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Protein

Aurora kinase A-interacting protein

Gene

AURKAIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
Aurora kinase A-interacting protein
Short name:
AURKA-interacting protein
Alternative name(s):
28S ribosomal protein S38, mitochondrial
Short name:
MRP-S38
Mitochondrial small ribosomal subunit protein mS381 Publication
Gene namesi
Name:AURKAIP1
Synonyms:AIP, AKIP, MRPS38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000175756.13
HGNCiHGNC:24114 AURKAIP1
MIMi609183 gene
neXtProtiNX_Q9NWT8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175756
PharmGKBiPA142672568

Chemistry databases

ChEMBLiCHEMBL5910

Polymorphism and mutation databases

BioMutaiAURKAIP1
DMDMi30912743

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000645361 – 199Aurora kinase A-interacting proteinAdd BLAST199

Proteomic databases

EPDiQ9NWT8
MaxQBiQ9NWT8
PaxDbiQ9NWT8
PeptideAtlasiQ9NWT8
PRIDEiQ9NWT8
TopDownProteomicsiQ9NWT8

PTM databases

iPTMnetiQ9NWT8
PhosphoSitePlusiQ9NWT8

Expressioni

Tissue specificityi

Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis.

Gene expression databases

BgeeiENSG00000175756
CleanExiHS_AIP
HS_AURKAIP1
ExpressionAtlasiQ9NWT8 baseline and differential
GenevisibleiQ9NWT8 HS

Organism-specific databases

HPAiHPA031821

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:23908630, PubMed:25838379). Interacts with Aurora-A (PubMed:12244051).3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120331, 53 interactors
IntActiQ9NWT8, 251 interactors
STRINGi9606.ENSP00000319778

Chemistry databases

BindingDBiQ9NWT8

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50A31-199[»]
ProteinModelPortaliQ9NWT8
SMRiQ9NWT8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IY6U Eukaryota
ENOG4111QH2 LUCA
GeneTreeiENSGT00390000012802
HOGENOMiHOG000004845
HOVERGENiHBG010333
InParanoidiQ9NWT8
KOiK16830
OMAiPQIQCKN
OrthoDBiEOG091G0MVA
PhylomeDBiQ9NWT8
TreeFamiTF332330

Family and domain databases

InterProiView protein in InterPro
IPR013177 DUF1713
PfamiView protein in Pfam
PF08213 DUF1713, 1 hit
SMARTiView protein in SMART
SM01155 DUF1713, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NWT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLGRLTSQL LRAVPWAGGR PPWPVSGVLG SRVCGPLYST SPAGPGRAAS
60 70 80 90 100
LPRKGAQLEL EEMLVPRKMS VSPLESWLTA RCFLPRLDTG TAGTVAPPQS
110 120 130 140 150
YQCPPSQIGE GAEQGDEGVA DAPQIQCKNV LKIRRRKMNH HKYRKLVKKT
160 170 180 190
RFLRRKVQEG RLRRKQIKFE KDLRRIWLKA GLKEAPEGWQ TPKIYLRGK
Length:199
Mass (Da):22,354
Last modified:October 1, 2000 - v1
Checksum:i2332CF162862477F
GO

Sequence cautioni

The sequence AAH22808 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020132107Q → H. Corresponds to variant dbSNP:rs3736374Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000615 mRNA Translation: BAA91289.1
AL139287 Genomic DNA No translation available.
BC022808 mRNA Translation: AAH22808.1 Different initiation.
BC062333 mRNA Translation: AAH62333.1
CCDSiCCDS25.1
RefSeqiNP_001120701.1, NM_001127229.1
NP_001120702.1, NM_001127230.1
NP_060370.1, NM_017900.2
UniGeneiHs.632515

Genome annotation databases

EnsembliENST00000321751; ENSP00000319778; ENSG00000175756
ENST00000338338; ENSP00000340656; ENSG00000175756
ENST00000338370; ENSP00000342676; ENSG00000175756
ENST00000378853; ENSP00000368130; ENSG00000175756
GeneIDi54998
KEGGihsa:54998
UCSCiuc001afb.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAKIP_HUMAN
AccessioniPrimary (citable) accession number: Q9NWT8
Secondary accession number(s): Q5TA36, Q8TBD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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