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Protein

p21-activated protein kinase-interacting protein 1

Gene

PAK1IP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868).2 Publications

GO - Biological processi

  • cell proliferation Source: Ensembl
  • negative regulation of signal transduction Source: UniProtKB-KW
  • palate development Source: Ensembl
  • regulation of signal transduction by p53 class mediator Source: UniProtKB
  • ribosomal large subunit biogenesis Source: UniProtKB

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processRibosome biogenesis

Enzyme and pathway databases

SignaLinkiQ9NWT1.

Names & Taxonomyi

Protein namesi
Recommended name:
p21-activated protein kinase-interacting protein 1
Alternative name(s):
PAK/PLC-interacting protein 1
Short name:
hPIP1
PAK1-interacting protein 1
WD repeat-containing protein 84
Gene namesi
Name:PAK1IP1
Synonyms:PIP1, WDR84
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000111845.4.
HGNCiHGNC:20882. PAK1IP1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111845.
PharmGKBiPA134928299.

Polymorphism and mutation databases

BioMutaiPAK1IP1.
DMDMi71153057.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511251 – 392p21-activated protein kinase-interacting protein 1Add BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei320PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NWT1.
MaxQBiQ9NWT1.
PaxDbiQ9NWT1.
PeptideAtlasiQ9NWT1.
PRIDEiQ9NWT1.

2D gel databases

SWISS-2DPAGEiQ9NWT1.

PTM databases

iPTMnetiQ9NWT1.
PhosphoSitePlusiQ9NWT1.

Expressioni

Tissue specificityi

Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus.1 Publication

Gene expression databases

BgeeiENSG00000111845.
CleanExiHS_PAK1IP1.
ExpressionAtlasiQ9NWT1. baseline and differential.
GenevisibleiQ9NWT1. HS.

Organism-specific databases

HPAiHPA030112.

Interactioni

Subunit structurei

Interacts with PAK1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MEOX2P502224EBI-7641942,EBI-748397

Protein-protein interaction databases

BioGridi120335. 29 interactors.
IntActiQ9NWT1. 6 interactors.
MINTiMINT-3057412.
STRINGi9606.ENSP00000368887.

Structurei

3D structure databases

ProteinModelPortaliQ9NWT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati33 – 72WD 1Add BLAST40
Repeati73 – 113WD 2Add BLAST41
Repeati114 – 155WD 3Add BLAST42
Repeati156 – 195WD 4Add BLAST40
Repeati196 – 235WD 5Add BLAST40
Repeati236 – 275WD 6Add BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0294. Eukaryota.
ENOG410XRDQ. LUCA.
GeneTreeiENSGT00390000001263.
HOGENOMiHOG000007618.
HOVERGENiHBG082144.
InParanoidiQ9NWT1.
KOiK14830.
OMAiVAGSYEQ.
OrthoDBiEOG091G0JNV.
PhylomeDBiQ9NWT1.
TreeFamiTF326684.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 3 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 5 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9NWT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELVAGCYEQ VLFGFAVHPE PEACGDHEQW TLVADFTHHA HTASLSAVAV
60 70 80 90 100
NSRFVVTGSK DETIHIYDMK KKIEHGALVH HSGTITCLKF YGNRHLISGA
110 120 130 140 150
EDGLICIWDA KKWECLKSIK AHKGQVTFLS IHPSGKLALS VGTDKTLRTW
160 170 180 190 200
NLVEGRSAFI KNIKQNAHIV EWSPRGEQYV VIIQNKIDIY QLDTASISGT
210 220 230 240 250
ITNEKRISSV KFLSESVLAV AGDEEVIRFF DCDSLVCLCE FKAHENRVKD
260 270 280 290 300
MFSFEIPEHH VIVSASSDGF IKMWKLKQDK KVPPSLLCEI NTNARLTCLG
310 320 330 340 350
VWLDKVADMK ESLPPAAEPS PVSKEQSKIG KKEPGDTVHK EEKRSKPNTK
360 370 380 390
KRGLTGDSKK ATKESGLIST KKRKMVEMLE KKRKKKKIKT MQ
Length:392
Mass (Da):43,964
Last modified:July 19, 2005 - v2
Checksum:i7600CDDFCB4F363A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22E → K in BAA91296 (PubMed:14702039).Curated1
Sequence conflicti124G → R in AAK57477 (PubMed:11371639).Curated1
Sequence conflicti201I → V in AAH10907 (PubMed:15489334).Curated1
Sequence conflicti257P → L in AAK57477 (PubMed:11371639).Curated1
Sequence conflicti273M → R in AAK57477 (PubMed:11371639).Curated1
Sequence conflicti277K → E in AAH10907 (PubMed:15489334).Curated1
Sequence conflicti311Missing in BAA91296 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283303 mRNA. Translation: AAK57477.1.
AK000631 mRNA. Translation: BAA91296.1.
AL358777 Genomic DNA. No translation available.
BC010907 mRNA. Translation: AAH10907.1.
CCDSiCCDS34339.1.
RefSeqiNP_060376.2. NM_017906.2.
UniGeneiHs.310231.

Genome annotation databases

EnsembliENST00000379568; ENSP00000368887; ENSG00000111845.
GeneIDi55003.
KEGGihsa:55003.
UCSCiuc003mzg.4. human.

Similar proteinsi

Entry informationi

Entry nameiPK1IP_HUMAN
AccessioniPrimary (citable) accession number: Q9NWT1
Secondary accession number(s): Q5T4J2, Q96QJ8, Q96T87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: September 27, 2017
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot