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Q9NWU5

- RM22_HUMAN

UniProt

Q9NWU5 - RM22_HUMAN

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Protein

39S ribosomal protein L22, mitochondrial

Gene

MRPL22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L22, mitochondrial
Short name:
L22mt
Short name:
MRP-L22
Alternative name(s):
39S ribosomal protein L25, mitochondrial
Short name:
L25mt
Short name:
MRP-L25
Gene namesi
Name:MRPL22
Synonyms:MRPL25, RPML25
ORF Names:HSPC158
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:14480. MRPL22.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. large ribosomal subunit Source: InterPro
  2. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30952.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4040MitochondrionBy similarityAdd
BLAST
Chaini41 – 20616639S ribosomal protein L22, mitochondrialPRO_0000261644Add
BLAST

Proteomic databases

MaxQBiQ9NWU5.
PaxDbiQ9NWU5.
PRIDEiQ9NWU5.

PTM databases

PhosphoSiteiQ9NWU5.

Expressioni

Gene expression databases

BgeeiQ9NWU5.
CleanExiHS_MRPL22.
ExpressionAtlasiQ9NWU5. baseline and differential.
GenevestigatoriQ9NWU5.

Organism-specific databases

HPAiHPA047063.

Interactioni

Protein-protein interaction databases

BioGridi118862. 19 interactions.
IntActiQ9NWU5. 2 interactions.
MINTiMINT-6782667.
STRINGi9606.ENSP00000411177.

Structurei

3D structure databases

ProteinModelPortaliQ9NWU5.
SMRiQ9NWU5. Positions 72-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi176 – 1838Poly-Pro

Sequence similaritiesi

Belongs to the ribosomal protein L22P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0091.
GeneTreeiENSGT00390000002110.
HOGENOMiHOG000048027.
HOVERGENiHBG093486.
InParanoidiQ9NWU5.
KOiK02890.
OrthoDBiEOG79CZ0R.
PhylomeDBiQ9NWU5.
TreeFamiTF315111.

Family and domain databases

Gene3Di3.90.470.10. 1 hit.
InterProiIPR001063. Ribosomal_L22.
IPR005727. Ribosomal_L22_bac/chlpt-type.
[Graphical view]
PANTHERiPTHR13501. PTHR13501. 1 hit.
PfamiPF00237. Ribosomal_L22. 1 hit.
[Graphical view]
SUPFAMiSSF54843. SSF54843. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NWU5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAVLGQLG ALWIHNLRSR GKLALGVLPQ SYIHTSASLD ISRKWEKKNK
60 70 80 90 100
IVYPPQLPGE PRRPAEIYHC RRQIKYSKDK MWYLAKLIRG MSIDQALAQL
110 120 130 140 150
EFNDKKGAKI IKEVLLEAQD MAVRDHNVEF RSNLYIAEST SGRGQCLKRI
160 170 180 190 200
RYHGRGRFGI MEKVYCHYFV KLVEGPPPPP EPPKTAVAHA KEYIQQLRSR

TIVHTL
Length:206
Mass (Da):23,641
Last modified:October 1, 2000 - v1
Checksum:iEDF999932609F05D
GO
Isoform 2 (identifier: Q9NWU5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-87: Missing.

Show »
Length:120
Mass (Da):13,734
Checksum:i6CED8B2464B72378
GO
Isoform 3 (identifier: Q9NWU5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Show »
Length:126
Mass (Da):14,509
Checksum:i93AB1871CCD4CF74
GO

Sequence cautioni

The sequence AAF29122.1 differs from that shown. Reason: Frameshift at position 197. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti154 – 1541G → S.
Corresponds to variant rs3749671 [ dbSNP | Ensembl ].
VAR_029471

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8080Missing in isoform 3. 1 PublicationVSP_044501Add
BLAST
Alternative sequencei2 – 8786Missing in isoform 2. 1 PublicationVSP_021745Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161507 mRNA. Translation: AAF29122.1. Frameshift.
AK000601 mRNA. Translation: BAA91282.1.
AK302784 mRNA. Translation: BAG63988.1.
CR933679 mRNA. Translation: CAI45973.1.
AC008410 Genomic DNA. No translation available.
AC008421 Genomic DNA. No translation available.
BC012565 mRNA. Translation: AAH12565.1.
AB051622 Genomic DNA. Translation: BAB54950.1.
CCDSiCCDS4331.1. [Q9NWU5-1]
CCDS43391.1. [Q9NWU5-3]
RefSeqiNP_001014990.1. NM_001014990.2. [Q9NWU5-3]
NP_054899.2. NM_014180.3. [Q9NWU5-1]
UniGeneiHs.483924.

Genome annotation databases

EnsembliENST00000265229; ENSP00000265229; ENSG00000082515. [Q9NWU5-3]
ENST00000523037; ENSP00000431040; ENSG00000082515. [Q9NWU5-1]
ENST00000614620; ENSP00000481879; ENSG00000082515.
GeneIDi29093.
KEGGihsa:29093.
UCSCiuc003lvy.4. human. [Q9NWU5-1]

Polymorphism databases

DMDMi74753031.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161507 mRNA. Translation: AAF29122.1 . Frameshift.
AK000601 mRNA. Translation: BAA91282.1 .
AK302784 mRNA. Translation: BAG63988.1 .
CR933679 mRNA. Translation: CAI45973.1 .
AC008410 Genomic DNA. No translation available.
AC008421 Genomic DNA. No translation available.
BC012565 mRNA. Translation: AAH12565.1 .
AB051622 Genomic DNA. Translation: BAB54950.1 .
CCDSi CCDS4331.1. [Q9NWU5-1 ]
CCDS43391.1. [Q9NWU5-3 ]
RefSeqi NP_001014990.1. NM_001014990.2. [Q9NWU5-3 ]
NP_054899.2. NM_014180.3. [Q9NWU5-1 ]
UniGenei Hs.483924.

3D structure databases

ProteinModelPortali Q9NWU5.
SMRi Q9NWU5. Positions 72-174.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118862. 19 interactions.
IntActi Q9NWU5. 2 interactions.
MINTi MINT-6782667.
STRINGi 9606.ENSP00000411177.

PTM databases

PhosphoSitei Q9NWU5.

Polymorphism databases

DMDMi 74753031.

Proteomic databases

MaxQBi Q9NWU5.
PaxDbi Q9NWU5.
PRIDEi Q9NWU5.

Protocols and materials databases

DNASUi 29093.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265229 ; ENSP00000265229 ; ENSG00000082515 . [Q9NWU5-3 ]
ENST00000523037 ; ENSP00000431040 ; ENSG00000082515 . [Q9NWU5-1 ]
ENST00000614620 ; ENSP00000481879 ; ENSG00000082515 .
GeneIDi 29093.
KEGGi hsa:29093.
UCSCi uc003lvy.4. human. [Q9NWU5-1 ]

Organism-specific databases

CTDi 29093.
GeneCardsi GC05P154300.
HGNCi HGNC:14480. MRPL22.
HPAi HPA047063.
MIMi 611835. gene.
neXtProti NX_Q9NWU5.
PharmGKBi PA30952.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0091.
GeneTreei ENSGT00390000002110.
HOGENOMi HOG000048027.
HOVERGENi HBG093486.
InParanoidi Q9NWU5.
KOi K02890.
OrthoDBi EOG79CZ0R.
PhylomeDBi Q9NWU5.
TreeFami TF315111.

Enzyme and pathway databases

Reactomei REACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Miscellaneous databases

ChiTaRSi MRPL22. human.
GeneWikii MRPL22.
GenomeRNAii 29093.
NextBioi 52107.
PROi Q9NWU5.
SOURCEi Search...

Gene expression databases

Bgeei Q9NWU5.
CleanExi HS_MRPL22.
ExpressionAtlasi Q9NWU5. baseline and differential.
Genevestigatori Q9NWU5.

Family and domain databases

Gene3Di 3.90.470.10. 1 hit.
InterProi IPR001063. Ribosomal_L22.
IPR005727. Ribosomal_L22_bac/chlpt-type.
[Graphical view ]
PANTHERi PTHR13501. PTHR13501. 1 hit.
Pfami PF00237. Ribosomal_L22. 1 hit.
[Graphical view ]
SUPFAMi SSF54843. SSF54843. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Carcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Retina.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  6. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 170-206.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM22_HUMAN
AccessioniPrimary (citable) accession number: Q9NWU5
Secondary accession number(s): A6NGJ8
, Q5H9Q1, Q96Q51, Q9P006
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3