UniProtKB - Q9NWM3 (CUED1_HUMAN)
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Protein
CUE domain-containing protein 1
Gene
CUEDC1
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Names & Taxonomyi
Protein namesi | Recommended name: CUE domain-containing protein 1 |
Gene namesi | Name:CUEDC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000180891.12 |
HGNCi | HGNC:31350 CUEDC1 |
neXtProti | NX_Q9NWM3 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000180891 |
PharmGKBi | PA134913154 |
Polymorphism and mutation databases
DMDMi | 47116934 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079559 | 1 – 386 | CUE domain-containing protein 1Add BLAST | 386 |
Proteomic databases
EPDi | Q9NWM3 |
MaxQBi | Q9NWM3 |
PaxDbi | Q9NWM3 |
PeptideAtlasi | Q9NWM3 |
PRIDEi | Q9NWM3 |
PTM databases
iPTMneti | Q9NWM3 |
PhosphoSitePlusi | Q9NWM3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180891 |
CleanExi | HS_CUEDC1 |
ExpressionAtlasi | Q9NWM3 baseline and differential |
Genevisiblei | Q9NWM3 HS |
Organism-specific databases
HPAi | HPA023050 HPA024836 |
Interactioni
Protein-protein interaction databases
BioGridi | 13564246 interactors. |
IntActi | Q9NWM3 7 interactors. |
MINTi | Q9NWM3 |
STRINGi | 9606.ENSP00000353373 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 48 – 57 | Combined sources | 10 | |
Beta strandi | 59 – 61 | Combined sources | 3 | |
Helixi | 63 – 73 | Combined sources | 11 | |
Helixi | 77 – 89 | Combined sources | 13 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DHY | NMR | - | A | 37-90 | [»] | |
ProteinModelPortali | Q9NWM3 | |||||
SMRi | Q9NWM3 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NWM3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 46 – 89 | CUEPROSITE-ProRule annotationAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 110 – 154 | Pro-richAdd BLAST | 45 |
Phylogenomic databases
eggNOGi | KOG4588 Eukaryota ENOG4111S1H LUCA |
GeneTreei | ENSGT00390000006762 |
HOGENOMi | HOG000007372 |
HOVERGENi | HBG051264 |
InParanoidi | Q9NWM3 |
OMAi | DANVSPQ |
OrthoDBi | EOG091G0C64 |
PhylomeDBi | Q9NWM3 |
TreeFami | TF324332 |
Family and domain databases
InterProi | View protein in InterPro IPR003892 CUE IPR009060 UBA-like_sf |
Pfami | View protein in Pfam PF02845 CUE, 1 hit |
SMARTi | View protein in SMART SM00546 CUE, 1 hit |
SUPFAMi | SSF46934 SSF46934, 1 hit |
PROSITEi | View protein in PROSITE PS51140 CUE, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NWM3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MTSLFRRSSS GSGGGGTAGA RGGGGGTAAP QELNNSRPAR QVRRLEFNQA
60 70 80 90 100
MDDFKTMFPN MDYDIIECVL RANSGAVDAT IDQLLQMNLE GGGSSGGVYE
110 120 130 140 150
DSSDSEDSIP PEILERTLEP DSSDEEPPPV YSPPAYHMHV FDRPYPLAPP
160 170 180 190 200
TPPPRIDALG SGAPTSQRRY RNWNPPLLGN LPDDFLRILP QQLDSIQGNA
210 220 230 240 250
GGPKPGSGEG CPPAMAGPGP GDQESRWKQY LEDERIALFL QNEEFMKELQ
260 270 280 290 300
RNRDFLLALE RDRLKYESQK SKSSSVAVGN DFGFSSPVPG TGDANPAVSE
310 320 330 340 350
DALFRDKLKH MGKSTRRKLF ELARAFSEKT KMRKSKRKHL LKHQSLGAAA
360 370 380
STANLLDDVE GHACDEDFRG RRQEAPKVEE GLREGQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 47 | F → L in BAA91452 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050933 | 169 | R → H. Corresponds to variant dbSNP:rs17762338Ensembl. | 1 | |
Natural variantiVAR_021951 | 205 | P → S. Corresponds to variant dbSNP:rs2304942Ensembl. | 1 | |
Natural variantiVAR_033765 | 316 | R → Q. Corresponds to variant dbSNP:rs34800498Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010316 | 233 – 260 | Missing in isoform 2. 1 PublicationAdd BLAST | 28 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000746 mRNA Translation: BAA91357.1 AK000977 mRNA Translation: BAA91452.1 CH471109 Genomic DNA Translation: EAW94498.1 CH471109 Genomic DNA Translation: EAW94501.1 BC056882 mRNA Translation: AAH56882.1 |
CCDSi | CCDS11599.1 [Q9NWM3-1] |
RefSeqi | NP_001258804.1, NM_001271875.1 [Q9NWM3-1] NP_001278954.1, NM_001292025.1 [Q9NWM3-1] XP_006721963.1, XM_006721900.2 [Q9NWM3-1] |
UniGenei | Hs.46679 |
Genome annotation databases
Ensembli | ENST00000360238; ENSP00000353373; ENSG00000180891 [Q9NWM3-1] ENST00000407144; ENSP00000384712; ENSG00000180891 [Q9NWM3-1] ENST00000577830; ENSP00000462717; ENSG00000180891 [Q9NWM3-1] |
GeneIDi | 404093 |
KEGGi | hsa:404093 |
UCSCi | uc002ivd.3 human [Q9NWM3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | CUED1_HUMAN | |
Accessioni | Q9NWM3Primary (citable) accession number: Q9NWM3 Secondary accession number(s): D3DTZ2, Q9NWD0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | October 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |