Q9NWU5 (RM22_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L22, mitochondrial
Short name=L22mt
Short name=MRP-L22

Alternative name(s):
39S ribosomal protein L25, mitochondrial
Short name=L25mt
Short name=MRP-L25

Gene names

Name:	MRPL22
Synonyms:	MRPL25, RPML25
ORF Names:	HSPC158

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the ribosomal protein L22P family.
Sequence caution	The sequence AAF29122.1 differs from that shown. Reason: Frameshift at position 197.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	large ribosomal subunit Inferred from electronic annotation. Source: InterPro mitochondrion Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NWU5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NWU5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2-87: Missing.

Isoform 3 (identifier: Q9NWU5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 40	40	Mitochondrion By similarity
	Chain	41 – 206	166	39S ribosomal protein L22, mitochondrial		PRO_0000261644
Regions
	Compositional bias	176 – 183	8	Poly-Pro
Natural variations
	Alternative sequence	1 – 80	80	Missing in isoform 3.		VSP_044501
	Alternative sequence	2 – 87	86	Missing in isoform 2.		VSP_021745
	Natural variant	154	1	G → S. Corresponds to variant rs3749671 [ dbSNP | Ensembl ].		VAR_029471

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: EDF999932609F05D	FASTA	206	23,641
	10 20 30 40 50 60 MAAAVLGQLG ALWIHNLRSR GKLALGVLPQ SYIHTSASLD ISRKWEKKNK IVYPPQLPGE 70 80 90 100 110 120 PRRPAEIYHC RRQIKYSKDK MWYLAKLIRG MSIDQALAQL EFNDKKGAKI IKEVLLEAQD 130 140 150 160 170 180 MAVRDHNVEF RSNLYIAEST SGRGQCLKRI RYHGRGRFGI MEKVYCHYFV KLVEGPPPPP 190 200 EPPKTAVAHA KEYIQQLRSR TIVHTL
	Isoform 2 [UniParc]. Checksum: 6CED8B2464B72378	FASTA	120	13,734
	10 20 30 40 50 60 MIRGMSIDQA LAQLEFNDKK GAKIIKEVLL EAQDMAVRDH NVEFRSNLYI AESTSGRGQC 70 80 90 100 110 120 LKRIRYHGRG RFGIMEKVYC HYFVKLVEGP PPPPEPPKTA VAHAKEYIQQ LRSRTIVHTL
	Isoform 3 [UniParc]. Checksum: 93AB1871CCD4CF74	FASTA	126	14,509
	10 20 30 40 50 60 MWYLAKLIRG MSIDQALAQL EFNDKKGAKI IKEVLLEAQD MAVRDHNVEF RSNLYIAEST 70 80 90 100 110 120 SGRGQCLKRI RYHGRGRFGI MEKVYCHYFV KLVEGPPPPP EPPKTAVAHA KEYIQQLRSR TIVHTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Umbilical cord blood.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Carcinoma.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Retina.
[4]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.
[6]	"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders." Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T. Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 170-206.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF161507 mRNA. Translation: AAF29122.1. Frameshift. AK000601 mRNA. Translation: BAA91282.1. AK302784 mRNA. Translation: BAG63988.1. CR933679 mRNA. Translation: CAI45973.1. AC008410 Genomic DNA. No translation available. AC008421 Genomic DNA. No translation available. BC012565 mRNA. Translation: AAH12565.1. AB051622 Genomic DNA. Translation: BAB54950.1.
IPI	IPI00556611. IPI00977524.
RefSeq	NP_001014990.1. NM_001014990.2. NP_054899.2. NM_014180.3.
UniGene	Hs.483924.
3D structure databases
HSSP	HSSP built from PDB template 1BXE based on UniProtKB P48286.
ProteinModelPortal	Q9NWU5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NWU5. 1 interaction.
STRING	9606.ENSP00000411177.
PTM databases
PhosphoSite	Q9NWU5.
Polymorphism databases
DMDM	74753031.
Proteomic databases
PaxDb	Q9NWU5.
PRIDE	Q9NWU5.
Protocols and materials databases
DNASU	29093.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265229; ENSP00000265229; ENSG00000082515. ENST00000523037; ENSP00000431040; ENSG00000082515.
GeneID	29093.
KEGG	hsa:29093.
UCSC	uc003lvy.4. human.
Organism-specific databases
CTD	29093.
GeneCards	GC05P154300.
HGNC	HGNC:14480. MRPL22.
HPA	HPA047063.
MIM	611835. gene.
neXtProt	NX_Q9NWU5.
PharmGKB	PA30952.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0091.
HOGENOM	HOG000048027.
HOVERGEN	HBG093486.
InParanoid	Q9NWU5.
KO	K02890.
OrthoDB	EOG45490K.
Gene expression databases
ArrayExpress	Q9NWU5.
Bgee	Q9NWU5.
CleanEx	HS_MRPL22.
Genevestigator	Q9NWU5.
GermOnline	ENSG00000082515. Homo sapiens.
Family and domain databases
Gene3D	3.90.470.10. 1 hit.
InterPro	IPR001063. Ribosomal_L22. IPR005727. Ribosomal_L22_bac/chlpt-type. [Graphical view]
PANTHER	PTHR13501. PTHR13501. 1 hit.
Pfam	PF00237. Ribosomal_L22. 1 hit. [Graphical view]
SUPFAM	SSF54843. Ribosomal_L22. 1 hit.
PROSITE	PS00464. RIBOSOMAL_L22. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MRPL22. human.
GenomeRNAi	29093.
NextBio	52107.
SOURCE	Search...

Entry information

Entry name

RM22_HUMAN

Accession

Primary (citable) accession number: Q9NWU5
Secondary accession number(s): A6NGJ8 , Q5H9Q1, Q96Q51, Q9P006

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.