Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thioredoxin-like protein 4B

Gene

TXNL4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G2 transition.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140830-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein 4B
Alternative name(s):
Dim1-like protein
Gene namesi
Name:TXNL4B
Synonyms:DIM2, DLP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:26041. TXNL4B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140830.
PharmGKBiPA134944912.

Polymorphism and mutation databases

BioMutaiTXNL4B.
DMDMi51702156.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002182891 – 149Thioredoxin-like protein 4BAdd BLAST149

Proteomic databases

EPDiQ9NX01.
MaxQBiQ9NX01.
PaxDbiQ9NX01.
PeptideAtlasiQ9NX01.
PRIDEiQ9NX01.

PTM databases

iPTMnetiQ9NX01.
PhosphoSitePlusiQ9NX01.

Expressioni

Gene expression databases

BgeeiENSG00000140830.
CleanExiHS_TXNL4B.
ExpressionAtlasiQ9NX01. baseline and differential.
GenevisibleiQ9NX01. HS.

Organism-specific databases

HPAiHPA065865.

Interactioni

Subunit structurei

Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
BHLHE40O145033EBI-10309345,EBI-711810
PLEKHF2Q9H8W43EBI-10309345,EBI-742388
PNMA5Q96PV43EBI-10309345,EBI-10171633
RELQ048643EBI-10309345,EBI-307352
TCF4P158843EBI-10309345,EBI-533224

Protein-protein interaction databases

BioGridi120295. 13 interactors.
IntActiQ9NX01. 9 interactors.
STRINGi9606.ENSP00000268483.

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 20Combined sources10
Beta strandi23 – 31Combined sources9
Beta strandi33 – 35Combined sources3
Helixi36 – 49Combined sources14
Turni50 – 55Combined sources6
Beta strandi56 – 62Combined sources7
Turni63 – 65Combined sources3
Helixi68 – 72Combined sources5
Beta strandi77 – 85Combined sources9
Beta strandi88 – 93Combined sources6
Beta strandi95 – 97Combined sources3
Beta strandi102 – 104Combined sources3
Helixi109 – 124Combined sources16
Beta strandi128 – 131Combined sources4
Helixi136 – 138Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XBSX-ray2.50A1-149[»]
3GIXX-ray1.33A/B2-149[»]
4IN0X-ray1.33A/B2-149[»]
ProteinModelPortaliQ9NX01.
SMRiQ9NX01.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NX01.

Family & Domainsi

Sequence similaritiesi

Belongs to the DIM1 family.Curated

Phylogenomic databases

eggNOGiKOG3414. Eukaryota.
ENOG4111FE6. LUCA.
GeneTreeiENSGT00390000010779.
HOGENOMiHOG000198385.
HOVERGENiHBG053996.
InParanoidiQ9NX01.
OMAiMSLFLPK.
OrthoDBiEOG091G0QHA.
PhylomeDBiQ9NX01.
TreeFamiTF332397.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR004123. Dim1.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12052. PTHR12052. 1 hit.
PfamiPF02966. DIM1. 1 hit.
[Graphical view]
PIRSFiPIRSF017199. mRNA_splic_U5. 1 hit.
SMARTiSM01410. DIM1. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NX01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSS
60 70 80 90 100
DLSKMAAIYL VDVDQTAVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT
110 120 130 140
KFVGSFKTKQ DFIDLIEVIY RGAMRGKLIV QSPIDPKNIP KYDLLYQDI
Length:149
Mass (Da):17,015
Last modified:October 1, 2000 - v1
Checksum:i4C63CF5C05425738
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY566808 mRNA. Translation: AAS68520.1.
AK000518 mRNA. Translation: BAA91224.1.
CR457240 mRNA. Translation: CAG33521.1.
CH471166 Genomic DNA. Translation: EAW59191.1.
CH471166 Genomic DNA. Translation: EAW59192.1.
BC009646 mRNA. Translation: AAH09646.1.
CCDSiCCDS10906.1.
RefSeqiNP_001135789.1. NM_001142317.1.
NP_001135790.1. NM_001142318.1.
NP_060323.1. NM_017853.2.
UniGeneiHs.134406.

Genome annotation databases

EnsembliENST00000268483; ENSP00000268483; ENSG00000140830.
ENST00000423037; ENSP00000408130; ENSG00000140830.
ENST00000426362; ENSP00000392310; ENSG00000140830.
GeneIDi54957.
KEGGihsa:54957.
UCSCiuc002fca.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY566808 mRNA. Translation: AAS68520.1.
AK000518 mRNA. Translation: BAA91224.1.
CR457240 mRNA. Translation: CAG33521.1.
CH471166 Genomic DNA. Translation: EAW59191.1.
CH471166 Genomic DNA. Translation: EAW59192.1.
BC009646 mRNA. Translation: AAH09646.1.
CCDSiCCDS10906.1.
RefSeqiNP_001135789.1. NM_001142317.1.
NP_001135790.1. NM_001142318.1.
NP_060323.1. NM_017853.2.
UniGeneiHs.134406.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XBSX-ray2.50A1-149[»]
3GIXX-ray1.33A/B2-149[»]
4IN0X-ray1.33A/B2-149[»]
ProteinModelPortaliQ9NX01.
SMRiQ9NX01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120295. 13 interactors.
IntActiQ9NX01. 9 interactors.
STRINGi9606.ENSP00000268483.

PTM databases

iPTMnetiQ9NX01.
PhosphoSitePlusiQ9NX01.

Polymorphism and mutation databases

BioMutaiTXNL4B.
DMDMi51702156.

Proteomic databases

EPDiQ9NX01.
MaxQBiQ9NX01.
PaxDbiQ9NX01.
PeptideAtlasiQ9NX01.
PRIDEiQ9NX01.

Protocols and materials databases

DNASUi54957.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268483; ENSP00000268483; ENSG00000140830.
ENST00000423037; ENSP00000408130; ENSG00000140830.
ENST00000426362; ENSP00000392310; ENSG00000140830.
GeneIDi54957.
KEGGihsa:54957.
UCSCiuc002fca.4. human.

Organism-specific databases

CTDi54957.
GeneCardsiTXNL4B.
HGNCiHGNC:26041. TXNL4B.
HPAiHPA065865.
neXtProtiNX_Q9NX01.
OpenTargetsiENSG00000140830.
PharmGKBiPA134944912.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3414. Eukaryota.
ENOG4111FE6. LUCA.
GeneTreeiENSGT00390000010779.
HOGENOMiHOG000198385.
HOVERGENiHBG053996.
InParanoidiQ9NX01.
OMAiMSLFLPK.
OrthoDBiEOG091G0QHA.
PhylomeDBiQ9NX01.
TreeFamiTF332397.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000140830-MONOMER.

Miscellaneous databases

ChiTaRSiTXNL4B. human.
EvolutionaryTraceiQ9NX01.
GeneWikiiTXNL4B.
GenomeRNAii54957.
PROiQ9NX01.

Gene expression databases

BgeeiENSG00000140830.
CleanExiHS_TXNL4B.
ExpressionAtlasiQ9NX01. baseline and differential.
GenevisibleiQ9NX01. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR004123. Dim1.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12052. PTHR12052. 1 hit.
PfamiPF02966. DIM1. 1 hit.
[Graphical view]
PIRSFiPIRSF017199. mRNA_splic_U5. 1 hit.
SMARTiSM01410. DIM1. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTXN4B_HUMAN
AccessioniPrimary (citable) accession number: Q9NX01
Secondary accession number(s): D3DWS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.