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Q9NWU5

- RM22_HUMAN

UniProt

Q9NWU5 - RM22_HUMAN

Protein

39S ribosomal protein L22, mitochondrial

Gene

MRPL22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L22, mitochondrial
    Short name:
    L22mt
    Short name:
    MRP-L22
    Alternative name(s):
    39S ribosomal protein L25, mitochondrial
    Short name:
    L25mt
    Short name:
    MRP-L25
    Gene namesi
    Name:MRPL22
    Synonyms:MRPL25, RPML25
    ORF Names:HSPC158
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:14480. MRPL22.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. large ribosomal subunit Source: InterPro
    2. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30952.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4040MitochondrionBy similarityAdd
    BLAST
    Chaini41 – 20616639S ribosomal protein L22, mitochondrialPRO_0000261644Add
    BLAST

    Proteomic databases

    MaxQBiQ9NWU5.
    PaxDbiQ9NWU5.
    PRIDEiQ9NWU5.

    PTM databases

    PhosphoSiteiQ9NWU5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NWU5.
    BgeeiQ9NWU5.
    CleanExiHS_MRPL22.
    GenevestigatoriQ9NWU5.

    Organism-specific databases

    HPAiHPA047063.

    Interactioni

    Protein-protein interaction databases

    BioGridi118862. 13 interactions.
    IntActiQ9NWU5. 2 interactions.
    MINTiMINT-6782667.
    STRINGi9606.ENSP00000411177.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NWU5.
    SMRiQ9NWU5. Positions 72-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi176 – 1838Poly-Pro

    Sequence similaritiesi

    Belongs to the ribosomal protein L22P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0091.
    HOGENOMiHOG000048027.
    HOVERGENiHBG093486.
    InParanoidiQ9NWU5.
    KOiK02890.
    OrthoDBiEOG79CZ0R.
    PhylomeDBiQ9NWU5.
    TreeFamiTF315111.

    Family and domain databases

    Gene3Di3.90.470.10. 1 hit.
    InterProiIPR001063. Ribosomal_L22.
    IPR005727. Ribosomal_L22_bac/chlpt-type.
    [Graphical view]
    PANTHERiPTHR13501. PTHR13501. 1 hit.
    PfamiPF00237. Ribosomal_L22. 1 hit.
    [Graphical view]
    SUPFAMiSSF54843. SSF54843. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NWU5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAVLGQLG ALWIHNLRSR GKLALGVLPQ SYIHTSASLD ISRKWEKKNK    50
    IVYPPQLPGE PRRPAEIYHC RRQIKYSKDK MWYLAKLIRG MSIDQALAQL 100
    EFNDKKGAKI IKEVLLEAQD MAVRDHNVEF RSNLYIAEST SGRGQCLKRI 150
    RYHGRGRFGI MEKVYCHYFV KLVEGPPPPP EPPKTAVAHA KEYIQQLRSR 200
    TIVHTL 206
    Length:206
    Mass (Da):23,641
    Last modified:October 1, 2000 - v1
    Checksum:iEDF999932609F05D
    GO
    Isoform 2 (identifier: Q9NWU5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2-87: Missing.

    Show »
    Length:120
    Mass (Da):13,734
    Checksum:i6CED8B2464B72378
    GO
    Isoform 3 (identifier: Q9NWU5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-80: Missing.

    Show »
    Length:126
    Mass (Da):14,509
    Checksum:i93AB1871CCD4CF74
    GO

    Sequence cautioni

    The sequence AAF29122.1 differs from that shown. Reason: Frameshift at position 197.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti154 – 1541G → S.
    Corresponds to variant rs3749671 [ dbSNP | Ensembl ].
    VAR_029471

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8080Missing in isoform 3. 1 PublicationVSP_044501Add
    BLAST
    Alternative sequencei2 – 8786Missing in isoform 2. 1 PublicationVSP_021745Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF161507 mRNA. Translation: AAF29122.1. Frameshift.
    AK000601 mRNA. Translation: BAA91282.1.
    AK302784 mRNA. Translation: BAG63988.1.
    CR933679 mRNA. Translation: CAI45973.1.
    AC008410 Genomic DNA. No translation available.
    AC008421 Genomic DNA. No translation available.
    BC012565 mRNA. Translation: AAH12565.1.
    AB051622 Genomic DNA. Translation: BAB54950.1.
    CCDSiCCDS4331.1. [Q9NWU5-1]
    CCDS43391.1. [Q9NWU5-3]
    RefSeqiNP_001014990.1. NM_001014990.2. [Q9NWU5-3]
    NP_054899.2. NM_014180.3. [Q9NWU5-1]
    UniGeneiHs.483924.

    Genome annotation databases

    EnsembliENST00000265229; ENSP00000265229; ENSG00000082515. [Q9NWU5-3]
    ENST00000523037; ENSP00000431040; ENSG00000082515. [Q9NWU5-1]
    GeneIDi29093.
    KEGGihsa:29093.
    UCSCiuc003lvy.4. human. [Q9NWU5-1]

    Polymorphism databases

    DMDMi74753031.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF161507 mRNA. Translation: AAF29122.1 . Frameshift.
    AK000601 mRNA. Translation: BAA91282.1 .
    AK302784 mRNA. Translation: BAG63988.1 .
    CR933679 mRNA. Translation: CAI45973.1 .
    AC008410 Genomic DNA. No translation available.
    AC008421 Genomic DNA. No translation available.
    BC012565 mRNA. Translation: AAH12565.1 .
    AB051622 Genomic DNA. Translation: BAB54950.1 .
    CCDSi CCDS4331.1. [Q9NWU5-1 ]
    CCDS43391.1. [Q9NWU5-3 ]
    RefSeqi NP_001014990.1. NM_001014990.2. [Q9NWU5-3 ]
    NP_054899.2. NM_014180.3. [Q9NWU5-1 ]
    UniGenei Hs.483924.

    3D structure databases

    ProteinModelPortali Q9NWU5.
    SMRi Q9NWU5. Positions 72-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118862. 13 interactions.
    IntActi Q9NWU5. 2 interactions.
    MINTi MINT-6782667.
    STRINGi 9606.ENSP00000411177.

    PTM databases

    PhosphoSitei Q9NWU5.

    Polymorphism databases

    DMDMi 74753031.

    Proteomic databases

    MaxQBi Q9NWU5.
    PaxDbi Q9NWU5.
    PRIDEi Q9NWU5.

    Protocols and materials databases

    DNASUi 29093.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265229 ; ENSP00000265229 ; ENSG00000082515 . [Q9NWU5-3 ]
    ENST00000523037 ; ENSP00000431040 ; ENSG00000082515 . [Q9NWU5-1 ]
    GeneIDi 29093.
    KEGGi hsa:29093.
    UCSCi uc003lvy.4. human. [Q9NWU5-1 ]

    Organism-specific databases

    CTDi 29093.
    GeneCardsi GC05P154300.
    HGNCi HGNC:14480. MRPL22.
    HPAi HPA047063.
    MIMi 611835. gene.
    neXtProti NX_Q9NWU5.
    PharmGKBi PA30952.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0091.
    HOGENOMi HOG000048027.
    HOVERGENi HBG093486.
    InParanoidi Q9NWU5.
    KOi K02890.
    OrthoDBi EOG79CZ0R.
    PhylomeDBi Q9NWU5.
    TreeFami TF315111.

    Miscellaneous databases

    ChiTaRSi MRPL22. human.
    GeneWikii MRPL22.
    GenomeRNAii 29093.
    NextBioi 52107.
    PROi Q9NWU5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NWU5.
    Bgeei Q9NWU5.
    CleanExi HS_MRPL22.
    Genevestigatori Q9NWU5.

    Family and domain databases

    Gene3Di 3.90.470.10. 1 hit.
    InterProi IPR001063. Ribosomal_L22.
    IPR005727. Ribosomal_L22_bac/chlpt-type.
    [Graphical view ]
    PANTHERi PTHR13501. PTHR13501. 1 hit.
    Pfami PF00237. Ribosomal_L22. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54843. SSF54843. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Umbilical cord blood.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Carcinoma.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Retina.
    4. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    6. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 170-206.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM22_HUMAN
    AccessioniPrimary (citable) accession number: Q9NWU5
    Secondary accession number(s): A6NGJ8
    , Q5H9Q1, Q96Q51, Q9P006
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3