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Reviewed, UniProtKB/Swiss-Prot Q9NWZ5 (UCKL1_HUMAN)

Last modified July 7, 2009. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Uridine-cytidine kinase-like 1
    EC=2.7.1.48
Gene names
Name: UCKL1
Synonyms: URKL1
ORF Names: F538
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length548 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May contribute to UTP accumulation needed for blast transformation and proliferation. Ref.1

Catalytic activity

ATP + uridine = ADP + UMP.

ATP + cytidine = ADP + CMP.

Pathway

Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.

Subunit structure

Interacts with RNF19B and EBV EBNA3. Ref.1 Ref.6

Subcellular location

Cytoplasm. Nucleus. Note: EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location. Ref.1

Tissue specificity

Ubiquitous. Ref.1

Post-translational modification

Ubiquitinated by RNF19B; which induces proteasomal degradation. Ref.6

Sequence similarities

Belongs to the uridine kinase family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NWZ5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NWZ5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     303-548: RELSVRAALA...SDEEEVAYTG → GCAGLGTPVP...DHRCVHSARR
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9NWZ5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     386-395: GKCYAGKQIT → DHRCVHSARR
     396-548: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 548548Uridine-cytidine kinase-like 1
PRO_0000164460

Regions

Nucleotide binding105 – 1128ATP Potential

Amino acid modifications

Modified residue161Phosphoserine Ref.7
Modified residue561Phosphoserine Ref.8
Modified residue1071Phosphoserine By similarity

Natural variations

Alternative sequence303 – 548246RELSV…VAYTG → GCAGLGTPVPPAAPDAERPE EHAAGTGHAHHHQVRAHLGT GRPRARAPAQLLAPQGQGDQ SRRVHLLLQETDAAAHRARA LLPALSGLRRTDPAGAGLCG QVLCGEADHRCVHSARR in isoform 2.
VSP_021802
Alternative sequence386 – 39510GKCYAGKQIT → DHRCVHSARR in isoform 3.
VSP_025641
Alternative sequence396 – 548153Missing in isoform 3.
VSP_025642

Experimental info

Sequence conflict2901D → N in CAE54074. Ref.1
Sequence conflict2901D → N in BAA91230. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 13, 2005. Version 2.
Checksum: 0CD0351A802FE199

FASTA54861,141
        10         20         30         40         50         60 
MAAPPARADA DPSPTSPPTA RDTPGRQAEK SETACEDRSN AESLDRLLPP VGTGRSPRKR 

        70         80         90        100        110        120 
TTSQCKSEPP LLRTSKRTIY TAGRPPWYNE HGTQSKEAFA IGLGGGSASG KTTVARMIIE 

       130        140        150        160        170        180 
ALDVPWVVLL SMDSFYKVLT EQQQEQAAHN NFNFDHPDAF DFDLIISTLK KLKQGKSVKV 

       190        200        210        220        230        240 
PIYDFTTHSR KKDWKTLYGA NVIIFEGIMA FADKTLLELL DMKIFVDTDS DIRLVRRLRR 

       250        260        270        280        290        300 
DISERGRDIE GVIKQYNKFV KPSFDQYIQP TMRLADIVVP RGSGNTVAID LIVQHVHSQL 

       310        320        330        340        350        360 
EERELSVRAA LASAHQCHPL PRTLSVLKST PQVRGMHTII RDKETSRDEF IFYSKRLMRL 

       370        380        390        400        410        420 
LIEHALSFLP FQDCVVQTPQ GQDYAGKCYA GKQITGVSIL RAGETMEPAL RAVCKDVRIG 

       430        440        450        460        470        480 
TILIQTNQLT GEPELHYLRL PKDISDDHVI LMDCTVSTGA AAMMAVRVLL DHDVPEDKIF 

       490        500        510        520        530        540 
LLSLLMAEMG VHSVAYAFPR VRIITTAVDK RVNDLFRIIP GIGNFGDRYF GTDAVPDGSD 


EEEVAYTG 

« Hide

Isoform 2.

Checksum: 1D1F11E75305AD25
Show »

FASTA41945,972
Isoform 3.

Checksum: 437D0B1A665CCE30
Show »

FASTA39544,568

References

« Hide 'large scale' references
[1]"Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase."
Kashuba E., Kashuba V., Sandalova T., Klein G., Szekely L.
BMC Cell Biol. 3:23-23(2002) [PubMed: 12199906] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), INTERACTION WITH EBV EBNA3, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, FUNCTION.
Tissue: Heart.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Spleen.
[4]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta.
[6]"NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase."
Fortier J.M., Kornbluth J.
J. Immunol. 176:6454-6463(2006) [PubMed: 16709802] [Abstract]
Cited for: INTERACTION WITH RNF19B, UBIQUITINATION.
[7]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, MASS SPECTROMETRY.
Tissue: Epithelium.
[8]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56, MASS SPECTROMETRY.

Cross-references

Sequence databases

AJ605558 mRNA. Translation: CAE54074.1.
AK000524 mRNA. Translation: BAA91230.1.
AK223220 mRNA. Translation: BAD96940.1.
AL118506 Genomic DNA. Translation: CAI21904.1.
BC033078 mRNA. Translation: AAH33078.1.
IPIIPI00384294.
IPI00844311.
IPI00847664.
RefSeqNP_060329.2.
UniGeneHs.504998

3D structure databases

HSSPHSSP built from PDB template 1JLS based on UniProtKB Q26998.
ModBaseSearch...

PTM databases

PhosphoSiteQ9NWZ5.

Proteomic databases

PRIDEQ9NWZ5.

Genome annotation databases

EnsemblENSG00000198276. Homo sapiens. [Contig view]
GeneID54963.
KEGGhsa:54963.
UCSCuc010gkn.1. human.

Organism-specific databases

GeneCardsGC20M062041.
HGNCHGNC:15938. UCKL1.
HPAHPA004722.
HPA004769.
MIM610866. gene.
PharmGKBPA38058.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9NWZ5.
OMAQ9NWZ5. CEDRSNA.

Enzyme and pathway databases

BRENDA2.7.1.48. 247.

Gene expression databases

ArrayExpressQ9NWZ5.
BgeeQ9NWZ5.
CleanExHS_UCKL1.
GermOnlineENSG00000198276. Homo sapiens.

Family and domain databases

InterProIPR006083. PRK_URK.
IPR000764. Uridine_kinase.
[Graphical view]
PANTHERPTHR10285:SF6. Uridine_kin. 1 hit.
PfamPF00485. PRK. 1 hit.
[Graphical view]
PRINTSPR00988. URIDINKINASE.
TIGRFAMsTIGR00235. udk. 1 hit.
ProtoNetSearch...

Other Resources

NextBio58176.
SOURCESearch...

Entry information

Entry nameUCKL1_HUMAN
AccessionPrimary (citable) accession number: Q9NWZ5
Secondary accession number(s): Q5JWV0 expand/collapse secondary AC list , Q70AQ5, Q8N524, Q9H3Z2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: September 13, 2005
Last modified: July 7, 2009
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents