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Protein

Aurora kinase A-interacting protein

Gene

AURKAIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
Aurora kinase A-interacting protein
Short name:
AURKA-interacting protein
Alternative name(s):
28S ribosomal protein S38, mitochondrial
Short name:
MRP-S38
Mitochondrial small ribosomal subunit protein mS381 Publication
Gene namesi
Name:AURKAIP1
Synonyms:AIP, AKIP, MRPS38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000175756.13.
HGNCiHGNC:24114. AURKAIP1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175756.
PharmGKBiPA142672568.

Chemistry databases

ChEMBLiCHEMBL5910.

Polymorphism and mutation databases

BioMutaiAURKAIP1.
DMDMi30912743.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000645361 – 199Aurora kinase A-interacting proteinAdd BLAST199

Proteomic databases

EPDiQ9NWT8.
MaxQBiQ9NWT8.
PaxDbiQ9NWT8.
PeptideAtlasiQ9NWT8.
PRIDEiQ9NWT8.
TopDownProteomicsiQ9NWT8.

PTM databases

iPTMnetiQ9NWT8.
PhosphoSitePlusiQ9NWT8.

Expressioni

Tissue specificityi

Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis.

Gene expression databases

BgeeiENSG00000175756.
CleanExiHS_AIP.
HS_AURKAIP1.
ExpressionAtlasiQ9NWT8. baseline and differential.
GenevisibleiQ9NWT8. HS.

Organism-specific databases

HPAiHPA031821.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:23908630, PubMed:25838379). Interacts with Aurora-A (PubMed:12244051).3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120331. 53 interactors.
IntActiQ9NWT8. 8 interactors.
STRINGi9606.ENSP00000319778.

Chemistry databases

BindingDBiQ9NWT8.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50A31-199[»]
ProteinModelPortaliQ9NWT8.
SMRiQ9NWT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IY6U. Eukaryota.
ENOG4111QH2. LUCA.
GeneTreeiENSGT00390000012802.
HOGENOMiHOG000004845.
HOVERGENiHBG010333.
InParanoidiQ9NWT8.
KOiK16830.
OMAiPQIQCKN.
OrthoDBiEOG091G0MVA.
PhylomeDBiQ9NWT8.
TreeFamiTF332330.

Family and domain databases

InterProiView protein in InterPro
IPR013177. DUF1713.
PfamiView protein in Pfam
PF08213. DUF1713. 1 hit.
SMARTiView protein in SMART
SM01155. DUF1713. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NWT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLGRLTSQL LRAVPWAGGR PPWPVSGVLG SRVCGPLYST SPAGPGRAAS
60 70 80 90 100
LPRKGAQLEL EEMLVPRKMS VSPLESWLTA RCFLPRLDTG TAGTVAPPQS
110 120 130 140 150
YQCPPSQIGE GAEQGDEGVA DAPQIQCKNV LKIRRRKMNH HKYRKLVKKT
160 170 180 190
RFLRRKVQEG RLRRKQIKFE KDLRRIWLKA GLKEAPEGWQ TPKIYLRGK
Length:199
Mass (Da):22,354
Last modified:October 1, 2000 - v1
Checksum:i2332CF162862477F
GO

Sequence cautioni

The sequence AAH22808 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020132107Q → H. Corresponds to variant dbSNP:rs3736374Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000615 mRNA. Translation: BAA91289.1.
AL139287 Genomic DNA. No translation available.
BC022808 mRNA. Translation: AAH22808.1. Different initiation.
BC062333 mRNA. Translation: AAH62333.1.
CCDSiCCDS25.1.
RefSeqiNP_001120701.1. NM_001127229.1.
NP_001120702.1. NM_001127230.1.
NP_060370.1. NM_017900.2.
UniGeneiHs.632515.

Genome annotation databases

EnsembliENST00000321751; ENSP00000319778; ENSG00000175756.
ENST00000338338; ENSP00000340656; ENSG00000175756.
ENST00000338370; ENSP00000342676; ENSG00000175756.
ENST00000378853; ENSP00000368130; ENSG00000175756.
GeneIDi54998.
KEGGihsa:54998.
UCSCiuc001afb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAKIP_HUMAN
AccessioniPrimary (citable) accession number: Q9NWT8
Secondary accession number(s): Q5TA36, Q8TBD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families