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Q9NWV4

- CA123_HUMAN

UniProt

Q9NWV4 - CA123_HUMAN

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Protein

UPF0587 protein C1orf123

Gene
C1orf123
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0587 protein C1orf123
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:26059. C1orf123.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672441.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160UPF0587 protein C1orf123PRO_0000264151Add
BLAST

Proteomic databases

MaxQBiQ9NWV4.
PaxDbiQ9NWV4.
PeptideAtlasiQ9NWV4.
PRIDEiQ9NWV4.

2D gel databases

REPRODUCTION-2DPAGEIPI00016605.

PTM databases

PhosphoSiteiQ9NWV4.

Expressioni

Gene expression databases

ArrayExpressiQ9NWV4.
BgeeiQ9NWV4.
CleanExiHS_C1orf123.
GenevestigatoriQ9NWV4.

Organism-specific databases

HPAiHPA043835.

Interactioni

Protein-protein interaction databases

BioGridi120322. 3 interactions.
IntActiQ9NWV4. 2 interactions.
MINTiMINT-3075882.
STRINGi9606.ENSP00000294360.

Structurei

3D structure databases

ProteinModelPortaliQ9NWV4.
SMRiQ9NWV4. Positions 1-156.

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0587 family.

Phylogenomic databases

eggNOGiNOG238543.
HOGENOMiHOG000167115.
HOVERGENiHBG058057.
InParanoidiQ9NWV4.
OMAiDCRGVEP.
OrthoDBiEOG7CCBSF.
PhylomeDBiQ9NWV4.
TreeFamiTF105959.

Family and domain databases

InterProiIPR008584. DUF866_euk.
[Graphical view]
PANTHERiPTHR12857. PTHR12857. 1 hit.
PfamiPF05907. DUF866. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NWV4-1 [UniParc]FASTAAdd to Basket

« Hide

MGKIALQLKA TLENITNLRP VGEDFRWYLK MKCGNCGEIS DKWQYIRLMD    50
SVALKGGRGS ASMVQKCKLC ARENSIEILS STIKPYNAED NENFKTIVEF 100
ECRGLEPVDF QPQAGFAAEG VESGTAFSDI NLQEKDWTDY DEKAQESVGI 150
YEVTHQFVKC 160
Length:160
Mass (Da):18,048
Last modified:October 1, 2000 - v1
Checksum:i7CACEEE7CE781CBC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000587 mRNA. Translation: BAA91272.1.
CR457246 mRNA. Translation: CAG33527.1.
AL606760 Genomic DNA. Translation: CAI18911.1.
BC010908 mRNA. Translation: AAH10908.1.
CCDSiCCDS576.1.
RefSeqiNP_060357.1. NM_017887.1.
UniGeneiHs.525391.

Genome annotation databases

EnsembliENST00000294360; ENSP00000294360; ENSG00000162384.
GeneIDi54987.
KEGGihsa:54987.
UCSCiuc001cvd.3. human.

Polymorphism databases

DMDMi74753033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000587 mRNA. Translation: BAA91272.1 .
CR457246 mRNA. Translation: CAG33527.1 .
AL606760 Genomic DNA. Translation: CAI18911.1 .
BC010908 mRNA. Translation: AAH10908.1 .
CCDSi CCDS576.1.
RefSeqi NP_060357.1. NM_017887.1.
UniGenei Hs.525391.

3D structure databases

ProteinModelPortali Q9NWV4.
SMRi Q9NWV4. Positions 1-156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120322. 3 interactions.
IntActi Q9NWV4. 2 interactions.
MINTi MINT-3075882.
STRINGi 9606.ENSP00000294360.

PTM databases

PhosphoSitei Q9NWV4.

Polymorphism databases

DMDMi 74753033.

2D gel databases

REPRODUCTION-2DPAGE IPI00016605.

Proteomic databases

MaxQBi Q9NWV4.
PaxDbi Q9NWV4.
PeptideAtlasi Q9NWV4.
PRIDEi Q9NWV4.

Protocols and materials databases

DNASUi 54987.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000294360 ; ENSP00000294360 ; ENSG00000162384 .
GeneIDi 54987.
KEGGi hsa:54987.
UCSCi uc001cvd.3. human.

Organism-specific databases

CTDi 54987.
GeneCardsi GC01M053679.
H-InvDB HIX0000595.
HGNCi HGNC:26059. C1orf123.
HPAi HPA043835.
neXtProti NX_Q9NWV4.
PharmGKBi PA142672441.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG238543.
HOGENOMi HOG000167115.
HOVERGENi HBG058057.
InParanoidi Q9NWV4.
OMAi DCRGVEP.
OrthoDBi EOG7CCBSF.
PhylomeDBi Q9NWV4.
TreeFami TF105959.

Miscellaneous databases

ChiTaRSi C1orf123. human.
GenomeRNAii 54987.
NextBioi 58279.

Gene expression databases

ArrayExpressi Q9NWV4.
Bgeei Q9NWV4.
CleanExi HS_C1orf123.
Genevestigatori Q9NWV4.

Family and domain databases

InterProi IPR008584. DUF866_euk.
[Graphical view ]
PANTHERi PTHR12857. PTHR12857. 1 hit.
Pfami PF05907. DUF866. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Lubec G., Afjehi-Sadat L.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 10-26, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain and Cajal-Retzius cell.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCA123_HUMAN
AccessioniPrimary (citable) accession number: Q9NWV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

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