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Protein

Ankyrin repeat and SOCS box protein 6

Gene

ASB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 6
Short name:
ASB-6
Gene namesi
Name:ASB6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:17181. ASB6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25034.

Polymorphism and mutation databases

BioMutaiASB6.
DMDMi41688801.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Ankyrin repeat and SOCS box protein 6PRO_0000066933Add
BLAST

Proteomic databases

EPDiQ9NWX5.
MaxQBiQ9NWX5.
PaxDbiQ9NWX5.
PeptideAtlasiQ9NWX5.
PRIDEiQ9NWX5.

PTM databases

iPTMnetiQ9NWX5.
PhosphoSiteiQ9NWX5.

Expressioni

Gene expression databases

BgeeiENSG00000148331.
CleanExiHS_ASB6.
ExpressionAtlasiQ9NWX5. baseline and differential.
GenevisibleiQ9NWX5. HS.

Organism-specific databases

HPAiHPA004341.

Interactioni

Subunit structurei

Binds APS. Identified in a complex with TCEB1 and TCEB2 (By similarity). Interacts with CUL5 and RNF7.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-6425205,EBI-10175124
L3MBTL3Q96JM73EBI-6425205,EBI-2686809
RNF41Q9H4P43EBI-6425205,EBI-2130266

Protein-protein interaction databases

BioGridi126612. 50 interactions.
IntActiQ9NWX5. 7 interactions.
MINTiMINT-1500280.
STRINGi9606.ENSP00000277458.

Structurei

3D structure databases

ProteinModelPortaliQ9NWX5.
SMRiQ9NWX5. Positions 39-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati67 – 9731ANK 1Add
BLAST
Repeati102 – 13130ANK 2Add
BLAST
Repeati136 – 16631ANK 3Add
BLAST
Repeati170 – 20536ANK 4Add
BLAST
Repeati226 – 25530ANK 5Add
BLAST
Repeati260 – 28930ANK 6Add
BLAST
Domaini360 – 41556SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000006784.
HOGENOMiHOG000152147.
HOVERGENiHBG037329.
InParanoidiQ9NWX5.
KOiK10328.
OMAiFCFQVTQ.
OrthoDBiEOG091G07QG.
PhylomeDBiQ9NWX5.
TreeFamiTF330837.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NWX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPFLHGFRRI IFEYQPLVDA ILGSLGIQDP ERQESLDRPS YVASEESRIL
60 70 80 90 100
VLTELLERKA HSPFYQEGVS NALLKMAELG LTRAADVLLR HGANLNFEDP
110 120 130 140 150
VTYYTALHIA VLRNQPDMVE LLVHHGADVN RRDRIHESSP LDLASEEPER
160 170 180 190 200
LPCLQRLLDL GADVNAADKH GKTALLHALA SSDGVQIHNT ENIRLLLEGG
210 220 230 240 250
ADVKATTKDG DTVFTCIIFL LGETVGGDKE EAQMINRFCF QVTRLLLAHG
260 270 280 290 300
ADPSECPAHE SLTHICLKSF KLHFPLLRFL LESGAAYNCS LHGASCWSGF
310 320 330 340 350
HIIFERLCSH PGCTEDESHA DLLRKAETVL DLMVTNSQKL QLPENFDIHP
360 370 380 390 400
VGSLAEKIQA LHFSLRQLES YPPPLKHLCR VAIRLYLQPW PVDVKVKALP
410 420
LPDRLKWYLL SEHSGSVEDD I
Length:421
Mass (Da):47,136
Last modified:October 1, 2000 - v1
Checksum:i2DBAF086B54FF1CB
GO
Isoform 2 (identifier: Q9NWX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-421: IHESSPLDLA...EHSGSVEDDI → EKLLCSMLWP...PWEGTKRRPR

Note: No experimental confirmation available.
Show »
Length:197
Mass (Da):22,373
Checksum:iDFF0F90AE956C069
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei135 – 421287IHESS…VEDDI → EKLLCSMLWPAATGCRSTIL RTFVSYWKEGQTSRPPPKMG TQCSPASSSCLVRPWEGTKR RPR in isoform 2. 1 PublicationVSP_042006Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000555 mRNA. Translation: BAA91250.1.
AK023004 mRNA. Translation: BAB14355.1.
AL590369 Genomic DNA. Translation: CAI14509.1.
AL590369 Genomic DNA. Translation: CAI14510.1.
CH471090 Genomic DNA. Translation: EAW87899.1.
CH471090 Genomic DNA. Translation: EAW87900.1.
BC001719 mRNA. Translation: AAH01719.1.
BC065913 mRNA. Translation: AAH65913.1.
CCDSiCCDS6924.1. [Q9NWX5-1]
CCDS6925.1. [Q9NWX5-2]
RefSeqiNP_001189332.1. NM_001202403.1.
NP_060343.1. NM_017873.3. [Q9NWX5-1]
NP_821066.1. NM_177999.2. [Q9NWX5-2]
UniGeneiHs.125037.

Genome annotation databases

EnsembliENST00000277458; ENSP00000277458; ENSG00000148331. [Q9NWX5-1]
ENST00000277459; ENSP00000277459; ENSG00000148331. [Q9NWX5-2]
GeneIDi140459.
KEGGihsa:140459.
UCSCiuc004byf.3. human. [Q9NWX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000555 mRNA. Translation: BAA91250.1.
AK023004 mRNA. Translation: BAB14355.1.
AL590369 Genomic DNA. Translation: CAI14509.1.
AL590369 Genomic DNA. Translation: CAI14510.1.
CH471090 Genomic DNA. Translation: EAW87899.1.
CH471090 Genomic DNA. Translation: EAW87900.1.
BC001719 mRNA. Translation: AAH01719.1.
BC065913 mRNA. Translation: AAH65913.1.
CCDSiCCDS6924.1. [Q9NWX5-1]
CCDS6925.1. [Q9NWX5-2]
RefSeqiNP_001189332.1. NM_001202403.1.
NP_060343.1. NM_017873.3. [Q9NWX5-1]
NP_821066.1. NM_177999.2. [Q9NWX5-2]
UniGeneiHs.125037.

3D structure databases

ProteinModelPortaliQ9NWX5.
SMRiQ9NWX5. Positions 39-290.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126612. 50 interactions.
IntActiQ9NWX5. 7 interactions.
MINTiMINT-1500280.
STRINGi9606.ENSP00000277458.

PTM databases

iPTMnetiQ9NWX5.
PhosphoSiteiQ9NWX5.

Polymorphism and mutation databases

BioMutaiASB6.
DMDMi41688801.

Proteomic databases

EPDiQ9NWX5.
MaxQBiQ9NWX5.
PaxDbiQ9NWX5.
PeptideAtlasiQ9NWX5.
PRIDEiQ9NWX5.

Protocols and materials databases

DNASUi140459.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277458; ENSP00000277458; ENSG00000148331. [Q9NWX5-1]
ENST00000277459; ENSP00000277459; ENSG00000148331. [Q9NWX5-2]
GeneIDi140459.
KEGGihsa:140459.
UCSCiuc004byf.3. human. [Q9NWX5-1]

Organism-specific databases

CTDi140459.
GeneCardsiASB6.
HGNCiHGNC:17181. ASB6.
HPAiHPA004341.
MIMi615051. gene.
neXtProtiNX_Q9NWX5.
PharmGKBiPA25034.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00390000006784.
HOGENOMiHOG000152147.
HOVERGENiHBG037329.
InParanoidiQ9NWX5.
KOiK10328.
OMAiFCFQVTQ.
OrthoDBiEOG091G07QG.
PhylomeDBiQ9NWX5.
TreeFamiTF330837.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiASB6. human.
GeneWikiiASB6.
GenomeRNAii140459.
PROiQ9NWX5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148331.
CleanExiHS_ASB6.
ExpressionAtlasiQ9NWX5. baseline and differential.
GenevisibleiQ9NWX5. HS.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001496. SOCS_box.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASB6_HUMAN
AccessioniPrimary (citable) accession number: Q9NWX5
Secondary accession number(s): Q5SZB7, Q9BV15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.