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Q9NWW0 (HPIP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Host cell factor C1 regulator 1
Alternative name(s):
HCF-1 beta-propeller-interacting protein
Gene names
Name:HCFC1R1
Synonyms:HPIP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus. Ref.1

Subunit structure

Interacts with HCFC1. Ref.1

Subcellular location

Cytoplasm. Nucleus. Note: Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Ref.1

Tissue specificity

Widely expressed. Ref.1

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NWW0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NWW0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     32-51: SSPLRGAVPMSTKRRLEEEQ → R

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 138138Host cell factor C1 regulator 1
PRO_0000338978

Regions

Region76 – 794Interaction with HCFC1
Motif110 – 11910Nuclear export signal

Natural variations

Alternative sequence32 – 5120SSPLR…LEEEQ → R in isoform 2.
VSP_034082
Natural variant921P → Q. Ref.5
Corresponds to variant rs10508 [ dbSNP | Ensembl ].
VAR_043849

Experimental info

Mutagenesis76 – 794DHPY → AAPA: Loss of interaction with HCFC1. Ref.1
Mutagenesis117 – 1193LRL → ARA: Reduces nuclear export. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 34A9A04735276A16

FASTA13815,291
        10         20         30         40         50         60 
MILQQPLQRG PQGGAQRLPR AALGVTWGLD ASSPLRGAVP MSTKRRLEEE QEPLRKQFLS 

        70         80         90        100        110        120 
EENMATHFSQ LSLHNDHPYC SPPMTFSPAL PPLRSPCSEL LLWRYPGSLI PEALRLLRLG 

       130 
DTPSPPYPAT PAGDIMEL 

« Hide

Isoform 2 [UniParc].

Checksum: 827839C0CE4B2FAF
Show »

FASTA11913,193

References

« Hide 'large scale' references
[1]"Interaction of HCF-1 with a cellular nuclear export factor."
Mahajan S.S., Little M.M., Vazquez R., Wilson A.C.
J. Biol. Chem. 277:44292-44299(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF 76-ASP--TYR-79 AND 117-LEU--LEU-119, INTERACTION WITH HCFC1.
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-92.
Tissue: Mammary gland and PNS.
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY116892 mRNA. Translation: AAM49798.1.
AK000575 mRNA. Translation: BAA91265.1.
CR457245 mRNA. Translation: CAG33526.1.
CH471112 Genomic DNA. Translation: EAW85425.1.
CH471112 Genomic DNA. Translation: EAW85426.1.
BC064026 mRNA. Translation: AAH64026.1.
BC080178 mRNA. Translation: AAH80178.1.
CCDSCCDS10490.1. [Q9NWW0-1]
CCDS32375.1. [Q9NWW0-2]
RefSeqNP_001002017.1. NM_001002017.2. [Q9NWW0-2]
NP_001002018.1. NM_001002018.2. [Q9NWW0-1]
NP_001275594.1. NM_001288665.1. [Q9NWW0-1]
NP_001275595.1. NM_001288666.1. [Q9NWW0-2]
NP_001275596.1. NM_001288667.1.
NP_001275597.1. NM_001288668.1.
NP_060355.1. NM_017885.3. [Q9NWW0-1]
UniGeneHs.423103.

3D structure databases

ProteinModelPortalQ9NWW0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120320. 2 interactions.
IntActQ9NWW0. 1 interaction.
MINTMINT-1424323.
STRING9606.ENSP00000248089.

Proteomic databases

PaxDbQ9NWW0.
PRIDEQ9NWW0.

Protocols and materials databases

DNASU54985.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000248089; ENSP00000248089; ENSG00000103145. [Q9NWW0-1]
ENST00000396916; ENSP00000380123; ENSG00000103145. [Q9NWW0-1]
ENST00000574151; ENSP00000459178; ENSG00000103145. [Q9NWW0-2]
ENST00000574980; ENSP00000460639; ENSG00000103145. [Q9NWW0-1]
GeneID54985.
KEGGhsa:54985.
UCSCuc002csx.1. human. [Q9NWW0-1]
uc002csz.1. human. [Q9NWW0-2]

Organism-specific databases

CTD54985.
GeneCardsGC16M003072.
HGNCHGNC:21198. HCFC1R1.
HPAHPA059647.
neXtProtNX_Q9NWW0.
PharmGKBPA134951485.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43982.
HOGENOMHOG000112942.
HOVERGENHBG107981.
InParanoidQ9NWW0.
OMARYPGNLI.
OrthoDBEOG776SRN.
PhylomeDBQ9NWW0.
TreeFamTF338381.

Gene expression databases

ArrayExpressQ9NWW0.
BgeeQ9NWW0.
CleanExHS_HCFC1R1.
GenevestigatorQ9NWW0.

Family and domain databases

InterProIPR029195. HCFC1R1.
[Graphical view]
PfamPF15226. HPIP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHCFC1R1. human.
GenomeRNAi54985.
NextBio58261.
PROQ9NWW0.

Entry information

Entry nameHPIP_HUMAN
AccessionPrimary (citable) accession number: Q9NWW0
Secondary accession number(s): D3DUA7, Q68EN7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM