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Protein

Calcium uniporter regulatory subunit MCUb, mitochondrial

Gene

CCDC109B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Protein family/group databases

TCDBi1.A.77.1.12. the mg(2+)/ca(2+) uniporter (mcu) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium uniporter regulatory subunit MCUb, mitochondrial
Short name:
MCUb
Alternative name(s):
Coiled-coil domain-containing protein 109B
Gene namesi
Name:CCDC109B
Synonyms:MCUB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26076. CCDC109B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei220 – 24021HelicalSequence analysisAdd
BLAST
Transmembranei250 – 27021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • calcium channel complex Source: UniProtKB
  • integral component of mitochondrial inner membrane Source: UniProtKB
  • intrinsic component of membrane Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • uniplex complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145008731.

Polymorphism and mutation databases

BioMutaiCCDC109B.
DMDMi143955289.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3535MitochondrionSequence analysisAdd
BLAST
Chaini36 – 336301Calcium uniporter regulatory subunit MCUb, mitochondrialPRO_0000282980Add
BLAST

Proteomic databases

EPDiQ9NWR8.
MaxQBiQ9NWR8.
PaxDbiQ9NWR8.
PeptideAtlasiQ9NWR8.
PRIDEiQ9NWR8.

PTM databases

iPTMnetiQ9NWR8.
PhosphoSiteiQ9NWR8.

Expressioni

Gene expression databases

BgeeiQ9NWR8.
CleanExiHS_CCDC109B.
GenevisibleiQ9NWR8. HS.

Organism-specific databases

HPAiHPA048776.

Interactioni

Subunit structurei

Heterotetramer with MCU; this reduces MCU channel activity. Homooligomer (By similarity). Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1.By similarity1 Publication

Protein-protein interaction databases

BioGridi120345. 8 interactions.
IntActiQ9NWR8. 2 interactions.
MINTiMINT-1391505.
STRINGi9606.ENSP00000378145.

Structurei

3D structure databases

ProteinModelPortaliQ9NWR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili179 – 21032Sequence analysisAdd
BLAST
Coiled coili297 – 32327Sequence analysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2966. Eukaryota.
ENOG410Y3YU. LUCA.
GeneTreeiENSGT00390000004496.
HOGENOMiHOG000008081.
HOVERGENiHBG060246.
InParanoidiQ9NWR8.
OMAiRKERCQF.
OrthoDBiEOG7HF1JN.
PhylomeDBiQ9NWR8.
TreeFamiTF314435.

Family and domain databases

InterProiIPR006769. Coiled-coil-dom_prot_109_C.
[Graphical view]
PfamiPF04678. MCU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NWR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQRGLWPWR TRLLPTPGTW RPARPWPLPP PPQVLRVKLC GNVKYYQSHH
60 70 80 90 100
YSTVVPPDEI TVIYRHGLPL VTLTLPSRKE RCQFVVKPML STVGSFLQDL
110 120 130 140 150
QNEDKGIKTA AIFTADGNMI SASTLMDILL MNDFKLVINK IAYDVQCPKR
160 170 180 190 200
EKPSNEHTAE MEHMKSLVHR LFTILHLEES QKKREHHLLE KIDHLKEQLQ
210 220 230 240 250
PLEQVKAGIE AHSEAKTSGL LWAGLALLSI QGGALAWLTW WVYSWDIMEP
260 270 280 290 300
VTYFITFANS MVFFAYFIVT RQDYTYSAVK SRQFLQFFHK KSKQQHFDVQ
310 320 330
QYNKLKEDLA KAKESLKQAR HSLCLQMQVE ELNEKN
Length:336
Mass (Da):39,082
Last modified:April 3, 2007 - v2
Checksum:i90C4BEBD5B1EFFD9
GO

Sequence cautioni

The sequence AAH02633.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA91309.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti193 – 1931D → G in CAG33515 (Ref. 4) Curated
Sequence conflicti214 – 2141E → G in CAG33515 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631I → N.
Corresponds to variant rs4698744 [ dbSNP | Ensembl ].
VAR_060149
Natural varianti253 – 2531Y → F.
Corresponds to variant rs13846 [ dbSNP | Ensembl ].
VAR_031443
Natural varianti255 – 2551I → V.1 Publication
Corresponds to variant rs1053680 [ dbSNP | Ensembl ].
VAR_031444

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000654 mRNA. Translation: BAA91309.1. Different initiation.
AK291098 mRNA. Translation: BAF83787.1.
CH471057 Genomic DNA. Translation: EAX06242.1.
BC002633 mRNA. Translation: AAH02633.1. Different initiation.
CR457234 mRNA. Translation: CAG33515.1.
CCDSiCCDS3683.2.
RefSeqiNP_060388.2. NM_017918.4.
UniGeneiHs.234149.

Genome annotation databases

EnsembliENST00000394650; ENSP00000378145; ENSG00000005059.
GeneIDi55013.
KEGGihsa:55013.
UCSCiuc011cfs.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000654 mRNA. Translation: BAA91309.1. Different initiation.
AK291098 mRNA. Translation: BAF83787.1.
CH471057 Genomic DNA. Translation: EAX06242.1.
BC002633 mRNA. Translation: AAH02633.1. Different initiation.
CR457234 mRNA. Translation: CAG33515.1.
CCDSiCCDS3683.2.
RefSeqiNP_060388.2. NM_017918.4.
UniGeneiHs.234149.

3D structure databases

ProteinModelPortaliQ9NWR8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120345. 8 interactions.
IntActiQ9NWR8. 2 interactions.
MINTiMINT-1391505.
STRINGi9606.ENSP00000378145.

Protein family/group databases

TCDBi1.A.77.1.12. the mg(2+)/ca(2+) uniporter (mcu) family.

PTM databases

iPTMnetiQ9NWR8.
PhosphoSiteiQ9NWR8.

Polymorphism and mutation databases

BioMutaiCCDC109B.
DMDMi143955289.

Proteomic databases

EPDiQ9NWR8.
MaxQBiQ9NWR8.
PaxDbiQ9NWR8.
PeptideAtlasiQ9NWR8.
PRIDEiQ9NWR8.

Protocols and materials databases

DNASUi55013.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394650; ENSP00000378145; ENSG00000005059.
GeneIDi55013.
KEGGihsa:55013.
UCSCiuc011cfs.3. human.

Organism-specific databases

CTDi55013.
GeneCardsiCCDC109B.
HGNCiHGNC:26076. CCDC109B.
HPAiHPA048776.
neXtProtiNX_Q9NWR8.
PharmGKBiPA145008731.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2966. Eukaryota.
ENOG410Y3YU. LUCA.
GeneTreeiENSGT00390000004496.
HOGENOMiHOG000008081.
HOVERGENiHBG060246.
InParanoidiQ9NWR8.
OMAiRKERCQF.
OrthoDBiEOG7HF1JN.
PhylomeDBiQ9NWR8.
TreeFamiTF314435.

Miscellaneous databases

ChiTaRSiCCDC109B. human.
GenomeRNAii55013.
PROiQ9NWR8.

Gene expression databases

BgeeiQ9NWR8.
CleanExiHS_CCDC109B.
GenevisibleiQ9NWR8. HS.

Family and domain databases

InterProiIPR006769. Coiled-coil-dom_prot_109_C.
[Graphical view]
PfamiPF04678. MCU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-336, VARIANT VAL-255.
  5. Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN THE UNIPLEX COMPLEX.

Entry informationi

Entry nameiMCUB_HUMAN
AccessioniPrimary (citable) accession number: Q9NWR8
Secondary accession number(s): A8K4Y3, Q6IAC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: July 6, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.