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Protein

Glucose-induced degradation protein 8 homolog

Gene

GID8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-induced degradation protein 8 homolog
Alternative name(s):
Two hybrid-associated protein 1 with RanBPM
Short name:
Twa1
Gene namesi
Name:GID8
Synonyms:C20orf11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15857. GID8.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25649.

Polymorphism and mutation databases

BioMutaiGID8.
DMDMi28201788.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Glucose-induced degradation protein 8 homologPRO_0000079411Add
BLAST

Proteomic databases

EPDiQ9NWU2.
MaxQBiQ9NWU2.
PaxDbiQ9NWU2.
PeptideAtlasiQ9NWU2.
PRIDEiQ9NWU2.

PTM databases

iPTMnetiQ9NWU2.
PhosphoSiteiQ9NWU2.

Expressioni

Gene expression databases

BgeeiQ9NWU2.
CleanExiHS_C20orf11.
GenevisibleiQ9NWU2. HS.

Organism-specific databases

HPAiHPA049929.
HPA055047.

Interactioni

Subunit structurei

Interacts with RANBP9. Part of a complex consisting of RANBP9, MKLN1 and GID8.1 Publication

Protein-protein interaction databases

BioGridi120327. 38 interactions.
IntActiQ9NWU2. 6 interactions.
STRINGi9606.ENSP00000266069.

Structurei

3D structure databases

ProteinModelPortaliQ9NWU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 5733LisHPROSITE-ProRule annotationAdd
BLAST
Domaini63 – 12058CTLHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili116 – 14631Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the GID8 family.Curated
Contains 1 CTLH domain.PROSITE-ProRule annotation
Contains 1 LisH domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2659. Eukaryota.
ENOG410XRG3. LUCA.
GeneTreeiENSGT00390000015162.
HOGENOMiHOG000182512.
HOVERGENiHBG051150.
InParanoidiQ9NWU2.
OMAiWAENTAR.
OrthoDBiEOG75MVX9.
PhylomeDBiQ9NWU2.
TreeFamiTF300176.

Family and domain databases

InterProiIPR013144. CRA_dom.
IPR024964. CTLH/CRA.
IPR006595. CTLH_C.
IPR006594. LisH.
[Graphical view]
PfamiPF10607. CLTH. 1 hit.
PF08513. LisH. 1 hit.
[Graphical view]
SMARTiSM00757. CRA. 1 hit.
SM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NWU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYAEKPDEI TKDEWMEKLN NLHVQRADMN RLIMNYLVTE GFKEAAEKFR
60 70 80 90 100
MESGIEPSVD LETLDERIKI REMILKGQIQ EAIALINSLH PELLDTNRYL
110 120 130 140 150
YFHLQQQHLI ELIRQRETEA ALEFAQTQLA EQGEESRECL TEMERTLALL
160 170 180 190 200
AFDSPEESPF GDLLHTMQRQ KVWSEVNQAV LDYENRESTP KLAKLLKLLL
210 220
WAQNELDQKK VKYPKMTDLS KGVIEEPK
Length:228
Mass (Da):26,749
Last modified:October 1, 2000 - v1
Checksum:i21466BDCB335DE98
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591V → L in AAH32120 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000609 mRNA. Translation: BAA91285.1.
AL121673 Genomic DNA. Translation: CAC08553.1.
CH471077 Genomic DNA. Translation: EAW75318.1.
CH471077 Genomic DNA. Translation: EAW75319.1.
BC032120 mRNA. Translation: AAH32120.1.
CCDSiCCDS13510.1.
RefSeqiNP_060366.1. NM_017896.2.
UniGeneiHs.353013.

Genome annotation databases

EnsembliENST00000266069; ENSP00000266069; ENSG00000101193.
GeneIDi54994.
KEGGihsa:54994.
UCSCiuc002ydy.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000609 mRNA. Translation: BAA91285.1.
AL121673 Genomic DNA. Translation: CAC08553.1.
CH471077 Genomic DNA. Translation: EAW75318.1.
CH471077 Genomic DNA. Translation: EAW75319.1.
BC032120 mRNA. Translation: AAH32120.1.
CCDSiCCDS13510.1.
RefSeqiNP_060366.1. NM_017896.2.
UniGeneiHs.353013.

3D structure databases

ProteinModelPortaliQ9NWU2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120327. 38 interactions.
IntActiQ9NWU2. 6 interactions.
STRINGi9606.ENSP00000266069.

PTM databases

iPTMnetiQ9NWU2.
PhosphoSiteiQ9NWU2.

Polymorphism and mutation databases

BioMutaiGID8.
DMDMi28201788.

Proteomic databases

EPDiQ9NWU2.
MaxQBiQ9NWU2.
PaxDbiQ9NWU2.
PeptideAtlasiQ9NWU2.
PRIDEiQ9NWU2.

Protocols and materials databases

DNASUi54994.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266069; ENSP00000266069; ENSG00000101193.
GeneIDi54994.
KEGGihsa:54994.
UCSCiuc002ydy.4. human.

Organism-specific databases

CTDi54994.
GeneCardsiGID8.
H-InvDBHIX0203033.
HGNCiHGNC:15857. GID8.
HPAiHPA049929.
HPA055047.
MIMi611625. gene.
neXtProtiNX_Q9NWU2.
PharmGKBiPA25649.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2659. Eukaryota.
ENOG410XRG3. LUCA.
GeneTreeiENSGT00390000015162.
HOGENOMiHOG000182512.
HOVERGENiHBG051150.
InParanoidiQ9NWU2.
OMAiWAENTAR.
OrthoDBiEOG75MVX9.
PhylomeDBiQ9NWU2.
TreeFamiTF300176.

Miscellaneous databases

GenomeRNAii54994.
PROiQ9NWU2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NWU2.
CleanExiHS_C20orf11.
GenevisibleiQ9NWU2. HS.

Family and domain databases

InterProiIPR013144. CRA_dom.
IPR024964. CTLH/CRA.
IPR006595. CTLH_C.
IPR006594. LisH.
[Graphical view]
PfamiPF10607. CLTH. 1 hit.
PF08513. LisH. 1 hit.
[Graphical view]
SMARTiSM00757. CRA. 1 hit.
SM00668. CTLH. 1 hit.
SM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50897. CTLH. 1 hit.
PS50896. LISH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM."
    Umeda M., Nishitani H., Nishimoto T.
    Gene 303:47-54(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH RANBP9, IDENTIFICATION IN A COMPLEX WITH MKLN1 AND RANBP9.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastric carcinoma.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiGID8_HUMAN
AccessioniPrimary (citable) accession number: Q9NWU2
Secondary accession number(s): E1P5I3, Q8N5M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.