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Protein

Uncharacterized protein C1orf109

Gene

C1orf109

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May promote cancer cell proliferation by controlling the G1 to S phase transition.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf109Curated
Gene namesi
Name:C1orf109Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116922.14.
HGNCiHGNC:26039. C1orf109.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi104S → A: Abolishes phosphorylation by CK2 kinase; when associated with A-134 and A-182. 1 Publication1
Mutagenesisi134S → A: Abolishes phosphorylation by CK2 kinase; when associated with A-104 and A-182. 1 Publication1
Mutagenesisi182S → A: Abolishes phosphorylation by CK2 kinase; when associated with A-104 and A-134. 1 Publication1

Organism-specific databases

DisGeNETi54955.
OpenTargetsiENSG00000116922.
PharmGKBiPA142672493.

Polymorphism and mutation databases

BioMutaiC1orf109.
DMDMi74761780.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743821 – 203Uncharacterized protein C1orf109Add BLAST203

Post-translational modificationi

Phosphorylated on serines by CK2 kinase.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NX04.
MaxQBiQ9NX04.
PaxDbiQ9NX04.
PeptideAtlasiQ9NX04.
PRIDEiQ9NX04.

PTM databases

iPTMnetiQ9NX04.
PhosphoSitePlusiQ9NX04.

Expressioni

Gene expression databases

BgeeiENSG00000116922.
CleanExiHS_C1orf109.
ExpressionAtlasiQ9NX04. baseline and differential.
GenevisibleiQ9NX04. HS.

Organism-specific databases

HPAiHPA027110.
HPA027127.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120293. 50 interactors.
IntActiQ9NX04. 118 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9NX04.
SMRiQ9NX04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IGVE. Eukaryota.
ENOG41127GW. LUCA.
GeneTreeiENSGT00390000008551.
HOVERGENiHBG080964.
InParanoidiQ9NX04.
OMAiCFPVVEE.
OrthoDBiEOG091G0KY0.
PhylomeDBiQ9NX04.
TreeFamiTF332524.

Family and domain databases

InterProiView protein in InterPro
IPR029159. CK2S.
PfamiView protein in Pfam
PF15011. CK2S. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTQDRPLLAV QEALKKCFPV VEEQQGLWQS ALRDCQPLLS SLSNLAEQLQ
60 70 80 90 100
AAQNLRFEDV PALRAFPDLK ERLRRKQLVA GDIVLDKLGE RLAILLKVRD
110 120 130 140 150
MVSSHVERVF QIYEQHADTV GIDAVLQPSA VSPSVADMLE WLQDIERHYR
160 170 180 190 200
KSYLKRKYLL SSIQWGDLAN IQALPKAWDR ISKDEHQDLV QDILLNVSFF

LEE
Length:203
Mass (Da):23,373
Last modified:October 1, 2000 - v1
Checksum:iCBD3883CB1A2C281
GO
Isoform 2 (identifier: Q9NX04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-113: RKQLVAGDIV...SHVERVFQIY → QPSSSRCETW...ALMLSCSLQQ
     114-203: Missing.

Show »
Length:113
Mass (Da):12,861
Checksum:iC243446688C8499F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02273375 – 113RKQLV…VFQIY → QPSSSRCETWSAAMWSECFR SMSNTQTQLALMLSCSLQQ in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_022734114 – 203Missing in isoform 2. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000515 mRNA. Translation: BAA91221.1.
CH471059 Genomic DNA. Translation: EAX07327.1.
CH471059 Genomic DNA. Translation: EAX07329.1.
CH471059 Genomic DNA. Translation: EAX07330.1.
BC018109 mRNA. Translation: AAH18109.1.
BC063843 mRNA. Translation: AAH63843.1.
CCDSiCCDS423.1. [Q9NX04-1]
RefSeqiNP_001289959.1. NM_001303030.1.
NP_001289960.1. NM_001303031.1.
NP_060320.1. NM_017850.2. [Q9NX04-1]
XP_016857035.1. XM_017001546.1.
XP_016857036.1. XM_017001547.1.
XP_016857040.1. XM_017001551.1.
XP_016857041.1. XM_017001552.1.
XP_016857042.1. XM_017001553.1.
XP_016857043.1. XM_017001554.1.
XP_016857044.1. XM_017001555.1.
XP_016857045.1. XM_017001556.1. [Q9NX04-1]
UniGeneiHs.272673.
Hs.733219.

Genome annotation databases

EnsembliENST00000358011; ENSP00000350704; ENSG00000116922. [Q9NX04-1]
ENST00000464085; ENSP00000477159; ENSG00000116922. [Q9NX04-1]
ENST00000494120; ENSP00000477273; ENSG00000116922. [Q9NX04-2]
GeneIDi54955.
KEGGihsa:54955.
UCSCiuc001cbn.4. human. [Q9NX04-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCA109_HUMAN
AccessioniPrimary (citable) accession number: Q9NX04
Secondary accession number(s): D3DPT1, Q8WVD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot