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Q9NWQ4 (GPT2L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G patch domain-containing protein 2-like
Gene names
Name:GPATCH2L
Synonyms:C14orf118, KIAA1152
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length482 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence caution

The sequence BAA86466.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAA91325.1 differs from that shown. Reason: Frameshift at position 344.

The sequence BAA91411.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SUV39H1O434632EBI-5666657,EBI-349968

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NWQ4-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NWQ4-1)

The sequence of this isoform differs from the canonical sequence as follows:
     329-351: ETSINTLGTERISHIISDPRQKE → VIPLTVSLAQWGDNIPYGSCVSY
     352-482: Missing.
Isoform 4 (identifier: Q9NWQ4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     351-369: EKNKALASDFPHISACAHE → DFWLPSAGKRERNQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 482482G patch domain-containing protein 2-like
PRO_0000089927

Regions

Compositional bias33 – 4816Arg-rich

Amino acid modifications

Modified residue861Phosphoserine Ref.6 Ref.9 Ref.10 Ref.11
Modified residue881Phosphoserine Ref.6 Ref.9 Ref.10 Ref.11
Modified residue911Phosphothreonine Ref.11
Modified residue4471Phosphoserine Ref.10 Ref.11
Modified residue4491Phosphoserine Ref.11

Natural variations

Alternative sequence329 – 35123ETSIN…PRQKE → VIPLTVSLAQWGDNIPYGSC VSY in isoform 2.
VSP_014714
Alternative sequence351 – 36919EKNKA…ACAHE → DFWLPSAGKRERNQ in isoform 4.
VSP_039861
Alternative sequence352 – 482131Missing in isoform 2.
VSP_014716
Natural variant1321V → E.
Corresponds to variant rs17104086 [ dbSNP | Ensembl ].
VAR_056838

Experimental info

Sequence conflict1871S → L in BAA91325. Ref.2
Sequence conflict2411R → G in BAA91325. Ref.2
Sequence conflict4111D → V in BAA91411. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 1BA1C5B38DC6373E

FASTA48254,260
        10         20         30         40         50         60 
MDELVHDLAS ALEQTSEQNK LGELWEEMAL SPRQQRRQLR KRRGRKRRSD FTHLAEHTCC 

        70         80         90        100        110        120 
YSEASESSLD EATKDCREVA PVTNFSDSDD TMVAKRHPAL NAIVKSKQHS WHESDSFTEN 

       130        140        150        160        170        180 
APCRPLRRRR KVKRVTSEVA ASLQQKLKVS DWSYERGCRF KSAKKQRLSR WKENTPWTSS 

       190        200        210        220        230        240 
GHGLCESAEN RTFLSKTGRK ERMECETDEQ KQGSDENMSE CETSSVCSSS DTGLFTNDEG 

       250        260        270        280        290        300 
RQGDDEQSDW FYEGECVPGF TVPNLLPKWA PDHCSEVERM DSGLDKFSDS TFLLPSRPAQ 

       310        320        330        340        350        360 
RGYHTRLNRL PGAAARCLRK GRRRLVGKET SINTLGTERI SHIISDPRQK EKNKALASDF 

       370        380        390        400        410        420 
PHISACAHEF NPLSPLYSLD VLADASHRRC SPAHCSARQA NVHWGPPCSR DIKRKRKPVA 

       430        440        450        460        470        480 
TASLSSPSAV HMDAVEPTTP ASQAPKSPSS EWLVRTSAAE KATDATTATF FKMPQEKSPG 


YS 

« Hide

Isoform 2 [UniParc].

Checksum: 17549F20A3E6A6C1
Show »

FASTA35140,051
Isoform 4 [UniParc].

Checksum: 4E062C76A034A1DD
Show »

FASTA47753,895

References

[1]"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 176-482 (ISOFORM 4).
Tissue: Embryo, Ileal mucosa and Placenta.
[3]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Lung.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-88, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-88, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[10]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; SER-88 AND SER-447, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; SER-88; THR-91; SER-447 AND SER-449, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB032978 mRNA. Translation: BAA86466.1. Different initiation.
AK000696 mRNA. Translation: BAA91325.1. Frameshift.
AK000895 mRNA. Translation: BAA91411.1. Different initiation.
AK023523 mRNA. Translation: BAG51204.1.
AC016526 Genomic DNA. Translation: AAG38637.1.
CH471061 Genomic DNA. Translation: EAW81252.1.
CH471061 Genomic DNA. Translation: EAW81253.1.
BC058032 mRNA. Translation: AAH58032.1.
RefSeqNP_060396.2. NM_017926.3.
NP_060442.2. NM_017972.3.
UniGeneHs.410231.

3D structure databases

ProteinModelPortalQ9NWQ4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120800. 4 interactions.
IntActQ9NWQ4. 5 interactions.
MINTMINT-8417617.

PTM databases

PhosphoSiteQ9NWQ4.

Polymorphism databases

DMDM308153614.

Proteomic databases

PaxDbQ9NWQ4.
PRIDEQ9NWQ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261530; ENSP00000261530; ENSG00000089916. [Q9NWQ4-3]
ENST00000312858; ENSP00000323775; ENSG00000089916. [Q9NWQ4-4]
ENST00000556663; ENSP00000450657; ENSG00000089916. [Q9NWQ4-1]
ENST00000557263; ENSP00000451587; ENSG00000089916. [Q9NWQ4-1]
GeneID55668.
KEGGhsa:55668.
UCSCuc001xsh.3. human. [Q9NWQ4-3]
uc001xsi.3. human. [Q9NWQ4-4]
uc001xsj.1. human. [Q9NWQ4-1]

Organism-specific databases

CTD55668.
GeneCardsGC14P076619.
H-InvDBHIX0011833.
HGNCHGNC:20210. GPATCH2L.
HPAHPA018856.
neXtProtNX_Q9NWQ4.
PharmGKBPA134963976.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG310293.
HOGENOMHOG000294060.
HOVERGENHBG081274.
KOK17569.
OMAWLVRTSA.
PhylomeDBQ9NWQ4.
TreeFamTF331954.

Gene expression databases

ArrayExpressQ9NWQ4.
BgeeQ9NWQ4.
CleanExHS_C14orf118.
GenevestigatorQ9NWQ4.

Family and domain databases

InterProIPR026291. Gpatch2.
[Graphical view]
PANTHERPTHR14195. PTHR14195. 1 hit.
ProtoNetSearch...

Other

ChiTaRSC14orf118. human.
GenomeRNAi55668.
NextBio60430.

Entry information

Entry nameGPT2L_HUMAN
AccessionPrimary (citable) accession number: Q9NWQ4
Secondary accession number(s): B3KN42 expand/collapse secondary AC list , Q6PEJ7, Q9H3M3, Q9NWH0, Q9ULR8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM