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Protein

Glucose-induced degradation protein 8 homolog

Gene

GID8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-induced degradation protein 8 homolog
Alternative name(s):
Two hybrid-associated protein 1 with RanBPM
Short name:
Twa1
Gene namesi
Name:GID8
Synonyms:C20orf11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101193.7
HGNCiHGNC:15857 GID8
MIMi611625 gene
neXtProtiNX_Q9NWU2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54994
OpenTargetsiENSG00000101193
PharmGKBiPA25649

Polymorphism and mutation databases

BioMutaiGID8
DMDMi28201788

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794111 – 228Glucose-induced degradation protein 8 homologAdd BLAST228

Proteomic databases

EPDiQ9NWU2
MaxQBiQ9NWU2
PaxDbiQ9NWU2
PeptideAtlasiQ9NWU2
PRIDEiQ9NWU2

PTM databases

iPTMnetiQ9NWU2
PhosphoSitePlusiQ9NWU2

Expressioni

Gene expression databases

BgeeiENSG00000101193
CleanExiHS_C20orf11
GenevisibleiQ9NWU2 HS

Organism-specific databases

HPAiHPA049929
HPA055047

Interactioni

Subunit structurei

Interacts with RANBP9. Part of a complex consisting of RANBP9, MKLN1 and GID8.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120327, 60 interactors
CORUMiQ9NWU2
IntActiQ9NWU2, 29 interactors
STRINGi9606.ENSP00000266069

Structurei

3D structure databases

ProteinModelPortaliQ9NWU2
SMRiQ9NWU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 57LisHPROSITE-ProRule annotationAdd BLAST33
Domaini63 – 120CTLHPROSITE-ProRule annotationAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili116 – 146Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the GID8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2659 Eukaryota
ENOG410XRG3 LUCA
GeneTreeiENSGT00390000015162
HOGENOMiHOG000182512
HOVERGENiHBG051150
InParanoidiQ9NWU2
OMAiQNGRIQE
OrthoDBiEOG091G0J0O
PhylomeDBiQ9NWU2
TreeFamiTF300176

Family and domain databases

InterProiView protein in InterPro
IPR013144 CRA_dom
IPR024964 CTLH/CRA
IPR006595 CTLH_C
IPR006594 LisH
PfamiView protein in Pfam
PF10607 CLTH, 1 hit
PF08513 LisH, 1 hit
SMARTiView protein in SMART
SM00757 CRA, 1 hit
SM00668 CTLH, 1 hit
SM00667 LisH, 1 hit
PROSITEiView protein in PROSITE
PS50897 CTLH, 1 hit
PS50896 LISH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NWU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYAEKPDEI TKDEWMEKLN NLHVQRADMN RLIMNYLVTE GFKEAAEKFR
60 70 80 90 100
MESGIEPSVD LETLDERIKI REMILKGQIQ EAIALINSLH PELLDTNRYL
110 120 130 140 150
YFHLQQQHLI ELIRQRETEA ALEFAQTQLA EQGEESRECL TEMERTLALL
160 170 180 190 200
AFDSPEESPF GDLLHTMQRQ KVWSEVNQAV LDYENRESTP KLAKLLKLLL
210 220
WAQNELDQKK VKYPKMTDLS KGVIEEPK
Length:228
Mass (Da):26,749
Last modified:October 1, 2000 - v1
Checksum:i21466BDCB335DE98
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59V → L in AAH32120 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000609 mRNA Translation: BAA91285.1
AL121673 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75318.1
CH471077 Genomic DNA Translation: EAW75319.1
BC032120 mRNA Translation: AAH32120.1
CCDSiCCDS13510.1
RefSeqiNP_060366.1, NM_017896.2
UniGeneiHs.353013

Genome annotation databases

EnsembliENST00000266069; ENSP00000266069; ENSG00000101193
GeneIDi54994
KEGGihsa:54994
UCSCiuc002ydy.4 human

Similar proteinsi

Entry informationi

Entry nameiGID8_HUMAN
AccessioniPrimary (citable) accession number: Q9NWU2
Secondary accession number(s): E1P5I3, Q8N5M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health