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Protein

39S ribosomal protein L22, mitochondrial

Gene

MRPL22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L22, mitochondrial
Short name:
L22mt
Short name:
MRP-L22
Alternative name(s):
39S ribosomal protein L25, mitochondrial
Short name:
L25mt
Short name:
MRP-L25
Gene namesi
Name:MRPL22
Synonyms:MRPL25, RPML25
ORF Names:HSPC158
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:14480. MRPL22.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30952.

Polymorphism and mutation databases

BioMutaiMRPL22.
DMDMi74753031.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4040MitochondrionBy similarityAdd
BLAST
Chaini41 – 20616639S ribosomal protein L22, mitochondrialPRO_0000261644Add
BLAST

Proteomic databases

MaxQBiQ9NWU5.
PaxDbiQ9NWU5.
PRIDEiQ9NWU5.

PTM databases

PhosphoSiteiQ9NWU5.

Expressioni

Gene expression databases

BgeeiQ9NWU5.
CleanExiHS_MRPL22.
ExpressionAtlasiQ9NWU5. baseline and differential.
GenevisibleiQ9NWU5. HS.

Organism-specific databases

HPAiHPA047063.

Interactioni

Protein-protein interaction databases

BioGridi118862. 21 interactions.
IntActiQ9NWU5. 2 interactions.
MINTiMINT-6782667.
STRINGi9606.ENSP00000431040.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40T1-206[»]
ProteinModelPortaliQ9NWU5.
SMRiQ9NWU5. Positions 41-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi176 – 1838Poly-Pro

Sequence similaritiesi

Belongs to the ribosomal protein L22P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0091.
GeneTreeiENSGT00390000002110.
HOGENOMiHOG000048027.
HOVERGENiHBG093486.
InParanoidiQ9NWU5.
KOiK02890.
OrthoDBiEOG79CZ0R.
PhylomeDBiQ9NWU5.
TreeFamiTF315111.

Family and domain databases

Gene3Di3.90.470.10. 1 hit.
InterProiIPR001063. Ribosomal_L22.
IPR005727. Ribosomal_L22_bac/chlpt-type.
[Graphical view]
PANTHERiPTHR13501. PTHR13501. 1 hit.
PfamiPF00237. Ribosomal_L22. 1 hit.
[Graphical view]
SUPFAMiSSF54843. SSF54843. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NWU5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAVLGQLG ALWIHNLRSR GKLALGVLPQ SYIHTSASLD ISRKWEKKNK
60 70 80 90 100
IVYPPQLPGE PRRPAEIYHC RRQIKYSKDK MWYLAKLIRG MSIDQALAQL
110 120 130 140 150
EFNDKKGAKI IKEVLLEAQD MAVRDHNVEF RSNLYIAEST SGRGQCLKRI
160 170 180 190 200
RYHGRGRFGI MEKVYCHYFV KLVEGPPPPP EPPKTAVAHA KEYIQQLRSR

TIVHTL
Length:206
Mass (Da):23,641
Last modified:October 1, 2000 - v1
Checksum:iEDF999932609F05D
GO
Isoform 2 (identifier: Q9NWU5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-87: Missing.

Show »
Length:120
Mass (Da):13,734
Checksum:i6CED8B2464B72378
GO
Isoform 3 (identifier: Q9NWU5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Show »
Length:126
Mass (Da):14,509
Checksum:i93AB1871CCD4CF74
GO

Sequence cautioni

The sequence AAF29122.1 differs from that shown. Reason: Frameshift at position 197. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti154 – 1541G → S.
Corresponds to variant rs3749671 [ dbSNP | Ensembl ].
VAR_029471

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8080Missing in isoform 3. 1 PublicationVSP_044501Add
BLAST
Alternative sequencei2 – 8786Missing in isoform 2. 1 PublicationVSP_021745Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161507 mRNA. Translation: AAF29122.1. Frameshift.
AK000601 mRNA. Translation: BAA91282.1.
AK302784 mRNA. Translation: BAG63988.1.
CR933679 mRNA. Translation: CAI45973.1.
AC008410 Genomic DNA. No translation available.
AC008421 Genomic DNA. No translation available.
BC012565 mRNA. Translation: AAH12565.1.
AB051622 Genomic DNA. Translation: BAB54950.1.
CCDSiCCDS4331.1. [Q9NWU5-1]
CCDS43391.1. [Q9NWU5-3]
RefSeqiNP_001014990.1. NM_001014990.2. [Q9NWU5-3]
NP_054899.2. NM_014180.3. [Q9NWU5-1]
UniGeneiHs.483924.

Genome annotation databases

EnsembliENST00000265229; ENSP00000265229; ENSG00000082515. [Q9NWU5-3]
ENST00000523037; ENSP00000431040; ENSG00000082515. [Q9NWU5-1]
GeneIDi29093.
KEGGihsa:29093.
UCSCiuc003lvy.4. human. [Q9NWU5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161507 mRNA. Translation: AAF29122.1. Frameshift.
AK000601 mRNA. Translation: BAA91282.1.
AK302784 mRNA. Translation: BAG63988.1.
CR933679 mRNA. Translation: CAI45973.1.
AC008410 Genomic DNA. No translation available.
AC008421 Genomic DNA. No translation available.
BC012565 mRNA. Translation: AAH12565.1.
AB051622 Genomic DNA. Translation: BAB54950.1.
CCDSiCCDS4331.1. [Q9NWU5-1]
CCDS43391.1. [Q9NWU5-3]
RefSeqiNP_001014990.1. NM_001014990.2. [Q9NWU5-3]
NP_054899.2. NM_014180.3. [Q9NWU5-1]
UniGeneiHs.483924.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40T1-206[»]
ProteinModelPortaliQ9NWU5.
SMRiQ9NWU5. Positions 41-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118862. 21 interactions.
IntActiQ9NWU5. 2 interactions.
MINTiMINT-6782667.
STRINGi9606.ENSP00000431040.

PTM databases

PhosphoSiteiQ9NWU5.

Polymorphism and mutation databases

BioMutaiMRPL22.
DMDMi74753031.

Proteomic databases

MaxQBiQ9NWU5.
PaxDbiQ9NWU5.
PRIDEiQ9NWU5.

Protocols and materials databases

DNASUi29093.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265229; ENSP00000265229; ENSG00000082515. [Q9NWU5-3]
ENST00000523037; ENSP00000431040; ENSG00000082515. [Q9NWU5-1]
GeneIDi29093.
KEGGihsa:29093.
UCSCiuc003lvy.4. human. [Q9NWU5-1]

Organism-specific databases

CTDi29093.
GeneCardsiGC05P154300.
HGNCiHGNC:14480. MRPL22.
HPAiHPA047063.
MIMi611835. gene.
neXtProtiNX_Q9NWU5.
PharmGKBiPA30952.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0091.
GeneTreeiENSGT00390000002110.
HOGENOMiHOG000048027.
HOVERGENiHBG093486.
InParanoidiQ9NWU5.
KOiK02890.
OrthoDBiEOG79CZ0R.
PhylomeDBiQ9NWU5.
TreeFamiTF315111.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL22. human.
GeneWikiiMRPL22.
GenomeRNAii29093.
NextBioi52107.
PROiQ9NWU5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NWU5.
CleanExiHS_MRPL22.
ExpressionAtlasiQ9NWU5. baseline and differential.
GenevisibleiQ9NWU5. HS.

Family and domain databases

Gene3Di3.90.470.10. 1 hit.
InterProiIPR001063. Ribosomal_L22.
IPR005727. Ribosomal_L22_bac/chlpt-type.
[Graphical view]
PANTHERiPTHR13501. PTHR13501. 1 hit.
PfamiPF00237. Ribosomal_L22. 1 hit.
[Graphical view]
SUPFAMiSSF54843. SSF54843. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Carcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Retina.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  6. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 170-206.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM22_HUMAN
AccessioniPrimary (citable) accession number: Q9NWU5
Secondary accession number(s): A6NGJ8
, Q5H9Q1, Q96Q51, Q9P006
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.