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Protein

Zinc finger protein 446

Gene

ZNF446

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri332 – 35928C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri395 – 42228C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 45028C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 446
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 20
Gene namesi
Name:ZNF446
Synonyms:ZKSCAN20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:21036. ZNF446.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • extracellular space Source: UniProtKB
  • nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134863395.

Polymorphism and mutation databases

BioMutaiZNF446.
DMDMi55976772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Zinc finger protein 446PRO_0000047596Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei137 – 1371PhosphoserineCombined sources
Modified residuei308 – 3081PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NWS9.
PaxDbiQ9NWS9.
PRIDEiQ9NWS9.

PTM databases

iPTMnetiQ9NWS9.
PhosphoSiteiQ9NWS9.

Expressioni

Gene expression databases

BgeeiQ9NWS9.
CleanExiHS_ZNF446.
ExpressionAtlasiQ9NWS9. baseline and differential.
GenevisibleiQ9NWS9. HS.

Organism-specific databases

HPAiHPA052786.

Interactioni

Protein-protein interaction databases

BioGridi120795. 37 interactions.
IntActiQ9NWS9. 1 interaction.
STRINGi9606.ENSP00000472802.

Structurei

3D structure databases

ProteinModelPortaliQ9NWS9.
SMRiQ9NWS9. Positions 22-109, 321-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 10883SCAN boxPROSITE-ProRule annotationAdd
BLAST
Domaini208 – 25447KRABAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi274 – 33158Pro-richAdd
BLAST

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.Curated
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri332 – 35928C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri395 – 42228C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 45028C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129746.
HOGENOMiHOG000234619.
HOVERGENiHBG098310.
InParanoidiQ9NWS9.
OMAiHPPRIQE.
PhylomeDBiQ9NWS9.
TreeFamiTF337489.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR027768. Zfp446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PTHR10032:SF73. PTHR10032:SF73. 2 hits.
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NWS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPLGPPCL PVMDPETTLE EPETARLRFR GFCYQEVAGP REALARLREL
60 70 80 90 100
CCQWLQPEAH SKEQMLEMLV LEQFLGTLPP EIQAWVRGQR PGSPEEAAAL
110 120 130 140 150
VEGLQHDPGQ LLGWITAHVL KQEVLPAAQK TEEPLGSPHP SGTVESPGEG
160 170 180 190 200
PQDTRIEGSV QLSCSVKEEP NVDGQEVAPS SPPLAAQSPE GNHGHQEPAS
210 220 230 240 250
TSFHPPRIQE EWGLLDRSQK ELYWDAMLEK YGTVVSLGLP PHQPEAQAQS
260 270 280 290 300
ELGMLLTGTG VCRSLRSGNE SEGPPGCPEA QPPQGPGPAA WEGLSGAATP
310 320 330 340 350
APTVRPGTPP VPTQPTPAET RLEPAATPRK PYTCEQCGRG FDWKSVFVIH
360 370 380 390 400
HRTHTSGPGV QSPGLATGES TEKPPQGEVA FPHHPRRSLT GPRSYPCEEC
410 420 430 440 450
GCSFSWKSQL VIHRKSHTGQ RRHFCSDCGR AFDWKSQLVI HRKGHRPEVP
Length:450
Mass (Da):48,957
Last modified:October 1, 2000 - v1
Checksum:i8D8B65137855E91E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti192 – 1921N → H.
Corresponds to variant rs893185 [ dbSNP | Ensembl ].
VAR_033566
Natural varianti300 – 3001P → S.
Corresponds to variant rs36095067 [ dbSNP | Ensembl ].
VAR_033567
Natural varianti387 – 3871R → H.
Corresponds to variant rs882610 [ dbSNP | Ensembl ].
VAR_052833

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000633 mRNA. Translation: BAA91298.1.
AY280800 mRNA. Translation: AAQ16304.1.
CCDSiCCDS12982.1.
RefSeqiNP_060378.1. NM_017908.3.
XP_005259109.1. XM_005259052.3.
UniGeneiHs.710284.

Genome annotation databases

EnsembliENST00000594369; ENSP00000472802; ENSG00000083838.
GeneIDi55663.
UCSCiuc002qsz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000633 mRNA. Translation: BAA91298.1.
AY280800 mRNA. Translation: AAQ16304.1.
CCDSiCCDS12982.1.
RefSeqiNP_060378.1. NM_017908.3.
XP_005259109.1. XM_005259052.3.
UniGeneiHs.710284.

3D structure databases

ProteinModelPortaliQ9NWS9.
SMRiQ9NWS9. Positions 22-109, 321-450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120795. 37 interactions.
IntActiQ9NWS9. 1 interaction.
STRINGi9606.ENSP00000472802.

PTM databases

iPTMnetiQ9NWS9.
PhosphoSiteiQ9NWS9.

Polymorphism and mutation databases

BioMutaiZNF446.
DMDMi55976772.

Proteomic databases

MaxQBiQ9NWS9.
PaxDbiQ9NWS9.
PRIDEiQ9NWS9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000594369; ENSP00000472802; ENSG00000083838.
GeneIDi55663.
UCSCiuc002qsz.4. human.

Organism-specific databases

CTDi55663.
GeneCardsiZNF446.
HGNCiHGNC:21036. ZNF446.
HPAiHPA052786.
neXtProtiNX_Q9NWS9.
PharmGKBiPA134863395.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129746.
HOGENOMiHOG000234619.
HOVERGENiHBG098310.
InParanoidiQ9NWS9.
OMAiHPPRIQE.
PhylomeDBiQ9NWS9.
TreeFamiTF337489.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF446. human.
GenomeRNAii55663.
NextBioi60407.
PROiQ9NWS9.

Gene expression databases

BgeeiQ9NWS9.
CleanExiHS_ZNF446.
ExpressionAtlasiQ9NWS9. baseline and differential.
GenevisibleiQ9NWS9. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR027768. Zfp446.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 2 hits.
PTHR10032:SF73. PTHR10032:SF73. 2 hits.
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a human novel znf gene."
    Luo K.T., Yu L.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  4. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137 AND THR-308, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiZN446_HUMAN
AccessioniPrimary (citable) accession number: Q9NWS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.