Q9NX02 (NALP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NACHT, LRR and PYD domains-containing protein 2

Alternative name(s):
Nucleotide-binding site protein 1
PYRIN domain and NACHT domain-containing protein 1
PYRIN-containing APAF1-like protein 2

Gene names

Name:	NLRP2
Synonyms:	NALP2, NBS1, PAN1, PYPAF2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1062 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Ref.9
Subunit structure	Interacts with CHUK, IKBKB and IKBKG, as well as with full-length PYCARD and with the DAPIN domain of NAPL1, but not the full-length protein. Ref.8 Ref.9
Subcellular location	Cytoplasm Ref.8 Ref.9.
Tissue specificity	Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain. Ref.9
Induction	By interferons and bacterial lipopolysaccharides (LPS). Ref.9
Domain	The DAPIN domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD. When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding.
Sequence similarities	Belongs to the NLRP family. Contains 1 DAPIN domain. Contains 8 LRR (leucine-rich) repeats. Contains 1 NACHT domain.
Sequence caution	The sequence AAG15253.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA91377.1 differs from that shown. Reason: Erroneous initiation. The sequence BAD92537.1 differs from that shown. Reason: Frameshift at position 769. The sequence BAD92537.1 differs from that shown. Reason: Erroneous prediction of the initiator methionine.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Leucine-rich repeat Repeat
Ligand	ATP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from direct assay Ref.8. Source: HGNC positive regulation of interleukin-1 beta secretion Inferred from direct assay Ref.8. Source: HGNC
Cellular_component	cytoplasm Inferred from direct assay Ref.8. Source: HGNC
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PYDC2	Q56P42	6	EBI-6374482,EBI-6374418

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NX02-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NX02-2)

The sequence of this isoform differs from the canonical sequence as follows:
     133-154: Missing.

Isoform 3 (identifier: Q9NX02-3)

The sequence of this isoform differs from the canonical sequence as follows:
     847-1062: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 4 (identifier: Q9NX02-4)

The sequence of this isoform differs from the canonical sequence as follows:
     109-132: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q9NX02-5)

The sequence of this isoform differs from the canonical sequence as follows:
     47-69: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1062	1062	NACHT, LRR and PYD domains-containing protein 2		PRO_0000080888
Regions
	Domain	1 – 94	94	DAPIN
	Domain	207 – 526	320	NACHT
	Repeat	812 – 832	21	LRR 1
	Repeat	841 – 861	21	LRR 2
	Repeat	869 – 889	21	LRR 3
	Repeat	898 – 918	21	LRR 4
	Repeat	926 – 946	21	LRR 5
	Repeat	955 – 976	22	LRR 6
	Repeat	983 – 1003	21	LRR 7
	Repeat	1010 – 1033	24	LRR 8
	Nucleotide binding	213 – 220	8	ATP Potential
	Compositional bias	518 – 523	6	Poly-Glu
Amino acid modifications
	Modified residue	671	1	Phosphoserine Ref.11
Natural variations
	Alternative sequence	47 – 69	23	Missing in isoform 5.		VSP_044898
	Alternative sequence	109 – 132	24	Missing in isoform 4.		VSP_017085
	Alternative sequence	133 – 154	22	Missing in isoform 2.		VSP_005522
	Alternative sequence	847 – 1062	216	Missing in isoform 3.		VSP_017086
	Natural variant	221	1	T → M. Corresponds to variant rs17699678 [ dbSNP | Ensembl ].		VAR_053616
	Natural variant	302	1	E → Q. Corresponds to variant rs3745904 [ dbSNP | Ensembl ].		VAR_053617
	Natural variant	364	1	R → K. Ref.1 Corresponds to variant rs4306647 [ dbSNP | Ensembl ].		VAR_025011
	Natural variant	516	1	T → A. Ref.4 Corresponds to variant rs61735082 [ dbSNP | Ensembl ].		VAR_068977
	Natural variant	522	1	E → G. Ref.4 Corresponds to variant rs61735083 [ dbSNP | Ensembl ].		VAR_068978
	Natural variant	529	1	T → A. Ref.4 Ref.5 Corresponds to variant rs34804158 [ dbSNP | Ensembl ].		VAR_068979
	Natural variant	884	1	G → R. Corresponds to variant rs59779270 [ dbSNP | Ensembl ].		VAR_062140
	Natural variant	1052	1	A → E. Ref.7 Corresponds to variant rs1043673 [ dbSNP | Ensembl ].		VAR_020006
Experimental info
	Sequence conflict	1	1	M → V in AAG15253. Ref.1
	Sequence conflict	35	1	L → P in AAG15253. Ref.1
	Sequence conflict	46	1	E → G in BAG64129. Ref.4
	Sequence conflict	58	1	I → V in AAH39269. Ref.7
	Sequence conflict	175	1	W → C in BAD96973. Ref.5
	Sequence conflict	175	1	W → C in BAD96989. Ref.5
	Sequence conflict	216	1	G → S in BAG64129. Ref.4
	Sequence conflict	304	1	I → S in BAB15293. Ref.4
	Sequence conflict	980	1	Missing in AAG15253. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 4DBB0F6E9C2BC8A7	FASTA	1,062	120,515
	10 20 30 40 50 60 MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA DGKQLVEILT 70 80 90 100 110 120 THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF NKRKPLSLGI TRKERPPLDV 130 140 150 160 170 180 DEMLERFKTE AQAFTETKGN VICLGKEVFK GKKPDKDNRC RYILKTKFRE MWKSWPGDSK 190 200 210 220 230 240 EVQVMAERYK MLIPFSNPRV LPGPFSYTVV LYGPAGLGKT TLAQKLMLDW AEDNLIHKFK 250 260 270 280 290 300 YAFYLSCREL SRLGPCSFAE LVFRDWPELQ DDIPHILAQA RKILFVIDGF DELGAAPGAL 310 320 330 340 350 360 IEDICGDWEK KKPVPVLLGS LLNRVMLPKA ALLVTTRPRA LRDLRILAEE PIYIRVEGFL 370 380 390 400 410 420 EEDRRAYFLR HFGDEDQAMR AFELMRSNAA LFQLGSAPAV CWIVCTTLKL QMEKGEDPVP 430 440 450 460 470 480 TCLTRTGLFL RFLCSRFPQG AQLRGALRTL SLLAAQGLWA QTSVLHREDL ERLGVQESDL 490 500 510 520 530 540 RLFLDGDILR QDRVSKGCYS FIHLSFQQFL TALFYTLEKE EEEDRDGHTW DIGDVQKLLS 550 560 570 580 590 600 GVERLRNPDL IQAGYYSFGL ANEKRAKELE ATFGCRMSPD IKQELLRCDI SCKGGHSTVT 610 620 630 640 650 660 DLQELLGCLY ESQEEELVKE VMAQFKEISL HLNAVDVVPS SFCVKHCRNL QKMSLQVIKE 670 680 690 700 710 720 NLPENVTASE SDAEVERSQD DQHMLPFWTD LCSIFGSNKD LMGLAINDSF LSASLVRILC 730 740 750 760 770 780 EQIASDTCHL QRVVFKNISP ADAHRNLCLA LRGHKTVTYL TLQGNDQDDM FPALCEVLRH 790 800 810 820 830 840 PECNLRYLGL VSCSATTQQW ADLSLALEVN QSLTCVNLSD NELLDEGAKL LYTTLRHPKC 850 860 870 880 890 900 FLQRLSLENC HLTEANCKDL AAVLVVSREL THLCLAKNPI GNTGVKFLCE GLRYPECKLQ 910 920 930 940 950 960 TLVLWNCDIT SDGCCDLTKL LQEKSSLLCL DLGLNHIGVK GMKFLCEALR KPLCNLRCLW 970 980 990 1000 1010 1020 LWGCSIPPFS CEDLCSALSC NQSLVTLDLG QNPLGSSGVK MLFETLTCSS GTLRTLRLKI 1030 1040 1050 1060 DDFNDELNKL LEEIEEKNPQ LIIDTEKHHP WAERPSSHDF MI
	Isoform 2 [UniParc]. Checksum: 0FF49C18762CEDB4	FASTA	1,040	118,138
	10 20 30 40 50 60 MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA DGKQLVEILT 70 80 90 100 110 120 THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF NKRKPLSLGI TRKERPPLDV 130 140 150 160 170 180 DEMLERFKTE AQDKDNRCRY ILKTKFREMW KSWPGDSKEV QVMAERYKML IPFSNPRVLP 190 200 210 220 230 240 GPFSYTVVLY GPAGLGKTTL AQKLMLDWAE DNLIHKFKYA FYLSCRELSR LGPCSFAELV 250 260 270 280 290 300 FRDWPELQDD IPHILAQARK ILFVIDGFDE LGAAPGALIE DICGDWEKKK PVPVLLGSLL 310 320 330 340 350 360 NRVMLPKAAL LVTTRPRALR DLRILAEEPI YIRVEGFLEE DRRAYFLRHF GDEDQAMRAF 370 380 390 400 410 420 ELMRSNAALF QLGSAPAVCW IVCTTLKLQM EKGEDPVPTC LTRTGLFLRF LCSRFPQGAQ 430 440 450 460 470 480 LRGALRTLSL LAAQGLWAQT SVLHREDLER LGVQESDLRL FLDGDILRQD RVSKGCYSFI 490 500 510 520 530 540 HLSFQQFLTA LFYTLEKEEE EDRDGHTWDI GDVQKLLSGV ERLRNPDLIQ AGYYSFGLAN 550 560 570 580 590 600 EKRAKELEAT FGCRMSPDIK QELLRCDISC KGGHSTVTDL QELLGCLYES QEEELVKEVM 610 620 630 640 650 660 AQFKEISLHL NAVDVVPSSF CVKHCRNLQK MSLQVIKENL PENVTASESD AEVERSQDDQ 670 680 690 700 710 720 HMLPFWTDLC SIFGSNKDLM GLAINDSFLS ASLVRILCEQ IASDTCHLQR VVFKNISPAD 730 740 750 760 770 780 AHRNLCLALR GHKTVTYLTL QGNDQDDMFP ALCEVLRHPE CNLRYLGLVS CSATTQQWAD 790 800 810 820 830 840 LSLALEVNQS LTCVNLSDNE LLDEGAKLLY TTLRHPKCFL QRLSLENCHL TEANCKDLAA 850 860 870 880 890 900 VLVVSRELTH LCLAKNPIGN TGVKFLCEGL RYPECKLQTL VLWNCDITSD GCCDLTKLLQ 910 920 930 940 950 960 EKSSLLCLDL GLNHIGVKGM KFLCEALRKP LCNLRCLWLW GCSIPPFSCE DLCSALSCNQ 970 980 990 1000 1010 1020 SLVTLDLGQN PLGSSGVKML FETLTCSSGT LRTLRLKIDD FNDELNKLLE EIEEKNPQLI 1030 1040 IDTEKHHPWA ERPSSHDFMI
	Isoform 3 [UniParc]. Checksum: 22DD3265062DC0CB	FASTA	846	96,383
	10 20 30 40 50 60 MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA DGKQLVEILT 70 80 90 100 110 120 THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF NKRKPLSLGI TRKERPPLDV 130 140 150 160 170 180 DEMLERFKTE AQAFTETKGN VICLGKEVFK GKKPDKDNRC RYILKTKFRE MWKSWPGDSK 190 200 210 220 230 240 EVQVMAERYK MLIPFSNPRV LPGPFSYTVV LYGPAGLGKT TLAQKLMLDW AEDNLIHKFK 250 260 270 280 290 300 YAFYLSCREL SRLGPCSFAE LVFRDWPELQ DDIPHILAQA RKILFVIDGF DELGAAPGAL 310 320 330 340 350 360 IEDICGDWEK KKPVPVLLGS LLNRVMLPKA ALLVTTRPRA LRDLRILAEE PIYIRVEGFL 370 380 390 400 410 420 EEDRRAYFLR HFGDEDQAMR AFELMRSNAA LFQLGSAPAV CWIVCTTLKL QMEKGEDPVP 430 440 450 460 470 480 TCLTRTGLFL RFLCSRFPQG AQLRGALRTL SLLAAQGLWA QTSVLHREDL ERLGVQESDL 490 500 510 520 530 540 RLFLDGDILR QDRVSKGCYS FIHLSFQQFL TALFYTLEKE EEEDRDGHTW DIGDVQKLLS 550 560 570 580 590 600 GVERLRNPDL IQAGYYSFGL ANEKRAKELE ATFGCRMSPD IKQELLRCDI SCKGGHSTVT 610 620 630 640 650 660 DLQELLGCLY ESQEEELVKE VMAQFKEISL HLNAVDVVPS SFCVKHCRNL QKMSLQVIKE 670 680 690 700 710 720 NLPENVTASE SDAEVERSQD DQHMLPFWTD LCSIFGSNKD LMGLAINDSF LSASLVRILC 730 740 750 760 770 780 EQIASDTCHL QRVVFKNISP ADAHRNLCLA LRGHKTVTYL TLQGNDQDDM FPALCEVLRH 790 800 810 820 830 840 PECNLRYLGL VSCSATTQQW ADLSLALEVN QSLTCVNLSD NELLDEGAKL LYTTLRHPKC FLQRLS
	Isoform 4 [UniParc]. Checksum: AA066954D53827F2	FASTA	1,038	117,674
	10 20 30 40 50 60 MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA DGKQLVEILT 70 80 90 100 110 120 THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF NKRKPLSLAF TETKGNVICL 130 140 150 160 170 180 GKEVFKGKKP DKDNRCRYIL KTKFREMWKS WPGDSKEVQV MAERYKMLIP FSNPRVLPGP 190 200 210 220 230 240 FSYTVVLYGP AGLGKTTLAQ KLMLDWAEDN LIHKFKYAFY LSCRELSRLG PCSFAELVFR 250 260 270 280 290 300 DWPELQDDIP HILAQARKIL FVIDGFDELG AAPGALIEDI CGDWEKKKPV PVLLGSLLNR 310 320 330 340 350 360 VMLPKAALLV TTRPRALRDL RILAEEPIYI RVEGFLEEDR RAYFLRHFGD EDQAMRAFEL 370 380 390 400 410 420 MRSNAALFQL GSAPAVCWIV CTTLKLQMEK GEDPVPTCLT RTGLFLRFLC SRFPQGAQLR 430 440 450 460 470 480 GALRTLSLLA AQGLWAQTSV LHREDLERLG VQESDLRLFL DGDILRQDRV SKGCYSFIHL 490 500 510 520 530 540 SFQQFLTALF YTLEKEEEED RDGHTWDIGD VQKLLSGVER LRNPDLIQAG YYSFGLANEK 550 560 570 580 590 600 RAKELEATFG CRMSPDIKQE LLRCDISCKG GHSTVTDLQE LLGCLYESQE EELVKEVMAQ 610 620 630 640 650 660 FKEISLHLNA VDVVPSSFCV KHCRNLQKMS LQVIKENLPE NVTASESDAE VERSQDDQHM 670 680 690 700 710 720 LPFWTDLCSI FGSNKDLMGL AINDSFLSAS LVRILCEQIA SDTCHLQRVV FKNISPADAH 730 740 750 760 770 780 RNLCLALRGH KTVTYLTLQG NDQDDMFPAL CEVLRHPECN LRYLGLVSCS ATTQQWADLS 790 800 810 820 830 840 LALEVNQSLT CVNLSDNELL DEGAKLLYTT LRHPKCFLQR LSLENCHLTE ANCKDLAAVL 850 860 870 880 890 900 VVSRELTHLC LAKNPIGNTG VKFLCEGLRY PECKLQTLVL WNCDITSDGC CDLTKLLQEK 910 920 930 940 950 960 SSLLCLDLGL NHIGVKGMKF LCEALRKPLC NLRCLWLWGC SIPPFSCEDL CSALSCNQSL 970 980 990 1000 1010 1020 VTLDLGQNPL GSSGVKMLFE TLTCSSGTLR TLRLKIDDFN DELNKLLEEI EEKNPQLIID 1030 TEKHHPWAER PSSHDFMI
	Isoform 5 [UniParc]. Checksum: B55EABADF1A74126	FASTA	1,039	117,883
	10 20 30 40 50 60 MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEMASL QVFEKMHRMD 70 80 90 100 110 120 LSERAKDEVR EAALKSFNKR KPLSLGITRK ERPPLDVDEM LERFKTEAQA FTETKGNVIC 130 140 150 160 170 180 LGKEVFKGKK PDKDNRCRYI LKTKFREMWK SWPGDSKEVQ VMAERYKMLI PFSNPRVLPG 190 200 210 220 230 240 PFSYTVVLYG PAGLGKTTLA QKLMLDWAED NLIHKFKYAF YLSCRELSRL GPCSFAELVF 250 260 270 280 290 300 RDWPELQDDI PHILAQARKI LFVIDGFDEL GAAPGALIED ICGDWEKKKP VPVLLGSLLN 310 320 330 340 350 360 RVMLPKAALL VTTRPRALRD LRILAEEPIY IRVEGFLEED RRAYFLRHFG DEDQAMRAFE 370 380 390 400 410 420 LMRSNAALFQ LGSAPAVCWI VCTTLKLQME KGEDPVPTCL TRTGLFLRFL CSRFPQGAQL 430 440 450 460 470 480 RGALRTLSLL AAQGLWAQTS VLHREDLERL GVQESDLRLF LDGDILRQDR VSKGCYSFIH 490 500 510 520 530 540 LSFQQFLTAL FYTLEKEEEE DRDGHTWDIG DVQKLLSGVE RLRNPDLIQA GYYSFGLANE 550 560 570 580 590 600 KRAKELEATF GCRMSPDIKQ ELLRCDISCK GGHSTVTDLQ ELLGCLYESQ EEELVKEVMA 610 620 630 640 650 660 QFKEISLHLN AVDVVPSSFC VKHCRNLQKM SLQVIKENLP ENVTASESDA EVERSQDDQH 670 680 690 700 710 720 MLPFWTDLCS IFGSNKDLMG LAINDSFLSA SLVRILCEQI ASDTCHLQRV VFKNISPADA 730 740 750 760 770 780 HRNLCLALRG HKTVTYLTLQ GNDQDDMFPA LCEVLRHPEC NLRYLGLVSC SATTQQWADL 790 800 810 820 830 840 SLALEVNQSL TCVNLSDNEL LDEGAKLLYT TLRHPKCFLQ RLSLENCHLT EANCKDLAAV 850 860 870 880 890 900 LVVSRELTHL CLAKNPIGNT GVKFLCEGLR YPECKLQTLV LWNCDITSDG CCDLTKLLQE 910 920 930 940 950 960 KSSLLCLDLG LNHIGVKGMK FLCEALRKPL CNLRCLWLWG CSIPPFSCED LCSALSCNQS 970 980 990 1000 1010 1020 LVTLDLGQNP LGSSGVKMLF ETLTCSSGTL RTLRLKIDDF NDELNKLLEE IEEKNPQLII 1030 DTEKHHPWAE RPSSHDFMI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The PYRIN domain: a novel motif found in apoptosis and inflammation proteins." Bertin J., DiStefano P.S. Cell Death Differ. 7:1273-1274(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT LYS-364.
[2]	"The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation." Martinon F., Hofmann K., Tschopp J. Curr. Biol. 11:R118-R120(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing." Wang L., Manji G.A., Grenier J.M., Al-Garawi A., Merriam S., Lora J.M., Geddes B.J., Briskin M., DiStefano P.S., Bertin J. J. Biol. Chem. 277:29874-29880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), VARIANTS ALA-516; GLY-522 AND ALA-529. Tissue: Colon, Kidney epithelium and Testis.
[5]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT ALA-529. Tissue: Brain and Gastric mucosa.
[6]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT GLU-1052. Tissue: Lung, Placenta and Testis.
[8]	"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder." Agostini L., Martinon F., Burns K., McDermott M.F., Hawkins P.N., Tschopp J. Immunity 20:319-325(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PYCARD AND CARD8, SUBCELLULAR LOCATION.
[9]	"PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages." Bruey J.-M., Bruey-Sedano N., Newman R., Chandler S., Stehlik C., Reed J.C. J. Biol. Chem. 279:51897-51907(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CHUK; IKBKB; IKBKG AND PYCARD, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-671, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF298547 mRNA. Translation: AAG15253.1. Different initiation. AF310106 mRNA. Translation: AAG30289.1. AF464764 mRNA. Translation: AAL69962.1. AK000517 mRNA. Translation: BAA91223.1. AK000784 mRNA. Translation: BAA91377.1. Different initiation. AK025952 mRNA. Translation: BAB15293.1. AK302989 mRNA. Translation: BAG64129.1. AB209300 mRNA. Translation: BAD92537.1. Sequence problems. AK223253 mRNA. Translation: BAD96973.1. AK223269 mRNA. Translation: BAD96989.1. AC011476 Genomic DNA. No translation available. BC001039 mRNA. Translation: AAH01039.1. BC003592 mRNA. Translation: AAH03592.1. BC039269 mRNA. Translation: AAH39269.1.
IPI	IPI00016480. IPI00218560. IPI00719706. IPI00719715. IPI00956334.
RefSeq	NP_001167552.1. NM_001174081.1. NP_001167553.1. NM_001174082.1. NP_001167554.1. NM_001174083.1. NP_060322.1. NM_017852.3.
UniGene	Hs.369279.
3D structure databases
ProteinModelPortal	Q9NX02.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NX02. 1 interaction.
MINT	MINT-5006655.
STRING	9606.ENSP00000263437.
PTM databases
PhosphoSite	Q9NX02.
Polymorphism databases
DMDM	17380148.
Proteomic databases
PaxDb	Q9NX02.
PeptideAtlas	Q9NX02.
PRIDE	Q9NX02.
Protocols and materials databases
DNASU	55655.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339757; ENSP00000344074; ENSG00000022556. ENST00000391721; ENSP00000375601; ENSG00000022556. ENST00000427260; ENSP00000402474; ENSG00000022556. ENST00000448584; ENSP00000409370; ENSG00000022556. ENST00000537859; ENSP00000440601; ENSG00000022556. ENST00000538819; ENSP00000441133; ENSG00000022556. ENST00000543010; ENSP00000445135; ENSG00000022556. ENST00000570593; ENSP00000460522; ENSG00000262886. ENST00000570685; ENSP00000461424; ENSG00000262615. ENST00000571180; ENSP00000460452; ENSG00000262929. ENST00000571222; ENSP00000461575; ENSG00000262886. ENST00000571225; ENSP00000458740; ENSG00000262811. ENST00000571455; ENSP00000461312; ENSG00000262886. ENST00000571463; ENSP00000459338; ENSG00000262175. ENST00000571477; ENSP00000460381; ENSG00000262615. ENST00000571726; ENSP00000459236; ENSG00000262811. ENST00000571803; ENSP00000459395; ENSG00000262929. ENST00000572005; ENSP00000460139; ENSG00000262329. ENST00000572364; ENSP00000460916; ENSG00000262175. ENST00000572395; ENSP00000461821; ENSG00000262260. ENST00000572489; ENSP00000459160; ENSG00000262260. ENST00000572533; ENSP00000461414; ENSG00000262929. ENST00000572578; ENSP00000459694; ENSG00000262615. ENST00000572889; ENSP00000461004; ENSG00000262329. ENST00000572900; ENSP00000461005; ENSG00000262615. ENST00000573210; ENSP00000459905; ENSG00000262175. ENST00000573459; ENSP00000459970; ENSG00000262811. ENST00000573475; ENSP00000460406; ENSG00000262615. ENST00000573873; ENSP00000459149; ENSG00000262811. ENST00000573958; ENSP00000460195; ENSG00000262175. ENST00000574136; ENSP00000461485; ENSG00000262886. ENST00000574207; ENSP00000458572; ENSG00000262886. ENST00000574360; ENSP00000460511; ENSG00000262260. ENST00000574414; ENSP00000461278; ENSG00000262329. ENST00000574461; ENSP00000460772; ENSG00000262929. ENST00000574477; ENSP00000460785; ENSG00000262615. ENST00000574535; ENSP00000459670; ENSG00000262260. ENST00000574917; ENSP00000458960; ENSG00000262329. ENST00000575196; ENSP00000458701; ENSG00000262615. ENST00000575232; ENSP00000460135; ENSG00000262929. ENST00000575413; ENSP00000460995; ENSG00000262929. ENST00000575438; ENSP00000460021; ENSG00000262175. ENST00000575466; ENSP00000459584; ENSG00000262260. ENST00000575523; ENSP00000460378; ENSG00000262329. ENST00000575835; ENSP00000461657; ENSG00000262329. ENST00000576177; ENSP00000459755; ENSG00000262260. ENST00000576228; ENSP00000458915; ENSG00000262886. ENST00000576464; ENSP00000461311; ENSG00000262175. ENST00000576515; ENSP00000459053; ENSG00000262329. ENST00000576631; ENSP00000458217; ENSG00000262811. ENST00000576647; ENSP00000458345; ENSG00000262929. ENST00000576821; ENSP00000459428; ENSG00000262886. ENST00000576909; ENSP00000460773; ENSG00000262260. ENST00000576923; ENSP00000459402; ENSG00000262811. ENST00000576968; ENSP00000458817; ENSG00000262811. ENST00000577030; ENSP00000459166; ENSG00000262175.
GeneID	55655.
KEGG	hsa:55655.
UCSC	uc002qij.3. human. uc010esn.3. human. uc010esp.3. human.
Organism-specific databases
CTD	55655.
GeneCards	GC19P055476.
HGNC	HGNC:22948. NLRP2.
HPA	HPA020765.
MIM	609364. gene.
neXtProt	NX_Q9NX02.
PharmGKB	PA162397946.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146691.
HOVERGEN	HBG103856.
InParanoid	Q9NX02.
OMA	VFEKMHR.
PhylomeDB	Q9NX02.
Gene expression databases
ArrayExpress	Q9NX02.
Bgee	Q9NX02.
CleanEx	HS_NLRP2.
Genevestigator	Q9NX02.
GermOnline	ENSG00000022556. Homo sapiens.
Family and domain databases
Gene3D	1.10.533.10. 1 hit.
InterPro	IPR004020. DAPIN. IPR011029. DEATH-like_dom. IPR007111. NACHT_NTPase. [Graphical view]
Pfam	PF02758. PYRIN. 1 hit. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 1 hit.
PROSITE	PS50824. DAPIN. 1 hit. PS50837. NACHT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55655.
NextBio	60371.
SOURCE	Search...

Entry information

Entry name

NALP2_HUMAN

Accession

Primary (citable) accession number: Q9NX02
Secondary accession number(s): B4DZL7 , I3L0G4, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 129 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.