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Protein

NACHT, LRR and PYD domains-containing protein 2

Gene

NLRP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi213 – 220ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • Pyrin domain binding Source: HGNC

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Immunity, Inflammatory response, Innate immunity

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000022556-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 2
Alternative name(s):
Nucleotide-binding site protein 1
PYRIN domain and NACHT domain-containing protein 1
PYRIN-containing APAF1-like protein 2
Gene namesi
Name:NLRP2
Synonyms:NALP2, NBS1, PAN1, PYPAF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:22948. NLRP2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • Golgi apparatus Source: HPA
  • intracellular membrane-bounded organelle Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55655.
OpenTargetsiENSG00000022556.
ENSG00000273992.
ENSG00000274638.
ENSG00000275082.
ENSG00000275399.
ENSG00000275796.
ENSG00000275843.
ENSG00000278682.
ENSG00000278789.
PharmGKBiPA162397946.

Polymorphism and mutation databases

BioMutaiNLRP2.
DMDMi17380148.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000808881 – 1062NACHT, LRR and PYD domains-containing protein 2Add BLAST1062

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei671PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NX02.
MaxQBiQ9NX02.
PaxDbiQ9NX02.
PeptideAtlasiQ9NX02.
PRIDEiQ9NX02.

PTM databases

iPTMnetiQ9NX02.
PhosphoSitePlusiQ9NX02.

Expressioni

Tissue specificityi

Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain.1 Publication

Inductioni

By interferons and bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiENSG00000022556.
CleanExiHS_NLRP2.
ExpressionAtlasiQ9NX02. baseline and differential.
GenevisibleiQ9NX02. HS.

Organism-specific databases

HPAiHPA020765.
HPA021183.

Interactioni

Subunit structurei

Interacts with CHUK (PubMed:15456791). Interacts with IKBKB (PubMed:15456791). Interacts with IKBKG (PubMed:15456791). Interacts with MEFV (PubMed:17431422). Interacts with PYCARD (PubMed:15030775, PubMed:15456791). Interacts (via pyrin domain) with PYDC2 (PubMed:17178784). Interacts with CARD8 (PubMed:15030775).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PYDC2Q56P426EBI-6374482,EBI-6374418

GO - Molecular functioni

  • Pyrin domain binding Source: HGNC

Protein-protein interaction databases

BioGridi120787. 19 interactors.
DIPiDIP-42460N.
IntActiQ9NX02. 9 interactors.
MINTiMINT-5006655.
STRINGi9606.ENSP00000409370.

Structurei

3D structure databases

ProteinModelPortaliQ9NX02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 94PyrinPROSITE-ProRule annotationAdd BLAST94
Domaini207 – 526NACHTPROSITE-ProRule annotationAdd BLAST320
Repeati812 – 832LRR 1Add BLAST21
Repeati841 – 861LRR 2Add BLAST21
Repeati869 – 889LRR 3Add BLAST21
Repeati898 – 918LRR 4Add BLAST21
Repeati926 – 946LRR 5Add BLAST21
Repeati955 – 976LRR 6Add BLAST22
Repeati983 – 1003LRR 7Add BLAST21
Repeati1010 – 1033LRR 8Add BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi518 – 523Poly-Glu6

Domaini

When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding.
The pyrin domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD.

Sequence similaritiesi

Belongs to the NLRP family.Curated
Contains 8 LRR (leucine-rich) repeats.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation
Contains 1 pyrin domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IM14. Eukaryota.
ENOG410ZI5C. LUCA.
GeneTreeiENSGT00860000133669.
HOVERGENiHBG103856.
InParanoidiQ9NX02.
KOiK19409.
OMAiEILTSHC.
OrthoDBiEOG091G01Q7.
PhylomeDBiQ9NX02.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 4 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50824. DAPIN. 1 hit.
PS50837. NACHT. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NX02-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA
60 70 80 90 100
DGKQLVEILT THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF
110 120 130 140 150
NKRKPLSLGI TRKERPPLDV DEMLERFKTE AQAFTETKGN VICLGKEVFK
160 170 180 190 200
GKKPDKDNRC RYILKTKFRE MWKSWPGDSK EVQVMAERYK MLIPFSNPRV
210 220 230 240 250
LPGPFSYTVV LYGPAGLGKT TLAQKLMLDW AEDNLIHKFK YAFYLSCREL
260 270 280 290 300
SRLGPCSFAE LVFRDWPELQ DDIPHILAQA RKILFVIDGF DELGAAPGAL
310 320 330 340 350
IEDICGDWEK KKPVPVLLGS LLNRVMLPKA ALLVTTRPRA LRDLRILAEE
360 370 380 390 400
PIYIRVEGFL EEDRRAYFLR HFGDEDQAMR AFELMRSNAA LFQLGSAPAV
410 420 430 440 450
CWIVCTTLKL QMEKGEDPVP TCLTRTGLFL RFLCSRFPQG AQLRGALRTL
460 470 480 490 500
SLLAAQGLWA QTSVLHREDL ERLGVQESDL RLFLDGDILR QDRVSKGCYS
510 520 530 540 550
FIHLSFQQFL TALFYTLEKE EEEDRDGHTW DIGDVQKLLS GVERLRNPDL
560 570 580 590 600
IQAGYYSFGL ANEKRAKELE ATFGCRMSPD IKQELLRCDI SCKGGHSTVT
610 620 630 640 650
DLQELLGCLY ESQEEELVKE VMAQFKEISL HLNAVDVVPS SFCVKHCRNL
660 670 680 690 700
QKMSLQVIKE NLPENVTASE SDAEVERSQD DQHMLPFWTD LCSIFGSNKD
710 720 730 740 750
LMGLAINDSF LSASLVRILC EQIASDTCHL QRVVFKNISP ADAHRNLCLA
760 770 780 790 800
LRGHKTVTYL TLQGNDQDDM FPALCEVLRH PECNLRYLGL VSCSATTQQW
810 820 830 840 850
ADLSLALEVN QSLTCVNLSD NELLDEGAKL LYTTLRHPKC FLQRLSLENC
860 870 880 890 900
HLTEANCKDL AAVLVVSREL THLCLAKNPI GNTGVKFLCE GLRYPECKLQ
910 920 930 940 950
TLVLWNCDIT SDGCCDLTKL LQEKSSLLCL DLGLNHIGVK GMKFLCEALR
960 970 980 990 1000
KPLCNLRCLW LWGCSIPPFS CEDLCSALSC NQSLVTLDLG QNPLGSSGVK
1010 1020 1030 1040 1050
MLFETLTCSS GTLRTLRLKI DDFNDELNKL LEEIEEKNPQ LIIDTEKHHP
1060
WAERPSSHDF MI
Length:1,062
Mass (Da):120,515
Last modified:October 1, 2000 - v1
Checksum:i4DBB0F6E9C2BC8A7
GO
Isoform 2 (identifier: Q9NX02-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-154: Missing.

Show »
Length:1,040
Mass (Da):118,138
Checksum:i0FF49C18762CEDB4
GO
Isoform 3 (identifier: Q9NX02-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     847-1062: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:846
Mass (Da):96,383
Checksum:i22DD3265062DC0CB
GO
Isoform 4 (identifier: Q9NX02-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-132: Missing.

Note: No experimental confirmation available.
Show »
Length:1,038
Mass (Da):117,674
Checksum:iAA066954D53827F2
GO
Isoform 5 (identifier: Q9NX02-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-69: Missing.

Note: No experimental confirmation available.
Show »
Length:1,039
Mass (Da):117,883
Checksum:iB55EABADF1A74126
GO

Sequence cautioni

The sequence AAG15253 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91377 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92537 differs from that shown. Erroneous prediction of the initiator methionine.Curated
The sequence BAD92537 differs from that shown. Reason: Frameshift at position 769.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → V in AAG15253 (PubMed:11270363).Curated1
Sequence conflicti35L → P in AAG15253 (PubMed:11270363).Curated1
Sequence conflicti46E → G in BAG64129 (PubMed:14702039).Curated1
Sequence conflicti58I → V in AAH39269 (PubMed:15489334).Curated1
Sequence conflicti175W → C in BAD96973 (Ref. 5) Curated1
Sequence conflicti175W → C in BAD96989 (Ref. 5) Curated1
Sequence conflicti216G → S in BAG64129 (PubMed:14702039).Curated1
Sequence conflicti304I → S in BAB15293 (PubMed:14702039).Curated1
Sequence conflicti980Missing in AAG15253 (PubMed:11270363).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053616221T → M.Corresponds to variant rs17699678dbSNPEnsembl.1
Natural variantiVAR_053617302E → Q.Corresponds to variant rs3745904dbSNPEnsembl.1
Natural variantiVAR_025011364R → K.1 PublicationCorresponds to variant rs4306647dbSNPEnsembl.1
Natural variantiVAR_068977516T → A.1 PublicationCorresponds to variant rs61735082dbSNPEnsembl.1
Natural variantiVAR_068978522E → G.1 PublicationCorresponds to variant rs61735083dbSNPEnsembl.1
Natural variantiVAR_068979529T → A.2 PublicationsCorresponds to variant rs34804158dbSNPEnsembl.1
Natural variantiVAR_062140884G → R.Corresponds to variant rs59779270dbSNPEnsembl.1
Natural variantiVAR_0200061052A → E.1 PublicationCorresponds to variant rs1043673dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04489847 – 69Missing in isoform 5. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_017085109 – 132Missing in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_005522133 – 154Missing in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_017086847 – 1062Missing in isoform 3. 1 PublicationAdd BLAST216

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298547 mRNA. Translation: AAG15253.1. Different initiation.
AF310106 mRNA. Translation: AAG30289.1.
AF464764 mRNA. Translation: AAL69962.1.
AK000517 mRNA. Translation: BAA91223.1.
AK000784 mRNA. Translation: BAA91377.1. Different initiation.
AK025952 mRNA. Translation: BAB15293.1.
AK302989 mRNA. Translation: BAG64129.1.
AB209300 mRNA. Translation: BAD92537.1. Sequence problems.
AK223253 mRNA. Translation: BAD96973.1.
AK223269 mRNA. Translation: BAD96989.1.
AC011476 Genomic DNA. No translation available.
BC001039 mRNA. Translation: AAH01039.1.
BC003592 mRNA. Translation: AAH03592.1.
BC039269 mRNA. Translation: AAH39269.1.
CCDSiCCDS12913.1. [Q9NX02-1]
CCDS54318.1. [Q9NX02-5]
CCDS54319.1. [Q9NX02-2]
RefSeqiNP_001167552.1. NM_001174081.1. [Q9NX02-1]
NP_001167553.1. NM_001174082.1. [Q9NX02-2]
NP_001167554.1. NM_001174083.1. [Q9NX02-5]
NP_060322.1. NM_017852.3. [Q9NX02-1]
UniGeneiHs.369279.

Genome annotation databases

EnsembliENST00000339757; ENSP00000344074; ENSG00000022556. [Q9NX02-2]
ENST00000391721; ENSP00000375601; ENSG00000022556. [Q9NX02-4]
ENST00000427260; ENSP00000402474; ENSG00000022556. [Q9NX02-5]
ENST00000448584; ENSP00000409370; ENSG00000022556. [Q9NX02-1]
ENST00000537859; ENSP00000440601; ENSG00000022556. [Q9NX02-2]
ENST00000543010; ENSP00000445135; ENSG00000022556. [Q9NX02-1]
ENST00000611410; ENSP00000479220; ENSG00000275843. [Q9NX02-1]
ENST00000611642; ENSP00000484150; ENSG00000275082. [Q9NX02-5]
ENST00000611676; ENSP00000481999; ENSG00000275399. [Q9NX02-2]
ENST00000611679; ENSP00000484354; ENSG00000278682. [Q9NX02-1]
ENST00000611772; ENSP00000479109; ENSG00000278682. [Q9NX02-1]
ENST00000613062; ENSP00000483281; ENSG00000273992. [Q9NX02-1]
ENST00000613485; ENSP00000484351; ENSG00000273992. [Q9NX02-2]
ENST00000613825; ENSP00000483963; ENSG00000274638. [Q9NX02-1]
ENST00000613851; ENSP00000482628; ENSG00000278789. [Q9NX02-5]
ENST00000615173; ENSP00000482889; ENSG00000273992. [Q9NX02-1]
ENST00000615391; ENSP00000481851; ENSG00000275399. [Q9NX02-1]
ENST00000615521; ENSP00000479352; ENSG00000275399. [Q9NX02-1]
ENST00000616040; ENSP00000478876; ENSG00000278789. [Q9NX02-1]
ENST00000616903; ENSP00000482355; ENSG00000275399. [Q9NX02-5]
ENST00000616919; ENSP00000481564; ENSG00000278789. [Q9NX02-2]
ENST00000618018; ENSP00000483886; ENSG00000275843. [Q9NX02-2]
ENST00000618694; ENSP00000482465; ENSG00000275843. [Q9NX02-5]
ENST00000618731; ENSP00000478787; ENSG00000273992. [Q9NX02-2]
ENST00000618789; ENSP00000478318; ENSG00000275796. [Q9NX02-5]
ENST00000618943; ENSP00000482309; ENSG00000274638. [Q9NX02-5]
ENST00000619281; ENSP00000478265; ENSG00000278789. [Q9NX02-1]
ENST00000619454; ENSP00000483528; ENSG00000274638. [Q9NX02-1]
ENST00000619664; ENSP00000478774; ENSG00000275796. [Q9NX02-1]
ENST00000619885; ENSP00000483389; ENSG00000278682. [Q9NX02-2]
ENST00000621057; ENSP00000484382; ENSG00000273992. [Q9NX02-4]
ENST00000621200; ENSP00000479783; ENSG00000275082. [Q9NX02-1]
ENST00000621239; ENSP00000479713; ENSG00000275082. [Q9NX02-1]
ENST00000621594; ENSP00000478450; ENSG00000275843. [Q9NX02-1]
ENST00000622042; ENSP00000482253; ENSG00000275796. [Q9NX02-1]
ENST00000622216; ENSP00000482044; ENSG00000275082. [Q9NX02-2]
ENST00000622444; ENSP00000482065; ENSG00000278682. [Q9NX02-5]
ENST00000622600; ENSP00000482727; ENSG00000274638. [Q9NX02-2]
ENST00000622773; ENSP00000484759; ENSG00000273992. [Q9NX02-5]
ENST00000622864; ENSP00000477726; ENSG00000275796. [Q9NX02-2]
GeneIDi55655.
KEGGihsa:55655.
UCSCiuc002qij.4. human. [Q9NX02-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF298547 mRNA. Translation: AAG15253.1. Different initiation.
AF310106 mRNA. Translation: AAG30289.1.
AF464764 mRNA. Translation: AAL69962.1.
AK000517 mRNA. Translation: BAA91223.1.
AK000784 mRNA. Translation: BAA91377.1. Different initiation.
AK025952 mRNA. Translation: BAB15293.1.
AK302989 mRNA. Translation: BAG64129.1.
AB209300 mRNA. Translation: BAD92537.1. Sequence problems.
AK223253 mRNA. Translation: BAD96973.1.
AK223269 mRNA. Translation: BAD96989.1.
AC011476 Genomic DNA. No translation available.
BC001039 mRNA. Translation: AAH01039.1.
BC003592 mRNA. Translation: AAH03592.1.
BC039269 mRNA. Translation: AAH39269.1.
CCDSiCCDS12913.1. [Q9NX02-1]
CCDS54318.1. [Q9NX02-5]
CCDS54319.1. [Q9NX02-2]
RefSeqiNP_001167552.1. NM_001174081.1. [Q9NX02-1]
NP_001167553.1. NM_001174082.1. [Q9NX02-2]
NP_001167554.1. NM_001174083.1. [Q9NX02-5]
NP_060322.1. NM_017852.3. [Q9NX02-1]
UniGeneiHs.369279.

3D structure databases

ProteinModelPortaliQ9NX02.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120787. 19 interactors.
DIPiDIP-42460N.
IntActiQ9NX02. 9 interactors.
MINTiMINT-5006655.
STRINGi9606.ENSP00000409370.

PTM databases

iPTMnetiQ9NX02.
PhosphoSitePlusiQ9NX02.

Polymorphism and mutation databases

BioMutaiNLRP2.
DMDMi17380148.

Proteomic databases

EPDiQ9NX02.
MaxQBiQ9NX02.
PaxDbiQ9NX02.
PeptideAtlasiQ9NX02.
PRIDEiQ9NX02.

Protocols and materials databases

DNASUi55655.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339757; ENSP00000344074; ENSG00000022556. [Q9NX02-2]
ENST00000391721; ENSP00000375601; ENSG00000022556. [Q9NX02-4]
ENST00000427260; ENSP00000402474; ENSG00000022556. [Q9NX02-5]
ENST00000448584; ENSP00000409370; ENSG00000022556. [Q9NX02-1]
ENST00000537859; ENSP00000440601; ENSG00000022556. [Q9NX02-2]
ENST00000543010; ENSP00000445135; ENSG00000022556. [Q9NX02-1]
ENST00000611410; ENSP00000479220; ENSG00000275843. [Q9NX02-1]
ENST00000611642; ENSP00000484150; ENSG00000275082. [Q9NX02-5]
ENST00000611676; ENSP00000481999; ENSG00000275399. [Q9NX02-2]
ENST00000611679; ENSP00000484354; ENSG00000278682. [Q9NX02-1]
ENST00000611772; ENSP00000479109; ENSG00000278682. [Q9NX02-1]
ENST00000613062; ENSP00000483281; ENSG00000273992. [Q9NX02-1]
ENST00000613485; ENSP00000484351; ENSG00000273992. [Q9NX02-2]
ENST00000613825; ENSP00000483963; ENSG00000274638. [Q9NX02-1]
ENST00000613851; ENSP00000482628; ENSG00000278789. [Q9NX02-5]
ENST00000615173; ENSP00000482889; ENSG00000273992. [Q9NX02-1]
ENST00000615391; ENSP00000481851; ENSG00000275399. [Q9NX02-1]
ENST00000615521; ENSP00000479352; ENSG00000275399. [Q9NX02-1]
ENST00000616040; ENSP00000478876; ENSG00000278789. [Q9NX02-1]
ENST00000616903; ENSP00000482355; ENSG00000275399. [Q9NX02-5]
ENST00000616919; ENSP00000481564; ENSG00000278789. [Q9NX02-2]
ENST00000618018; ENSP00000483886; ENSG00000275843. [Q9NX02-2]
ENST00000618694; ENSP00000482465; ENSG00000275843. [Q9NX02-5]
ENST00000618731; ENSP00000478787; ENSG00000273992. [Q9NX02-2]
ENST00000618789; ENSP00000478318; ENSG00000275796. [Q9NX02-5]
ENST00000618943; ENSP00000482309; ENSG00000274638. [Q9NX02-5]
ENST00000619281; ENSP00000478265; ENSG00000278789. [Q9NX02-1]
ENST00000619454; ENSP00000483528; ENSG00000274638. [Q9NX02-1]
ENST00000619664; ENSP00000478774; ENSG00000275796. [Q9NX02-1]
ENST00000619885; ENSP00000483389; ENSG00000278682. [Q9NX02-2]
ENST00000621057; ENSP00000484382; ENSG00000273992. [Q9NX02-4]
ENST00000621200; ENSP00000479783; ENSG00000275082. [Q9NX02-1]
ENST00000621239; ENSP00000479713; ENSG00000275082. [Q9NX02-1]
ENST00000621594; ENSP00000478450; ENSG00000275843. [Q9NX02-1]
ENST00000622042; ENSP00000482253; ENSG00000275796. [Q9NX02-1]
ENST00000622216; ENSP00000482044; ENSG00000275082. [Q9NX02-2]
ENST00000622444; ENSP00000482065; ENSG00000278682. [Q9NX02-5]
ENST00000622600; ENSP00000482727; ENSG00000274638. [Q9NX02-2]
ENST00000622773; ENSP00000484759; ENSG00000273992. [Q9NX02-5]
ENST00000622864; ENSP00000477726; ENSG00000275796. [Q9NX02-2]
GeneIDi55655.
KEGGihsa:55655.
UCSCiuc002qij.4. human. [Q9NX02-1]

Organism-specific databases

CTDi55655.
DisGeNETi55655.
GeneCardsiNLRP2.
HGNCiHGNC:22948. NLRP2.
HPAiHPA020765.
HPA021183.
MIMi609364. gene.
neXtProtiNX_Q9NX02.
OpenTargetsiENSG00000022556.
ENSG00000273992.
ENSG00000274638.
ENSG00000275082.
ENSG00000275399.
ENSG00000275796.
ENSG00000275843.
ENSG00000278682.
ENSG00000278789.
PharmGKBiPA162397946.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IM14. Eukaryota.
ENOG410ZI5C. LUCA.
GeneTreeiENSGT00860000133669.
HOVERGENiHBG103856.
InParanoidiQ9NX02.
KOiK19409.
OMAiEILTSHC.
OrthoDBiEOG091G01Q7.
PhylomeDBiQ9NX02.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000022556-MONOMER.

Miscellaneous databases

GeneWikiiNLRP2.
GenomeRNAii55655.
PROiQ9NX02.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000022556.
CleanExiHS_NLRP2.
ExpressionAtlasiQ9NX02. baseline and differential.
GenevisibleiQ9NX02. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 2 hits.
3.80.10.10. 1 hit.
InterProiIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 4 hits.
PF02758. PYRIN. 1 hit.
[Graphical view]
SMARTiSM01289. PYRIN. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50824. DAPIN. 1 hit.
PS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNALP2_HUMAN
AccessioniPrimary (citable) accession number: Q9NX02
Secondary accession number(s): B4DZL7
, I3L0G4, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 165 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.