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Protein

F-box only protein 34

Gene

FBXO34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178974-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 34
Gene namesi
Name:FBXO34
Synonyms:FBX34
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20201. FBXO34.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178974.
PharmGKBiPA134910884.

Polymorphism and mutation databases

BioMutaiFBXO34.
DMDMi61252689.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199261 – 711F-box only protein 34Add BLAST711

Proteomic databases

PaxDbiQ9NWN3.
PRIDEiQ9NWN3.

PTM databases

iPTMnetiQ9NWN3.
PhosphoSitePlusiQ9NWN3.

Expressioni

Gene expression databases

BgeeiENSG00000178974.
CleanExiHS_FBXO34.
ExpressionAtlasiQ9NWN3. baseline and differential.
GenevisibleiQ9NWN3. HS.

Organism-specific databases

HPAiHPA052592.
HPA057135.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-719816,EBI-10171697
MDFIQ997503EBI-719816,EBI-724076
MTUS2Q5JR593EBI-719816,EBI-742948

Protein-protein interaction databases

BioGridi120359. 14 interactors.
IntActiQ9NWN3. 6 interactors.
MINTiMINT-1378648.
STRINGi9606.ENSP00000313159.

Structurei

3D structure databases

ProteinModelPortaliQ9NWN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini572 – 624F-boxPROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJQD. Eukaryota.
ENOG410ZZJ3. LUCA.
GeneTreeiENSGT00530000064222.
HOGENOMiHOG000237319.
HOVERGENiHBG051576.
InParanoidiQ9NWN3.
KOiK10311.
OMAiPACHSFN.
OrthoDBiEOG091G02P1.
PhylomeDBiQ9NWN3.
TreeFamiTF331673.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NWN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLKPYWKLQ KKEHPPEVSR ETQRTPMNHQ KAVNDETCKA SHITSSVFPS
60 70 80 90 100
ASLGKASSRK PFGILSPNVL CSMSGKSPVE SSLNVKTKKN APSATIHQGE
110 120 130 140 150
EEGPLDIWAV VKPGNTKEKI AFFASHQCSN RIGSMKIKSS WDIDGRATKR
160 170 180 190 200
RKKSGDLKKA KVQVERMREV NSRCYQPEPF ACGIEHCSVH YVSDSGDGVY
210 220 230 240 250
AGRPLSVIQM VAFLEQRASA LLASCSKNCT NSPAIVRFSG QSRGVPAVSE
260 270 280 290 300
SYSAPGACEE PTERGNLEVG EPQSEPVRVL DMVAKLESEC LKRQGQREPG
310 320 330 340 350
SLSRNNSFRR NVGRVLLANS TQADEGKTKK GVLEAPDTQV NPVGSVSVDC
360 370 380 390 400
GPSRADRCSP KEDQAWDGAS QDCPPLPAGV SFHIDSAELE PGSQTAVKNS
410 420 430 440 450
NRYDVEMTDE LVGLPFSSHT YSQASELPTD AVDCMSRELV SLTSRNPDQR
460 470 480 490 500
KESLCISITV SKVDKDQPSI LNSCEDPVPG MLFFLPPGQH LSDYSQLNES
510 520 530 540 550
TTKESSEASQ LEDAAGGDSA SEEKSGSAEP FVLPASSVES TLPVLEASSW
560 570 580 590 600
KKQVSHDFLE TRFKIQQLLE PQQYMAFLPH HIMVKIFRLL PTKSLVALKC
610 620 630 640 650
TCCYFKFIIE YYNIRPADSR WVRDPRYRED PCKQCKKKYV KGDVSLCRWH
660 670 680 690 700
PKPYCQALPY GPGYWMCCHR SQKGFPGCKL GLHDNHWVPA CHSFNRAIHK
710
KAKGTEAEEE Y
Length:711
Mass (Da):78,711
Last modified:March 15, 2005 - v2
Checksum:i6D289A9320AE9C42
GO

Sequence cautioni

The sequence BAA91346 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD62596 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049047432V → A.Corresponds to variant rs35070799dbSNPEnsembl.1
Natural variantiVAR_021489470I → N.3 PublicationsCorresponds to variant rs1045002dbSNPEnsembl.1
Natural variantiVAR_021490533L → P.3 PublicationsCorresponds to variant rs3742569dbSNPEnsembl.1
Natural variantiVAR_049048704G → V.Corresponds to variant rs10138395dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248268 mRNA. Translation: CAD62596.1. Different initiation.
BC095482 mRNA. Translation: AAH95482.2.
BC109120 mRNA. Translation: AAI09121.1.
BC109121 mRNA. Translation: AAI09122.1.
AK000732 mRNA. Translation: BAA91346.1. Different initiation.
CR457249 mRNA. Translation: CAG33530.1.
CCDSiCCDS32086.1.
RefSeqiNP_060413.2. NM_017943.3.
NP_689417.1. NM_152231.1.
XP_005267848.1. XM_005267791.4.
XP_006720248.1. XM_006720185.3.
XP_016876881.1. XM_017021392.1.
XP_016876882.1. XM_017021393.1.
UniGeneiHs.525348.
Hs.654725.

Genome annotation databases

EnsembliENST00000313833; ENSP00000313159; ENSG00000178974.
ENST00000440021; ENSP00000394117; ENSG00000178974.
GeneIDi55030.
KEGGihsa:55030.
UCSCiuc001xbu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248268 mRNA. Translation: CAD62596.1. Different initiation.
BC095482 mRNA. Translation: AAH95482.2.
BC109120 mRNA. Translation: AAI09121.1.
BC109121 mRNA. Translation: AAI09122.1.
AK000732 mRNA. Translation: BAA91346.1. Different initiation.
CR457249 mRNA. Translation: CAG33530.1.
CCDSiCCDS32086.1.
RefSeqiNP_060413.2. NM_017943.3.
NP_689417.1. NM_152231.1.
XP_005267848.1. XM_005267791.4.
XP_006720248.1. XM_006720185.3.
XP_016876881.1. XM_017021392.1.
XP_016876882.1. XM_017021393.1.
UniGeneiHs.525348.
Hs.654725.

3D structure databases

ProteinModelPortaliQ9NWN3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120359. 14 interactors.
IntActiQ9NWN3. 6 interactors.
MINTiMINT-1378648.
STRINGi9606.ENSP00000313159.

PTM databases

iPTMnetiQ9NWN3.
PhosphoSitePlusiQ9NWN3.

Polymorphism and mutation databases

BioMutaiFBXO34.
DMDMi61252689.

Proteomic databases

PaxDbiQ9NWN3.
PRIDEiQ9NWN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313833; ENSP00000313159; ENSG00000178974.
ENST00000440021; ENSP00000394117; ENSG00000178974.
GeneIDi55030.
KEGGihsa:55030.
UCSCiuc001xbu.4. human.

Organism-specific databases

CTDi55030.
GeneCardsiFBXO34.
H-InvDBHIX0011685.
HGNCiHGNC:20201. FBXO34.
HPAiHPA052592.
HPA057135.
MIMi609104. gene.
neXtProtiNX_Q9NWN3.
OpenTargetsiENSG00000178974.
PharmGKBiPA134910884.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJQD. Eukaryota.
ENOG410ZZJ3. LUCA.
GeneTreeiENSGT00530000064222.
HOGENOMiHOG000237319.
HOVERGENiHBG051576.
InParanoidiQ9NWN3.
KOiK10311.
OMAiPACHSFN.
OrthoDBiEOG091G02P1.
PhylomeDBiQ9NWN3.
TreeFamiTF331673.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178974-MONOMER.

Miscellaneous databases

ChiTaRSiFBXO34. human.
GenomeRNAii55030.
PROiQ9NWN3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178974.
CleanExiHS_FBXO34.
ExpressionAtlasiQ9NWN3. baseline and differential.
GenevisibleiQ9NWN3. HS.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX34_HUMAN
AccessioniPrimary (citable) accession number: Q9NWN3
Secondary accession number(s): Q2VPB5, Q4VBP5, Q86TY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: March 15, 2005
Last modified: November 30, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.