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Q9NWV4

- CA123_HUMAN

UniProt

Q9NWV4 - CA123_HUMAN

Protein

UPF0587 protein C1orf123

Gene

C1orf123

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    UPF0587 protein C1orf123
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:26059. C1orf123.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672441.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 160160UPF0587 protein C1orf123PRO_0000264151Add
    BLAST

    Proteomic databases

    MaxQBiQ9NWV4.
    PaxDbiQ9NWV4.
    PeptideAtlasiQ9NWV4.
    PRIDEiQ9NWV4.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00016605.

    PTM databases

    PhosphoSiteiQ9NWV4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NWV4.
    BgeeiQ9NWV4.
    CleanExiHS_C1orf123.
    GenevestigatoriQ9NWV4.

    Organism-specific databases

    HPAiHPA043835.

    Interactioni

    Protein-protein interaction databases

    BioGridi120322. 3 interactions.
    IntActiQ9NWV4. 2 interactions.
    MINTiMINT-3075882.
    STRINGi9606.ENSP00000294360.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NWV4.
    SMRiQ9NWV4. Positions 1-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0587 family.Curated

    Phylogenomic databases

    eggNOGiNOG238543.
    HOGENOMiHOG000167115.
    HOVERGENiHBG058057.
    InParanoidiQ9NWV4.
    OMAiDCRGVEP.
    OrthoDBiEOG7CCBSF.
    PhylomeDBiQ9NWV4.
    TreeFamiTF105959.

    Family and domain databases

    InterProiIPR008584. DUF866_euk.
    [Graphical view]
    PANTHERiPTHR12857. PTHR12857. 1 hit.
    PfamiPF05907. DUF866. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NWV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKIALQLKA TLENITNLRP VGEDFRWYLK MKCGNCGEIS DKWQYIRLMD    50
    SVALKGGRGS ASMVQKCKLC ARENSIEILS STIKPYNAED NENFKTIVEF 100
    ECRGLEPVDF QPQAGFAAEG VESGTAFSDI NLQEKDWTDY DEKAQESVGI 150
    YEVTHQFVKC 160
    Length:160
    Mass (Da):18,048
    Last modified:October 1, 2000 - v1
    Checksum:i7CACEEE7CE781CBC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000587 mRNA. Translation: BAA91272.1.
    CR457246 mRNA. Translation: CAG33527.1.
    AL606760 Genomic DNA. Translation: CAI18911.1.
    BC010908 mRNA. Translation: AAH10908.1.
    CCDSiCCDS576.1.
    RefSeqiNP_060357.1. NM_017887.1.
    UniGeneiHs.525391.

    Genome annotation databases

    EnsembliENST00000294360; ENSP00000294360; ENSG00000162384.
    GeneIDi54987.
    KEGGihsa:54987.
    UCSCiuc001cvd.3. human.

    Polymorphism databases

    DMDMi74753033.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000587 mRNA. Translation: BAA91272.1 .
    CR457246 mRNA. Translation: CAG33527.1 .
    AL606760 Genomic DNA. Translation: CAI18911.1 .
    BC010908 mRNA. Translation: AAH10908.1 .
    CCDSi CCDS576.1.
    RefSeqi NP_060357.1. NM_017887.1.
    UniGenei Hs.525391.

    3D structure databases

    ProteinModelPortali Q9NWV4.
    SMRi Q9NWV4. Positions 1-156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120322. 3 interactions.
    IntActi Q9NWV4. 2 interactions.
    MINTi MINT-3075882.
    STRINGi 9606.ENSP00000294360.

    PTM databases

    PhosphoSitei Q9NWV4.

    Polymorphism databases

    DMDMi 74753033.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00016605.

    Proteomic databases

    MaxQBi Q9NWV4.
    PaxDbi Q9NWV4.
    PeptideAtlasi Q9NWV4.
    PRIDEi Q9NWV4.

    Protocols and materials databases

    DNASUi 54987.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294360 ; ENSP00000294360 ; ENSG00000162384 .
    GeneIDi 54987.
    KEGGi hsa:54987.
    UCSCi uc001cvd.3. human.

    Organism-specific databases

    CTDi 54987.
    GeneCardsi GC01M053679.
    H-InvDB HIX0000595.
    HGNCi HGNC:26059. C1orf123.
    HPAi HPA043835.
    neXtProti NX_Q9NWV4.
    PharmGKBi PA142672441.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238543.
    HOGENOMi HOG000167115.
    HOVERGENi HBG058057.
    InParanoidi Q9NWV4.
    OMAi DCRGVEP.
    OrthoDBi EOG7CCBSF.
    PhylomeDBi Q9NWV4.
    TreeFami TF105959.

    Miscellaneous databases

    ChiTaRSi C1orf123. human.
    GenomeRNAii 54987.
    NextBioi 58279.

    Gene expression databases

    ArrayExpressi Q9NWV4.
    Bgeei Q9NWV4.
    CleanExi HS_C1orf123.
    Genevestigatori Q9NWV4.

    Family and domain databases

    InterProi IPR008584. DUF866_euk.
    [Graphical view ]
    PANTHERi PTHR12857. PTHR12857. 1 hit.
    Pfami PF05907. DUF866. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. Lubec G., Afjehi-Sadat L.
      Submitted (MAR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 10-26, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Brain and Cajal-Retzius cell.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCA123_HUMAN
    AccessioniPrimary (citable) accession number: Q9NWV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3