWEHCCPW
860 870 880 890 900
IYFDGKLFQS KLIKAGRERV SLVELCDGQA DLATKVEKMR QSILEGVNMN
910 920 930 940 950
HPPPSALLPS PTFVPPMVPS LYPVSLYSRA MGSMPLPPQG RSRGFAGLHP
960 970 980 990 1000
IPPQGGKLEI AGMVVGQWAG SRSSRGRGSF GMQVVSVGGP GKGHGKEQTG
1010 1020 1030 1040 1050
RGSKGHKKGN KQGSSDGVSK SLELHQGRSR SQVNGNSGAL IKEEKSDHRL
1060 1070 1080 1090
PAPSQCALSR DSNECNNGNR YLPMNNREKN HLQEQKLETV AQRKED
Length:1,096
Mass (Da):120,588
Last modified:November 2, 2010 - v3
Checksum:i0BF2647EF9BFE1F1
GO
Isoform 2 (identifier: Q9NX05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-238: VFQSL → QAAML
     239-1096: Missing.

Show »
Length:238
Mass (Da):25,477
Checksum:iB4BCB860C18784D9
GO

Sequence cautioni

The sequence AAM82751.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAA91219.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821I → T.4 Publications
Corresponds to variant rs2495783 [ dbSNP | Ensembl ].
VAR_047538
Natural varianti934 – 9341M → I.
Corresponds to variant rs41304786 [ dbSNP | Ensembl ].
VAR_062001

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei234 – 2385VFQSL → QAAML in isoform 2. 3 PublicationsVSP_010519
Alternative sequencei239 – 1096858Missing in isoform 2. 3 PublicationsVSP_010520Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150025 mRNA. Translation: AAO24121.1.
AY121803 mRNA. Translation: AAM82751.1. Sequence problems.
AK000513 mRNA. Translation: BAA91219.1. Sequence problems.
AL589872 Genomic DNA. No translation available.
Z84469 Genomic DNA. No translation available.
BC016138 mRNA. Translation: AAH16138.2.
BC136413 mRNA. Translation: AAI36414.1.
CCDSiCCDS14356.1. [Q9NX05-1]
CCDS55421.1. [Q9NX05-2]
RefSeqiNP_060318.4. NM_017848.5.
NP_940858.2. NM_198456.2.
UniGeneiHs.86045.

Genome annotation databases

EnsembliENST00000375180; ENSP00000364324; ENSG00000184083.
ENST00000477084; ENSP00000420718; ENSG00000184083.
GeneIDi54954.
UCSCiuc004dsz.4. human. [Q9NX05-1]
uc004dta.2. human. [Q9NX05-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150025 mRNA. Translation: AAO24121.1.
AY121803 mRNA. Translation: AAM82751.1. Sequence problems.
AK000513 mRNA. Translation: BAA91219.1. Sequence problems.
AL589872 Genomic DNA. No translation available.
Z84469 Genomic DNA. No translation available.
BC016138 mRNA. Translation: AAH16138.2.
BC136413 mRNA. Translation: AAI36414.1.
CCDSiCCDS14356.1. [Q9NX05-1]
CCDS55421.1. [Q9NX05-2]
RefSeqiNP_060318.4. NM_017848.5.
NP_940858.2. NM_198456.2.
UniGeneiHs.86045.

3D structure databases

ProteinModelPortaliQ9NX05.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120292. 2 interactions.
IntActiQ9NX05. 3 interactions.
STRINGi9606.ENSP00000364324.

PTM databases

PhosphoSiteiQ9NX05.

Polymorphism and mutation databases

BioMutaiFAM120C.
DMDMi311033453.

Proteomic databases

MaxQBiQ9NX05.
PaxDbiQ9NX05.
PRIDEiQ9NX05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375180; ENSP00000364324; ENSG00000184083.
ENST00000477084; ENSP00000420718; ENSG00000184083.
GeneIDi54954.
UCSCiuc004dsz.4. human. [Q9NX05-1]
uc004dta.2. human. [Q9NX05-2]

Organism-specific databases

CTDi54954.
GeneCardsiGC0XM054097.
H-InvDBHIX0020105.
HGNCiHGNC:16949. FAM120C.
HPAiHPA047677.
MIMi300741. gene.
neXtProtiNX_Q9NX05.
PharmGKBiPA134932227.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG40155.
HOGENOMiHOG000112430.
HOVERGENiHBG050957.
InParanoidiQ9NX05.
PhylomeDBiQ9NX05.
TreeFamiTF328642.

Miscellaneous databases

GeneWikiiFAM120C_(gene).
GenomeRNAii54954.
NextBioi58136.
PROiQ9NX05.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NX05.
CleanExiHS_FAM120C.
ExpressionAtlasiQ9NX05. baseline and differential.
GenevisibleiQ9NX05. HS.

Family and domain databases

InterProiIPR026785. Coact_PPARg-like_2.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERiPTHR15976:SF15. PTHR15976:SF15. 1 hit.
SUPFAMiSSF88723. SSF88723. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34."
    Holden S., Raymond F.L.
    Gene 318:149-161(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT THR-82.
    Tissue: Brain.
  2. "Cloning and identification of genes which are differentially expressed in carcinoma."
    Dong X.-Y., Chen W.-F.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT THR-82.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-82.
    Tissue: Signet-ring cell carcinoma.
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-82.
    Tissue: Brain and Skin.

Entry informationi

Entry nameiF120C_HUMAN
AccessioniPrimary (citable) accession number: Q9NX05
Secondary accession number(s): B2RMT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 2, 2010
Last modified: July 22, 2015
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.