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Protein

Uncharacterized protein C1orf109

Gene

C1orf109

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf109
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26039. C1orf109.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672493.

Polymorphism and mutation databases

BioMutaiC1orf109.
DMDMi74761780.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Uncharacterized protein C1orf109PRO_0000274382Add
BLAST

Proteomic databases

MaxQBiQ9NX04.
PaxDbiQ9NX04.
PRIDEiQ9NX04.

PTM databases

PhosphoSiteiQ9NX04.

Expressioni

Gene expression databases

BgeeiQ9NX04.
CleanExiHS_C1orf109.
ExpressionAtlasiQ9NX04. baseline and differential.
GenevisibleiQ9NX04. HS.

Organism-specific databases

HPAiHPA027110.
HPA027127.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-8643161,EBI-717810
C1orf94Q6P1W53EBI-8643161,EBI-946029
CCDC36Q8IYA83EBI-8643161,EBI-8638439
CEP55D3DR373EBI-8643161,EBI-10173536
CINPQ9BW665EBI-8643161,EBI-739784
CRXO431863EBI-8643161,EBI-748171
GOLGA2Q083793EBI-8643161,EBI-618309
IKZF1Q134223EBI-8643161,EBI-745305
IKZF3Q9UKT93EBI-8643161,EBI-747204
KATNAL1Q9BW623EBI-8643161,EBI-743591
KIFC3Q9BVG84EBI-8643161,EBI-2125614
KRT13A1A4E93EBI-8643161,EBI-10171552
KRT19P087273EBI-8643161,EBI-742756
KRT31Q153233EBI-8643161,EBI-948001
KRT40Q6A1623EBI-8643161,EBI-10171697
LDOC1O957513EBI-8643161,EBI-740738
LZTS2Q9BRK43EBI-8643161,EBI-741037
MEOX2A4D1273EBI-8643161,EBI-10172134
MKRN2Q9H0003EBI-8643161,EBI-2341005
MTUS2Q5JR593EBI-8643161,EBI-742948
NECAB2H3BTW23EBI-8643161,EBI-10172876
PDE4DIPQ5VU433EBI-8643161,EBI-1105124
PHC2Q8IXK03EBI-8643161,EBI-713786
PLK4O004443EBI-8643161,EBI-746202
PPP1R12CQ9BZL4-53EBI-8643161,EBI-10289057
RELQ048643EBI-8643161,EBI-307352
RINT1Q6NUQ13EBI-8643161,EBI-726876
RNF41Q9H4P43EBI-8643161,EBI-2130266
SDCBPO005603EBI-8643161,EBI-727004
SPAG5Q96R063EBI-8643161,EBI-413317
SPERTQ8NA613EBI-8643161,EBI-741724
STX11O755583EBI-8643161,EBI-714135
TADA2AO754783EBI-8643161,EBI-742268
TCF12Q990813EBI-8643161,EBI-722877
TCF4P158843EBI-8643161,EBI-533224
TFIP11Q9UBB93EBI-8643161,EBI-1105213
TRAF1Q130773EBI-8643161,EBI-359224
TRIM42A1L4B63EBI-8643161,EBI-10172216
TRIM54Q9BYV23EBI-8643161,EBI-2130429
USHBP1Q8N6Y03EBI-8643161,EBI-739895
VPS52Q8N1B43EBI-8643161,EBI-2799833
ZBED1O960064EBI-8643161,EBI-740037
ZNF398Q8TD174EBI-8643161,EBI-8643207

Protein-protein interaction databases

BioGridi120293. 46 interactions.
IntActiQ9NX04. 44 interactions.
STRINGi9606.ENSP00000350704.

Structurei

3D structure databases

ProteinModelPortaliQ9NX04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG45850.
GeneTreeiENSGT00390000008551.
HOVERGENiHBG080964.
InParanoidiQ9NX04.
OMAiCFPVVEE.
OrthoDBiEOG7VDXQS.
PhylomeDBiQ9NX04.
TreeFamiTF332524.

Family and domain databases

InterProiIPR029159. CK2S.
[Graphical view]
PfamiPF15011. CK2S. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTQDRPLLAV QEALKKCFPV VEEQQGLWQS ALRDCQPLLS SLSNLAEQLQ
60 70 80 90 100
AAQNLRFEDV PALRAFPDLK ERLRRKQLVA GDIVLDKLGE RLAILLKVRD
110 120 130 140 150
MVSSHVERVF QIYEQHADTV GIDAVLQPSA VSPSVADMLE WLQDIERHYR
160 170 180 190 200
KSYLKRKYLL SSIQWGDLAN IQALPKAWDR ISKDEHQDLV QDILLNVSFF

LEE
Length:203
Mass (Da):23,373
Last modified:October 1, 2000 - v1
Checksum:iCBD3883CB1A2C281
GO
Isoform 2 (identifier: Q9NX04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-113: RKQLVAGDIV...SHVERVFQIY → QPSSSRCETW...ALMLSCSLQQ
     114-203: Missing.

Show »
Length:113
Mass (Da):12,861
Checksum:iC243446688C8499F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei75 – 11339RKQLV…VFQIY → QPSSSRCETWSAAMWSECFR SMSNTQTQLALMLSCSLQQ in isoform 2. 1 PublicationVSP_022733Add
BLAST
Alternative sequencei114 – 20390Missing in isoform 2. 1 PublicationVSP_022734Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000515 mRNA. Translation: BAA91221.1.
CH471059 Genomic DNA. Translation: EAX07327.1.
CH471059 Genomic DNA. Translation: EAX07329.1.
CH471059 Genomic DNA. Translation: EAX07330.1.
BC018109 mRNA. Translation: AAH18109.1.
BC063843 mRNA. Translation: AAH63843.1.
CCDSiCCDS423.1. [Q9NX04-1]
RefSeqiNP_001289959.1. NM_001303030.1.
NP_001289960.1. NM_001303031.1.
NP_060320.1. NM_017850.2. [Q9NX04-1]
UniGeneiHs.272673.

Genome annotation databases

EnsembliENST00000358011; ENSP00000350704; ENSG00000116922.
ENST00000464085; ENSP00000477159; ENSG00000116922.
ENST00000494120; ENSP00000477273; ENSG00000116922. [Q9NX04-2]
GeneIDi54955.
KEGGihsa:54955.
UCSCiuc001cbp.3. human. [Q9NX04-1]
uc001cbq.1. human. [Q9NX04-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000515 mRNA. Translation: BAA91221.1.
CH471059 Genomic DNA. Translation: EAX07327.1.
CH471059 Genomic DNA. Translation: EAX07329.1.
CH471059 Genomic DNA. Translation: EAX07330.1.
BC018109 mRNA. Translation: AAH18109.1.
BC063843 mRNA. Translation: AAH63843.1.
CCDSiCCDS423.1. [Q9NX04-1]
RefSeqiNP_001289959.1. NM_001303030.1.
NP_001289960.1. NM_001303031.1.
NP_060320.1. NM_017850.2. [Q9NX04-1]
UniGeneiHs.272673.

3D structure databases

ProteinModelPortaliQ9NX04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120293. 46 interactions.
IntActiQ9NX04. 44 interactions.
STRINGi9606.ENSP00000350704.

PTM databases

PhosphoSiteiQ9NX04.

Polymorphism and mutation databases

BioMutaiC1orf109.
DMDMi74761780.

Proteomic databases

MaxQBiQ9NX04.
PaxDbiQ9NX04.
PRIDEiQ9NX04.

Protocols and materials databases

DNASUi54955.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358011; ENSP00000350704; ENSG00000116922.
ENST00000464085; ENSP00000477159; ENSG00000116922.
ENST00000494120; ENSP00000477273; ENSG00000116922. [Q9NX04-2]
GeneIDi54955.
KEGGihsa:54955.
UCSCiuc001cbp.3. human. [Q9NX04-1]
uc001cbq.1. human. [Q9NX04-2]

Organism-specific databases

CTDi54955.
GeneCardsiGC01M038147.
HGNCiHGNC:26039. C1orf109.
HPAiHPA027110.
HPA027127.
MIMi614799. gene.
neXtProtiNX_Q9NX04.
PharmGKBiPA142672493.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45850.
GeneTreeiENSGT00390000008551.
HOVERGENiHBG080964.
InParanoidiQ9NX04.
OMAiCFPVVEE.
OrthoDBiEOG7VDXQS.
PhylomeDBiQ9NX04.
TreeFamiTF332524.

Miscellaneous databases

GeneWikiiC1orf109_(gene).
GenomeRNAii54955.
NextBioi58140.
PROiQ9NX04.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NX04.
CleanExiHS_C1orf109.
ExpressionAtlasiQ9NX04. baseline and differential.
GenevisibleiQ9NX04. HS.

Family and domain databases

InterProiIPR029159. CK2S.
[Graphical view]
PfamiPF15011. CK2S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Uterus.

Entry informationi

Entry nameiCA109_HUMAN
AccessioniPrimary (citable) accession number: Q9NX04
Secondary accession number(s): D3DPT1, Q8WVD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2000
Last modified: July 22, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.