Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UPF0609 protein C4orf27

Gene

C4orf27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0609 protein C4orf27
Gene namesi
Name:C4orf27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26051. C4orf27.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145149735.

Polymorphism and mutation databases

BioMutaiC4orf27.
DMDMi296434433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346UPF0609 protein C4orf27PRO_0000294446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei19 – 191N6-acetyllysineBy similarity
Modified residuei186 – 1861N6-acetyllysineCombined sources
Modified residuei233 – 2331N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NWY4.
MaxQBiQ9NWY4.
PaxDbiQ9NWY4.
PRIDEiQ9NWY4.

PTM databases

iPTMnetiQ9NWY4.
PhosphoSiteiQ9NWY4.

Expressioni

Gene expression databases

BgeeiQ9NWY4.
CleanExiHS_C4orf27.
GenevisibleiQ9NWY4. HS.

Organism-specific databases

HPAiHPA043467.

Interactioni

Protein-protein interaction databases

BioGridi120306. 8 interactions.
IntActiQ9NWY4. 2 interactions.
MINTiMINT-1375600.
STRINGi9606.ENSP00000406598.

Structurei

3D structure databases

ProteinModelPortaliQ9NWY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0609 family.Curated

Phylogenomic databases

eggNOGiKOG3952. Eukaryota.
ENOG410XQRN. LUCA.
GeneTreeiENSGT00390000014876.
HOGENOMiHOG000006966.
HOVERGENiHBG107624.
InParanoidiQ9NWY4.
OMAiRPQFIAI.
OrthoDBiEOG77M8NQ.
PhylomeDBiQ9NWY4.
TreeFamiTF317026.

Family and domain databases

InterProiIPR019361. DUF2228_C2H2_APLF-like.
[Graphical view]
PANTHERiPTHR13386. PTHR13386. 1 hit.
PfamiPF10228. DUF2228. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NWY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGGGGKRRP GGEGPQCEKT TDVKKSKFCE ADVSSDLRKE VENHYKLSLP
60 70 80 90 100
EDFYHFWKFC EELDPEKPSD SLSASLGLQL VGPYDILAGK HKTKKKSTGL
110 120 130 140 150
NFNLHWRFYY DPPEFQTIII GDNKTQYHMG YFRDSPDEFP VYVGINEAKK
160 170 180 190 200
NCIIVPNGDN VFAAVKLFLT KKLREITDKK KINLLKNIDE KLTEAARELG
210 220 230 240 250
YSLEQRTVKM KQRDKKVVTK TFHGAGLVVP VDKNDVGYRE LPETDADLKR
260 270 280 290 300
ICKTIVEAAS DEERLKAFAP IQEMMTFVQF ANDECDYGMG LELGMDLFCY
310 320 330 340
GSHYFHKVAG QLLPLAYNLL KRNLFAEIIE EHLANRSQEN IDQLAA
Length:346
Mass (Da):39,436
Last modified:May 18, 2010 - v2
Checksum:iDF411C9AE254E1E1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti174 – 1741R → K.3 Publications
Corresponds to variant rs1047642 [ dbSNP | Ensembl ].
VAR_033183
Natural varianti331 – 3311E → D.
Corresponds to variant rs1047706 [ dbSNP | Ensembl ].
VAR_033184

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136673 mRNA. Translation: CAB66608.1.
AK000541 mRNA. Translation: BAA91241.1.
AC106878 Genomic DNA. No translation available.
BC010367 mRNA. Translation: AAH10367.1.
CCDSiCCDS3813.1.
RefSeqiNP_060337.2. NM_017867.2.
UniGeneiHs.406756.

Genome annotation databases

EnsembliENST00000393381; ENSP00000406598; ENSG00000056050.
GeneIDi54969.
KEGGihsa:54969.
UCSCiuc003isl.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136673 mRNA. Translation: CAB66608.1.
AK000541 mRNA. Translation: BAA91241.1.
AC106878 Genomic DNA. No translation available.
BC010367 mRNA. Translation: AAH10367.1.
CCDSiCCDS3813.1.
RefSeqiNP_060337.2. NM_017867.2.
UniGeneiHs.406756.

3D structure databases

ProteinModelPortaliQ9NWY4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120306. 8 interactions.
IntActiQ9NWY4. 2 interactions.
MINTiMINT-1375600.
STRINGi9606.ENSP00000406598.

PTM databases

iPTMnetiQ9NWY4.
PhosphoSiteiQ9NWY4.

Polymorphism and mutation databases

BioMutaiC4orf27.
DMDMi296434433.

Proteomic databases

EPDiQ9NWY4.
MaxQBiQ9NWY4.
PaxDbiQ9NWY4.
PRIDEiQ9NWY4.

Protocols and materials databases

DNASUi54969.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393381; ENSP00000406598; ENSG00000056050.
GeneIDi54969.
KEGGihsa:54969.
UCSCiuc003isl.5. human.

Organism-specific databases

CTDi54969.
GeneCardsiC4orf27.
H-InvDBHIX0004633.
HIX0163998.
HGNCiHGNC:26051. C4orf27.
HPAiHPA043467.
neXtProtiNX_Q9NWY4.
PharmGKBiPA145149735.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3952. Eukaryota.
ENOG410XQRN. LUCA.
GeneTreeiENSGT00390000014876.
HOGENOMiHOG000006966.
HOVERGENiHBG107624.
InParanoidiQ9NWY4.
OMAiRPQFIAI.
OrthoDBiEOG77M8NQ.
PhylomeDBiQ9NWY4.
TreeFamiTF317026.

Miscellaneous databases

GenomeRNAii54969.
PROiQ9NWY4.

Gene expression databases

BgeeiQ9NWY4.
CleanExiHS_C4orf27.
GenevisibleiQ9NWY4. HS.

Family and domain databases

InterProiIPR019361. DUF2228_C2H2_APLF-like.
[Graphical view]
PANTHERiPTHR13386. PTHR13386. 1 hit.
PfamiPF10228. DUF2228. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-174.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-174.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-174.
    Tissue: Skin.
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-186 AND LYS-233, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCD027_HUMAN
AccessioniPrimary (citable) accession number: Q9NWY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.