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Protein

Thioredoxin-like protein 4B

Gene

TXNL4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G2 transition.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein 4B
Alternative name(s):
Dim1-like protein
Gene namesi
Name:TXNL4B
Synonyms:DIM2, DLP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26041. TXNL4B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944912.

Polymorphism and mutation databases

BioMutaiTXNL4B.
DMDMi51702156.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Thioredoxin-like protein 4BPRO_0000218289Add
BLAST

Proteomic databases

MaxQBiQ9NX01.
PaxDbiQ9NX01.
PRIDEiQ9NX01.

PTM databases

PhosphoSiteiQ9NX01.

Expressioni

Gene expression databases

BgeeiQ9NX01.
CleanExiHS_TXNL4B.
ExpressionAtlasiQ9NX01. baseline and differential.
GenevisibleiQ9NX01. HS.

Interactioni

Subunit structurei

Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BHLHE40O145033EBI-10309345,EBI-711810
PLEKHF2Q9H8W43EBI-10309345,EBI-742388
PNMA5Q96PV43EBI-10309345,EBI-10171633
RELQ048643EBI-10309345,EBI-307352
TCF4P158843EBI-10309345,EBI-533224

Protein-protein interaction databases

BioGridi120295. 13 interactions.
IntActiQ9NX01. 5 interactions.
STRINGi9606.ENSP00000268483.

Structurei

Secondary structure

1
149
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 2010Combined sources
Beta strandi23 – 319Combined sources
Beta strandi33 – 353Combined sources
Helixi36 – 4914Combined sources
Turni50 – 556Combined sources
Beta strandi56 – 627Combined sources
Turni63 – 653Combined sources
Helixi68 – 725Combined sources
Beta strandi77 – 859Combined sources
Beta strandi88 – 936Combined sources
Beta strandi95 – 973Combined sources
Beta strandi102 – 1043Combined sources
Helixi109 – 12416Combined sources
Beta strandi128 – 1314Combined sources
Helixi136 – 1383Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XBSX-ray2.50A1-149[»]
3GIXX-ray1.33A/B2-149[»]
4IN0X-ray1.33A/B2-149[»]
ProteinModelPortaliQ9NX01.
SMRiQ9NX01. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NX01.

Family & Domainsi

Sequence similaritiesi

Belongs to the DIM1 family.Curated

Phylogenomic databases

eggNOGiCOG0526.
GeneTreeiENSGT00390000010779.
HOGENOMiHOG000198385.
HOVERGENiHBG053996.
InParanoidiQ9NX01.
OMAiMSLFLPK.
PhylomeDBiQ9NX01.
TreeFamiTF332397.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR004123. Dim1.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12052. PTHR12052. 1 hit.
PfamiPF02966. DIM1. 1 hit.
[Graphical view]
PIRSFiPIRSF017199. mRNA_splic_U5. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NX01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSS
60 70 80 90 100
DLSKMAAIYL VDVDQTAVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT
110 120 130 140
KFVGSFKTKQ DFIDLIEVIY RGAMRGKLIV QSPIDPKNIP KYDLLYQDI
Length:149
Mass (Da):17,015
Last modified:October 1, 2000 - v1
Checksum:i4C63CF5C05425738
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY566808 mRNA. Translation: AAS68520.1.
AK000518 mRNA. Translation: BAA91224.1.
CR457240 mRNA. Translation: CAG33521.1.
CH471166 Genomic DNA. Translation: EAW59191.1.
CH471166 Genomic DNA. Translation: EAW59192.1.
BC009646 mRNA. Translation: AAH09646.1.
CCDSiCCDS10906.1.
RefSeqiNP_001135789.1. NM_001142317.1.
NP_001135790.1. NM_001142318.1.
NP_060323.1. NM_017853.2.
UniGeneiHs.134406.

Genome annotation databases

EnsembliENST00000268483; ENSP00000268483; ENSG00000140830.
ENST00000423037; ENSP00000408130; ENSG00000140830.
ENST00000426362; ENSP00000392310; ENSG00000140830.
GeneIDi54957.
KEGGihsa:54957.
UCSCiuc002fca.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY566808 mRNA. Translation: AAS68520.1.
AK000518 mRNA. Translation: BAA91224.1.
CR457240 mRNA. Translation: CAG33521.1.
CH471166 Genomic DNA. Translation: EAW59191.1.
CH471166 Genomic DNA. Translation: EAW59192.1.
BC009646 mRNA. Translation: AAH09646.1.
CCDSiCCDS10906.1.
RefSeqiNP_001135789.1. NM_001142317.1.
NP_001135790.1. NM_001142318.1.
NP_060323.1. NM_017853.2.
UniGeneiHs.134406.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XBSX-ray2.50A1-149[»]
3GIXX-ray1.33A/B2-149[»]
4IN0X-ray1.33A/B2-149[»]
ProteinModelPortaliQ9NX01.
SMRiQ9NX01. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120295. 13 interactions.
IntActiQ9NX01. 5 interactions.
STRINGi9606.ENSP00000268483.

PTM databases

PhosphoSiteiQ9NX01.

Polymorphism and mutation databases

BioMutaiTXNL4B.
DMDMi51702156.

Proteomic databases

MaxQBiQ9NX01.
PaxDbiQ9NX01.
PRIDEiQ9NX01.

Protocols and materials databases

DNASUi54957.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268483; ENSP00000268483; ENSG00000140830.
ENST00000423037; ENSP00000408130; ENSG00000140830.
ENST00000426362; ENSP00000392310; ENSG00000140830.
GeneIDi54957.
KEGGihsa:54957.
UCSCiuc002fca.3. human.

Organism-specific databases

CTDi54957.
GeneCardsiGC16M072118.
HGNCiHGNC:26041. TXNL4B.
neXtProtiNX_Q9NX01.
PharmGKBiPA134944912.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0526.
GeneTreeiENSGT00390000010779.
HOGENOMiHOG000198385.
HOVERGENiHBG053996.
InParanoidiQ9NX01.
OMAiMSLFLPK.
PhylomeDBiQ9NX01.
TreeFamiTF332397.

Miscellaneous databases

ChiTaRSiTXNL4B. human.
EvolutionaryTraceiQ9NX01.
GeneWikiiTXNL4B.
GenomeRNAii54957.
NextBioi58148.
PROiQ9NX01.

Gene expression databases

BgeeiQ9NX01.
CleanExiHS_TXNL4B.
ExpressionAtlasiQ9NX01. baseline and differential.
GenevisibleiQ9NX01. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR004123. Dim1.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12052. PTHR12052. 1 hit.
PfamiPF02966. DIM1. 1 hit.
[Graphical view]
PIRSFiPIRSF017199. mRNA_splic_U5. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression."
    Sun X., Zhang H., Wang D., Ma D., Shen Y., Shang Y.
    J. Biol. Chem. 279:32839-32847(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2."
    Simeoni F., Arvai A., Bello P., Gondeau C., Hopfner K.-P., Neyroz P., Heitz F., Tainer J., Divita G.
    Biochemistry 44:11997-12008(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiTXN4B_HUMAN
AccessioniPrimary (citable) accession number: Q9NX01
Secondary accession number(s): D3DWS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2000
Last modified: July 22, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.