Q9NX01 (TXN4B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thioredoxin-like protein 4B

Alternative name(s):
Dim1-like protein

Gene names

Name:	TXNL4B
Synonyms:	DIM2, DLP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G2 transition. Ref.1
Subunit structure	Homodimer. Interacts with the U5-102 kDa protein subunit of the spliceosome. Ref.7
Subcellular location	Nucleus Ref.1.
Sequence similarities	Belongs to the DIM1 family.

Ontologies

Keywords
Biological process	Cell cycle mRNA processing mRNA splicing
Cellular component	Nucleus
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: InterPro
Cellular_component	spliceosomal complex Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 149

149

Thioredoxin-like protein 4B

PRO_0000218289

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

149

Helix Strand Turn

Details...

Helix

11 – 20

10

Beta strand

23 – 31

9

Beta strand

33 – 35

3

Helix

36 – 49

14

Turn

50 – 55

6

Beta strand

56 – 62

7

Turn

63 – 65

3

Helix

68 – 72

5

Beta strand

77 – 85

9

Beta strand

88 – 93

6

Beta strand

95 – 97

3

Beta strand

102 – 104

3

Helix

109 – 124

16

Beta strand

128 – 131

4

Helix

136 – 138

3

Sequences

	Sequence		Length	Mass (Da)
	Q9NX01 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 4C63CF5C05425738	FASTA	149	17,015
	10 20 30 40 50 60 MSFLLPKLTS KKEVDQAIKS TAEKVLVLRF GRDEDPVCLQ LDDILSKTSS DLSKMAAIYL 70 80 90 100 110 120 VDVDQTAVYT QYFDISYIPS TVFFFNGQHM KVDYGSPDHT KFVGSFKTKQ DFIDLIEVIY 130 140 RGAMRGKLIV QSPIDPKNIP KYDLLYQDI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression." Sun X., Zhang H., Wang D., Ma D., Shen Y., Shang Y. J. Biol. Chem. 279:32839-32847(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2." Simeoni F., Arvai A., Bello P., Gondeau C., Hopfner K.-P., Neyroz P., Heitz F., Tainer J., Divita G. Biochemistry 44:11997-12008(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS), SUBUNIT.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY566808 mRNA. Translation: AAS68520.1.
AK000518 mRNA. Translation: BAA91224.1.
CR457240 mRNA. Translation: CAG33521.1.
CH471166 Genomic DNA. Translation: EAW59191.1.
CH471166 Genomic DNA. Translation: EAW59192.1.
BC009646 mRNA. Translation: AAH09646.1.

IPI

IPI00016481.

RefSeq

NP_001135789.1. NM_001142317.1.
NP_001135790.1. NM_001142318.1.
NP_060323.1. NM_017853.2.

UniGene

Hs.134406.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XBS	X-ray	2.50	A	1-149	[»]
3GIX	X-ray	1.33	A/B	2-149	[»]
4IN0	X-ray	1.33	A/B	2-149	[»]

ProteinModelPortal

Q9NX01.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000268483.

PTM databases

PhosphoSite

Q9NX01.

Polymorphism databases

DMDM

51702156.

Proteomic databases

PaxDb

Q9NX01.

PRIDE

Q9NX01.

Protocols and materials databases

DNASU

54957.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000268483; ENSP00000268483; ENSG00000140830.
ENST00000423037; ENSP00000408130; ENSG00000140830.
ENST00000426362; ENSP00000392310; ENSG00000140830.

GeneID

54957.

KEGG

hsa:54957.

UCSC

uc002fca.3. human.

Organism-specific databases

CTD

54957.

GeneCards

GC16M072118.

HGNC

HGNC:26041. TXNL4B.

neXtProt

NX_Q9NX01.

PharmGKB

PA134944912.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0526.

HOGENOM

HOG000198385.

HOVERGEN

HBG053996.

InParanoid

Q9NX01.

OMA

MSLFLPK.

OrthoDB

EOG4MSD0G.

PhylomeDB

Q9NX01.

Gene expression databases

ArrayExpress

Q9NX01.

Bgee

Q9NX01.

CleanEx

HS_TXNL4B.

Genevestigator

Q9NX01.

GermOnline

ENSG00000140830. Homo sapiens.

Family and domain databases

Gene3D

3.40.30.10. 1 hit.

InterPro

IPR004123. mRNA_splic_U5.
IPR012336. Thioredoxin-like_fold.
[Graphical view]

PANTHER

PTHR12052. PTHR12052. 1 hit.

Pfam

PF02966. DIM1. 1 hit.
[Graphical view]

PIRSF

PIRSF017199. mRNA_splic_U5. 1 hit.

SUPFAM

SSF52833. Thiordxn-like_fd. 1 hit.

ProtoNet

Search...

Other

ChiTaRS

TXNL4B. human.

EvolutionaryTrace

Q9NX01.

GenomeRNAi

54957.

NextBio

58148.

Entry information

Entry name

TXN4B_HUMAN

Accession

Primary (citable) accession number: Q9NX01
Secondary accession number(s): D3DWS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.