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Protein

BRISC and BRCA1-A complex member 1

Gene

BABAM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component.3 Publications

GO - Biological processi

  1. chromatin modification Source: UniProtKB-KW
  2. double-strand break repair Source: UniProtKB
  3. G2 DNA damage checkpoint Source: UniProtKB
  4. positive regulation of DNA repair Source: UniProtKB
  5. protein K63-linked deubiquitination Source: UniProtKB
  6. response to ionizing radiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
BRISC and BRCA1-A complex member 1
Alternative name(s):
Mediator of RAP80 interactions and targeting subunit of 40 kDa
New component of the BRCA1-A complex
Gene namesi
Name:BABAM1
Synonyms:C19orf62, MERIT40, NBA1
ORF Names:HSPC142
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:25008. BABAM1.

Subcellular locationi

Cytoplasm. Nucleus
Note: Localizes at sites of DNA damage at double-strand breaks (DSBs).

GO - Cellular componenti

  1. BRCA1-A complex Source: UniProtKB
  2. BRISC complex Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. nucleoplasm Source: HPA
  5. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162378767.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329BRISC and BRCA1-A complex member 1PRO_0000288458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine3 Publications
Modified residuei29 – 291Phosphoserine1 Publication
Modified residuei49 – 491Phosphoserine3 Publications
Modified residuei62 – 621Phosphoserine2 Publications
Modified residuei65 – 651Phosphothreonine1 Publication
Modified residuei66 – 661Phosphoserine3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9NWV8.
PaxDbiQ9NWV8.
PRIDEiQ9NWV8.

PTM databases

PhosphoSiteiQ9NWV8.

Expressioni

Gene expression databases

BgeeiQ9NWV8.
CleanExiHS_C19orf62.
ExpressionAtlasiQ9NWV8. baseline and differential.
GenevestigatoriQ9NWV8.

Interactioni

Subunit structurei

Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas and BRE/BRCC45. Component of the BRISC complex, at least composed of the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BREQ9NXR73EBI-745725,EBI-949389
TNKS2Q9H2K24EBI-745725,EBI-4398527

Protein-protein interaction databases

BioGridi118855. 58 interactions.
IntActiQ9NWV8. 73 interactions.
MINTiMINT-4712566.
STRINGi9606.ENSP00000352408.

Structurei

3D structure databases

ProteinModelPortaliQ9NWV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni95 – 298204VWFA-likeAdd
BLAST

Domaini

The VWFA-like region is similar to the VWFA domain. Its presence reveals similarities between the structure of the 19S proteasome and the BRCA1-A complexes.1 Publication

Sequence similaritiesi

Belongs to the BABAM1 family.Curated

Phylogenomic databases

eggNOGiNOG76997.
GeneTreeiENSGT00390000016934.
InParanoidiQ9NWV8.
OMAiSCSTFNI.
OrthoDBiEOG7VB2FR.
PhylomeDBiQ9NWV8.
TreeFamiTF329070.

Family and domain databases

InterProiIPR026126. BABAM1.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR15660. PTHR15660. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NWV8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVAEPSSPT EEEEEEEEHS AEPRPRTRSN PEGAEDRAVG AQASVGSRSE
60 70 80 90 100
GEGEAASADD GSLNTSGAGP KSWQVPPPAP EVQIRTPRVN CPEKVIICLD
110 120 130 140 150
LSEEMSLPKL ESFNGSKTNA LNVSQKMIEM FVRTKHKIDK SHEFALVVVN
160 170 180 190 200
DDTAWLSGLT SDPRELCSCL YDLETASCST FNLEGLFSLI QQKTELPVTE
210 220 230 240 250
NVQTIPPPYV VRTILVYSRP PCQPQFSLTE PMKKMFQCPY FFFDVVYIHN
260 270 280 290 300
GTEEKEEEMS WKDMFAFMGS LDTKGTSYKY EVALAGPALE LHNCMAKLLA
310 320
HPLQRPCQSH ASYSLLEEED EAIEVEATV
Length:329
Mass (Da):36,560
Last modified:October 1, 2000 - v1
Checksum:i7A84D8EE6D03C1DB
GO
Isoform 2 (identifier: Q9NWV8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: MEVAEPSSPT...SLPKLESFNG → MMGASTLQEP...HHGSTVQRKC
     263-329: Missing.

Note: No experimental confirmation available.

Show »
Length:184
Mass (Da):21,028
Checksum:iFC1769F1757DAC76
GO
Isoform 3 (identifier: Q9NWV8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-190: Missing.
     234-329: KMFQCPYFFF...DEAIEVEATV → VGEAWEREGCLQP

Note: No experimental confirmation available.

Show »
Length:171
Mass (Da):18,621
Checksum:i1848B7FE13066DF1
GO

Sequence cautioni

The sequence AAF29106.1 differs from that shown. Reason: Frameshift at position 263. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti76 – 761P → S in CAG38557 (Ref. 4) Curated
Sequence conflicti288 – 2881A → V in CAG38557 (Ref. 4) Curated
Sequence conflicti302 – 3021P → S in CAG38557 (Ref. 4) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 115115MEVAE…ESFNG → MMGASTLQEPALSPGRCPRQ PLRSKFGHHGSTVQRKC in isoform 2. 1 PublicationVSP_037246Add
BLAST
Alternative sequencei116 – 19075Missing in isoform 3. 1 PublicationVSP_037247Add
BLAST
Alternative sequencei234 – 32996KMFQC…VEATV → VGEAWEREGCLQP in isoform 3. 1 PublicationVSP_037248Add
BLAST
Alternative sequencei263 – 32967Missing in isoform 2. 1 PublicationVSP_037249Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161491 mRNA. Translation: AAF29106.1. Frameshift.
AL136692 mRNA. Translation: CAB66627.1.
AK000578 mRNA. Translation: BAA91268.1.
AK299493 mRNA. Translation: BAG61451.1.
AK301193 mRNA. Translation: BAG62773.1.
CR533526 mRNA. Translation: CAG38557.1.
AC104522 Genomic DNA. No translation available.
BC000788 mRNA. Translation: AAH00788.1.
BC006244 mRNA. Translation: AAH06244.1.
BC091491 mRNA. Translation: AAH91491.1.
CCDSiCCDS46012.1. [Q9NWV8-1]
RefSeqiNP_001028721.1. NM_001033549.2. [Q9NWV8-1]
NP_001275685.1. NM_001288756.1. [Q9NWV8-1]
NP_001275686.1. NM_001288757.1.
NP_054892.2. NM_014173.3. [Q9NWV8-1]
UniGeneiHs.190722.

Genome annotation databases

EnsembliENST00000359435; ENSP00000352408; ENSG00000105393. [Q9NWV8-1]
ENST00000598188; ENSP00000471605; ENSG00000105393. [Q9NWV8-1]
ENST00000601043; ENSP00000470920; ENSG00000105393. [Q9NWV8-1]
GeneIDi29086.
KEGGihsa:29086.
UCSCiuc002nfu.3. human. [Q9NWV8-1]
uc010xpl.1. human. [Q9NWV8-3]

Polymorphism databases

DMDMi74734678.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161491 mRNA. Translation: AAF29106.1. Frameshift.
AL136692 mRNA. Translation: CAB66627.1.
AK000578 mRNA. Translation: BAA91268.1.
AK299493 mRNA. Translation: BAG61451.1.
AK301193 mRNA. Translation: BAG62773.1.
CR533526 mRNA. Translation: CAG38557.1.
AC104522 Genomic DNA. No translation available.
BC000788 mRNA. Translation: AAH00788.1.
BC006244 mRNA. Translation: AAH06244.1.
BC091491 mRNA. Translation: AAH91491.1.
CCDSiCCDS46012.1. [Q9NWV8-1]
RefSeqiNP_001028721.1. NM_001033549.2. [Q9NWV8-1]
NP_001275685.1. NM_001288756.1. [Q9NWV8-1]
NP_001275686.1. NM_001288757.1.
NP_054892.2. NM_014173.3. [Q9NWV8-1]
UniGeneiHs.190722.

3D structure databases

ProteinModelPortaliQ9NWV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118855. 58 interactions.
IntActiQ9NWV8. 73 interactions.
MINTiMINT-4712566.
STRINGi9606.ENSP00000352408.

PTM databases

PhosphoSiteiQ9NWV8.

Polymorphism databases

DMDMi74734678.

Proteomic databases

MaxQBiQ9NWV8.
PaxDbiQ9NWV8.
PRIDEiQ9NWV8.

Protocols and materials databases

DNASUi29086.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359435; ENSP00000352408; ENSG00000105393. [Q9NWV8-1]
ENST00000598188; ENSP00000471605; ENSG00000105393. [Q9NWV8-1]
ENST00000601043; ENSP00000470920; ENSG00000105393. [Q9NWV8-1]
GeneIDi29086.
KEGGihsa:29086.
UCSCiuc002nfu.3. human. [Q9NWV8-1]
uc010xpl.1. human. [Q9NWV8-3]

Organism-specific databases

CTDi29086.
GeneCardsiGC19P017899.
H-InvDBHIX0014885.
HGNCiHGNC:25008. BABAM1.
MIMi612766. gene.
neXtProtiNX_Q9NWV8.
PharmGKBiPA162378767.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG76997.
GeneTreeiENSGT00390000016934.
InParanoidiQ9NWV8.
OMAiSCSTFNI.
OrthoDBiEOG7VB2FR.
PhylomeDBiQ9NWV8.
TreeFamiTF329070.

Miscellaneous databases

ChiTaRSiBABAM1. human.
GeneWikiiC19orf62.
GenomeRNAii29086.
NextBioi52072.
PROiQ9NWV8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NWV8.
CleanExiHS_C19orf62.
ExpressionAtlasiQ9NWV8. baseline and differential.
GenevestigatoriQ9NWV8.

Family and domain databases

InterProiIPR026126. BABAM1.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR15660. PTHR15660. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain and Spleen.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovary, Pituitary and Placenta.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49 AND SER-66, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1."
    Cooper E.M., Cutcliffe C., Kristiansen T.Z., Pandey A., Pickart C.M., Cohen R.E.
    EMBO J. 28:621-631(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE BRISC COMPLEX.
  12. "MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks."
    Shao G., Patterson-Fortin J., Messick T.E., Feng D., Shanbhag N., Wang Y., Greenberg R.A.
    Genes Dev. 23:740-754(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE BRCA1-A COMPLEX, SUBCELLULAR LOCATION.
  13. "NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control."
    Wang B., Hurov K., Hofmann K., Elledge S.J.
    Genes Dev. 23:729-739(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE BRCA1-A COMPLEX, SUBCELLULAR LOCATION, DOMAIN VWFA-LIKE, INTERACTION WITH FAM175A.
  14. "MERIT40 facilitates BRCA1 localization and DNA damage repair."
    Feng L., Huang J., Chen J.
    Genes Dev. 23:719-728(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE BRCA1-A COMPLEX, SUBCELLULAR LOCATION, INTERACTION WITH BRE.
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29; SER-49; THR-65 AND SER-66, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-62 AND SER-66, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiBABA1_HUMAN
AccessioniPrimary (citable) accession number: Q9NWV8
Secondary accession number(s): A8MQT0
, B4DRY9, B4DVR1, Q6FIA0, Q9P018
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2000
Last modified: March 4, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.