Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NX02

- NALP2_HUMAN

UniProt

Q9NX02 - NALP2_HUMAN

Protein

NACHT, LRR and PYD domains-containing protein 2

Gene

NLRP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi213 – 2208ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. Pyrin domain binding Source: HGNC

    GO - Biological processi

    1. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC
    2. positive regulation of interleukin-1 beta secretion Source: HGNC

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 2
    Alternative name(s):
    Nucleotide-binding site protein 1
    PYRIN domain and NACHT domain-containing protein 1
    PYRIN-containing APAF1-like protein 2
    Gene namesi
    Name:NLRP2
    Synonyms:NALP2, NBS1, PAN1, PYPAF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:22948. NLRP2.

    Subcellular locationi

    Cytoplasm 2 Publications

    GO - Cellular componenti

    1. cytoplasm Source: HGNC

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162397946.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10621062NACHT, LRR and PYD domains-containing protein 2PRO_0000080888Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei671 – 6711Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NX02.
    PaxDbiQ9NX02.
    PeptideAtlasiQ9NX02.
    PRIDEiQ9NX02.

    PTM databases

    PhosphoSiteiQ9NX02.

    Expressioni

    Tissue specificityi

    Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.1 Publication

    Inductioni

    By interferons and bacterial lipopolysaccharides (LPS).1 Publication

    Gene expression databases

    ArrayExpressiQ9NX02.
    BgeeiQ9NX02.
    CleanExiHS_NLRP2.
    GenevestigatoriQ9NX02.

    Organism-specific databases

    HPAiHPA020765.
    HPA048863.

    Interactioni

    Subunit structurei

    Interacts with CHUK, IKBKB, IKBKG and MEFV, as well as with full-length PYCARD and with the DAPIN domain of NAPL1, but not the full-length protein.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PYDC2Q56P426EBI-6374482,EBI-6374418

    Protein-protein interaction databases

    BioGridi120787. 10 interactions.
    DIPiDIP-42460N.
    IntActiQ9NX02. 1 interaction.
    MINTiMINT-5006655.
    STRINGi9606.ENSP00000263437.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NX02.
    SMRiQ9NX02. Positions 2-94, 204-229, 690-1019.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9494DAPINPROSITE-ProRule annotationAdd
    BLAST
    Domaini207 – 526320NACHTPROSITE-ProRule annotationAdd
    BLAST
    Repeati812 – 83221LRR 1Add
    BLAST
    Repeati841 – 86121LRR 2Add
    BLAST
    Repeati869 – 88921LRR 3Add
    BLAST
    Repeati898 – 91821LRR 4Add
    BLAST
    Repeati926 – 94621LRR 5Add
    BLAST
    Repeati955 – 97622LRR 6Add
    BLAST
    Repeati983 – 100321LRR 7Add
    BLAST
    Repeati1010 – 103324LRR 8Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi518 – 5236Poly-Glu

    Domaini

    The DAPIN domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD.
    When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding.

    Sequence similaritiesi

    Belongs to the NLRP family.Curated
    Contains 1 DAPIN domain.PROSITE-ProRule annotation
    Contains 8 LRR (leucine-rich) repeats.Curated
    Contains 1 NACHT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG146691.
    HOVERGENiHBG103856.
    InParanoidiQ9NX02.
    OMAiELLRCDI.
    PhylomeDBiQ9NX02.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR004020. DAPIN.
    IPR011029. DEATH-like_dom.
    IPR007111. NACHT_NTPase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF02758. PYRIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEiPS50824. DAPIN. 1 hit.
    PS50837. NACHT. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NX02-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA     50
    DGKQLVEILT THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF 100
    NKRKPLSLGI TRKERPPLDV DEMLERFKTE AQAFTETKGN VICLGKEVFK 150
    GKKPDKDNRC RYILKTKFRE MWKSWPGDSK EVQVMAERYK MLIPFSNPRV 200
    LPGPFSYTVV LYGPAGLGKT TLAQKLMLDW AEDNLIHKFK YAFYLSCREL 250
    SRLGPCSFAE LVFRDWPELQ DDIPHILAQA RKILFVIDGF DELGAAPGAL 300
    IEDICGDWEK KKPVPVLLGS LLNRVMLPKA ALLVTTRPRA LRDLRILAEE 350
    PIYIRVEGFL EEDRRAYFLR HFGDEDQAMR AFELMRSNAA LFQLGSAPAV 400
    CWIVCTTLKL QMEKGEDPVP TCLTRTGLFL RFLCSRFPQG AQLRGALRTL 450
    SLLAAQGLWA QTSVLHREDL ERLGVQESDL RLFLDGDILR QDRVSKGCYS 500
    FIHLSFQQFL TALFYTLEKE EEEDRDGHTW DIGDVQKLLS GVERLRNPDL 550
    IQAGYYSFGL ANEKRAKELE ATFGCRMSPD IKQELLRCDI SCKGGHSTVT 600
    DLQELLGCLY ESQEEELVKE VMAQFKEISL HLNAVDVVPS SFCVKHCRNL 650
    QKMSLQVIKE NLPENVTASE SDAEVERSQD DQHMLPFWTD LCSIFGSNKD 700
    LMGLAINDSF LSASLVRILC EQIASDTCHL QRVVFKNISP ADAHRNLCLA 750
    LRGHKTVTYL TLQGNDQDDM FPALCEVLRH PECNLRYLGL VSCSATTQQW 800
    ADLSLALEVN QSLTCVNLSD NELLDEGAKL LYTTLRHPKC FLQRLSLENC 850
    HLTEANCKDL AAVLVVSREL THLCLAKNPI GNTGVKFLCE GLRYPECKLQ 900
    TLVLWNCDIT SDGCCDLTKL LQEKSSLLCL DLGLNHIGVK GMKFLCEALR 950
    KPLCNLRCLW LWGCSIPPFS CEDLCSALSC NQSLVTLDLG QNPLGSSGVK 1000
    MLFETLTCSS GTLRTLRLKI DDFNDELNKL LEEIEEKNPQ LIIDTEKHHP 1050
    WAERPSSHDF MI 1062
    Length:1,062
    Mass (Da):120,515
    Last modified:October 1, 2000 - v1
    Checksum:i4DBB0F6E9C2BC8A7
    GO
    Isoform 2 (identifier: Q9NX02-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         133-154: Missing.

    Show »
    Length:1,040
    Mass (Da):118,138
    Checksum:i0FF49C18762CEDB4
    GO
    Isoform 3 (identifier: Q9NX02-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         847-1062: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:846
    Mass (Da):96,383
    Checksum:i22DD3265062DC0CB
    GO
    Isoform 4 (identifier: Q9NX02-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         109-132: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,038
    Mass (Da):117,674
    Checksum:iAA066954D53827F2
    GO
    Isoform 5 (identifier: Q9NX02-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         47-69: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,039
    Mass (Da):117,883
    Checksum:iB55EABADF1A74126
    GO

    Sequence cautioni

    The sequence BAD92537.1 differs from that shown. Reason: Erroneous prediction of the initiator methionine.
    The sequence BAD92537.1 differs from that shown. Reason: Frameshift at position 769.
    The sequence AAG15253.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA91377.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 11M → V in AAG15253. (PubMed:11270363)Curated
    Sequence conflicti35 – 351L → P in AAG15253. (PubMed:11270363)Curated
    Sequence conflicti46 – 461E → G in BAG64129. (PubMed:14702039)Curated
    Sequence conflicti58 – 581I → V in AAH39269. (PubMed:15489334)Curated
    Sequence conflicti175 – 1751W → C in BAD96973. 1 PublicationCurated
    Sequence conflicti175 – 1751W → C in BAD96989. 1 PublicationCurated
    Sequence conflicti216 – 2161G → S in BAG64129. (PubMed:14702039)Curated
    Sequence conflicti304 – 3041I → S in BAB15293. (PubMed:14702039)Curated
    Sequence conflicti980 – 9801Missing in AAG15253. (PubMed:11270363)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti221 – 2211T → M.
    Corresponds to variant rs17699678 [ dbSNP | Ensembl ].
    VAR_053616
    Natural varianti302 – 3021E → Q.
    Corresponds to variant rs3745904 [ dbSNP | Ensembl ].
    VAR_053617
    Natural varianti364 – 3641R → K.1 Publication
    Corresponds to variant rs4306647 [ dbSNP | Ensembl ].
    VAR_025011
    Natural varianti516 – 5161T → A.1 Publication
    Corresponds to variant rs61735082 [ dbSNP | Ensembl ].
    VAR_068977
    Natural varianti522 – 5221E → G.1 Publication
    Corresponds to variant rs61735083 [ dbSNP | Ensembl ].
    VAR_068978
    Natural varianti529 – 5291T → A.2 Publications
    Corresponds to variant rs34804158 [ dbSNP | Ensembl ].
    VAR_068979
    Natural varianti884 – 8841G → R.
    Corresponds to variant rs59779270 [ dbSNP | Ensembl ].
    VAR_062140
    Natural varianti1052 – 10521A → E.1 Publication
    Corresponds to variant rs1043673 [ dbSNP | Ensembl ].
    VAR_020006

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei47 – 6923Missing in isoform 5. 1 PublicationVSP_044898Add
    BLAST
    Alternative sequencei109 – 13224Missing in isoform 4. 1 PublicationVSP_017085Add
    BLAST
    Alternative sequencei133 – 15422Missing in isoform 2. 1 PublicationVSP_005522Add
    BLAST
    Alternative sequencei847 – 1062216Missing in isoform 3. 1 PublicationVSP_017086Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF298547 mRNA. Translation: AAG15253.1. Different initiation.
    AF310106 mRNA. Translation: AAG30289.1.
    AF464764 mRNA. Translation: AAL69962.1.
    AK000517 mRNA. Translation: BAA91223.1.
    AK000784 mRNA. Translation: BAA91377.1. Different initiation.
    AK025952 mRNA. Translation: BAB15293.1.
    AK302989 mRNA. Translation: BAG64129.1.
    AB209300 mRNA. Translation: BAD92537.1. Sequence problems.
    AK223253 mRNA. Translation: BAD96973.1.
    AK223269 mRNA. Translation: BAD96989.1.
    AC011476 Genomic DNA. No translation available.
    BC001039 mRNA. Translation: AAH01039.1.
    BC003592 mRNA. Translation: AAH03592.1.
    BC039269 mRNA. Translation: AAH39269.1.
    CCDSiCCDS12913.1. [Q9NX02-1]
    CCDS54318.1. [Q9NX02-5]
    CCDS54319.1. [Q9NX02-2]
    RefSeqiNP_001167552.1. NM_001174081.1. [Q9NX02-1]
    NP_001167553.1. NM_001174082.1. [Q9NX02-2]
    NP_001167554.1. NM_001174083.1. [Q9NX02-5]
    NP_060322.1. NM_017852.3. [Q9NX02-1]
    UniGeneiHs.369279.

    Genome annotation databases

    EnsembliENST00000339757; ENSP00000344074; ENSG00000022556. [Q9NX02-2]
    ENST00000391721; ENSP00000375601; ENSG00000022556. [Q9NX02-4]
    ENST00000427260; ENSP00000402474; ENSG00000022556. [Q9NX02-5]
    ENST00000448584; ENSP00000409370; ENSG00000022556. [Q9NX02-1]
    ENST00000537859; ENSP00000440601; ENSG00000022556. [Q9NX02-2]
    ENST00000543010; ENSP00000445135; ENSG00000022556. [Q9NX02-1]
    GeneIDi55655.
    KEGGihsa:55655.
    UCSCiuc002qij.3. human. [Q9NX02-1]
    uc010esn.3. human. [Q9NX02-4]
    uc010esp.3. human. [Q9NX02-2]

    Polymorphism databases

    DMDMi17380148.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF298547 mRNA. Translation: AAG15253.1 . Different initiation.
    AF310106 mRNA. Translation: AAG30289.1 .
    AF464764 mRNA. Translation: AAL69962.1 .
    AK000517 mRNA. Translation: BAA91223.1 .
    AK000784 mRNA. Translation: BAA91377.1 . Different initiation.
    AK025952 mRNA. Translation: BAB15293.1 .
    AK302989 mRNA. Translation: BAG64129.1 .
    AB209300 mRNA. Translation: BAD92537.1 . Sequence problems.
    AK223253 mRNA. Translation: BAD96973.1 .
    AK223269 mRNA. Translation: BAD96989.1 .
    AC011476 Genomic DNA. No translation available.
    BC001039 mRNA. Translation: AAH01039.1 .
    BC003592 mRNA. Translation: AAH03592.1 .
    BC039269 mRNA. Translation: AAH39269.1 .
    CCDSi CCDS12913.1. [Q9NX02-1 ]
    CCDS54318.1. [Q9NX02-5 ]
    CCDS54319.1. [Q9NX02-2 ]
    RefSeqi NP_001167552.1. NM_001174081.1. [Q9NX02-1 ]
    NP_001167553.1. NM_001174082.1. [Q9NX02-2 ]
    NP_001167554.1. NM_001174083.1. [Q9NX02-5 ]
    NP_060322.1. NM_017852.3. [Q9NX02-1 ]
    UniGenei Hs.369279.

    3D structure databases

    ProteinModelPortali Q9NX02.
    SMRi Q9NX02. Positions 2-94, 204-229, 690-1019.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120787. 10 interactions.
    DIPi DIP-42460N.
    IntActi Q9NX02. 1 interaction.
    MINTi MINT-5006655.
    STRINGi 9606.ENSP00000263437.

    PTM databases

    PhosphoSitei Q9NX02.

    Polymorphism databases

    DMDMi 17380148.

    Proteomic databases

    MaxQBi Q9NX02.
    PaxDbi Q9NX02.
    PeptideAtlasi Q9NX02.
    PRIDEi Q9NX02.

    Protocols and materials databases

    DNASUi 55655.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339757 ; ENSP00000344074 ; ENSG00000022556 . [Q9NX02-2 ]
    ENST00000391721 ; ENSP00000375601 ; ENSG00000022556 . [Q9NX02-4 ]
    ENST00000427260 ; ENSP00000402474 ; ENSG00000022556 . [Q9NX02-5 ]
    ENST00000448584 ; ENSP00000409370 ; ENSG00000022556 . [Q9NX02-1 ]
    ENST00000537859 ; ENSP00000440601 ; ENSG00000022556 . [Q9NX02-2 ]
    ENST00000543010 ; ENSP00000445135 ; ENSG00000022556 . [Q9NX02-1 ]
    GeneIDi 55655.
    KEGGi hsa:55655.
    UCSCi uc002qij.3. human. [Q9NX02-1 ]
    uc010esn.3. human. [Q9NX02-4 ]
    uc010esp.3. human. [Q9NX02-2 ]

    Organism-specific databases

    CTDi 55655.
    GeneCardsi GC19P055476.
    HGNCi HGNC:22948. NLRP2.
    HPAi HPA020765.
    HPA048863.
    MIMi 609364. gene.
    neXtProti NX_Q9NX02.
    PharmGKBi PA162397946.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146691.
    HOVERGENi HBG103856.
    InParanoidi Q9NX02.
    OMAi ELLRCDI.
    PhylomeDBi Q9NX02.

    Miscellaneous databases

    GeneWikii NLRP2.
    GenomeRNAii 55655.
    NextBioi 60371.
    PROi Q9NX02.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NX02.
    Bgeei Q9NX02.
    CleanExi HS_NLRP2.
    Genevestigatori Q9NX02.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR004020. DAPIN.
    IPR011029. DEATH-like_dom.
    IPR007111. NACHT_NTPase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF02758. PYRIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    SSF52540. SSF52540. 2 hits.
    PROSITEi PS50824. DAPIN. 1 hit.
    PS50837. NACHT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The PYRIN domain: a novel motif found in apoptosis and inflammation proteins."
      Bertin J., DiStefano P.S.
      Cell Death Differ. 7:1273-1274(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT LYS-364.
    2. "The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation."
      Martinon F., Hofmann K., Tschopp J.
      Curr. Biol. 11:R118-R120(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing."
      Wang L., Manji G.A., Grenier J.M., Al-Garawi A., Merriam S., Lora J.M., Geddes B.J., Briskin M., DiStefano P.S., Bertin J.
      J. Biol. Chem. 277:29874-29880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), VARIANTS ALA-516; GLY-522 AND ALA-529.
      Tissue: Colon, Kidney epithelium and Testis.
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT ALA-529.
      Tissue: Brain and Gastric mucosa.
    6. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT GLU-1052.
      Tissue: Lung, Placenta and Testis.
    8. "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder."
      Agostini L., Martinon F., Burns K., McDermott M.F., Hawkins P.N., Tschopp J.
      Immunity 20:319-325(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PYCARD AND CARD8, SUBCELLULAR LOCATION.
    9. "PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages."
      Bruey J.-M., Bruey-Sedano N., Newman R., Chandler S., Stehlik C., Reed J.C.
      J. Biol. Chem. 279:51897-51907(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CHUK; IKBKB; IKBKG AND PYCARD, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
    10. "The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing."
      Papin S., Cuenin S., Agostini L., Martinon F., Werner S., Beer H.D., Grutter C., Grutter M., Tschopp J.
      Cell Death Differ. 14:1457-1466(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MEFV.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-671, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNALP2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NX02
    Secondary accession number(s): B4DZL7
    , I3L0G4, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 142 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3