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Q9NX01

- TXN4B_HUMAN

UniProt

Q9NX01 - TXN4B_HUMAN

Protein

Thioredoxin-like protein 4B

Gene

TXNL4B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G2 transition.1 Publication

    GO - Biological processi

    1. mitotic nuclear division Source: InterPro
    2. mRNA processing Source: UniProtKB-KW
    3. RNA splicing Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, mRNA processing, mRNA splicing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thioredoxin-like protein 4B
    Alternative name(s):
    Dim1-like protein
    Gene namesi
    Name:TXNL4B
    Synonyms:DIM2, DLP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:26041. TXNL4B.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. spliceosomal complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134944912.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 149149Thioredoxin-like protein 4BPRO_0000218289Add
    BLAST

    Proteomic databases

    MaxQBiQ9NX01.
    PaxDbiQ9NX01.
    PRIDEiQ9NX01.

    PTM databases

    PhosphoSiteiQ9NX01.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NX01.
    BgeeiQ9NX01.
    CleanExiHS_TXNL4B.
    GenevestigatoriQ9NX01.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome.1 Publication

    Protein-protein interaction databases

    BioGridi120295. 8 interactions.
    STRINGi9606.ENSP00000268483.

    Structurei

    Secondary structure

    1
    149
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi11 – 2010
    Beta strandi23 – 319
    Beta strandi33 – 353
    Helixi36 – 4914
    Turni50 – 556
    Beta strandi56 – 627
    Turni63 – 653
    Helixi68 – 725
    Beta strandi77 – 859
    Beta strandi88 – 936
    Beta strandi95 – 973
    Beta strandi102 – 1043
    Helixi109 – 12416
    Beta strandi128 – 1314
    Helixi136 – 1383

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1XBSX-ray2.50A1-149[»]
    3GIXX-ray1.33A/B2-149[»]
    4IN0X-ray1.33A/B2-149[»]
    ProteinModelPortaliQ9NX01.
    SMRiQ9NX01. Positions 2-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NX01.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DIM1 family.Curated

    Phylogenomic databases

    eggNOGiCOG0526.
    HOGENOMiHOG000198385.
    HOVERGENiHBG053996.
    InParanoidiQ9NX01.
    OMAiMSLFLPK.
    PhylomeDBiQ9NX01.
    TreeFamiTF332397.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR004123. mRNA_splic_U5.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR12052. PTHR12052. 1 hit.
    PfamiPF02966. DIM1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017199. mRNA_splic_U5. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9NX01-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSS    50
    DLSKMAAIYL VDVDQTAVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT 100
    KFVGSFKTKQ DFIDLIEVIY RGAMRGKLIV QSPIDPKNIP KYDLLYQDI 149
    Length:149
    Mass (Da):17,015
    Last modified:October 1, 2000 - v1
    Checksum:i4C63CF5C05425738
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY566808 mRNA. Translation: AAS68520.1.
    AK000518 mRNA. Translation: BAA91224.1.
    CR457240 mRNA. Translation: CAG33521.1.
    CH471166 Genomic DNA. Translation: EAW59191.1.
    CH471166 Genomic DNA. Translation: EAW59192.1.
    BC009646 mRNA. Translation: AAH09646.1.
    CCDSiCCDS10906.1.
    RefSeqiNP_001135789.1. NM_001142317.1.
    NP_001135790.1. NM_001142318.1.
    NP_060323.1. NM_017853.2.
    UniGeneiHs.134406.

    Genome annotation databases

    EnsembliENST00000268483; ENSP00000268483; ENSG00000140830.
    ENST00000423037; ENSP00000408130; ENSG00000140830.
    ENST00000426362; ENSP00000392310; ENSG00000140830.
    GeneIDi54957.
    KEGGihsa:54957.
    UCSCiuc002fca.3. human.

    Polymorphism databases

    DMDMi51702156.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY566808 mRNA. Translation: AAS68520.1 .
    AK000518 mRNA. Translation: BAA91224.1 .
    CR457240 mRNA. Translation: CAG33521.1 .
    CH471166 Genomic DNA. Translation: EAW59191.1 .
    CH471166 Genomic DNA. Translation: EAW59192.1 .
    BC009646 mRNA. Translation: AAH09646.1 .
    CCDSi CCDS10906.1.
    RefSeqi NP_001135789.1. NM_001142317.1.
    NP_001135790.1. NM_001142318.1.
    NP_060323.1. NM_017853.2.
    UniGenei Hs.134406.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1XBS X-ray 2.50 A 1-149 [» ]
    3GIX X-ray 1.33 A/B 2-149 [» ]
    4IN0 X-ray 1.33 A/B 2-149 [» ]
    ProteinModelPortali Q9NX01.
    SMRi Q9NX01. Positions 2-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120295. 8 interactions.
    STRINGi 9606.ENSP00000268483.

    PTM databases

    PhosphoSitei Q9NX01.

    Polymorphism databases

    DMDMi 51702156.

    Proteomic databases

    MaxQBi Q9NX01.
    PaxDbi Q9NX01.
    PRIDEi Q9NX01.

    Protocols and materials databases

    DNASUi 54957.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000268483 ; ENSP00000268483 ; ENSG00000140830 .
    ENST00000423037 ; ENSP00000408130 ; ENSG00000140830 .
    ENST00000426362 ; ENSP00000392310 ; ENSG00000140830 .
    GeneIDi 54957.
    KEGGi hsa:54957.
    UCSCi uc002fca.3. human.

    Organism-specific databases

    CTDi 54957.
    GeneCardsi GC16M072118.
    HGNCi HGNC:26041. TXNL4B.
    neXtProti NX_Q9NX01.
    PharmGKBi PA134944912.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0526.
    HOGENOMi HOG000198385.
    HOVERGENi HBG053996.
    InParanoidi Q9NX01.
    OMAi MSLFLPK.
    PhylomeDBi Q9NX01.
    TreeFami TF332397.

    Miscellaneous databases

    ChiTaRSi TXNL4B. human.
    EvolutionaryTracei Q9NX01.
    GeneWikii TXNL4B.
    GenomeRNAii 54957.
    NextBioi 58148.
    PROi Q9NX01.

    Gene expression databases

    ArrayExpressi Q9NX01.
    Bgeei Q9NX01.
    CleanExi HS_TXNL4B.
    Genevestigatori Q9NX01.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR004123. mRNA_splic_U5.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR12052. PTHR12052. 1 hit.
    Pfami PF02966. DIM1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017199. mRNA_splic_U5. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression."
      Sun X., Zhang H., Wang D., Ma D., Shen Y., Shang Y.
      J. Biol. Chem. 279:32839-32847(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2."
      Simeoni F., Arvai A., Bello P., Gondeau C., Hopfner K.-P., Neyroz P., Heitz F., Tainer J., Divita G.
      Biochemistry 44:11997-12008(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), SUBUNIT.

    Entry informationi

    Entry nameiTXN4B_HUMAN
    AccessioniPrimary (citable) accession number: Q9NX01
    Secondary accession number(s): D3DWS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3