SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9NX01

- TXN4B_HUMAN

UniProt

Q9NX01 - TXN4B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Thioredoxin-like protein 4B
Gene
TXNL4B, DIM2, DLP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G2 transition.1 Publication

GO - Biological processi

  1. RNA splicing Source: UniProtKB-KW
  2. mRNA processing Source: UniProtKB-KW
  3. mitotic nuclear division Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle, mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein 4B
Alternative name(s):
Dim1-like protein
Gene namesi
Name:TXNL4B
Synonyms:DIM2, DLP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:26041. TXNL4B.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. spliceosomal complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944912.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Thioredoxin-like protein 4B
PRO_0000218289Add
BLAST

Proteomic databases

MaxQBiQ9NX01.
PaxDbiQ9NX01.
PRIDEiQ9NX01.

PTM databases

PhosphoSiteiQ9NX01.

Expressioni

Gene expression databases

ArrayExpressiQ9NX01.
BgeeiQ9NX01.
CleanExiHS_TXNL4B.
GenevestigatoriQ9NX01.

Interactioni

Subunit structurei

Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome.1 Publication

Protein-protein interaction databases

BioGridi120295. 8 interactions.
STRINGi9606.ENSP00000268483.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 2010
Beta strandi23 – 319
Beta strandi33 – 353
Helixi36 – 4914
Turni50 – 556
Beta strandi56 – 627
Turni63 – 653
Helixi68 – 725
Beta strandi77 – 859
Beta strandi88 – 936
Beta strandi95 – 973
Beta strandi102 – 1043
Helixi109 – 12416
Beta strandi128 – 1314
Helixi136 – 1383

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XBSX-ray2.50A1-149[»]
3GIXX-ray1.33A/B2-149[»]
4IN0X-ray1.33A/B2-149[»]
ProteinModelPortaliQ9NX01.
SMRiQ9NX01. Positions 2-142.

Miscellaneous databases

EvolutionaryTraceiQ9NX01.

Family & Domainsi

Sequence similaritiesi

Belongs to the DIM1 family.

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000198385.
HOVERGENiHBG053996.
InParanoidiQ9NX01.
OMAiMSLFLPK.
PhylomeDBiQ9NX01.
TreeFamiTF332397.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR004123. mRNA_splic_U5.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12052. PTHR12052. 1 hit.
PfamiPF02966. DIM1. 1 hit.
[Graphical view]
PIRSFiPIRSF017199. mRNA_splic_U5. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NX01-1 [UniParc]FASTAAdd to Basket

« Hide

MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSS    50
DLSKMAAIYL VDVDQTAVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT 100
KFVGSFKTKQ DFIDLIEVIY RGAMRGKLIV QSPIDPKNIP KYDLLYQDI 149
Length:149
Mass (Da):17,015
Last modified:October 1, 2000 - v1
Checksum:i4C63CF5C05425738
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY566808 mRNA. Translation: AAS68520.1.
AK000518 mRNA. Translation: BAA91224.1.
CR457240 mRNA. Translation: CAG33521.1.
CH471166 Genomic DNA. Translation: EAW59191.1.
CH471166 Genomic DNA. Translation: EAW59192.1.
BC009646 mRNA. Translation: AAH09646.1.
CCDSiCCDS10906.1.
RefSeqiNP_001135789.1. NM_001142317.1.
NP_001135790.1. NM_001142318.1.
NP_060323.1. NM_017853.2.
UniGeneiHs.134406.

Genome annotation databases

EnsembliENST00000268483; ENSP00000268483; ENSG00000140830.
ENST00000423037; ENSP00000408130; ENSG00000140830.
ENST00000426362; ENSP00000392310; ENSG00000140830.
GeneIDi54957.
KEGGihsa:54957.
UCSCiuc002fca.3. human.

Polymorphism databases

DMDMi51702156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY566808 mRNA. Translation: AAS68520.1 .
AK000518 mRNA. Translation: BAA91224.1 .
CR457240 mRNA. Translation: CAG33521.1 .
CH471166 Genomic DNA. Translation: EAW59191.1 .
CH471166 Genomic DNA. Translation: EAW59192.1 .
BC009646 mRNA. Translation: AAH09646.1 .
CCDSi CCDS10906.1.
RefSeqi NP_001135789.1. NM_001142317.1.
NP_001135790.1. NM_001142318.1.
NP_060323.1. NM_017853.2.
UniGenei Hs.134406.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XBS X-ray 2.50 A 1-149 [» ]
3GIX X-ray 1.33 A/B 2-149 [» ]
4IN0 X-ray 1.33 A/B 2-149 [» ]
ProteinModelPortali Q9NX01.
SMRi Q9NX01. Positions 2-142.
ModBasei Search...

Protein-protein interaction databases

BioGridi 120295. 8 interactions.
STRINGi 9606.ENSP00000268483.

PTM databases

PhosphoSitei Q9NX01.

Polymorphism databases

DMDMi 51702156.

Proteomic databases

MaxQBi Q9NX01.
PaxDbi Q9NX01.
PRIDEi Q9NX01.

Protocols and materials databases

DNASUi 54957.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000268483 ; ENSP00000268483 ; ENSG00000140830 .
ENST00000423037 ; ENSP00000408130 ; ENSG00000140830 .
ENST00000426362 ; ENSP00000392310 ; ENSG00000140830 .
GeneIDi 54957.
KEGGi hsa:54957.
UCSCi uc002fca.3. human.

Organism-specific databases

CTDi 54957.
GeneCardsi GC16M072118.
HGNCi HGNC:26041. TXNL4B.
neXtProti NX_Q9NX01.
PharmGKBi PA134944912.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0526.
HOGENOMi HOG000198385.
HOVERGENi HBG053996.
InParanoidi Q9NX01.
OMAi MSLFLPK.
PhylomeDBi Q9NX01.
TreeFami TF332397.

Miscellaneous databases

ChiTaRSi TXNL4B. human.
EvolutionaryTracei Q9NX01.
GeneWikii TXNL4B.
GenomeRNAii 54957.
NextBioi 58148.
PROi Q9NX01.

Gene expression databases

ArrayExpressi Q9NX01.
Bgeei Q9NX01.
CleanExi HS_TXNL4B.
Genevestigatori Q9NX01.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR004123. mRNA_splic_U5.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR12052. PTHR12052. 1 hit.
Pfami PF02966. DIM1. 1 hit.
[Graphical view ]
PIRSFi PIRSF017199. mRNA_splic_U5. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression."
    Sun X., Zhang H., Wang D., Ma D., Shen Y., Shang Y.
    J. Biol. Chem. 279:32839-32847(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2."
    Simeoni F., Arvai A., Bello P., Gondeau C., Hopfner K.-P., Neyroz P., Heitz F., Tainer J., Divita G.
    Biochemistry 44:11997-12008(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiTXN4B_HUMAN
AccessioniPrimary (citable) accession number: Q9NX01
Secondary accession number(s): D3DWS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi