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Protein

Histone PARylation factor 1

Gene

HPF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP1 and is able to change amino acid specificity toward serine (PubMed:28190768). Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability (PubMed:27067600, PubMed:28190768).2 Publications

GO - Molecular functioni

  • histone binding Source: UniProtKB

GO - Biological processi

  • cellular response to DNA damage stimulus Source: UniProtKB
  • peptidyl-serine ADP-ribosylation Source: UniProtKB
  • regulation of protein ADP-ribosylation Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Histone PARylation factor 11 PublicationImported
Gene namesi
Name:HPF11 PublicationImported
Synonyms:C4orf27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000056050.6.
HGNCiHGNC:26051. HPF1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi238 – 239YR → AA: Loss of ability to bind PARP1 and histones. Abolishes PARP1 ability to mediate ADP-ribosylation. 2 Publications2

Organism-specific databases

OpenTargetsiENSG00000056050.
PharmGKBiPA145149735.

Polymorphism and mutation databases

BioMutaiC4orf27.
DMDMi296434433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002944461 – 346Histone PARylation factor 1Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei19N6-acetyllysineBy similarity1
Modified residuei186N6-acetyllysineCombined sources1
Modified residuei233N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NWY4.
MaxQBiQ9NWY4.
PaxDbiQ9NWY4.
PeptideAtlasiQ9NWY4.
PRIDEiQ9NWY4.

PTM databases

iPTMnetiQ9NWY4.
PhosphoSitePlusiQ9NWY4.

Expressioni

Gene expression databases

BgeeiENSG00000056050.
CleanExiHS_C4orf27.
GenevisibleiQ9NWY4. HS.

Organism-specific databases

HPAiHPA043467.

Interactioni

Subunit structurei

Interacts with PARP1 (via the PARP catalytic domain) (PubMed:27067600). Interacts with histone H2A and histone H3 in a PARP1-dependent manner (PubMed:27067600). Weakly interacts with PARP2 (via the PARP catalytic domain) (PubMed:27067600).1 Publication

GO - Molecular functioni

  • histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120306. 27 interactors.
IntActiQ9NWY4. 2 interactors.
MINTiMINT-1375600.
STRINGi9606.ENSP00000406598.

Structurei

3D structure databases

ProteinModelPortaliQ9NWY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni242 – 346Interaction with PARP11 PublicationAdd BLAST105

Sequence similaritiesi

Belongs to the HPF1 family.Curated

Phylogenomic databases

eggNOGiKOG3952. Eukaryota.
ENOG410XQRN. LUCA.
GeneTreeiENSGT00390000014876.
HOGENOMiHOG000006966.
HOVERGENiHBG107624.
InParanoidiQ9NWY4.
OMAiRPQFIAI.
OrthoDBiEOG091G0Q27.
PhylomeDBiQ9NWY4.
TreeFamiTF317026.

Family and domain databases

InterProiView protein in InterPro
IPR019361. HPF1.
PANTHERiPTHR13386. PTHR13386. 1 hit.
PfamiView protein in Pfam
PF10228. DUF2228. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NWY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGGGGKRRP GGEGPQCEKT TDVKKSKFCE ADVSSDLRKE VENHYKLSLP
60 70 80 90 100
EDFYHFWKFC EELDPEKPSD SLSASLGLQL VGPYDILAGK HKTKKKSTGL
110 120 130 140 150
NFNLHWRFYY DPPEFQTIII GDNKTQYHMG YFRDSPDEFP VYVGINEAKK
160 170 180 190 200
NCIIVPNGDN VFAAVKLFLT KKLREITDKK KINLLKNIDE KLTEAARELG
210 220 230 240 250
YSLEQRTVKM KQRDKKVVTK TFHGAGLVVP VDKNDVGYRE LPETDADLKR
260 270 280 290 300
ICKTIVEAAS DEERLKAFAP IQEMMTFVQF ANDECDYGMG LELGMDLFCY
310 320 330 340
GSHYFHKVAG QLLPLAYNLL KRNLFAEIIE EHLANRSQEN IDQLAA
Length:346
Mass (Da):39,436
Last modified:May 18, 2010 - v2
Checksum:iDF411C9AE254E1E1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033183174R → K3 PublicationsCorresponds to variant dbSNP:rs1047642Ensembl.1
Natural variantiVAR_033184331E → D. Corresponds to variant dbSNP:rs1047706Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136673 mRNA. Translation: CAB66608.1.
AK000541 mRNA. Translation: BAA91241.1.
AC106878 Genomic DNA. No translation available.
BC010367 mRNA. Translation: AAH10367.1.
CCDSiCCDS3813.1.
RefSeqiNP_060337.2. NM_017867.2.
UniGeneiHs.406756.

Genome annotation databases

EnsembliENST00000393381; ENSP00000406598; ENSG00000056050.
GeneIDi54969.
KEGGihsa:54969.
UCSCiuc003isl.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHPF1_HUMAN
AccessioniPrimary (citable) accession number: Q9NWY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 18, 2010
Last modified: September 27, 2017
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries