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Q9NX02 (NALP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NACHT, LRR and PYD domains-containing protein 2
Alternative name(s):
Nucleotide-binding site protein 1
PYRIN domain and NACHT domain-containing protein 1
PYRIN-containing APAF1-like protein 2
Gene names
Name:NLRP2
Synonyms:NALP2, NBS1, PAN1, PYPAF2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1062 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Ref.9

Subunit structure

Interacts with CHUK, IKBKB, IKBKG and MEFV, as well as with full-length PYCARD and with the DAPIN domain of NAPL1, but not the full-length protein. Ref.8 Ref.9 Ref.10

Subcellular location

Cytoplasm Ref.8 Ref.9.

Tissue specificity

Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain. Ref.9

Induction

By interferons and bacterial lipopolysaccharides (LPS). Ref.9

Domain

The DAPIN domain is necessary and sufficient for suppression of NFKB1 activation induced by TNF and for inducing IL1B secretion in collaboration with caspase-1. It is involved in interaction with PYCARD.

When isolated, the NACHT domain is involved in interaction with CARD8. This interaction is not detected for the full-length protein, maybe due to autoinhibition, this inhibition might by relieved by an inducible change in protein folding.

Sequence similarities

Belongs to the NLRP family.

Contains 1 DAPIN domain.

Contains 8 LRR (leucine-rich) repeats.

Contains 1 NACHT domain.

Sequence caution

The sequence AAG15253.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA91377.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAD92537.1 differs from that shown. Reason: Frameshift at position 769.

The sequence BAD92537.1 differs from that shown. Reason: Erroneous prediction of the initiator methionine.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PYDC2Q56P426EBI-6374482,EBI-6374418

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NX02-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NX02-2)

The sequence of this isoform differs from the canonical sequence as follows:
     133-154: Missing.
Isoform 3 (identifier: Q9NX02-3)

The sequence of this isoform differs from the canonical sequence as follows:
     847-1062: Missing.
Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 4 (identifier: Q9NX02-4)

The sequence of this isoform differs from the canonical sequence as follows:
     109-132: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: Q9NX02-5)

The sequence of this isoform differs from the canonical sequence as follows:
     47-69: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10621062NACHT, LRR and PYD domains-containing protein 2
PRO_0000080888

Regions

Domain1 – 9494DAPIN
Domain207 – 526320NACHT
Repeat812 – 83221LRR 1
Repeat841 – 86121LRR 2
Repeat869 – 88921LRR 3
Repeat898 – 91821LRR 4
Repeat926 – 94621LRR 5
Repeat955 – 97622LRR 6
Repeat983 – 100321LRR 7
Repeat1010 – 103324LRR 8
Nucleotide binding213 – 2208ATP Potential
Compositional bias518 – 5236Poly-Glu

Amino acid modifications

Modified residue6711Phosphoserine Ref.12

Natural variations

Alternative sequence47 – 6923Missing in isoform 5.
VSP_044898
Alternative sequence109 – 13224Missing in isoform 4.
VSP_017085
Alternative sequence133 – 15422Missing in isoform 2.
VSP_005522
Alternative sequence847 – 1062216Missing in isoform 3.
VSP_017086
Natural variant2211T → M.
Corresponds to variant rs17699678 [ dbSNP | Ensembl ].
VAR_053616
Natural variant3021E → Q.
Corresponds to variant rs3745904 [ dbSNP | Ensembl ].
VAR_053617
Natural variant3641R → K. Ref.1
Corresponds to variant rs4306647 [ dbSNP | Ensembl ].
VAR_025011
Natural variant5161T → A. Ref.4
Corresponds to variant rs61735082 [ dbSNP | Ensembl ].
VAR_068977
Natural variant5221E → G. Ref.4
Corresponds to variant rs61735083 [ dbSNP | Ensembl ].
VAR_068978
Natural variant5291T → A. Ref.4 Ref.5
Corresponds to variant rs34804158 [ dbSNP | Ensembl ].
VAR_068979
Natural variant8841G → R.
Corresponds to variant rs59779270 [ dbSNP | Ensembl ].
VAR_062140
Natural variant10521A → E. Ref.7
Corresponds to variant rs1043673 [ dbSNP | Ensembl ].
VAR_020006

Experimental info

Sequence conflict11M → V in AAG15253. Ref.1
Sequence conflict351L → P in AAG15253. Ref.1
Sequence conflict461E → G in BAG64129. Ref.4
Sequence conflict581I → V in AAH39269. Ref.7
Sequence conflict1751W → C in BAD96973. Ref.5
Sequence conflict1751W → C in BAD96989. Ref.5
Sequence conflict2161G → S in BAG64129. Ref.4
Sequence conflict3041I → S in BAB15293. Ref.4
Sequence conflict9801Missing in AAG15253. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 4DBB0F6E9C2BC8A7

FASTA1,062120,515
        10         20         30         40         50         60 
MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA DGKQLVEILT 

        70         80         90        100        110        120 
THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF NKRKPLSLGI TRKERPPLDV 

       130        140        150        160        170        180 
DEMLERFKTE AQAFTETKGN VICLGKEVFK GKKPDKDNRC RYILKTKFRE MWKSWPGDSK 

       190        200        210        220        230        240 
EVQVMAERYK MLIPFSNPRV LPGPFSYTVV LYGPAGLGKT TLAQKLMLDW AEDNLIHKFK 

       250        260        270        280        290        300 
YAFYLSCREL SRLGPCSFAE LVFRDWPELQ DDIPHILAQA RKILFVIDGF DELGAAPGAL 

       310        320        330        340        350        360 
IEDICGDWEK KKPVPVLLGS LLNRVMLPKA ALLVTTRPRA LRDLRILAEE PIYIRVEGFL 

       370        380        390        400        410        420 
EEDRRAYFLR HFGDEDQAMR AFELMRSNAA LFQLGSAPAV CWIVCTTLKL QMEKGEDPVP 

       430        440        450        460        470        480 
TCLTRTGLFL RFLCSRFPQG AQLRGALRTL SLLAAQGLWA QTSVLHREDL ERLGVQESDL 

       490        500        510        520        530        540 
RLFLDGDILR QDRVSKGCYS FIHLSFQQFL TALFYTLEKE EEEDRDGHTW DIGDVQKLLS 

       550        560        570        580        590        600 
GVERLRNPDL IQAGYYSFGL ANEKRAKELE ATFGCRMSPD IKQELLRCDI SCKGGHSTVT 

       610        620        630        640        650        660 
DLQELLGCLY ESQEEELVKE VMAQFKEISL HLNAVDVVPS SFCVKHCRNL QKMSLQVIKE 

       670        680        690        700        710        720 
NLPENVTASE SDAEVERSQD DQHMLPFWTD LCSIFGSNKD LMGLAINDSF LSASLVRILC 

       730        740        750        760        770        780 
EQIASDTCHL QRVVFKNISP ADAHRNLCLA LRGHKTVTYL TLQGNDQDDM FPALCEVLRH 

       790        800        810        820        830        840 
PECNLRYLGL VSCSATTQQW ADLSLALEVN QSLTCVNLSD NELLDEGAKL LYTTLRHPKC 

       850        860        870        880        890        900 
FLQRLSLENC HLTEANCKDL AAVLVVSREL THLCLAKNPI GNTGVKFLCE GLRYPECKLQ 

       910        920        930        940        950        960 
TLVLWNCDIT SDGCCDLTKL LQEKSSLLCL DLGLNHIGVK GMKFLCEALR KPLCNLRCLW 

       970        980        990       1000       1010       1020 
LWGCSIPPFS CEDLCSALSC NQSLVTLDLG QNPLGSSGVK MLFETLTCSS GTLRTLRLKI 

      1030       1040       1050       1060 
DDFNDELNKL LEEIEEKNPQ LIIDTEKHHP WAERPSSHDF MI 

« Hide

Isoform 2 [UniParc].

Checksum: 0FF49C18762CEDB4
Show »

FASTA1,040118,138
Isoform 3 [UniParc].

Checksum: 22DD3265062DC0CB
Show »

FASTA84696,383
Isoform 4 [UniParc].

Checksum: AA066954D53827F2
Show »

FASTA1,038117,674
Isoform 5 [UniParc].

Checksum: B55EABADF1A74126
Show »

FASTA1,039117,883

References

« Hide 'large scale' references
[1]"The PYRIN domain: a novel motif found in apoptosis and inflammation proteins."
Bertin J., DiStefano P.S.
Cell Death Differ. 7:1273-1274(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT LYS-364.
[2]"The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation."
Martinon F., Hofmann K., Tschopp J.
Curr. Biol. 11:R118-R120(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing."
Wang L., Manji G.A., Grenier J.M., Al-Garawi A., Merriam S., Lora J.M., Geddes B.J., Briskin M., DiStefano P.S., Bertin J.
J. Biol. Chem. 277:29874-29880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), VARIANTS ALA-516; GLY-522 AND ALA-529.
Tissue: Colon, Kidney epithelium and Testis.
[5]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT ALA-529.
Tissue: Brain and Gastric mucosa.
[6]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT GLU-1052.
Tissue: Lung, Placenta and Testis.
[8]"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder."
Agostini L., Martinon F., Burns K., McDermott M.F., Hawkins P.N., Tschopp J.
Immunity 20:319-325(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PYCARD AND CARD8, SUBCELLULAR LOCATION.
[9]"PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages."
Bruey J.-M., Bruey-Sedano N., Newman R., Chandler S., Stehlik C., Reed J.C.
J. Biol. Chem. 279:51897-51907(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CHUK; IKBKB; IKBKG AND PYCARD, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
[10]"The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing."
Papin S., Cuenin S., Agostini L., Martinon F., Werner S., Beer H.D., Grutter C., Grutter M., Tschopp J.
Cell Death Differ. 14:1457-1466(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MEFV.
[11]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-671, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF298547 mRNA. Translation: AAG15253.1. Different initiation.
AF310106 mRNA. Translation: AAG30289.1.
AF464764 mRNA. Translation: AAL69962.1.
AK000517 mRNA. Translation: BAA91223.1.
AK000784 mRNA. Translation: BAA91377.1. Different initiation.
AK025952 mRNA. Translation: BAB15293.1.
AK302989 mRNA. Translation: BAG64129.1.
AB209300 mRNA. Translation: BAD92537.1. Sequence problems.
AK223253 mRNA. Translation: BAD96973.1.
AK223269 mRNA. Translation: BAD96989.1.
AC011476 Genomic DNA. No translation available.
BC001039 mRNA. Translation: AAH01039.1.
BC003592 mRNA. Translation: AAH03592.1.
BC039269 mRNA. Translation: AAH39269.1.
RefSeqNP_001167552.1. NM_001174081.1.
NP_001167553.1. NM_001174082.1.
NP_001167554.1. NM_001174083.1.
NP_060322.1. NM_017852.3.
UniGeneHs.369279.

3D structure databases

ProteinModelPortalQ9NX02.
SMRQ9NX02. Positions 2-94, 632-1045.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120787. 10 interactions.
IntActQ9NX02. 1 interaction.
MINTMINT-5006655.
STRING9606.ENSP00000263437.

PTM databases

PhosphoSiteQ9NX02.

Polymorphism databases

DMDM17380148.

Proteomic databases

PaxDbQ9NX02.
PeptideAtlasQ9NX02.
PRIDEQ9NX02.

Protocols and materials databases

DNASU55655.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339757; ENSP00000344074; ENSG00000022556. [Q9NX02-2]
ENST00000391721; ENSP00000375601; ENSG00000022556. [Q9NX02-4]
ENST00000427260; ENSP00000402474; ENSG00000022556. [Q9NX02-5]
ENST00000448584; ENSP00000409370; ENSG00000022556. [Q9NX02-1]
ENST00000537859; ENSP00000440601; ENSG00000022556. [Q9NX02-2]
ENST00000538819; ENSP00000441133; ENSG00000022556. [Q9NX02-4]
ENST00000543010; ENSP00000445135; ENSG00000022556. [Q9NX02-1]
ENST00000570593; ENSP00000460522; ENSG00000262886. [Q9NX02-2]
ENST00000570685; ENSP00000461424; ENSG00000262615. [Q9NX02-5]
ENST00000571180; ENSP00000460452; ENSG00000262929. [Q9NX02-4]
ENST00000571222; ENSP00000461575; ENSG00000262886. [Q9NX02-2]
ENST00000571225; ENSP00000458740; ENSG00000262811. [Q9NX02-4]
ENST00000571455; ENSP00000461312; ENSG00000262886. [Q9NX02-1]
ENST00000571463; ENSP00000459338; ENSG00000262175. [Q9NX02-4]
ENST00000571477; ENSP00000460381; ENSG00000262615. [Q9NX02-1]
ENST00000571726; ENSP00000459236; ENSG00000262811. [Q9NX02-4]
ENST00000571803; ENSP00000459395; ENSG00000262929. [Q9NX02-1]
ENST00000572005; ENSP00000460139; ENSG00000262329. [Q9NX02-4]
ENST00000572364; ENSP00000460916; ENSG00000262175. [Q9NX02-1]
ENST00000572395; ENSP00000461821; ENSG00000262260. [Q9NX02-2]
ENST00000572489; ENSP00000459160; ENSG00000262260. [Q9NX02-1]
ENST00000572533; ENSP00000461414; ENSG00000262929. [Q9NX02-4]
ENST00000572578; ENSP00000459694; ENSG00000262615. [Q9NX02-2]
ENST00000572889; ENSP00000461004; ENSG00000262329. [Q9NX02-1]
ENST00000572900; ENSP00000461005; ENSG00000262615. [Q9NX02-1]
ENST00000573210; ENSP00000459905; ENSG00000262175. [Q9NX02-2]
ENST00000573459; ENSP00000459970; ENSG00000262811. [Q9NX02-1]
ENST00000573475; ENSP00000460406; ENSG00000262615. [Q9NX02-4]
ENST00000573873; ENSP00000459149; ENSG00000262811. [Q9NX02-5]
ENST00000573958; ENSP00000460195; ENSG00000262175. [Q9NX02-4]
ENST00000574136; ENSP00000461485; ENSG00000262886. [Q9NX02-5]
ENST00000574207; ENSP00000458572; ENSG00000262886. [Q9NX02-1]
ENST00000574360; ENSP00000460511; ENSG00000262260. [Q9NX02-5]
ENST00000574414; ENSP00000461278; ENSG00000262329. [Q9NX02-2]
ENST00000574461; ENSP00000460772; ENSG00000262929. [Q9NX02-2]
ENST00000574477; ENSP00000460785; ENSG00000262615. [Q9NX02-2]
ENST00000574535; ENSP00000459670; ENSG00000262260. [Q9NX02-1]
ENST00000574917; ENSP00000458960; ENSG00000262329. [Q9NX02-4]
ENST00000575196; ENSP00000458701; ENSG00000262615. [Q9NX02-4]
ENST00000575232; ENSP00000460135; ENSG00000262929. [Q9NX02-5]
ENST00000575413; ENSP00000460995; ENSG00000262929. [Q9NX02-2]
ENST00000575438; ENSP00000460021; ENSG00000262175. [Q9NX02-5]
ENST00000575466; ENSP00000459584; ENSG00000262260. [Q9NX02-4]
ENST00000575523; ENSP00000460378; ENSG00000262329. [Q9NX02-2]
ENST00000575835; ENSP00000461657; ENSG00000262329. [Q9NX02-5]
ENST00000576177; ENSP00000459755; ENSG00000262260. [Q9NX02-4]
ENST00000576228; ENSP00000458915; ENSG00000262886. [Q9NX02-4]
ENST00000576464; ENSP00000461311; ENSG00000262175. [Q9NX02-2]
ENST00000576515; ENSP00000459053; ENSG00000262329. [Q9NX02-1]
ENST00000576631; ENSP00000458217; ENSG00000262811. [Q9NX02-1]
ENST00000576647; ENSP00000458345; ENSG00000262929. [Q9NX02-1]
ENST00000576821; ENSP00000459428; ENSG00000262886. [Q9NX02-4]
ENST00000576909; ENSP00000460773; ENSG00000262260. [Q9NX02-2]
ENST00000576923; ENSP00000459402; ENSG00000262811. [Q9NX02-2]
ENST00000576968; ENSP00000458817; ENSG00000262811. [Q9NX02-2]
ENST00000577030; ENSP00000459166; ENSG00000262175. [Q9NX02-1]
ENST00000603135; ENSP00000473922; ENSG00000270370. [Q9NX02-4]
ENST00000603440; ENSP00000474339; ENSG00000270370. [Q9NX02-2]
ENST00000603613; ENSP00000473972; ENSG00000270370. [Q9NX02-1]
ENST00000603681; ENSP00000474069; ENSG00000270370. [Q9NX02-5]
ENST00000604054; ENSP00000474730; ENSG00000270370. [Q9NX02-1]
ENST00000604167; ENSP00000473693; ENSG00000270370. [Q9NX02-2]
ENST00000605842; ENSP00000474835; ENSG00000270370. [Q9NX02-4]
GeneID55655.
KEGGhsa:55655.
UCSCuc002qij.3. human. [Q9NX02-1]
uc010esn.3. human. [Q9NX02-4]
uc010esp.3. human. [Q9NX02-2]

Organism-specific databases

CTD55655.
GeneCardsGC19P055476.
HGNCHGNC:22948. NLRP2.
HPAHPA020765.
HPA048863.
MIM609364. gene.
neXtProtNX_Q9NX02.
PharmGKBPA162397946.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146691.
HOVERGENHBG103856.
InParanoidQ9NX02.
OMAELLRCDI.
PhylomeDBQ9NX02.

Gene expression databases

ArrayExpressQ9NX02.
BgeeQ9NX02.
CleanExHS_NLRP2.
GenevestigatorQ9NX02.

Family and domain databases

Gene3D1.10.533.10. 1 hit.
3.40.50.300. 1 hit.
InterProIPR004020. DAPIN.
IPR011029. DEATH-like_dom.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF02758. PYRIN. 1 hit.
[Graphical view]
SUPFAMSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEPS50824. DAPIN. 1 hit.
PS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNLRP2.
GenomeRNAi55655.
NextBio60371.
PROQ9NX02.
SOURCESearch...

Entry information

Entry nameNALP2_HUMAN
AccessionPrimary (citable) accession number: Q9NX02
Secondary accession number(s): B4DZL7 expand/collapse secondary AC list , I3L0G4, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM