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Protein

Uridine-cytidine kinase-like 1

Gene

UCKL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May contribute to UTP accumulation needed for blast transformation and proliferation.1 Publication

Catalytic activityi

ATP + uridine = ADP + UMP.
ATP + cytidine = ADP + CMP.

Pathwayi: CTP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes CTP from cytidine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Uridine-cytidine kinase 2 (UCK2), Uridine-cytidine kinase (UCK1), Uridine-cytidine kinase, Uridine-cytidine kinase 1 (UCK1), Uridine-cytidine kinase-like 1 (UCKL1), Uridine-cytidine kinase (UCK2)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CTP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from cytidine, the pathway CTP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine-cytidine kinase 2 (UCK2), Uridine-cytidine kinase (UCK1), Uridine-cytidine kinase, Uridine-cytidine kinase 1 (UCK1), Uridine-cytidine kinase-like 1 (UCKL1), Uridine-cytidine kinase (UCK2)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi105 – 112ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processHost-virus interaction
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-73614. Pyrimidine salvage.
UniPathwayiUPA00574; UER00637.
UPA00579; UER00640.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine-cytidine kinase-like 1 (EC:2.7.1.48)
Gene namesi
Name:UCKL1
Synonyms:URKL1
ORF Names:F538
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000198276.13.
HGNCiHGNC:15938. UCKL1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54963.
OpenTargetsiENSG00000198276.
PharmGKBiPA38058.

Chemistry databases

DrugBankiDB01632. Alpha-Phosphoribosylpyrophosphoric Acid.
DB04137. Guanosine-5'-Triphosphate.
DB03419. Uracil.
DB03685. Uridine-5'-Monophosphate.

Polymorphism and mutation databases

BioMutaiUCKL1.
DMDMi84029407.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001644601 – 548Uridine-cytidine kinase-like 1Add BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei63PhosphoserineBy similarity1
Modified residuei539PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated by RNF19B; which induces proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NWZ5.
MaxQBiQ9NWZ5.
PaxDbiQ9NWZ5.
PeptideAtlasiQ9NWZ5.
PRIDEiQ9NWZ5.

PTM databases

iPTMnetiQ9NWZ5.
PhosphoSitePlusiQ9NWZ5.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000198276.
CleanExiHS_UCKL1.
ExpressionAtlasiQ9NWZ5. baseline and differential.
GenevisibleiQ9NWZ5. HS.

Organism-specific databases

HPAiHPA004722.
HPA004769.

Interactioni

Subunit structurei

Interacts with RNF19B and EBV EBNA3.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120301. 18 interactors.
IntActiQ9NWZ5. 4 interactors.
STRINGi9606.ENSP00000346155.

Structurei

3D structure databases

ProteinModelPortaliQ9NWZ5.
SMRiQ9NWZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uridine kinase family.Curated

Phylogenomic databases

eggNOGiKOG4203. Eukaryota.
COG0035. LUCA.
COG0572. LUCA.
GeneTreeiENSGT00390000015696.
HOGENOMiHOG000262757.
HOVERGENiHBG055146.
InParanoidiQ9NWZ5.
KOiK00876.
OMAiCYAGKQI.
OrthoDBiEOG091G04SI.
PhylomeDBiQ9NWZ5.
TreeFamiTF105902.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
cd02023. UMPK. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR000836. PRibTrfase_dom.
IPR006083. PRK/URK.
IPR029057. PRTase-like.
IPR029933. UCKL1.
IPR000764. Uridine_kinase-like.
PANTHERiPTHR10285:SF68. PTHR10285:SF68. 1 hit.
PfamiView protein in Pfam
PF00485. PRK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR00235. udk. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NWZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPPARADA DPSPTSPPTA RDTPGRQAEK SETACEDRSN AESLDRLLPP
60 70 80 90 100
VGTGRSPRKR TTSQCKSEPP LLRTSKRTIY TAGRPPWYNE HGTQSKEAFA
110 120 130 140 150
IGLGGGSASG KTTVARMIIE ALDVPWVVLL SMDSFYKVLT EQQQEQAAHN
160 170 180 190 200
NFNFDHPDAF DFDLIISTLK KLKQGKSVKV PIYDFTTHSR KKDWKTLYGA
210 220 230 240 250
NVIIFEGIMA FADKTLLELL DMKIFVDTDS DIRLVRRLRR DISERGRDIE
260 270 280 290 300
GVIKQYNKFV KPSFDQYIQP TMRLADIVVP RGSGNTVAID LIVQHVHSQL
310 320 330 340 350
EERELSVRAA LASAHQCHPL PRTLSVLKST PQVRGMHTII RDKETSRDEF
360 370 380 390 400
IFYSKRLMRL LIEHALSFLP FQDCVVQTPQ GQDYAGKCYA GKQITGVSIL
410 420 430 440 450
RAGETMEPAL RAVCKDVRIG TILIQTNQLT GEPELHYLRL PKDISDDHVI
460 470 480 490 500
LMDCTVSTGA AAMMAVRVLL DHDVPEDKIF LLSLLMAEMG VHSVAYAFPR
510 520 530 540
VRIITTAVDK RVNDLFRIIP GIGNFGDRYF GTDAVPDGSD EEEVAYTG
Length:548
Mass (Da):61,141
Last modified:September 13, 2005 - v2
Checksum:i0CD0351A802FE199
GO
Isoform 2 (identifier: Q9NWZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     303-548: RELSVRAALA...SDEEEVAYTG → GCAGLGTPVP...DHRCVHSARR

Note: No experimental confirmation available.
Show »
Length:419
Mass (Da):45,972
Checksum:i1D1F11E75305AD25
GO
Isoform 3 (identifier: Q9NWZ5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-395: GKCYAGKQIT → DHRCVHSARR
     396-548: Missing.

Show »
Length:395
Mass (Da):44,568
Checksum:i437D0B1A665CCE30
GO
Isoform 4 (identifier: Q9NWZ5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MAAPPARADADPSPTSPPTARDTPGRQAEKSETACEDR → MSSPPAYPGIRISGCRALGAEGS

Show »
Length:533
Mass (Da):59,466
Checksum:iE578C67A1AB86E15
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti290D → N in CAE54074 (PubMed:12199906).Curated1
Sequence conflicti290D → N in BAA91230 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0431711 – 38MAAPP…ACEDR → MSSPPAYPGIRISGCRALGA EGS in isoform 4. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_021802303 – 548RELSV…VAYTG → GCAGLGTPVPPAAPDAERPE EHAAGTGHAHHHQVRAHLGT GRPRARAPAQLLAPQGQGDQ SRRVHLLLQETDAAAHRARA LLPALSGLRRTDPAGAGLCG QVLCGEADHRCVHSARR in isoform 2. 1 PublicationAdd BLAST246
Alternative sequenceiVSP_025641386 – 395GKCYAGKQIT → DHRCVHSARR in isoform 3. 1 Publication10
Alternative sequenceiVSP_025642396 – 548Missing in isoform 3. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ605558 mRNA. Translation: CAE54074.1.
AK000524 mRNA. Translation: BAA91230.1.
AK303688 mRNA. Translation: BAH14018.1.
AK223220 mRNA. Translation: BAD96940.1.
AL118506 Genomic DNA. Translation: CAI21904.1.
BC033078 mRNA. Translation: AAH33078.1.
CCDSiCCDS13547.1. [Q9NWZ5-1]
CCDS54479.1. [Q9NWZ5-4]
RefSeqiNP_001180308.1. NM_001193379.1. [Q9NWZ5-4]
NP_060329.2. NM_017859.3. [Q9NWZ5-1]
UniGeneiHs.504998.
Hs.695829.

Genome annotation databases

EnsembliENST00000354216; ENSP00000346155; ENSG00000198276. [Q9NWZ5-1]
ENST00000358711; ENSP00000351546; ENSG00000198276. [Q9NWZ5-2]
ENST00000369908; ENSP00000358924; ENSG00000198276. [Q9NWZ5-4]
GeneIDi54963.
KEGGihsa:54963.
UCSCiuc010gkn.4. human. [Q9NWZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUCKL1_HUMAN
AccessioniPrimary (citable) accession number: Q9NWZ5
Secondary accession number(s): B7Z8N2
, Q5JWV0, Q70AQ5, Q8N524, Q9H3Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: September 13, 2005
Last modified: October 25, 2017
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families