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Protein

Aurora kinase A-interacting protein

Gene

AURKAIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
Aurora kinase A-interacting protein
Short name:
AURKA-interacting protein
Alternative name(s):
28S ribosomal protein S38, mitochondrial
Short name:
MRP-S38
Gene namesi
Name:AURKAIP1
Synonyms:AIP, AKIP, MRPS38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24114. AURKAIP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672568.

Chemistry

ChEMBLiCHEMBL5910.

Polymorphism and mutation databases

BioMutaiAURKAIP1.
DMDMi30912743.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Aurora kinase A-interacting proteinPRO_0000064536Add
BLAST

Proteomic databases

EPDiQ9NWT8.
MaxQBiQ9NWT8.
PaxDbiQ9NWT8.
PRIDEiQ9NWT8.
TopDownProteomicsiQ9NWT8.

PTM databases

iPTMnetiQ9NWT8.
PhosphoSiteiQ9NWT8.

Expressioni

Tissue specificityi

Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis.

Gene expression databases

BgeeiQ9NWT8.
CleanExiHS_AIP.
HS_AURKAIP1.
ExpressionAtlasiQ9NWT8. baseline and differential.
GenevisibleiQ9NWT8. HS.

Organism-specific databases

HPAiHPA031821.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with Aurora-A.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AURKAO149652EBI-448665,EBI-448680
FAM9BQ8IZU03EBI-448665,EBI-10175124

Protein-protein interaction databases

BioGridi120331. 46 interactions.
IntActiQ9NWT8. 8 interactions.
STRINGi9606.ENSP00000319778.

Chemistry

BindingDBiQ9NWT8.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50A31-199[»]
ProteinModelPortaliQ9NWT8.
SMRiQ9NWT8. Positions 128-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IY6U. Eukaryota.
ENOG4111QH2. LUCA.
GeneTreeiENSGT00390000012802.
HOGENOMiHOG000004845.
HOVERGENiHBG010333.
InParanoidiQ9NWT8.
KOiK16830.
OMAiPQIQCKN.
OrthoDBiEOG7DNNWC.
PhylomeDBiQ9NWT8.
TreeFamiTF332330.

Family and domain databases

InterProiIPR013177. DUF1713.
[Graphical view]
PfamiPF08213. DUF1713. 1 hit.
[Graphical view]
SMARTiSM01155. DUF1713. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NWT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLGRLTSQL LRAVPWAGGR PPWPVSGVLG SRVCGPLYST SPAGPGRAAS
60 70 80 90 100
LPRKGAQLEL EEMLVPRKMS VSPLESWLTA RCFLPRLDTG TAGTVAPPQS
110 120 130 140 150
YQCPPSQIGE GAEQGDEGVA DAPQIQCKNV LKIRRRKMNH HKYRKLVKKT
160 170 180 190
RFLRRKVQEG RLRRKQIKFE KDLRRIWLKA GLKEAPEGWQ TPKIYLRGK
Length:199
Mass (Da):22,354
Last modified:October 1, 2000 - v1
Checksum:i2332CF162862477F
GO

Sequence cautioni

The sequence AAH22808.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti107 – 1071Q → H.
Corresponds to variant rs3736374 [ dbSNP | Ensembl ].
VAR_020132

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000615 mRNA. Translation: BAA91289.1.
AL139287 Genomic DNA. Translation: CAI23191.1.
BC022808 mRNA. Translation: AAH22808.1. Different initiation.
BC062333 mRNA. Translation: AAH62333.1.
CCDSiCCDS25.1.
RefSeqiNP_001120701.1. NM_001127229.1.
NP_001120702.1. NM_001127230.1.
NP_060370.1. NM_017900.2.
UniGeneiHs.632515.

Genome annotation databases

EnsembliENST00000321751; ENSP00000319778; ENSG00000175756.
ENST00000338338; ENSP00000340656; ENSG00000175756.
ENST00000338370; ENSP00000342676; ENSG00000175756.
ENST00000378853; ENSP00000368130; ENSG00000175756.
GeneIDi54998.
KEGGihsa:54998.
UCSCiuc001afb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000615 mRNA. Translation: BAA91289.1.
AL139287 Genomic DNA. Translation: CAI23191.1.
BC022808 mRNA. Translation: AAH22808.1. Different initiation.
BC062333 mRNA. Translation: AAH62333.1.
CCDSiCCDS25.1.
RefSeqiNP_001120701.1. NM_001127229.1.
NP_001120702.1. NM_001127230.1.
NP_060370.1. NM_017900.2.
UniGeneiHs.632515.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50A31-199[»]
ProteinModelPortaliQ9NWT8.
SMRiQ9NWT8. Positions 128-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120331. 46 interactions.
IntActiQ9NWT8. 8 interactions.
STRINGi9606.ENSP00000319778.

Chemistry

BindingDBiQ9NWT8.
ChEMBLiCHEMBL5910.

PTM databases

iPTMnetiQ9NWT8.
PhosphoSiteiQ9NWT8.

Polymorphism and mutation databases

BioMutaiAURKAIP1.
DMDMi30912743.

Proteomic databases

EPDiQ9NWT8.
MaxQBiQ9NWT8.
PaxDbiQ9NWT8.
PRIDEiQ9NWT8.
TopDownProteomicsiQ9NWT8.

Protocols and materials databases

DNASUi54998.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321751; ENSP00000319778; ENSG00000175756.
ENST00000338338; ENSP00000340656; ENSG00000175756.
ENST00000338370; ENSP00000342676; ENSG00000175756.
ENST00000378853; ENSP00000368130; ENSG00000175756.
GeneIDi54998.
KEGGihsa:54998.
UCSCiuc001afb.2. human.

Organism-specific databases

CTDi54998.
GeneCardsiAURKAIP1.
HGNCiHGNC:24114. AURKAIP1.
HPAiHPA031821.
MIMi609183. gene.
neXtProtiNX_Q9NWT8.
PharmGKBiPA142672568.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IY6U. Eukaryota.
ENOG4111QH2. LUCA.
GeneTreeiENSGT00390000012802.
HOGENOMiHOG000004845.
HOVERGENiHBG010333.
InParanoidiQ9NWT8.
KOiK16830.
OMAiPQIQCKN.
OrthoDBiEOG7DNNWC.
PhylomeDBiQ9NWT8.
TreeFamiTF332330.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiAURKAIP1. human.
GenomeRNAii54998.
PROiQ9NWT8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NWT8.
CleanExiHS_AIP.
HS_AURKAIP1.
ExpressionAtlasiQ9NWT8. baseline and differential.
GenevisibleiQ9NWT8. HS.

Family and domain databases

InterProiIPR013177. DUF1713.
[Graphical view]
PfamiPF08213. DUF1713. 1 hit.
[Graphical view]
SMARTiSM01155. DUF1713. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Prostate.
  4. "Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase."
    Kiat L.S., Hui K.M., Gopalan G.
    J. Biol. Chem. 277:45558-45565(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AURORA-A.
  5. "Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome."
    Koc E.C., Cimen H., Kumcuoglu B., Abu N., Akpinar G., Haque M.E., Spremulli L.L., Koc H.
    Front. Physiol. 4:183-183(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAKIP_HUMAN
AccessioniPrimary (citable) accession number: Q9NWT8
Secondary accession number(s): Q5TA36, Q8TBD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.