Reviewed,
UniProtKB/Swiss-Prot Q9NWM8 (FKB14_HUMAN)
Last modified
July 7, 2009.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: FK506-binding protein 14 EC=5.2.1.8 Alternative name(s): Peptidyl-prolyl cis-trans isomerase Short name=PPIase Short name=Rotamase 22 kDa FK506-binding protein FKBP-22 | ||||||
| Gene names |
| ||||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 211 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | PPIases accelerate the folding of proteins during protein synthesis. |
| Catalytic activity | Peptidylproline (omega=180) = peptidylproline (omega=0). |
| Subcellular location | Endoplasmic reticulum lumen Potential. |
| Sequence similarities | Contains 2 EF-hand domains. Contains 1 PPIase FKBP-type domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum |
| Domain | Repeat Signal |
| Ligand | Calcium |
| Molecular function | Isomerase Rotamase |
| PTM | Glycoprotein |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | protein folding Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW endoplasmic reticulum lumenInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-prolyl cis-trans isomerase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | Ref.4 | ||||||
| Chain | 20 – 211 | 192 | FK506-binding protein 14 | PRO_0000025521 | |||||
Regions | |||||||||
| Domain | 45 – 135 | 91 | PPIase FKBP-type | ||||||
| Domain | 135 – 170 | 36 | EF-hand 1 | ||||||
| Domain | 179 – 211 | 33 | EF-hand 2 | ||||||
| Calcium binding | 148 – 159 | 12 | 1 Potential | ||||||
| Calcium binding | 192 – 203 | 12 | 2 Potential | ||||||
| Motif | 208 – 211 | 4 | Prevents secretion from ER Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 176 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney. |
| [4] | "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-34. |
Cross-references
Sequence databases | |
|---|---|
| AY358643 mRNA. Translation: AAQ89006.1. AK000738 mRNA. Translation: BAA91351.1. BC005206 mRNA. Translation: AAH05206.1. | |
| IPI | IPI00017331. |
| RefSeq | NP_060416.1. |
| UniGene | Hs.571333 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FKL based on UniProtKB P18203. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q9NWM8. |
Genome annotation databases | |
| Ensembl | ENSG00000106080. Homo sapiens. [Contig view] |
| GeneID | 55033. |
| KEGG | hsa:55033. |
| UCSC | uc003tal.1. human. |
Organism-specific databases | |
| GeneCards | GC07M030019. |
| H-InvDB | HIX0006561. |
| HGNC | HGNC:18625. FKBP14. |
| HPA | HPA013329. |
| PharmGKB | PA38608. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9NWM8. |
| HOVERGEN | Q9NWM8. |
| OMA | Q9NWM8. NESHHDV. |
Enzyme and pathway databases | |
| BRENDA | 5.2.1.8. 247. |
Gene expression databases | |
| ArrayExpress | Q9NWM8. |
| Bgee | Q9NWM8. |
| CleanEx | HS_FKBP14. |
| GermOnline | ENSG00000106080. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR018247. EF_HAND_1. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca_bd. IPR000886. ER_targeting_sequence. IPR001179. PPIase_FKBP. [Graphical view] |
| PANTHER | PTHR10516. PPIase_FKBP. 1 hit. |
| Pfam | PF00254. FKBP_C. 1 hit. [Graphical view] |
| SMART | SM00054. EFh. 2 hits. [Graphical view] |
| PROSITE | PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 2 hits. PS00014. ER_TARGET. 1 hit. PS50059. FKBP_PPIASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 58455. |
Entry information
| Entry name | FKB14_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NWM8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with


