Q9NWW0 (HPIP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Host cell factor C1 regulator 1

Alternative name(s):
HCF-1 beta-propeller-interacting protein

Gene names

Name:	HCFC1R1
Synonyms:	HPIP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus. Ref.1
Subunit structure	Interacts with HCFC1. Ref.1
Subcellular location	Cytoplasm. Nucleus. Note: Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Ref.1
Tissue specificity	Widely expressed. Ref.1

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NWW0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NWW0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     32-51: SSPLRGAVPMSTKRRLEEEQ → R

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 138	138	Host cell factor C1 regulator 1		PRO_0000338978
Regions
	Region	76 – 79	4	Interaction with HCFC1
	Motif	110 – 119	10	Nuclear export signal
Natural variations
	Alternative sequence	32 – 51	20	SSPLR…LEEEQ → R in isoform 2.		VSP_034082
	Natural variant	92	1	P → Q. Ref.5 Corresponds to variant rs10508 [ dbSNP | Ensembl ].		VAR_043849
Experimental info
	Mutagenesis	76 – 79	4	DHPY → AAPA: Loss of interaction with HCFC1. Ref.1
	Mutagenesis	117 – 119	3	LRL → ARA: Reduces nuclear export. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 34A9A04735276A16	FASTA	138	15,291
	10 20 30 40 50 60 MILQQPLQRG PQGGAQRLPR AALGVTWGLD ASSPLRGAVP MSTKRRLEEE QEPLRKQFLS 70 80 90 100 110 120 EENMATHFSQ LSLHNDHPYC SPPMTFSPAL PPLRSPCSEL LLWRYPGSLI PEALRLLRLG 130 DTPSPPYPAT PAGDIMEL
	Isoform 2 [UniParc]. Checksum: 827839C0CE4B2FAF	FASTA	119	13,193
	10 20 30 40 50 60 MILQQPLQRG PQGGAQRLPR AALGVTWGLD AREPLRKQFL SEENMATHFS QLSLHNDHPY 70 80 90 100 110 CSPPMTFSPA LPPLRSPCSE LLLWRYPGSL IPEALRLLRL GDTPSPPYPA TPAGDIMEL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Interaction of HCF-1 with a cellular nuclear export factor." Mahajan S.S., Little M.M., Vazquez R., Wilson A.C. J. Biol. Chem. 277:44292-44299(2002) [PubMed: 12235138] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF 76-ASP--TYR-79 AND 117-LEU--LEU-119, INTERACTION WITH HCFC1. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-92. Tissue: Mammary gland and PNS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY116892 mRNA. Translation: AAM49798.1. AK000575 mRNA. Translation: BAA91265.1. CR457245 mRNA. Translation: CAG33526.1. CH471112 Genomic DNA. Translation: EAW85425.1. CH471112 Genomic DNA. Translation: EAW85426.1. BC064026 mRNA. Translation: AAH64026.1. BC080178 mRNA. Translation: AAH80178.1.
IPI	IPI00016599. IPI00470340.
RefSeq	NP_001002017.1. NM_001002017.1. NP_001002018.1. NM_001002018.1. NP_060355.1. NM_017885.2.
UniGene	Hs.728247.
3D structure databases
ProteinModelPortal	Q9NWW0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NWW0. 1 interaction.
MINT	MINT-1424323.
Proteomic databases
PRIDE	Q9NWW0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000248089; ENSP00000248089; ENSG00000103145. ENST00000396916; ENSP00000380123; ENSG00000103145.
GeneID	54985.
KEGG	hsa:54985.
UCSC	uc002csx.1. human. uc002csz.1. human.
Organism-specific databases
CTD	54985.
GeneCards	GC16M003045.
H-InvDB	HIX0012752.
HGNC	HGNC:21198. HCFC1R1.
neXtProt	NX_Q9NWW0.
PharmGKB	PA134951485.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07919.
GeneTree	ENSGT00390000015785.
HOVERGEN	HBG107981.
InParanoid	Q9NWW0.
OMA	RSPCSEL.
OrthoDB	EOG4THVVC.
PhylomeDB	Q9NWW0.
Gene expression databases
ArrayExpress	Q9NWW0.
Bgee	Q9NWW0.
CleanEx	HS_HCFC1R1.
Genevestigator	Q9NWW0.
Family and domain databases
ProtoNet	Search...
Other
NextBio	58261.

Entry information

Entry name

HPIP_HUMAN

Accession

Primary (citable) accession number: Q9NWW0
Secondary accession number(s): D3DUA7, Q68EN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	October 1, 2000
Last modified:	September 21, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.