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Protein

CUE domain-containing protein 1

Gene

CUEDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Names & Taxonomyi

Protein namesi
Recommended name:
CUE domain-containing protein 1
Gene namesi
Name:CUEDC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000180891.12
HGNCiHGNC:31350 CUEDC1
neXtProtiNX_Q9NWM3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180891
PharmGKBiPA134913154

Polymorphism and mutation databases

DMDMi47116934

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000795591 – 386CUE domain-containing protein 1Add BLAST386

Proteomic databases

EPDiQ9NWM3
MaxQBiQ9NWM3
PaxDbiQ9NWM3
PeptideAtlasiQ9NWM3
PRIDEiQ9NWM3

PTM databases

iPTMnetiQ9NWM3
PhosphoSitePlusiQ9NWM3

Expressioni

Gene expression databases

BgeeiENSG00000180891
CleanExiHS_CUEDC1
ExpressionAtlasiQ9NWM3 baseline and differential
GenevisibleiQ9NWM3 HS

Organism-specific databases

HPAiHPA023050
HPA024836

Interactioni

Protein-protein interaction databases

BioGridi13564246 interactors.
IntActiQ9NWM3 7 interactors.
MINTiQ9NWM3
STRINGi9606.ENSP00000353373

Structurei

Secondary structure

1386
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi48 – 57Combined sources10
Beta strandi59 – 61Combined sources3
Helixi63 – 73Combined sources11
Helixi77 – 89Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DHYNMR-A37-90[»]
ProteinModelPortaliQ9NWM3
SMRiQ9NWM3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NWM3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 89CUEPROSITE-ProRule annotationAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi110 – 154Pro-richAdd BLAST45

Phylogenomic databases

eggNOGiKOG4588 Eukaryota
ENOG4111S1H LUCA
GeneTreeiENSGT00390000006762
HOGENOMiHOG000007372
HOVERGENiHBG051264
InParanoidiQ9NWM3
OMAiDANVSPQ
OrthoDBiEOG091G0C64
PhylomeDBiQ9NWM3
TreeFamiTF324332

Family and domain databases

InterProiView protein in InterPro
IPR003892 CUE
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF02845 CUE, 1 hit
SMARTiView protein in SMART
SM00546 CUE, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS51140 CUE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NWM3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSLFRRSSS GSGGGGTAGA RGGGGGTAAP QELNNSRPAR QVRRLEFNQA
60 70 80 90 100
MDDFKTMFPN MDYDIIECVL RANSGAVDAT IDQLLQMNLE GGGSSGGVYE
110 120 130 140 150
DSSDSEDSIP PEILERTLEP DSSDEEPPPV YSPPAYHMHV FDRPYPLAPP
160 170 180 190 200
TPPPRIDALG SGAPTSQRRY RNWNPPLLGN LPDDFLRILP QQLDSIQGNA
210 220 230 240 250
GGPKPGSGEG CPPAMAGPGP GDQESRWKQY LEDERIALFL QNEEFMKELQ
260 270 280 290 300
RNRDFLLALE RDRLKYESQK SKSSSVAVGN DFGFSSPVPG TGDANPAVSE
310 320 330 340 350
DALFRDKLKH MGKSTRRKLF ELARAFSEKT KMRKSKRKHL LKHQSLGAAA
360 370 380
STANLLDDVE GHACDEDFRG RRQEAPKVEE GLREGQ
Length:386
Mass (Da):42,258
Last modified:October 1, 2000 - v1
Checksum:iF5530FA47C267895
GO
Isoform 2 (identifier: Q9NWM3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-260: Missing.

Note: No experimental confirmation available.
Show »
Length:358
Mass (Da):38,794
Checksum:i4E43A8DAD3273F17
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47F → L in BAA91452 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050933169R → H. Corresponds to variant dbSNP:rs17762338Ensembl.1
Natural variantiVAR_021951205P → S. Corresponds to variant dbSNP:rs2304942Ensembl.1
Natural variantiVAR_033765316R → Q. Corresponds to variant dbSNP:rs34800498Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010316233 – 260Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000746 mRNA Translation: BAA91357.1
AK000977 mRNA Translation: BAA91452.1
CH471109 Genomic DNA Translation: EAW94498.1
CH471109 Genomic DNA Translation: EAW94501.1
BC056882 mRNA Translation: AAH56882.1
CCDSiCCDS11599.1 [Q9NWM3-1]
RefSeqiNP_001258804.1, NM_001271875.1 [Q9NWM3-1]
NP_001278954.1, NM_001292025.1 [Q9NWM3-1]
XP_006721963.1, XM_006721900.2 [Q9NWM3-1]
UniGeneiHs.46679

Genome annotation databases

EnsembliENST00000360238; ENSP00000353373; ENSG00000180891 [Q9NWM3-1]
ENST00000407144; ENSP00000384712; ENSG00000180891 [Q9NWM3-1]
ENST00000577830; ENSP00000462717; ENSG00000180891 [Q9NWM3-1]
GeneIDi404093
KEGGihsa:404093
UCSCiuc002ivd.3 human [Q9NWM3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCUED1_HUMAN
AccessioniPrimary (citable) accession number: Q9NWM3
Secondary accession number(s): D3DTZ2, Q9NWD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome