ID   TXN4B_HUMAN             Reviewed;         149 AA.
AC   Q9NX01; D3DWS6;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   27-MAR-2024, entry version 165.
DE   RecName: Full=Thioredoxin-like protein 4B;
DE   AltName: Full=Dim1-like protein;
GN   Name=TXNL4B; Synonyms=DIM2, DLP;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=15161931; DOI=10.1074/jbc.m402522200;
RA   Sun X., Zhang H., Wang D., Ma D., Shen Y., Shang Y.;
RT   "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell
RT   cycle progression.";
RL   J. Biol. Chem. 279:32839-32847(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cervix;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [7]
RP   X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), AND SUBUNIT.
RX   PubMed=16142897; DOI=10.1021/bi050427o;
RA   Simeoni F., Arvai A., Bello P., Gondeau C., Hopfner K.-P., Neyroz P.,
RA   Heitz F., Tainer J., Divita G.;
RT   "Biochemical characterization and crystal structure of a Dim1 family
RT   associated protein: Dim2.";
RL   Biochemistry 44:11997-12008(2005).
CC   -!- FUNCTION: Essential role in pre-mRNA splicing. Required in cell cycle
CC       progression for S/G(2) transition. {ECO:0000269|PubMed:15161931}.
CC   -!- SUBUNIT: Homodimer. Interacts with the U5-102 kDa protein subunit of
CC       the spliceosome. {ECO:0000269|PubMed:16142897}.
CC   -!- INTERACTION:
CC       Q9NX01; Q9NZN9: AIPL1; NbExp=3; IntAct=EBI-10309345, EBI-6557414;
CC       Q9NX01; Q9NXW9: ALKBH4; NbExp=3; IntAct=EBI-10309345, EBI-8637516;
CC       Q9NX01; O14503: BHLHE40; NbExp=3; IntAct=EBI-10309345, EBI-711810;
CC       Q9NX01; Q86UT8: CENATAC; NbExp=6; IntAct=EBI-10309345, EBI-11028020;
CC       Q9NX01; P50221: MEOX1; NbExp=3; IntAct=EBI-10309345, EBI-2864512;
CC       Q9NX01; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10309345, EBI-16439278;
CC       Q9NX01; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-10309345, EBI-79165;
CC       Q9NX01; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-10309345, EBI-742388;
CC       Q9NX01; Q96PV4: PNMA5; NbExp=3; IntAct=EBI-10309345, EBI-10171633;
CC       Q9NX01; Q04864: REL; NbExp=3; IntAct=EBI-10309345, EBI-307352;
CC       Q9NX01; Q15637-4: SF1; NbExp=3; IntAct=EBI-10309345, EBI-12223157;
CC       Q9NX01; Q9NZD8: SPG21; NbExp=6; IntAct=EBI-10309345, EBI-742688;
CC       Q9NX01; P15884: TCF4; NbExp=4; IntAct=EBI-10309345, EBI-533224;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15161931}.
CC   -!- SIMILARITY: Belongs to the DIM1 family. {ECO:0000305}.
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DR   EMBL; AY566808; AAS68520.1; -; mRNA.
DR   EMBL; AK000518; BAA91224.1; -; mRNA.
DR   EMBL; CR457240; CAG33521.1; -; mRNA.
DR   EMBL; CH471166; EAW59191.1; -; Genomic_DNA.
DR   EMBL; CH471166; EAW59192.1; -; Genomic_DNA.
DR   EMBL; BC009646; AAH09646.1; -; mRNA.
DR   CCDS; CCDS10906.1; -.
DR   RefSeq; NP_001135789.1; NM_001142317.1.
DR   RefSeq; NP_001135790.1; NM_001142318.1.
DR   RefSeq; NP_060323.1; NM_017853.2.
DR   PDB; 1XBS; X-ray; 2.50 A; A=1-149.
DR   PDB; 3GIX; X-ray; 1.33 A; A/B=2-149.
DR   PDB; 4IN0; X-ray; 1.33 A; A/B=2-149.
DR   PDBsum; 1XBS; -.
DR   PDBsum; 3GIX; -.
DR   PDBsum; 4IN0; -.
DR   AlphaFoldDB; Q9NX01; -.
DR   SMR; Q9NX01; -.
DR   BioGRID; 120295; 41.
DR   IntAct; Q9NX01; 13.
DR   STRING; 9606.ENSP00000268483; -.
DR   GlyGen; Q9NX01; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q9NX01; -.
DR   PhosphoSitePlus; Q9NX01; -.
DR   BioMuta; TXNL4B; -.
DR   DMDM; 51702156; -.
DR   EPD; Q9NX01; -.
DR   jPOST; Q9NX01; -.
DR   MassIVE; Q9NX01; -.
DR   MaxQB; Q9NX01; -.
DR   PaxDb; 9606-ENSP00000268483; -.
DR   PeptideAtlas; Q9NX01; -.
DR   ProteomicsDB; 83008; -.
DR   Pumba; Q9NX01; -.
DR   Antibodypedia; 30184; 101 antibodies from 23 providers.
DR   DNASU; 54957; -.
DR   Ensembl; ENST00000268483.8; ENSP00000268483.3; ENSG00000140830.9.
DR   Ensembl; ENST00000423037.5; ENSP00000408130.1; ENSG00000140830.9.
DR   Ensembl; ENST00000426362.6; ENSP00000392310.2; ENSG00000140830.9.
DR   GeneID; 54957; -.
DR   KEGG; hsa:54957; -.
DR   MANE-Select; ENST00000268483.8; ENSP00000268483.3; NM_017853.3; NP_060323.1.
DR   UCSC; uc002fca.4; human.
DR   AGR; HGNC:26041; -.
DR   CTD; 54957; -.
DR   DisGeNET; 54957; -.
DR   GeneCards; TXNL4B; -.
DR   HGNC; HGNC:26041; TXNL4B.
DR   HPA; ENSG00000140830; Low tissue specificity.
DR   MIM; 617722; gene.
DR   neXtProt; NX_Q9NX01; -.
DR   OpenTargets; ENSG00000140830; -.
DR   PharmGKB; PA134944912; -.
DR   VEuPathDB; HostDB:ENSG00000140830; -.
DR   eggNOG; KOG3414; Eukaryota.
DR   GeneTree; ENSGT00390000010779; -.
DR   HOGENOM; CLU_117348_1_0_1; -.
DR   InParanoid; Q9NX01; -.
DR   OMA; AMKGKMI; -.
DR   OrthoDB; 3939228at2759; -.
DR   PhylomeDB; Q9NX01; -.
DR   TreeFam; TF332397; -.
DR   PathwayCommons; Q9NX01; -.
DR   SignaLink; Q9NX01; -.
DR   BioGRID-ORCS; 54957; 608 hits in 1149 CRISPR screens.
DR   ChiTaRS; TXNL4B; human.
DR   EvolutionaryTrace; Q9NX01; -.
DR   GeneWiki; TXNL4B; -.
DR   GenomeRNAi; 54957; -.
DR   Pharos; Q9NX01; Tbio.
DR   PRO; PR:Q9NX01; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; Q9NX01; Protein.
DR   Bgee; ENSG00000140830; Expressed in medial globus pallidus and 188 other cell types or tissues.
DR   ExpressionAtlas; Q9NX01; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR   GO; GO:0005682; C:U5 snRNP; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   CDD; cd02986; DLP; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR004123; Dim1.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR12052:SF4; THIOREDOXIN-LIKE PROTEIN 4B; 1.
DR   PANTHER; PTHR12052; THIOREDOXIN-LIKE PROTEN 4A, 4B; 1.
DR   Pfam; PF02966; DIM1; 1.
DR   PIRSF; PIRSF017199; mRNA_splic_U5; 1.
DR   SMART; SM01410; DIM1; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   Genevisible; Q9NX01; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Cell cycle; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..149
FT                   /note="Thioredoxin-like protein 4B"
FT                   /id="PRO_0000218289"
FT   HELIX           11..20
FT                   /evidence="ECO:0007829|PDB:4IN0"
FT   STRAND          23..31
FT                   /evidence="ECO:0007829|PDB:4IN0"
FT   STRAND          33..35
FT                   /evidence="ECO:0007829|PDB:1XBS"
FT   HELIX           36..49
FT                   /evidence="ECO:0007829|PDB:4IN0"
FT   TURN            50..55
FT                   /evidence="ECO:0007829|PDB:4IN0"
FT   STRAND          56..62
FT                   /evidence="ECO:0007829|PDB:4IN0"
FT   TURN            63..65
FT                   /evidence="ECO:0007829|PDB:4IN0"
FT   HELIX           68..72
FT                   /evidence="ECO:0007829|PDB:4IN0"
FT   STRAND          77..85
FT                   /evidence="ECO:0007829|PDB:4IN0"
FT   STRAND          88..93
FT                   /evidence="ECO:0007829|PDB:4IN0"
FT   STRAND          95..97
FT                   /evidence="ECO:0007829|PDB:4IN0"
FT   STRAND          102..104
FT                   /evidence="ECO:0007829|PDB:4IN0"
FT   HELIX           109..124
FT                   /evidence="ECO:0007829|PDB:4IN0"
FT   STRAND          128..131
FT                   /evidence="ECO:0007829|PDB:4IN0"
FT   HELIX           136..138
FT                   /evidence="ECO:0007829|PDB:4IN0"
SQ   SEQUENCE   149 AA;  17015 MW;  4C63CF5C05425738 CRC64;
     MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSS DLSKMAAIYL
     VDVDQTAVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT KFVGSFKTKQ DFIDLIEVIY
     RGAMRGKLIV QSPIDPKNIP KYDLLYQDI
//