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Q9NWQ4

- GPT2L_HUMAN

UniProt

Q9NWQ4 - GPT2L_HUMAN

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Protein
G patch domain-containing protein 2-like
Gene
GPATCH2L, C14orf118, KIAA1152
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G patch domain-containing protein 2-like
Gene namesi
Synonyms:C14orf118, KIAA1152
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20210. GPATCH2L.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134963976.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482G patch domain-containing protein 2-like
PRO_0000089927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei86 – 861Phosphoserine4 Publications
Modified residuei88 – 881Phosphoserine4 Publications
Modified residuei91 – 911Phosphothreonine1 Publication
Modified residuei447 – 4471Phosphoserine2 Publications
Modified residuei449 – 4491Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NWQ4.
PaxDbiQ9NWQ4.
PRIDEiQ9NWQ4.

PTM databases

PhosphoSiteiQ9NWQ4.

Expressioni

Gene expression databases

ArrayExpressiQ9NWQ4.
BgeeiQ9NWQ4.
CleanExiHS_C14orf118.
GenevestigatoriQ9NWQ4.

Organism-specific databases

HPAiHPA018856.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434632EBI-5666657,EBI-349968

Protein-protein interaction databases

BioGridi120800. 4 interactions.
IntActiQ9NWQ4. 5 interactions.
MINTiMINT-8417617.

Structurei

3D structure databases

ProteinModelPortaliQ9NWQ4.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 4816Arg-rich
Add
BLAST

Phylogenomic databases

eggNOGiNOG310293.
HOGENOMiHOG000294060.
HOVERGENiHBG081274.
KOiK17569.
OMAiWLVRTSA.
PhylomeDBiQ9NWQ4.
TreeFamiTF331954.

Family and domain databases

InterProiIPR026291. Gpatch2.
[Graphical view]
PANTHERiPTHR14195. PTHR14195. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NWQ4-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDELVHDLAS ALEQTSEQNK LGELWEEMAL SPRQQRRQLR KRRGRKRRSD    50
FTHLAEHTCC YSEASESSLD EATKDCREVA PVTNFSDSDD TMVAKRHPAL 100
NAIVKSKQHS WHESDSFTEN APCRPLRRRR KVKRVTSEVA ASLQQKLKVS 150
DWSYERGCRF KSAKKQRLSR WKENTPWTSS GHGLCESAEN RTFLSKTGRK 200
ERMECETDEQ KQGSDENMSE CETSSVCSSS DTGLFTNDEG RQGDDEQSDW 250
FYEGECVPGF TVPNLLPKWA PDHCSEVERM DSGLDKFSDS TFLLPSRPAQ 300
RGYHTRLNRL PGAAARCLRK GRRRLVGKET SINTLGTERI SHIISDPRQK 350
EKNKALASDF PHISACAHEF NPLSPLYSLD VLADASHRRC SPAHCSARQA 400
NVHWGPPCSR DIKRKRKPVA TASLSSPSAV HMDAVEPTTP ASQAPKSPSS 450
EWLVRTSAAE KATDATTATF FKMPQEKSPG YS 482
Length:482
Mass (Da):54,260
Last modified:October 5, 2010 - v3
Checksum:i1BA1C5B38DC6373E
GO
Isoform 2 (identifier: Q9NWQ4-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-351: ETSINTLGTERISHIISDPRQKE → VIPLTVSLAQWGDNIPYGSCVSY
     352-482: Missing.

Show »
Length:351
Mass (Da):40,051
Checksum:i17549F20A3E6A6C1
GO
Isoform 4 (identifier: Q9NWQ4-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-369: EKNKALASDFPHISACAHE → DFWLPSAGKRERNQ

Show »
Length:477
Mass (Da):53,895
Checksum:i4E062C76A034A1DD
GO

Sequence cautioni

The sequence BAA91325.1 differs from that shown. Reason: Frameshift at position 344.
The sequence BAA86466.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAA91411.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti132 – 1321V → E.
Corresponds to variant rs17104086 [ dbSNP | Ensembl ].
VAR_056838

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei329 – 35123ETSIN…PRQKE → VIPLTVSLAQWGDNIPYGSC VSY in isoform 2.
VSP_014714Add
BLAST
Alternative sequencei351 – 36919EKNKA…ACAHE → DFWLPSAGKRERNQ in isoform 4.
VSP_039861Add
BLAST
Alternative sequencei352 – 482131Missing in isoform 2.
VSP_014716Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1871S → L in BAA91325. 1 Publication
Sequence conflicti241 – 2411R → G in BAA91325. 1 Publication
Sequence conflicti411 – 4111D → V in BAA91411. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032978 mRNA. Translation: BAA86466.1. Different initiation.
AK000696 mRNA. Translation: BAA91325.1. Frameshift.
AK000895 mRNA. Translation: BAA91411.1. Different initiation.
AK023523 mRNA. Translation: BAG51204.1.
AC016526 Genomic DNA. Translation: AAG38637.1.
CH471061 Genomic DNA. Translation: EAW81252.1.
CH471061 Genomic DNA. Translation: EAW81253.1.
BC058032 mRNA. Translation: AAH58032.1.
CCDSiCCDS9848.1. [Q9NWQ4-3]
CCDS9849.1. [Q9NWQ4-4]
RefSeqiNP_060396.2. NM_017926.3. [Q9NWQ4-3]
NP_060442.2. NM_017972.3. [Q9NWQ4-4]
UniGeneiHs.410231.

Genome annotation databases

EnsembliENST00000261530; ENSP00000261530; ENSG00000089916. [Q9NWQ4-3]
ENST00000312858; ENSP00000323775; ENSG00000089916. [Q9NWQ4-4]
ENST00000556663; ENSP00000450657; ENSG00000089916. [Q9NWQ4-1]
ENST00000557263; ENSP00000451587; ENSG00000089916. [Q9NWQ4-1]
GeneIDi55668.
KEGGihsa:55668.
UCSCiuc001xsh.3. human. [Q9NWQ4-3]
uc001xsi.3. human. [Q9NWQ4-4]
uc001xsj.1. human. [Q9NWQ4-1]

Polymorphism databases

DMDMi308153614.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032978 mRNA. Translation: BAA86466.1 . Different initiation.
AK000696 mRNA. Translation: BAA91325.1 . Frameshift.
AK000895 mRNA. Translation: BAA91411.1 . Different initiation.
AK023523 mRNA. Translation: BAG51204.1 .
AC016526 Genomic DNA. Translation: AAG38637.1 .
CH471061 Genomic DNA. Translation: EAW81252.1 .
CH471061 Genomic DNA. Translation: EAW81253.1 .
BC058032 mRNA. Translation: AAH58032.1 .
CCDSi CCDS9848.1. [Q9NWQ4-3 ]
CCDS9849.1. [Q9NWQ4-4 ]
RefSeqi NP_060396.2. NM_017926.3. [Q9NWQ4-3 ]
NP_060442.2. NM_017972.3. [Q9NWQ4-4 ]
UniGenei Hs.410231.

3D structure databases

ProteinModelPortali Q9NWQ4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120800. 4 interactions.
IntActi Q9NWQ4. 5 interactions.
MINTi MINT-8417617.

PTM databases

PhosphoSitei Q9NWQ4.

Polymorphism databases

DMDMi 308153614.

Proteomic databases

MaxQBi Q9NWQ4.
PaxDbi Q9NWQ4.
PRIDEi Q9NWQ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261530 ; ENSP00000261530 ; ENSG00000089916 . [Q9NWQ4-3 ]
ENST00000312858 ; ENSP00000323775 ; ENSG00000089916 . [Q9NWQ4-4 ]
ENST00000556663 ; ENSP00000450657 ; ENSG00000089916 . [Q9NWQ4-1 ]
ENST00000557263 ; ENSP00000451587 ; ENSG00000089916 . [Q9NWQ4-1 ]
GeneIDi 55668.
KEGGi hsa:55668.
UCSCi uc001xsh.3. human. [Q9NWQ4-3 ]
uc001xsi.3. human. [Q9NWQ4-4 ]
uc001xsj.1. human. [Q9NWQ4-1 ]

Organism-specific databases

CTDi 55668.
GeneCardsi GC14P076619.
H-InvDB HIX0011833.
HGNCi HGNC:20210. GPATCH2L.
HPAi HPA018856.
neXtProti NX_Q9NWQ4.
PharmGKBi PA134963976.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG310293.
HOGENOMi HOG000294060.
HOVERGENi HBG081274.
KOi K17569.
OMAi WLVRTSA.
PhylomeDBi Q9NWQ4.
TreeFami TF331954.

Miscellaneous databases

ChiTaRSi C14orf118. human.
GenomeRNAii 55668.
NextBioi 60430.

Gene expression databases

ArrayExpressi Q9NWQ4.
Bgeei Q9NWQ4.
CleanExi HS_C14orf118.
Genevestigatori Q9NWQ4.

Family and domain databases

InterProi IPR026291. Gpatch2.
[Graphical view ]
PANTHERi PTHR14195. PTHR14195. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 176-482 (ISOFORM 4).
    Tissue: Embryo, Ileal mucosa and Placenta.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-88, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86 AND SER-88, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; SER-88 AND SER-447, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; SER-88; THR-91; SER-447 AND SER-449, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGPT2L_HUMAN
AccessioniPrimary (citable) accession number: Q9NWQ4
Secondary accession number(s): B3KN42
, Q6PEJ7, Q9H3M3, Q9NWH0, Q9ULR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2005
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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