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Protein

Uncharacterized protein C2orf42

Gene

C2orf42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C2orf42
Gene namesi
Name:C2orf42
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:26056. C2orf42.

Subcellular locationi

GO - Cellular componenti

  1. nuclear membrane Source: HPA
  2. nucleoplasm Source: HPA
  3. nucleus Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147358740.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 574574Uncharacterized protein C2orf42PRO_0000300121Add
BLAST

Proteomic databases

MaxQBiQ9NWW7.
PaxDbiQ9NWW7.
PRIDEiQ9NWW7.

PTM databases

PhosphoSiteiQ9NWW7.

Expressioni

Gene expression databases

BgeeiQ9NWW7.
ExpressionAtlasiQ9NWW7. baseline and differential.
GenevestigatoriQ9NWW7.

Organism-specific databases

HPAiHPA031840.
HPA031841.
HPA031842.

Interactioni

Protein-protein interaction databases

BioGridi120316. 3 interactions.
IntActiQ9NWW7. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9NWW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG82445.
GeneTreeiENSGT00390000011031.
HOGENOMiHOG000060318.
HOVERGENiHBG100869.
InParanoidiQ9NWW7.
OMAiSLKRQAC.
OrthoDBiEOG7N8ZW0.
PhylomeDBiQ9NWW7.
TreeFamiTF323774.

Family and domain databases

InterProiIPR026049. C2orf42.
IPR029269. Zf-tcix.
[Graphical view]
PANTHERiPTHR13518. PTHR13518. 1 hit.
PfamiPF14952. zf-tcix. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NWW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPNSLRTKV PAFLSDLGKA TLRGIRKCPR CGTYNGTRGL SCKNKTCGTI
60 70 80 90 100
FRYGARKQPS VEAVKIITGS DLQVYSVRQR DRGPDYRCFV ELGVSETTIQ
110 120 130 140 150
TVDGTIITQL SSGRCYVPSC LKAATQGVVE NQCQHIKLAV NCQAEATPLT
160 170 180 190 200
LKSSVLNAMQ ASPETKQTIW QLATEPTGPL VQRITKNILV VKCKASQKHS
210 220 230 240 250
LGYLHTSFVQ KVSGKSLPER RFFCSCQTLK SHKSNASKDE TAQRCIHFFA
260 270 280 290 300
CICAFASDET LAQEFSDFLN FDSSGLKEII VPQLGCHSES TVSACESTAS
310 320 330 340 350
KSKKRRKDEV SGAQMNSSLL PQDAVSSNLR KSGLKKPVVA SSLKRQACGQ
360 370 380 390 400
LLDEAQVTLS FQDWLASVTE RIHQTMHYQF DGKPEPLVFH IPQSFFDALQ
410 420 430 440 450
QRISIGSAKK RLPNSTTAFV RKDALPLGTF SKYTWHITNI LQVKQILDTP
460 470 480 490 500
EMPLEITRSF IQNRDGTYEL FKCPKVEVES IAETYGRIEK QPVLRPLELK
510 520 530 540 550
TFLKVGNTSP DQKEPTPFII EWIPDILPQS KIGELRIKFE YGHHRNGHVA
560 570
EYQDQRPPLD QPLELAPLTT ITFP
Length:574
Mass (Da):64,077
Last modified:October 1, 2000 - v1
Checksum:i53F6B0495328D7AA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti314 – 3141Q → P.
Corresponds to variant rs3213941 [ dbSNP | Ensembl ].
VAR_050712

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136834 mRNA. Translation: CAB66768.1.
AK000565 mRNA. Translation: BAA91258.1.
AK026303 mRNA. Translation: BAB15438.1.
AC016700 Genomic DNA. Translation: AAX93192.1.
CH471053 Genomic DNA. Translation: EAW99830.1.
CH471053 Genomic DNA. Translation: EAW99831.1.
BC002825 mRNA. Translation: AAH02825.1.
BC005079 mRNA. Translation: AAH05079.1.
CCDSiCCDS1899.1.
RefSeqiNP_060350.1. NM_017880.1.
XP_005264446.1. XM_005264389.1.
XP_005264447.1. XM_005264390.1.
XP_005264448.1. XM_005264391.1.
UniGeneiHs.720049.

Genome annotation databases

EnsembliENST00000264434; ENSP00000264434; ENSG00000115998.
ENST00000420306; ENSP00000404515; ENSG00000115998.
GeneIDi54980.
KEGGihsa:54980.
UCSCiuc002sgh.3. human.

Polymorphism databases

DMDMi74734680.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136834 mRNA. Translation: CAB66768.1.
AK000565 mRNA. Translation: BAA91258.1.
AK026303 mRNA. Translation: BAB15438.1.
AC016700 Genomic DNA. Translation: AAX93192.1.
CH471053 Genomic DNA. Translation: EAW99830.1.
CH471053 Genomic DNA. Translation: EAW99831.1.
BC002825 mRNA. Translation: AAH02825.1.
BC005079 mRNA. Translation: AAH05079.1.
CCDSiCCDS1899.1.
RefSeqiNP_060350.1. NM_017880.1.
XP_005264446.1. XM_005264389.1.
XP_005264447.1. XM_005264390.1.
XP_005264448.1. XM_005264391.1.
UniGeneiHs.720049.

3D structure databases

ProteinModelPortaliQ9NWW7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120316. 3 interactions.
IntActiQ9NWW7. 2 interactions.

PTM databases

PhosphoSiteiQ9NWW7.

Polymorphism databases

DMDMi74734680.

Proteomic databases

MaxQBiQ9NWW7.
PaxDbiQ9NWW7.
PRIDEiQ9NWW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264434; ENSP00000264434; ENSG00000115998.
ENST00000420306; ENSP00000404515; ENSG00000115998.
GeneIDi54980.
KEGGihsa:54980.
UCSCiuc002sgh.3. human.

Organism-specific databases

CTDi54980.
GeneCardsiGC02M070377.
HGNCiHGNC:26056. C2orf42.
HPAiHPA031840.
HPA031841.
HPA031842.
neXtProtiNX_Q9NWW7.
PharmGKBiPA147358740.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG82445.
GeneTreeiENSGT00390000011031.
HOGENOMiHOG000060318.
HOVERGENiHBG100869.
InParanoidiQ9NWW7.
OMAiSLKRQAC.
OrthoDBiEOG7N8ZW0.
PhylomeDBiQ9NWW7.
TreeFamiTF323774.

Miscellaneous databases

GenomeRNAii54980.
NextBioi58246.

Gene expression databases

BgeeiQ9NWW7.
ExpressionAtlasiQ9NWW7. baseline and differential.
GenevestigatoriQ9NWW7.

Family and domain databases

InterProiIPR026049. C2orf42.
IPR029269. Zf-tcix.
[Graphical view]
PANTHERiPTHR13518. PTHR13518. 1 hit.
PfamiPF14952. zf-tcix. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Signet-ring cell carcinoma and Small intestine.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Skin.

Entry informationi

Entry nameiCB042_HUMAN
AccessioniPrimary (citable) accession number: Q9NWW7
Secondary accession number(s): D6W5G3, Q9H629
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: March 4, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.