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Q9NX05 (F120C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Constitutive coactivator of PPAR-gamma-like protein 2
Alternative name(s):
Protein FAM120C
Tumor antigen BJ-HCC-21
Gene names
Name:FAM120C
Synonyms:CXorf17
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1096 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Expressed at low levels in a number of tissues. Ref.1

Sequence similarities

Belongs to the constitutive coactivator of PPAR-gamma family.

Sequence caution

The sequence AAM82751.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

The sequence BAA91219.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NX05-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NX05-2)

The sequence of this isoform differs from the canonical sequence as follows:
     234-238: VFQSL → QAAML
     239-1096: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10961096Constitutive coactivator of PPAR-gamma-like protein 2
PRO_0000221628

Natural variations

Alternative sequence234 – 2385VFQSL → QAAML in isoform 2.
VSP_010519
Alternative sequence239 – 1096858Missing in isoform 2.
VSP_010520
Natural variant821I → T. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs2495783 [ dbSNP | Ensembl ].
VAR_047538
Natural variant9341M → I.
Corresponds to variant rs41304786 [ dbSNP | Ensembl ].
VAR_062001

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 2, 2010. Version 3.
Checksum: 0BF2647EF9BFE1F1

FASTA1,096120,588
        10         20         30         40         50         60 
MGVQGFQEFL EKRCPGAVVP VDLLKLARTV SRQQQQQHLH RQLPPTAALA PGAPRAARGS 

        70         80         90        100        110        120 
VPLQPPLPPA ALGAYSGGAG PIRHHHPAHH FHHHGQAQPG LHPPLPPPPP PQLPGARVLV 

       130        140        150        160        170        180 
DAGSALPRLY GGYQTDWVCG GQWNAMLGYL SALCQACAYP GGDGLELVVM FPGGLGKDRL 

       190        200        210        220        230        240 
AEWGRRCQAE RQTAQLIVGH VGNKGTPPPR AWFLPPACLS HCVRLALIRF RVKVFQSLED 

       250        260        270        280        290        300 
HHLEVVAFFR ENGFHGLLAH DSEYALYNIP SYYSSHALKL SWNGKNLTTN QFLMQEVAKQ 

       310        320        330        340        350        360 
LGLKRMNFPI FAALLGNHIL PDEDLAAFHW SLLGPEHPLA SLKVRAHQLV LPPCDVVIKA 

       370        380        390        400        410        420 
VSEYVSSIKD PSNLDVVGKD VFKQSQSRTE DKIERFKKAV EYYSVTTKLS SLPVGPSFLG 

       430        440        450        460        470        480 
FRNNRLGNPP LPRNQVGTIS AGKPMFSHQV PQKVKYPPPF PVGPNSSLLF SSHALGESHA 

       490        500        510        520        530        540 
FSEDPMLQNS PFANWAVSYD SSASQFPNYL PSKASPPLGP DSSHSSSSDG DEPNGASSDH 

       550        560        570        580        590        600 
ITEAFHHQPE WGNPNRDRGS WAQPVDTGVS EASLGDGEPH IPSLLSMSTR NHMDITIPPL 

       610        620        630        640        650        660 
PPVAPEVLRV AEHRHRRGLM YPYIYHVLTK GEIKIPVCIE DECNMELPPA ALLFRSARQY 

       670        680        690        700        710        720 
VYGVLFSLAE TQRKMERLAM RRRLPVEVPS VILKEWSAYK GKSPQTPELV SALTFREWTC 

       730        740        750        760        770        780 
PNLKKLWLGK AVEDKNRRMR AFLACMKSDT PSMLNPANVP THLLLMCCVL RYMVQWPGGR 

       790        800        810        820        830        840 
ILHRHELDTF LAQAVSTQLY EPDRLQELKI EKLDARGIQL AALFMSGVDT ALFANDACGQ 

       850        860        870        880        890        900 
PVPWEHCCPW IYFDGKLFQS KLIKAGRERV SLVELCDGQA DLATKVEKMR QSILEGVNMN 

       910        920        930        940        950        960 
HPPPSALLPS PTFVPPMVPS LYPVSLYSRA MGSMPLPPQG RSRGFAGLHP IPPQGGKLEI 

       970        980        990       1000       1010       1020 
AGMVVGQWAG SRSSRGRGSF GMQVVSVGGP GKGHGKEQTG RGSKGHKKGN KQGSSDGVSK 

      1030       1040       1050       1060       1070       1080 
SLELHQGRSR SQVNGNSGAL IKEEKSDHRL PAPSQCALSR DSNECNNGNR YLPMNNREKN 

      1090 
HLQEQKLETV AQRKED 

« Hide

Isoform 2 [UniParc].

Checksum: B4BCB860C18784D9
Show »

FASTA23825,477

References

« Hide 'large scale' references
[1]"The human gene CXorf17 encodes a member of a novel family of putative transmembrane proteins: cDNA cloning and characterization of CXorf17 and its mouse ortholog orf34."
Holden S., Raymond F.L.
Gene 318:149-161(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT THR-82.
Tissue: Brain.
[2]"Cloning and identification of genes which are differentially expressed in carcinoma."
Dong X.-Y., Chen W.-F.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT THR-82.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-82.
Tissue: Signet-ring cell carcinoma.
[4]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT THR-82.
Tissue: Brain and Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY150025 mRNA. Translation: AAO24121.1.
AY121803 mRNA. Translation: AAM82751.1. Sequence problems.
AK000513 mRNA. Translation: BAA91219.1. Sequence problems.
AL589872 Genomic DNA. No translation available.
Z84469 Genomic DNA. No translation available.
BC016138 mRNA. Translation: AAH16138.2.
BC136413 mRNA. Translation: AAI36414.1.
RefSeqNP_060318.4. NM_017848.5.
NP_940858.2. NM_198456.2.
UniGeneHs.86045.

3D structure databases

ProteinModelPortalQ9NX05.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120292. 2 interactions.
IntActQ9NX05. 2 interactions.
STRING9606.ENSP00000364324.

PTM databases

PhosphoSiteQ9NX05.

Polymorphism databases

DMDM311033453.

Proteomic databases

MaxQBQ9NX05.
PaxDbQ9NX05.
PRIDEQ9NX05.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000375180; ENSP00000364324; ENSG00000184083. [Q9NX05-1]
ENST00000477084; ENSP00000420718; ENSG00000184083. [Q9NX05-2]
ENST00000594687; ENSP00000470416; ENSG00000268158. [Q9NX05-1]
ENST00000601479; ENSP00000469117; ENSG00000268158. [Q9NX05-2]
GeneID54954.
KEGGhsa:54954.
UCSCuc004dsz.4. human. [Q9NX05-1]
uc004dta.2. human. [Q9NX05-2]

Organism-specific databases

CTD54954.
GeneCardsGC0XM054097.
H-InvDBHIX0020105.
HGNCHGNC:16949. FAM120C.
HPAHPA047677.
MIM300741. gene.
neXtProtNX_Q9NX05.
PharmGKBPA134932227.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40155.
HOGENOMHOG000112430.
HOVERGENHBG050957.
InParanoidQ9NX05.
OMAQACAYPG.
PhylomeDBQ9NX05.
TreeFamTF328642.

Gene expression databases

ArrayExpressQ9NX05.
BgeeQ9NX05.
CleanExHS_FAM120C.
GenevestigatorQ9NX05.

Family and domain databases

InterProIPR026785. Coact_PPARg-like_2.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERPTHR15976:SF15. PTHR15976:SF15. 1 hit.
SUPFAMSSF88723. SSF88723. 1 hit.
ProtoNetSearch...

Other

GeneWikiFAM120C_(gene).
GenomeRNAi54954.
NextBio58136.
PROQ9NX05.
SOURCESearch...

Entry information

Entry nameF120C_HUMAN
AccessionPrimary (citable) accession number: Q9NX05
Secondary accession number(s): B2RMT7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM