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Q9NWW0

- HPIP_HUMAN

UniProt

Q9NWW0 - HPIP_HUMAN

Protein

Host cell factor C1 regulator 1

Gene

HCFC1R1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Host cell factor C1 regulator 1
    Alternative name(s):
    HCF-1 beta-propeller-interacting protein
    Gene namesi
    Name:HCFC1R1
    Synonyms:HPIP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:21198. HCFC1R1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi76 – 794DHPY → AAPA: Loss of interaction with HCFC1. 1 Publication
    Mutagenesisi117 – 1193LRL → ARA: Reduces nuclear export. 1 Publication

    Organism-specific databases

    PharmGKBiPA134951485.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 138138Host cell factor C1 regulator 1PRO_0000338978Add
    BLAST

    Proteomic databases

    PaxDbiQ9NWW0.
    PRIDEiQ9NWW0.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ9NWW0.
    BgeeiQ9NWW0.
    CleanExiHS_HCFC1R1.
    GenevestigatoriQ9NWW0.

    Organism-specific databases

    HPAiHPA059647.

    Interactioni

    Subunit structurei

    Interacts with HCFC1.1 Publication

    Protein-protein interaction databases

    BioGridi120320. 2 interactions.
    IntActiQ9NWW0. 1 interaction.
    MINTiMINT-1424323.
    STRINGi9606.ENSP00000248089.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NWW0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni76 – 794Interaction with HCFC1

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi110 – 11910Nuclear export signal

    Phylogenomic databases

    eggNOGiNOG43982.
    HOGENOMiHOG000112942.
    HOVERGENiHBG107981.
    InParanoidiQ9NWW0.
    OMAiRYPGNLI.
    OrthoDBiEOG776SRN.
    PhylomeDBiQ9NWW0.
    TreeFamiTF338381.

    Family and domain databases

    InterProiIPR029195. HCFC1R1.
    [Graphical view]
    PfamiPF15226. HPIP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NWW0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MILQQPLQRG PQGGAQRLPR AALGVTWGLD ASSPLRGAVP MSTKRRLEEE    50
    QEPLRKQFLS EENMATHFSQ LSLHNDHPYC SPPMTFSPAL PPLRSPCSEL 100
    LLWRYPGSLI PEALRLLRLG DTPSPPYPAT PAGDIMEL 138
    Length:138
    Mass (Da):15,291
    Last modified:October 1, 2000 - v1
    Checksum:i34A9A04735276A16
    GO
    Isoform 2 (identifier: Q9NWW0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         32-51: SSPLRGAVPMSTKRRLEEEQ → R

    Show »
    Length:119
    Mass (Da):13,193
    Checksum:i827839C0CE4B2FAF
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti92 – 921P → Q.1 Publication
    Corresponds to variant rs10508 [ dbSNP | Ensembl ].
    VAR_043849

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei32 – 5120SSPLR…LEEEQ → R in isoform 2. 2 PublicationsVSP_034082Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY116892 mRNA. Translation: AAM49798.1.
    AK000575 mRNA. Translation: BAA91265.1.
    CR457245 mRNA. Translation: CAG33526.1.
    CH471112 Genomic DNA. Translation: EAW85425.1.
    CH471112 Genomic DNA. Translation: EAW85426.1.
    BC064026 mRNA. Translation: AAH64026.1.
    BC080178 mRNA. Translation: AAH80178.1.
    CCDSiCCDS10490.1. [Q9NWW0-1]
    CCDS32375.1. [Q9NWW0-2]
    RefSeqiNP_001002017.1. NM_001002017.2. [Q9NWW0-2]
    NP_001002018.1. NM_001002018.2. [Q9NWW0-1]
    NP_001275594.1. NM_001288665.1. [Q9NWW0-1]
    NP_001275595.1. NM_001288666.1. [Q9NWW0-2]
    NP_001275596.1. NM_001288667.1.
    NP_001275597.1. NM_001288668.1.
    NP_060355.1. NM_017885.3. [Q9NWW0-1]
    UniGeneiHs.423103.

    Genome annotation databases

    EnsembliENST00000248089; ENSP00000248089; ENSG00000103145. [Q9NWW0-1]
    ENST00000574151; ENSP00000459178; ENSG00000103145. [Q9NWW0-2]
    ENST00000574980; ENSP00000460639; ENSG00000103145. [Q9NWW0-1]
    GeneIDi54985.
    KEGGihsa:54985.
    UCSCiuc002csx.1. human. [Q9NWW0-1]
    uc002csz.1. human. [Q9NWW0-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY116892 mRNA. Translation: AAM49798.1 .
    AK000575 mRNA. Translation: BAA91265.1 .
    CR457245 mRNA. Translation: CAG33526.1 .
    CH471112 Genomic DNA. Translation: EAW85425.1 .
    CH471112 Genomic DNA. Translation: EAW85426.1 .
    BC064026 mRNA. Translation: AAH64026.1 .
    BC080178 mRNA. Translation: AAH80178.1 .
    CCDSi CCDS10490.1. [Q9NWW0-1 ]
    CCDS32375.1. [Q9NWW0-2 ]
    RefSeqi NP_001002017.1. NM_001002017.2. [Q9NWW0-2 ]
    NP_001002018.1. NM_001002018.2. [Q9NWW0-1 ]
    NP_001275594.1. NM_001288665.1. [Q9NWW0-1 ]
    NP_001275595.1. NM_001288666.1. [Q9NWW0-2 ]
    NP_001275596.1. NM_001288667.1.
    NP_001275597.1. NM_001288668.1.
    NP_060355.1. NM_017885.3. [Q9NWW0-1 ]
    UniGenei Hs.423103.

    3D structure databases

    ProteinModelPortali Q9NWW0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120320. 2 interactions.
    IntActi Q9NWW0. 1 interaction.
    MINTi MINT-1424323.
    STRINGi 9606.ENSP00000248089.

    Proteomic databases

    PaxDbi Q9NWW0.
    PRIDEi Q9NWW0.

    Protocols and materials databases

    DNASUi 54985.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000248089 ; ENSP00000248089 ; ENSG00000103145 . [Q9NWW0-1 ]
    ENST00000574151 ; ENSP00000459178 ; ENSG00000103145 . [Q9NWW0-2 ]
    ENST00000574980 ; ENSP00000460639 ; ENSG00000103145 . [Q9NWW0-1 ]
    GeneIDi 54985.
    KEGGi hsa:54985.
    UCSCi uc002csx.1. human. [Q9NWW0-1 ]
    uc002csz.1. human. [Q9NWW0-2 ]

    Organism-specific databases

    CTDi 54985.
    GeneCardsi GC16M003072.
    HGNCi HGNC:21198. HCFC1R1.
    HPAi HPA059647.
    neXtProti NX_Q9NWW0.
    PharmGKBi PA134951485.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43982.
    HOGENOMi HOG000112942.
    HOVERGENi HBG107981.
    InParanoidi Q9NWW0.
    OMAi RYPGNLI.
    OrthoDBi EOG776SRN.
    PhylomeDBi Q9NWW0.
    TreeFami TF338381.

    Miscellaneous databases

    ChiTaRSi HCFC1R1. human.
    GenomeRNAii 54985.
    NextBioi 58261.
    PROi Q9NWW0.

    Gene expression databases

    ArrayExpressi Q9NWW0.
    Bgeei Q9NWW0.
    CleanExi HS_HCFC1R1.
    Genevestigatori Q9NWW0.

    Family and domain databases

    InterProi IPR029195. HCFC1R1.
    [Graphical view ]
    Pfami PF15226. HPIP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Interaction of HCF-1 with a cellular nuclear export factor."
      Mahajan S.S., Little M.M., Vazquez R., Wilson A.C.
      J. Biol. Chem. 277:44292-44299(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF 76-ASP--TYR-79 AND 117-LEU--LEU-119, INTERACTION WITH HCFC1.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-92.
      Tissue: Mammary gland and PNS.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHPIP_HUMAN
    AccessioniPrimary (citable) accession number: Q9NWW0
    Secondary accession number(s): D3DUA7, Q68EN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3