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Protein

UPF0587 protein C1orf123

Gene

C1orf123

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0587 protein C1orf123
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26059. C1orf123.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672441.

Polymorphism and mutation databases

BioMutaiC1orf123.
DMDMi74753033.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160UPF0587 protein C1orf123PRO_0000264151Add
BLAST

Proteomic databases

MaxQBiQ9NWV4.
PaxDbiQ9NWV4.
PeptideAtlasiQ9NWV4.
PRIDEiQ9NWV4.

2D gel databases

REPRODUCTION-2DPAGEIPI00016605.

PTM databases

PhosphoSiteiQ9NWV4.

Expressioni

Gene expression databases

BgeeiQ9NWV4.
CleanExiHS_C1orf123.
GenevisibleiQ9NWV4. HS.

Organism-specific databases

HPAiHPA043835.

Interactioni

Protein-protein interaction databases

BioGridi120322. 2 interactions.
IntActiQ9NWV4. 2 interactions.
MINTiMINT-3075882.
STRINGi9606.ENSP00000294360.

Structurei

3D structure databases

ProteinModelPortaliQ9NWV4.
SMRiQ9NWV4. Positions 1-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0587 family.Curated

Phylogenomic databases

eggNOGiNOG238543.
GeneTreeiENSGT00390000001523.
HOGENOMiHOG000167115.
HOVERGENiHBG058057.
InParanoidiQ9NWV4.
OMAiDCRGVEP.
OrthoDBiEOG7CCBSF.
PhylomeDBiQ9NWV4.
TreeFamiTF105959.

Family and domain databases

InterProiIPR008584. DUF866_euk.
[Graphical view]
PANTHERiPTHR12857. PTHR12857. 1 hit.
PfamiPF05907. DUF866. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NWV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIALQLKA TLENITNLRP VGEDFRWYLK MKCGNCGEIS DKWQYIRLMD
60 70 80 90 100
SVALKGGRGS ASMVQKCKLC ARENSIEILS STIKPYNAED NENFKTIVEF
110 120 130 140 150
ECRGLEPVDF QPQAGFAAEG VESGTAFSDI NLQEKDWTDY DEKAQESVGI
160
YEVTHQFVKC
Length:160
Mass (Da):18,048
Last modified:October 1, 2000 - v1
Checksum:i7CACEEE7CE781CBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000587 mRNA. Translation: BAA91272.1.
CR457246 mRNA. Translation: CAG33527.1.
AL606760 Genomic DNA. Translation: CAI18911.1.
BC010908 mRNA. Translation: AAH10908.1.
CCDSiCCDS576.1.
RefSeqiNP_060357.1. NM_017887.2.
UniGeneiHs.525391.

Genome annotation databases

EnsembliENST00000294360; ENSP00000294360; ENSG00000162384.
GeneIDi54987.
KEGGihsa:54987.
UCSCiuc001cvd.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000587 mRNA. Translation: BAA91272.1.
CR457246 mRNA. Translation: CAG33527.1.
AL606760 Genomic DNA. Translation: CAI18911.1.
BC010908 mRNA. Translation: AAH10908.1.
CCDSiCCDS576.1.
RefSeqiNP_060357.1. NM_017887.2.
UniGeneiHs.525391.

3D structure databases

ProteinModelPortaliQ9NWV4.
SMRiQ9NWV4. Positions 1-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120322. 2 interactions.
IntActiQ9NWV4. 2 interactions.
MINTiMINT-3075882.
STRINGi9606.ENSP00000294360.

PTM databases

PhosphoSiteiQ9NWV4.

Polymorphism and mutation databases

BioMutaiC1orf123.
DMDMi74753033.

2D gel databases

REPRODUCTION-2DPAGEIPI00016605.

Proteomic databases

MaxQBiQ9NWV4.
PaxDbiQ9NWV4.
PeptideAtlasiQ9NWV4.
PRIDEiQ9NWV4.

Protocols and materials databases

DNASUi54987.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294360; ENSP00000294360; ENSG00000162384.
GeneIDi54987.
KEGGihsa:54987.
UCSCiuc001cvd.3. human.

Organism-specific databases

CTDi54987.
GeneCardsiGC01M053679.
H-InvDBHIX0000595.
HGNCiHGNC:26059. C1orf123.
HPAiHPA043835.
neXtProtiNX_Q9NWV4.
PharmGKBiPA142672441.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG238543.
GeneTreeiENSGT00390000001523.
HOGENOMiHOG000167115.
HOVERGENiHBG058057.
InParanoidiQ9NWV4.
OMAiDCRGVEP.
OrthoDBiEOG7CCBSF.
PhylomeDBiQ9NWV4.
TreeFamiTF105959.

Miscellaneous databases

ChiTaRSiC1orf123. human.
GenomeRNAii54987.
NextBioi58279.
PROiQ9NWV4.

Gene expression databases

BgeeiQ9NWV4.
CleanExiHS_C1orf123.
GenevisibleiQ9NWV4. HS.

Family and domain databases

InterProiIPR008584. DUF866_euk.
[Graphical view]
PANTHERiPTHR12857. PTHR12857. 1 hit.
PfamiPF05907. DUF866. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Lubec G., Afjehi-Sadat L.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 10-26, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain and Cajal-Retzius cell.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCA123_HUMAN
AccessioniPrimary (citable) accession number: Q9NWV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.