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Protein

Zinc finger protein 446

Gene

ZNF446

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri332 – 359C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri395 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri423 – 450C2H2-type 3PROSITE-ProRule annotationAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 446
Alternative name(s):
Zinc finger protein with KRAB and SCAN domains 20
Gene namesi
Name:ZNF446
Synonyms:ZKSCAN20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000083838.15.
HGNCiHGNC:21036. ZNF446.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000083838.
PharmGKBiPA134863395.

Polymorphism and mutation databases

BioMutaiZNF446.
DMDMi55976772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475961 – 450Zinc finger protein 446Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei137PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei308PhosphothreonineCombined sources1
Cross-linki330Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NWS9.
MaxQBiQ9NWS9.
PaxDbiQ9NWS9.
PeptideAtlasiQ9NWS9.
PRIDEiQ9NWS9.

PTM databases

iPTMnetiQ9NWS9.
PhosphoSitePlusiQ9NWS9.

Expressioni

Gene expression databases

BgeeiENSG00000083838.
CleanExiHS_ZNF446.
ExpressionAtlasiQ9NWS9. baseline and differential.
GenevisibleiQ9NWS9. HS.

Organism-specific databases

HPAiHPA052786.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi120795. 39 interactors.
IntActiQ9NWS9. 53 interactors.
STRINGi9606.ENSP00000472802.

Structurei

3D structure databases

ProteinModelPortaliQ9NWS9.
SMRiQ9NWS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 108SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini208 – 254KRABAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi274 – 331Pro-richAdd BLAST58

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri332 – 359C2H2-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri395 – 422C2H2-type 2PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri423 – 450C2H2-type 3PROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00900000140852.
HOGENOMiHOG000234619.
HOVERGENiHBG098310.
InParanoidiQ9NWS9.
KOiK09229.
OMAiHPPRIQE.
OrthoDBiEOG091G08W1.
PhylomeDBiQ9NWS9.
TreeFamiTF337489.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR027764. Zfp18/Zfp446.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PANTHERiPTHR45403. PTHR45403. 3 hits.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
SSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NWS9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSPLGPPCL PVMDPETTLE EPETARLRFR GFCYQEVAGP REALARLREL
60 70 80 90 100
CCQWLQPEAH SKEQMLEMLV LEQFLGTLPP EIQAWVRGQR PGSPEEAAAL
110 120 130 140 150
VEGLQHDPGQ LLGWITAHVL KQEVLPAAQK TEEPLGSPHP SGTVESPGEG
160 170 180 190 200
PQDTRIEGSV QLSCSVKEEP NVDGQEVAPS SPPLAAQSPE GNHGHQEPAS
210 220 230 240 250
TSFHPPRIQE EWGLLDRSQK ELYWDAMLEK YGTVVSLGLP PHQPEAQAQS
260 270 280 290 300
ELGMLLTGTG VCRSLRSGNE SEGPPGCPEA QPPQGPGPAA WEGLSGAATP
310 320 330 340 350
APTVRPGTPP VPTQPTPAET RLEPAATPRK PYTCEQCGRG FDWKSVFVIH
360 370 380 390 400
HRTHTSGPGV QSPGLATGES TEKPPQGEVA FPHHPRRSLT GPRSYPCEEC
410 420 430 440 450
GCSFSWKSQL VIHRKSHTGQ RRHFCSDCGR AFDWKSQLVI HRKGHRPEVP
Length:450
Mass (Da):48,957
Last modified:October 1, 2000 - v1
Checksum:i8D8B65137855E91E
GO
Isoform 2 (identifier: Q9NWS9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     417-444: Missing.

Show »
Length:422
Mass (Da):45,648
Checksum:iD1878D81688F415E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033566192N → H1 PublicationCorresponds to variant dbSNP:rs893185Ensembl.1
Natural variantiVAR_033567300P → S. Corresponds to variant dbSNP:rs36095067Ensembl.1
Natural variantiVAR_052833387R → H1 PublicationCorresponds to variant dbSNP:rs882610Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058945417 – 444Missing in isoform 2. Add BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000633 mRNA. Translation: BAA91298.1.
AY280800 mRNA. Translation: AAQ16304.1.
BC017206 mRNA. Translation: AAH17206.1.
CCDSiCCDS12982.1. [Q9NWS9-1]
RefSeqiNP_060378.1. NM_017908.3. [Q9NWS9-1]
XP_005259109.1. XM_005259052.4. [Q9NWS9-1]
UniGeneiHs.710284.

Genome annotation databases

EnsembliENST00000594369; ENSP00000472802; ENSG00000083838. [Q9NWS9-1]
ENST00000610298; ENSP00000478778; ENSG00000083838. [Q9NWS9-2]
GeneIDi55663.
KEGGihsa:55663.
UCSCiuc002qsz.4. human. [Q9NWS9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN446_HUMAN
AccessioniPrimary (citable) accession number: Q9NWS9
Secondary accession number(s): Q96AF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families