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Protein

39S ribosomal protein L22, mitochondrial

Gene

MRPL22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L22, mitochondrial
Short name:
L22mt
Short name:
MRP-L22
Alternative name(s):
39S ribosomal protein L25, mitochondrial
Short name:
L25mt
Short name:
MRP-L25
Mitochondrial large ribosomal subunit protein uL22m1 Publication
Gene namesi
Name:MRPL22
Synonyms:MRPL25, RPML25
ORF Names:HSPC158
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:14480. MRPL22.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial large ribosomal subunit Source: UniProtKB
  • mitochondrion Source: UniProtKB

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi29093.
OpenTargetsiENSG00000082515.
PharmGKBiPA30952.

Polymorphism and mutation databases

BioMutaiMRPL22.
DMDMi74753031.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 40MitochondrionBy similarityAdd BLAST40
ChainiPRO_000026164441 – 20639S ribosomal protein L22, mitochondrialAdd BLAST166

Proteomic databases

EPDiQ9NWU5.
MaxQBiQ9NWU5.
PaxDbiQ9NWU5.
PeptideAtlasiQ9NWU5.
PRIDEiQ9NWU5.
TopDownProteomicsiQ9NWU5-1. [Q9NWU5-1]

PTM databases

iPTMnetiQ9NWU5.
PhosphoSitePlusiQ9NWU5.

Expressioni

Gene expression databases

BgeeiENSG00000082515.
CleanExiHS_MRPL22.
ExpressionAtlasiQ9NWU5. baseline and differential.
GenevisibleiQ9NWU5. HS.

Organism-specific databases

HPAiHPA047063.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi118862. 46 interactors.
IntActiQ9NWU5. 11 interactors.
MINTiMINT-6782667.
STRINGi9606.ENSP00000431040.

Structurei

Secondary structure

1206
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi44 – 48Combined sources5
Beta strandi58 – 60Combined sources3
Beta strandi66 – 76Combined sources11
Helixi78 – 88Combined sources11
Helixi93 – 102Combined sources10
Helixi106 – 124Combined sources19
Helixi131 – 133Combined sources3
Beta strandi134 – 143Combined sources10
Beta strandi147 – 150Combined sources4
Beta strandi160 – 163Combined sources4
Beta strandi166 – 176Combined sources11
Helixi186 – 199Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40T1-206[»]
ProteinModelPortaliQ9NWU5.
SMRiQ9NWU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi176 – 183Poly-Pro8

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1711. Eukaryota.
COG0091. LUCA.
GeneTreeiENSGT00390000002110.
HOGENOMiHOG000048027.
HOVERGENiHBG093486.
InParanoidiQ9NWU5.
KOiK02890.
PhylomeDBiQ9NWU5.
TreeFamiTF315111.

Family and domain databases

CDDicd00336. Ribosomal_L22. 1 hit.
InterProiView protein in InterPro
IPR001063. Ribosomal_L22.
IPR005727. Ribosomal_L22_bac/chlpt-type.
PANTHERiPTHR13501. PTHR13501. 1 hit.
PfamiView protein in Pfam
PF00237. Ribosomal_L22. 1 hit.
SUPFAMiSSF54843. SSF54843. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NWU5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAVLGQLG ALWIHNLRSR GKLALGVLPQ SYIHTSASLD ISRKWEKKNK
60 70 80 90 100
IVYPPQLPGE PRRPAEIYHC RRQIKYSKDK MWYLAKLIRG MSIDQALAQL
110 120 130 140 150
EFNDKKGAKI IKEVLLEAQD MAVRDHNVEF RSNLYIAEST SGRGQCLKRI
160 170 180 190 200
RYHGRGRFGI MEKVYCHYFV KLVEGPPPPP EPPKTAVAHA KEYIQQLRSR

TIVHTL
Length:206
Mass (Da):23,641
Last modified:October 1, 2000 - v1
Checksum:iEDF999932609F05D
GO
Isoform 2 (identifier: Q9NWU5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-87: Missing.

Show »
Length:120
Mass (Da):13,734
Checksum:i6CED8B2464B72378
GO
Isoform 3 (identifier: Q9NWU5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.

Show »
Length:126
Mass (Da):14,509
Checksum:i93AB1871CCD4CF74
GO

Sequence cautioni

The sequence AAF29122 differs from that shown. Reason: Frameshift at position 197.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029471154G → S. Corresponds to variant dbSNP:rs3749671Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0445011 – 80Missing in isoform 3. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_0217452 – 87Missing in isoform 2. 1 PublicationAdd BLAST86

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161507 mRNA. Translation: AAF29122.1. Frameshift.
AK000601 mRNA. Translation: BAA91282.1.
AK302784 mRNA. Translation: BAG63988.1.
CR933679 mRNA. Translation: CAI45973.1.
AC008410 Genomic DNA. No translation available.
AC008421 Genomic DNA. No translation available.
BC012565 mRNA. Translation: AAH12565.1.
AB051622 Genomic DNA. Translation: BAB54950.1.
CCDSiCCDS4331.1. [Q9NWU5-1]
CCDS43391.1. [Q9NWU5-3]
RefSeqiNP_001014990.1. NM_001014990.2. [Q9NWU5-3]
NP_054899.2. NM_014180.3. [Q9NWU5-1]
UniGeneiHs.483924.

Genome annotation databases

EnsembliENST00000265229; ENSP00000265229; ENSG00000082515. [Q9NWU5-3]
ENST00000523037; ENSP00000431040; ENSG00000082515. [Q9NWU5-1]
GeneIDi29093.
KEGGihsa:29093.
UCSCiuc003lvy.5. human. [Q9NWU5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161507 mRNA. Translation: AAF29122.1. Frameshift.
AK000601 mRNA. Translation: BAA91282.1.
AK302784 mRNA. Translation: BAG63988.1.
CR933679 mRNA. Translation: CAI45973.1.
AC008410 Genomic DNA. No translation available.
AC008421 Genomic DNA. No translation available.
BC012565 mRNA. Translation: AAH12565.1.
AB051622 Genomic DNA. Translation: BAB54950.1.
CCDSiCCDS4331.1. [Q9NWU5-1]
CCDS43391.1. [Q9NWU5-3]
RefSeqiNP_001014990.1. NM_001014990.2. [Q9NWU5-3]
NP_054899.2. NM_014180.3. [Q9NWU5-1]
UniGeneiHs.483924.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40T1-206[»]
ProteinModelPortaliQ9NWU5.
SMRiQ9NWU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118862. 46 interactors.
IntActiQ9NWU5. 11 interactors.
MINTiMINT-6782667.
STRINGi9606.ENSP00000431040.

PTM databases

iPTMnetiQ9NWU5.
PhosphoSitePlusiQ9NWU5.

Polymorphism and mutation databases

BioMutaiMRPL22.
DMDMi74753031.

Proteomic databases

EPDiQ9NWU5.
MaxQBiQ9NWU5.
PaxDbiQ9NWU5.
PeptideAtlasiQ9NWU5.
PRIDEiQ9NWU5.
TopDownProteomicsiQ9NWU5-1. [Q9NWU5-1]

Protocols and materials databases

DNASUi29093.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265229; ENSP00000265229; ENSG00000082515. [Q9NWU5-3]
ENST00000523037; ENSP00000431040; ENSG00000082515. [Q9NWU5-1]
GeneIDi29093.
KEGGihsa:29093.
UCSCiuc003lvy.5. human. [Q9NWU5-1]

Organism-specific databases

CTDi29093.
DisGeNETi29093.
GeneCardsiMRPL22.
HGNCiHGNC:14480. MRPL22.
HPAiHPA047063.
MIMi611835. gene.
neXtProtiNX_Q9NWU5.
OpenTargetsiENSG00000082515.
PharmGKBiPA30952.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1711. Eukaryota.
COG0091. LUCA.
GeneTreeiENSGT00390000002110.
HOGENOMiHOG000048027.
HOVERGENiHBG093486.
InParanoidiQ9NWU5.
KOiK02890.
PhylomeDBiQ9NWU5.
TreeFamiTF315111.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL22. human.
GeneWikiiMRPL22.
GenomeRNAii29093.
PROiPR:Q9NWU5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000082515.
CleanExiHS_MRPL22.
ExpressionAtlasiQ9NWU5. baseline and differential.
GenevisibleiQ9NWU5. HS.

Family and domain databases

CDDicd00336. Ribosomal_L22. 1 hit.
InterProiView protein in InterPro
IPR001063. Ribosomal_L22.
IPR005727. Ribosomal_L22_bac/chlpt-type.
PANTHERiPTHR13501. PTHR13501. 1 hit.
PfamiView protein in Pfam
PF00237. Ribosomal_L22. 1 hit.
SUPFAMiSSF54843. SSF54843. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM22_HUMAN
AccessioniPrimary (citable) accession number: Q9NWU5
Secondary accession number(s): A6NGJ8
, Q5H9Q1, Q96Q51, Q9P006
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: April 12, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.