CUEDC1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CUE domain-containing protein 1
Gene namesⁱ	Name:CUEDC1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31350. CUEDC1.

HGNCⁱ

HGNC:31350. CUEDC1.

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000180891.
PharmGKBⁱ	PA134913154.

Polymorphism and mutation databases

DMDMⁱ	47116934.

DMDMⁱ

47116934.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000079559	1 – 386	CUE domain-containing protein 1Add BLAST		386

Proteomic databases

EPDⁱ	Q9NWM3.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NWM3.
PaxDbⁱ	Q9NWM3.
PeptideAtlas More...PeptideAtlasⁱ	Q9NWM3.
PRIDEⁱ	Q9NWM3.

PTM databases

iPTMnetⁱ	Q9NWM3.
PhosphoSitePlusⁱ	Q9NWM3.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000180891.
CleanExⁱ	HS_CUEDC1.
ExpressionAtlasⁱ	Q9NWM3. baseline and differential.
Genevisibleⁱ	Q9NWM3. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA023050. HPA024836.

HPAⁱ

HPA023050.
HPA024836.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	135642. 43 interactors.
IntActⁱ	Q9NWM3. 7 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1182395.
STRINGⁱ	9606.ENSP00000353373.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	48 – 57	Combined sources	10
Beta strandⁱ	59 – 61	Combined sources	3
Helixⁱ	63 – 73	Combined sources	11
Helixⁱ	77 – 89	Combined sources	13

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DHY	NMR	-	A	37-90	[»]
ProteinModelPortalⁱ	Q9NWM3.
SMRⁱ	Q9NWM3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9NWM3.

EvolutionaryTraceⁱ

Q9NWM3.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	46 – 89	CUEPROSITE-ProRule annotationAdd BLAST		44

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	110 – 154	Pro-richAdd BLAST		45

Phylogenomic databases

eggNOGⁱ	KOG4588. Eukaryota. ENOG4111S1H. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006762.
HOGENOMⁱ	HOG000007372.
HOVERGENⁱ	HBG051264.
InParanoidⁱ	Q9NWM3.
OMAⁱ	ARVFTWQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0C64.
PhylomeDBⁱ	Q9NWM3.
TreeFamⁱ	TF324332.

Family and domain databases

InterProⁱ	View protein in InterPro IPR003892. CUE. IPR009060. UBA-like.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02845. CUE. 1 hit.
SMARTⁱ	View protein in SMART SM00546. CUE. 1 hit.
SUPFAMⁱ	SSF46934. SSF46934. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51140. CUE. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q9NWM3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSLFRRSSS GSGGGGTAGA RGGGGGTAAP QELNNSRPAR QVRRLEFNQA 
        60         70         80         90        100
MDDFKTMFPN MDYDIIECVL RANSGAVDAT IDQLLQMNLE GGGSSGGVYE 
       110        120        130        140        150
DSSDSEDSIP PEILERTLEP DSSDEEPPPV YSPPAYHMHV FDRPYPLAPP 
       160        170        180        190        200
TPPPRIDALG SGAPTSQRRY RNWNPPLLGN LPDDFLRILP QQLDSIQGNA 
       210        220        230        240        250
GGPKPGSGEG CPPAMAGPGP GDQESRWKQY LEDERIALFL QNEEFMKELQ 
       260        270        280        290        300
RNRDFLLALE RDRLKYESQK SKSSSVAVGN DFGFSSPVPG TGDANPAVSE 
       310        320        330        340        350
DALFRDKLKH MGKSTRRKLF ELARAFSEKT KMRKSKRKHL LKHQSLGAAA 
       360        370        380 
STANLLDDVE GHACDEDFRG RRQEAPKVEE GLREGQ

Length:386

Mass (Da):42,258

Last modified:October 1, 2000 - v1

Checksum:ⁱF5530FA47C267895

GO

Isoform 2 (identifier: Q9NWM3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
233-260: Missing.

« Hide

        10         20         30         40         50
MTSLFRRSSS GSGGGGTAGA RGGGGGTAAP QELNNSRPAR QVRRLEFNQA 
        60         70         80         90        100
MDDFKTMFPN MDYDIIECVL RANSGAVDAT IDQLLQMNLE GGGSSGGVYE 
       110        120        130        140        150
DSSDSEDSIP PEILERTLEP DSSDEEPPPV YSPPAYHMHV FDRPYPLAPP 
       160        170        180        190        200
TPPPRIDALG SGAPTSQRRY RNWNPPLLGN LPDDFLRILP QQLDSIQGNA 
       210        220        230        240        250
GGPKPGSGEG CPPAMAGPGP GDQESRWKQY LERDRLKYES QKSKSSSVAV 
       260        270        280        290        300
GNDFGFSSPV PGTGDANPAV SEDALFRDKL KHMGKSTRRK LFELARAFSE 
       310        320        330        340        350
KTKMRKSKRK HLLKHQSLGA AASTANLLDD VEGHACDEDF RGRRQEAPKV 

EEGLREGQ

Note: No experimental confirmation available.

Show »

Length:358

Mass (Da):38,794

Checksum:ⁱ4E43A8DAD3273F17

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	47	F → L in BAA91452 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_050933	169	R → H. Corresponds to variant dbSNP:rs17762338Ensembl.	1
Natural variantⁱVAR_021951	205	P → S. Corresponds to variant dbSNP:rs2304942Ensembl.	1
Natural variantⁱVAR_033765	316	R → Q. Corresponds to variant dbSNP:rs34800498Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_010316	233 – 260	Missing in isoform 2. 1 PublicationAdd BLAST		28

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000746 mRNA. Translation: BAA91357.1. AK000977 mRNA. Translation: BAA91452.1. CH471109 Genomic DNA. Translation: EAW94498.1. CH471109 Genomic DNA. Translation: EAW94501.1. BC056882 mRNA. Translation: AAH56882.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11599.1. [Q9NWM3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001258804.1. NM_001271875.1. [Q9NWM3-1] NP_001278954.1. NM_001292025.1. [Q9NWM3-1] XP_006721963.1. XM_006721900.2. [Q9NWM3-1]
UniGeneⁱ	Hs.46679.

Genome annotation databases

Ensemblⁱ	ENST00000360238; ENSP00000353373; ENSG00000180891. [Q9NWM3-1] ENST00000407144; ENSP00000384712; ENSG00000180891. [Q9NWM3-1] ENST00000577830; ENSP00000462717; ENSG00000180891. [Q9NWM3-1]
GeneIDⁱ	404093.
KEGGⁱ	hsa:404093.
UCSC genome browser More...UCSCⁱ	uc002ivd.3. human. [Q9NWM3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9NWM3	J3QLQ8 J3KT42	Homo sapiens (Human)	386	UniRef100_Q9NWM3	Cluster: CUE domain-containing protein 1	3

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9NWM3	J3QLQ8 J3KT42 UPI0005F53C9A UPI0005F3D146 UPI0007329EF3 UPI0007328526 UPI00045DBD96 UPI00045E35F3 UPI0000D9E2D8 UPI0005F38CAC +20	Homo sapiens (Human) Macaca nemestrina (Pig-tailed macaque) Macaca mulatta (Rhesus macaque) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Gorilla gorilla gorilla (Western lowland gorilla) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Papio anubis (Olive baboon) Pan troglodytes (Chimpanzee) And more	386	UniRef90_Q9NWM3	Cluster: CUE domain-containing protein 1	31
Q9NWM3-2	F7GIZ5	Callithrix jacchus (White-tufted-ear marmoset)	358	UniRef90_Q9NWM3-2	Cluster: Isoform 2 of CUE domain-containing protein 1	2

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
Q9NWM3	J3QLQ8 J3KT42 UPI0005F53C9A UPI0005F3D146 UPI0007329EF3 UPI0007328526 UPI00045DBD96 UPI00045E35F3 UPI0000D9E2D8 UPI0005F38CAC +28	Homo sapiens (Human) Macaca nemestrina (Pig-tailed macaque) Macaca mulatta (Rhesus macaque) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Gorilla gorilla gorilla (Western lowland gorilla) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Pan troglodytes (Chimpanzee) And more	386	UniRef50_Q9NWM3	Cluster: CUE domain-containing protein 1	39
Q9NWM3-2	F7GIZ5 F2Z3X3 UPI0003EC1E5E UPI000671310C UPI00077CE189 A0A1A8FMD9 UPI00077CE401	Callithrix jacchus (White-tufted-ear marmoset) Mus musculus (Mouse) Neolamprologus brichardi (Fairy cichlid) (Lamprologus brichardi) Anser cygnoides domesticus Nothobranchius furzeri (Turquoise killifish) Nothobranchius korthausae	358	UniRef50_Q9NWM3-2	Cluster: Isoform 2 of CUE domain-containing protein 1	8

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK000746 mRNA. Translation: BAA91357.1. AK000977 mRNA. Translation: BAA91452.1. CH471109 Genomic DNA. Translation: EAW94498.1. CH471109 Genomic DNA. Translation: EAW94501.1. BC056882 mRNA. Translation: AAH56882.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11599.1. [Q9NWM3-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001258804.1. NM_001271875.1. [Q9NWM3-1] NP_001278954.1. NM_001292025.1. [Q9NWM3-1] XP_006721963.1. XM_006721900.2. [Q9NWM3-1]
UniGeneⁱ	Hs.46679.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2DHY	NMR	-	A	37-90	[»]
ProteinModelPortalⁱ	Q9NWM3.
SMRⁱ	Q9NWM3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	135642. 43 interactors.
IntActⁱ	Q9NWM3. 7 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1182395.
STRINGⁱ	9606.ENSP00000353373.

PTM databases

iPTMnetⁱ	Q9NWM3.
PhosphoSitePlusⁱ	Q9NWM3.

Polymorphism and mutation databases

DMDMⁱ	47116934.

DMDMⁱ

47116934.

Proteomic databases

EPDⁱ	Q9NWM3.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NWM3.
PaxDbⁱ	Q9NWM3.
PeptideAtlas More...PeptideAtlasⁱ	Q9NWM3.
PRIDEⁱ	Q9NWM3.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000360238; ENSP00000353373; ENSG00000180891. [Q9NWM3-1] ENST00000407144; ENSP00000384712; ENSG00000180891. [Q9NWM3-1] ENST00000577830; ENSP00000462717; ENSG00000180891. [Q9NWM3-1]
GeneIDⁱ	404093.
KEGGⁱ	hsa:404093.
UCSC genome browser More...UCSCⁱ	uc002ivd.3. human. [Q9NWM3-1]

Organism-specific databases

CTDⁱ	404093.
GeneCardsⁱ	CUEDC1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31350. CUEDC1.
Human Protein Atlas More...HPAⁱ	HPA023050. HPA024836.
neXtProtⁱ	NX_Q9NWM3.
Open Targets More...OpenTargetsⁱ	ENSG00000180891.
PharmGKBⁱ	PA134913154.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4588. Eukaryota. ENOG4111S1H. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006762.
HOGENOMⁱ	HOG000007372.
HOVERGENⁱ	HBG051264.
InParanoidⁱ	Q9NWM3.
OMAⁱ	ARVFTWQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0C64.
PhylomeDBⁱ	Q9NWM3.
TreeFamⁱ	TF324332.

Miscellaneous databases

ChiTaRSⁱ	CUEDC1. human.
EvolutionaryTraceⁱ	Q9NWM3.
GenomeRNAiⁱ	404093.
Protein Ontology More...PROⁱ	PR:Q9NWM3.

Gene expression databases

Bgeeⁱ	ENSG00000180891.
CleanExⁱ	HS_CUEDC1.
ExpressionAtlasⁱ	Q9NWM3. baseline and differential.
Genevisibleⁱ	Q9NWM3. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR003892. CUE. IPR009060. UBA-like.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02845. CUE. 1 hit.
SMARTⁱ	View protein in SMART SM00546. CUE. 1 hit.
SUPFAMⁱ	SSF46934. SSF46934. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51140. CUE. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CUED1_HUMAN
Accessionⁱ	Q9NWM3Primary (citable) accession number: Q9NWM3 Secondary accession number(s): D3DTZ2, Q9NWD0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
	Last sequence update:	October 1, 2000
	Last modified:	August 30, 2017
	This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NWM3 (CUED1_HUMAN)

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CUE domain-containing protein 1

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ