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Protein

Host cell factor C1 regulator 1

Gene

HCFC1R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Host cell factor C1 regulator 1
Alternative name(s):
HCF-1 beta-propeller-interacting protein
Gene namesi
Name:HCFC1R1
Synonyms:HPIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:21198. HCFC1R1.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

  • Note: Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi76 – 794DHPY → AAPA: Loss of interaction with HCFC1. 1 Publication
Mutagenesisi117 – 1193LRL → ARA: Reduces nuclear export. 1 Publication

Organism-specific databases

PharmGKBiPA134951485.

Polymorphism and mutation databases

BioMutaiHCFC1R1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Host cell factor C1 regulator 1PRO_0000338978Add
BLAST

Proteomic databases

PaxDbiQ9NWW0.
PRIDEiQ9NWW0.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ9NWW0.
CleanExiHS_HCFC1R1.
ExpressionAtlasiQ9NWW0. baseline and differential.
GenevisibleiQ9NWW0. HS.

Organism-specific databases

HPAiHPA059647.

Interactioni

Subunit structurei

Interacts with HCFC1.1 Publication

Protein-protein interaction databases

BioGridi120320. 2 interactions.
IntActiQ9NWW0. 1 interaction.
MINTiMINT-1424323.

Structurei

3D structure databases

ProteinModelPortaliQ9NWW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni76 – 794Interaction with HCFC1

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi110 – 11910Nuclear export signal

Phylogenomic databases

eggNOGiNOG43982.
GeneTreeiENSGT00390000015785.
HOGENOMiHOG000112942.
HOVERGENiHBG107981.
InParanoidiQ9NWW0.
OrthoDBiEOG776SRN.
PhylomeDBiQ9NWW0.
TreeFamiTF338381.

Family and domain databases

InterProiIPR029195. HCFC1R1.
[Graphical view]
PfamiPF15226. HPIP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NWW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MILQQPLQRG PQGGAQRLPR AALGVTWGLD ASSPLRGAVP MSTKRRLEEE
60 70 80 90 100
QEPLRKQFLS EENMATHFSQ LSLHNDHPYC SPPMTFSPAL PPLRSPCSEL
110 120 130
LLWRYPGSLI PEALRLLRLG DTPSPPYPAT PAGDIMEL
Length:138
Mass (Da):15,291
Last modified:October 1, 2000 - v1
Checksum:i34A9A04735276A16
GO
Isoform 2 (identifier: Q9NWW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-51: SSPLRGAVPMSTKRRLEEEQ → R

Show »
Length:119
Mass (Da):13,193
Checksum:i827839C0CE4B2FAF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921P → Q.1 Publication
Corresponds to variant rs10508 [ dbSNP | Ensembl ].
VAR_043849

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei32 – 5120SSPLR…LEEEQ → R in isoform 2. 2 PublicationsVSP_034082Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY116892 mRNA. Translation: AAM49798.1.
AK000575 mRNA. Translation: BAA91265.1.
CR457245 mRNA. Translation: CAG33526.1.
CH471112 Genomic DNA. Translation: EAW85425.1.
CH471112 Genomic DNA. Translation: EAW85426.1.
BC064026 mRNA. Translation: AAH64026.1.
BC080178 mRNA. Translation: AAH80178.1.
CCDSiCCDS10490.1. [Q9NWW0-1]
CCDS32375.1. [Q9NWW0-2]
RefSeqiNP_001002017.1. NM_001002017.2. [Q9NWW0-2]
NP_001002018.1. NM_001002018.2. [Q9NWW0-1]
NP_001275594.1. NM_001288665.1. [Q9NWW0-1]
NP_001275595.1. NM_001288666.1. [Q9NWW0-2]
NP_001275596.1. NM_001288667.1.
NP_001275597.1. NM_001288668.1.
NP_060355.1. NM_017885.3. [Q9NWW0-1]
UniGeneiHs.423103.

Genome annotation databases

EnsembliENST00000248089; ENSP00000248089; ENSG00000103145. [Q9NWW0-1]
ENST00000574151; ENSP00000459178; ENSG00000103145. [Q9NWW0-2]
ENST00000574980; ENSP00000460639; ENSG00000103145. [Q9NWW0-1]
GeneIDi54985.
KEGGihsa:54985.
UCSCiuc002csx.1. human. [Q9NWW0-1]
uc002csz.1. human. [Q9NWW0-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY116892 mRNA. Translation: AAM49798.1.
AK000575 mRNA. Translation: BAA91265.1.
CR457245 mRNA. Translation: CAG33526.1.
CH471112 Genomic DNA. Translation: EAW85425.1.
CH471112 Genomic DNA. Translation: EAW85426.1.
BC064026 mRNA. Translation: AAH64026.1.
BC080178 mRNA. Translation: AAH80178.1.
CCDSiCCDS10490.1. [Q9NWW0-1]
CCDS32375.1. [Q9NWW0-2]
RefSeqiNP_001002017.1. NM_001002017.2. [Q9NWW0-2]
NP_001002018.1. NM_001002018.2. [Q9NWW0-1]
NP_001275594.1. NM_001288665.1. [Q9NWW0-1]
NP_001275595.1. NM_001288666.1. [Q9NWW0-2]
NP_001275596.1. NM_001288667.1.
NP_001275597.1. NM_001288668.1.
NP_060355.1. NM_017885.3. [Q9NWW0-1]
UniGeneiHs.423103.

3D structure databases

ProteinModelPortaliQ9NWW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120320. 2 interactions.
IntActiQ9NWW0. 1 interaction.
MINTiMINT-1424323.

Polymorphism and mutation databases

BioMutaiHCFC1R1.

Proteomic databases

PaxDbiQ9NWW0.
PRIDEiQ9NWW0.

Protocols and materials databases

DNASUi54985.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248089; ENSP00000248089; ENSG00000103145. [Q9NWW0-1]
ENST00000574151; ENSP00000459178; ENSG00000103145. [Q9NWW0-2]
ENST00000574980; ENSP00000460639; ENSG00000103145. [Q9NWW0-1]
GeneIDi54985.
KEGGihsa:54985.
UCSCiuc002csx.1. human. [Q9NWW0-1]
uc002csz.1. human. [Q9NWW0-2]

Organism-specific databases

CTDi54985.
GeneCardsiGC16M003072.
HGNCiHGNC:21198. HCFC1R1.
HPAiHPA059647.
neXtProtiNX_Q9NWW0.
PharmGKBiPA134951485.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43982.
GeneTreeiENSGT00390000015785.
HOGENOMiHOG000112942.
HOVERGENiHBG107981.
InParanoidiQ9NWW0.
OrthoDBiEOG776SRN.
PhylomeDBiQ9NWW0.
TreeFamiTF338381.

Miscellaneous databases

ChiTaRSiHCFC1R1. human.
GenomeRNAii54985.
NextBioi58261.
PROiQ9NWW0.

Gene expression databases

BgeeiQ9NWW0.
CleanExiHS_HCFC1R1.
ExpressionAtlasiQ9NWW0. baseline and differential.
GenevisibleiQ9NWW0. HS.

Family and domain databases

InterProiIPR029195. HCFC1R1.
[Graphical view]
PfamiPF15226. HPIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Interaction of HCF-1 with a cellular nuclear export factor."
    Mahajan S.S., Little M.M., Vazquez R., Wilson A.C.
    J. Biol. Chem. 277:44292-44299(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF 76-ASP--TYR-79 AND 117-LEU--LEU-119, INTERACTION WITH HCFC1.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-92.
    Tissue: Mammary gland and PNS.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHPIP_HUMAN
AccessioniPrimary (citable) accession number: Q9NWW0
Secondary accession number(s): D3DUA7, Q68EN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.