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Protein

CUE domain-containing protein 1

Gene

CUEDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
CUE domain-containing protein 1
Gene namesi
Name:CUEDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:31350. CUEDC1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134913154.

Polymorphism and mutation databases

DMDMi47116934.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 386386CUE domain-containing protein 1PRO_0000079559Add
BLAST

Proteomic databases

EPDiQ9NWM3.
MaxQBiQ9NWM3.
PaxDbiQ9NWM3.
PRIDEiQ9NWM3.

PTM databases

iPTMnetiQ9NWM3.
PhosphoSiteiQ9NWM3.

Expressioni

Gene expression databases

BgeeiQ9NWM3.
CleanExiHS_CUEDC1.
ExpressionAtlasiQ9NWM3. baseline and differential.
GenevisibleiQ9NWM3. HS.

Organism-specific databases

HPAiHPA023050.
HPA024836.

Interactioni

Protein-protein interaction databases

BioGridi135642. 25 interactions.
IntActiQ9NWM3. 7 interactions.
MINTiMINT-1182395.
STRINGi9606.ENSP00000353373.

Structurei

Secondary structure

1
386
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi48 – 5710Combined sources
Beta strandi59 – 613Combined sources
Helixi63 – 7311Combined sources
Helixi77 – 8913Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DHYNMR-A37-90[»]
ProteinModelPortaliQ9NWM3.
SMRiQ9NWM3. Positions 34-96.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NWM3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 8944CUEPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi110 – 15445Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 CUE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4588. Eukaryota.
ENOG4111S1H. LUCA.
GeneTreeiENSGT00390000006762.
HOGENOMiHOG000007372.
HOVERGENiHBG051264.
InParanoidiQ9NWM3.
OMAiPAYHMHV.
OrthoDBiEOG78SQMJ.
PhylomeDBiQ9NWM3.
TreeFamiTF324332.

Family and domain databases

InterProiIPR003892. CUE.
IPR009060. UBA-like.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NWM3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSLFRRSSS GSGGGGTAGA RGGGGGTAAP QELNNSRPAR QVRRLEFNQA
60 70 80 90 100
MDDFKTMFPN MDYDIIECVL RANSGAVDAT IDQLLQMNLE GGGSSGGVYE
110 120 130 140 150
DSSDSEDSIP PEILERTLEP DSSDEEPPPV YSPPAYHMHV FDRPYPLAPP
160 170 180 190 200
TPPPRIDALG SGAPTSQRRY RNWNPPLLGN LPDDFLRILP QQLDSIQGNA
210 220 230 240 250
GGPKPGSGEG CPPAMAGPGP GDQESRWKQY LEDERIALFL QNEEFMKELQ
260 270 280 290 300
RNRDFLLALE RDRLKYESQK SKSSSVAVGN DFGFSSPVPG TGDANPAVSE
310 320 330 340 350
DALFRDKLKH MGKSTRRKLF ELARAFSEKT KMRKSKRKHL LKHQSLGAAA
360 370 380
STANLLDDVE GHACDEDFRG RRQEAPKVEE GLREGQ
Length:386
Mass (Da):42,258
Last modified:October 1, 2000 - v1
Checksum:iF5530FA47C267895
GO
Isoform 2 (identifier: Q9NWM3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-260: Missing.

Note: No experimental confirmation available.
Show »
Length:358
Mass (Da):38,794
Checksum:i4E43A8DAD3273F17
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471F → L in BAA91452 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti169 – 1691R → H.
Corresponds to variant rs17762338 [ dbSNP | Ensembl ].
VAR_050933
Natural varianti205 – 2051P → S.
Corresponds to variant rs2304942 [ dbSNP | Ensembl ].
VAR_021951
Natural varianti316 – 3161R → Q.
Corresponds to variant rs34800498 [ dbSNP | Ensembl ].
VAR_033765

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei233 – 26028Missing in isoform 2. 1 PublicationVSP_010316Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000746 mRNA. Translation: BAA91357.1.
AK000977 mRNA. Translation: BAA91452.1.
CH471109 Genomic DNA. Translation: EAW94498.1.
CH471109 Genomic DNA. Translation: EAW94501.1.
BC056882 mRNA. Translation: AAH56882.1.
CCDSiCCDS11599.1. [Q9NWM3-1]
RefSeqiNP_001258804.1. NM_001271875.1. [Q9NWM3-1]
NP_001278954.1. NM_001292025.1. [Q9NWM3-1]
XP_006721963.1. XM_006721900.2. [Q9NWM3-1]
UniGeneiHs.46679.

Genome annotation databases

EnsembliENST00000360238; ENSP00000353373; ENSG00000180891. [Q9NWM3-1]
ENST00000407144; ENSP00000384712; ENSG00000180891. [Q9NWM3-1]
ENST00000577830; ENSP00000462717; ENSG00000180891. [Q9NWM3-1]
GeneIDi404093.
KEGGihsa:404093.
UCSCiuc002ivd.3. human. [Q9NWM3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000746 mRNA. Translation: BAA91357.1.
AK000977 mRNA. Translation: BAA91452.1.
CH471109 Genomic DNA. Translation: EAW94498.1.
CH471109 Genomic DNA. Translation: EAW94501.1.
BC056882 mRNA. Translation: AAH56882.1.
CCDSiCCDS11599.1. [Q9NWM3-1]
RefSeqiNP_001258804.1. NM_001271875.1. [Q9NWM3-1]
NP_001278954.1. NM_001292025.1. [Q9NWM3-1]
XP_006721963.1. XM_006721900.2. [Q9NWM3-1]
UniGeneiHs.46679.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DHYNMR-A37-90[»]
ProteinModelPortaliQ9NWM3.
SMRiQ9NWM3. Positions 34-96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135642. 25 interactions.
IntActiQ9NWM3. 7 interactions.
MINTiMINT-1182395.
STRINGi9606.ENSP00000353373.

PTM databases

iPTMnetiQ9NWM3.
PhosphoSiteiQ9NWM3.

Polymorphism and mutation databases

DMDMi47116934.

Proteomic databases

EPDiQ9NWM3.
MaxQBiQ9NWM3.
PaxDbiQ9NWM3.
PRIDEiQ9NWM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360238; ENSP00000353373; ENSG00000180891. [Q9NWM3-1]
ENST00000407144; ENSP00000384712; ENSG00000180891. [Q9NWM3-1]
ENST00000577830; ENSP00000462717; ENSG00000180891. [Q9NWM3-1]
GeneIDi404093.
KEGGihsa:404093.
UCSCiuc002ivd.3. human. [Q9NWM3-1]

Organism-specific databases

CTDi404093.
GeneCardsiCUEDC1.
HGNCiHGNC:31350. CUEDC1.
HPAiHPA023050.
HPA024836.
neXtProtiNX_Q9NWM3.
PharmGKBiPA134913154.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4588. Eukaryota.
ENOG4111S1H. LUCA.
GeneTreeiENSGT00390000006762.
HOGENOMiHOG000007372.
HOVERGENiHBG051264.
InParanoidiQ9NWM3.
OMAiPAYHMHV.
OrthoDBiEOG78SQMJ.
PhylomeDBiQ9NWM3.
TreeFamiTF324332.

Miscellaneous databases

ChiTaRSiCUEDC1. human.
EvolutionaryTraceiQ9NWM3.
GenomeRNAii404093.
PROiQ9NWM3.

Gene expression databases

BgeeiQ9NWM3.
CleanExiHS_CUEDC1.
ExpressionAtlasiQ9NWM3. baseline and differential.
GenevisibleiQ9NWM3. HS.

Family and domain databases

InterProiIPR003892. CUE.
IPR009060. UBA-like.
[Graphical view]
PfamiPF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00546. CUE. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Embryonic head and Hepatoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  4. "Solution structure of the CUE domain in the human CUE domain containing protein 1 (CUEDC1)."
    RIKEN structural genomics initiative (RSGI)
    Submitted (SEP-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 34-96.

Entry informationi

Entry nameiCUED1_HUMAN
AccessioniPrimary (citable) accession number: Q9NWM3
Secondary accession number(s): D3DTZ2, Q9NWD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.