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Protein

Asparagine synthetase domain-containing protein 1

Gene

ASNSD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21For GATase activityBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid biosynthesis, Asparagine biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Asparagine synthetase domain-containing protein 1
Alternative name(s):
HCV NS3-transactivated protein 1
Gene namesi
Name:ASNSD1
Synonyms:NS3TP1
ORF Names:Nbla00058
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24910. ASNSD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485312.

Polymorphism and mutation databases

BioMutaiASNSD1.
DMDMi311033363.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 643642Asparagine synthetase domain-containing protein 1PRO_0000324760Add
BLAST

Proteomic databases

EPDiQ9NWL6.
MaxQBiQ9NWL6.
PaxDbiQ9NWL6.
PeptideAtlasiQ9NWL6.
PRIDEiQ9NWL6.

PTM databases

iPTMnetiQ9NWL6.
PhosphoSiteiQ9NWL6.

Expressioni

Gene expression databases

BgeeiENSG00000138381.
CleanExiHS_ASNSD1.
ExpressionAtlasiQ9NWL6. baseline and differential.
GenevisibleiQ9NWL6. HS.

Organism-specific databases

HPAiHPA036132.
HPA036133.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120017. 3 interactions.
STRINGi9606.ENSP00000260952.

Structurei

3D structure databases

ProteinModelPortaliQ9NWL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 184183Glutamine amidotransferase type-2PROSITE-ProRule annotationAdd
BLAST
Domaini285 – 601317Asparagine synthetaseAdd
BLAST

Sequence similaritiesi

Contains 1 asparagine synthetase domain.Curated
Contains 1 glutamine amidotransferase type-2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiKOG0573. Eukaryota.
COG0367. LUCA.
GeneTreeiENSGT00390000012446.
HOGENOMiHOG000038438.
HOVERGENiHBG105031.
InParanoidiQ9NWL6.
OMAiCLFSAHV.
OrthoDBiEOG091G09V2.
PhylomeDBiQ9NWL6.
TreeFamiTF314578.

Family and domain databases

CDDicd01991. Asn_Synthase_B_C. 1 hit.
Gene3Di3.40.50.620. 2 hits.
3.60.20.10. 1 hit.
InterProiIPR001962. Asn_synthase.
IPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00733. Asn_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NWL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGICCSVNF SAEHFSQDLK EDLLYNLKQR GPNSSKQLLK SDVNYQCLFS
60 70 80 90 100
AHVLHLRGVL TTQPVEDERG NVFLWNGEIF SGIKVEAEEN DTQILFNYLS
110 120 130 140 150
SCKNESEILS LFSEVQGPWS FIYYQASSHY LWFGRDFFGR RSLLWHFSNL
160 170 180 190 200
GKSFCLSSVG TQTSGLANQW QEVPASGLFR IDLKSTVISG CIILQLYPWK
210 220 230 240 250
YISRENIIEE NVNSLSQISA DLPAFVSVVA NEAKLYLEKP VVPLNMMLPQ
260 270 280 290 300
AALETHCSNI SNVPPTREIL QVFLTDVHMK EVIQQFIDVL SVAVKKRVLC
310 320 330 340 350
LPRDENLTAN EVLKTCDRKA NVAILFSGGI DSMVIATLAD RHIPLDEPID
360 370 380 390 400
LLNVAFIAEE KTMPTTFNRE GNKQKNKCEI PSEEFSKDVA AAAADSPNKH
410 420 430 440 450
VSVPDRITGR AGLKELQAVS PSRIWNFVEI NVSMEELQKL RRTRICHLIR
460 470 480 490 500
PLDTVLDDSI GCAVWFASRG IGWLVAQEGV KSYQSNAKVV LTGIGADEQL
510 520 530 540 550
AGYSRHRVRF QSHGLEGLNK EIMMELGRIS SRNLGRDDRV IGDHGKEARF
560 570 580 590 600
PFLDENVVSF LNSLPIWEKA NLTLPRGIGE KLLLRLAAVE LGLTASALLP
610 620 630 640
KRAMQFGSRI AKMEKINEKA SDKCGRLQIM SLENLSIEKE TKL
Length:643
Mass (Da):72,080
Last modified:November 2, 2010 - v2
Checksum:iC40C4AAC1607299F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti190 – 1901G → R.5 Publications
Corresponds to variant rs1437880 [ dbSNP | Ensembl ].
VAR_039876
Natural varianti434 – 4341M → T.
Corresponds to variant rs35137531 [ dbSNP | Ensembl ].
VAR_039877

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY116969 mRNA. Translation: AAM77212.1.
AK000759 mRNA. Translation: BAA91364.1.
AC012488 Genomic DNA. Translation: AAX88843.1.
CH471058 Genomic DNA. Translation: EAX10898.1.
CH471058 Genomic DNA. Translation: EAX10899.1.
CH471058 Genomic DNA. Translation: EAX10900.1.
BC001243 mRNA. Translation: AAH01243.1.
AB075481 mRNA. Translation: BAE45745.1.
CCDSiCCDS2300.1.
RefSeqiNP_061921.1. NM_019048.2.
UniGeneiHs.101364.

Genome annotation databases

EnsembliENST00000260952; ENSP00000260952; ENSG00000138381.
GeneIDi54529.
KEGGihsa:54529.
UCSCiuc002uqt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY116969 mRNA. Translation: AAM77212.1.
AK000759 mRNA. Translation: BAA91364.1.
AC012488 Genomic DNA. Translation: AAX88843.1.
CH471058 Genomic DNA. Translation: EAX10898.1.
CH471058 Genomic DNA. Translation: EAX10899.1.
CH471058 Genomic DNA. Translation: EAX10900.1.
BC001243 mRNA. Translation: AAH01243.1.
AB075481 mRNA. Translation: BAE45745.1.
CCDSiCCDS2300.1.
RefSeqiNP_061921.1. NM_019048.2.
UniGeneiHs.101364.

3D structure databases

ProteinModelPortaliQ9NWL6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120017. 3 interactions.
STRINGi9606.ENSP00000260952.

PTM databases

iPTMnetiQ9NWL6.
PhosphoSiteiQ9NWL6.

Polymorphism and mutation databases

BioMutaiASNSD1.
DMDMi311033363.

Proteomic databases

EPDiQ9NWL6.
MaxQBiQ9NWL6.
PaxDbiQ9NWL6.
PeptideAtlasiQ9NWL6.
PRIDEiQ9NWL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260952; ENSP00000260952; ENSG00000138381.
GeneIDi54529.
KEGGihsa:54529.
UCSCiuc002uqt.4. human.

Organism-specific databases

CTDi54529.
GeneCardsiASNSD1.
HGNCiHGNC:24910. ASNSD1.
HPAiHPA036132.
HPA036133.
neXtProtiNX_Q9NWL6.
PharmGKBiPA143485312.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0573. Eukaryota.
COG0367. LUCA.
GeneTreeiENSGT00390000012446.
HOGENOMiHOG000038438.
HOVERGENiHBG105031.
InParanoidiQ9NWL6.
OMAiCLFSAHV.
OrthoDBiEOG091G09V2.
PhylomeDBiQ9NWL6.
TreeFamiTF314578.

Miscellaneous databases

ChiTaRSiASNSD1. human.
GenomeRNAii54529.
PROiQ9NWL6.

Gene expression databases

BgeeiENSG00000138381.
CleanExiHS_ASNSD1.
ExpressionAtlasiQ9NWL6. baseline and differential.
GenevisibleiQ9NWL6. HS.

Family and domain databases

CDDicd01991. Asn_Synthase_B_C. 1 hit.
Gene3Di3.40.50.620. 2 hits.
3.60.20.10. 1 hit.
InterProiIPR001962. Asn_synthase.
IPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00733. Asn_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASND1_HUMAN
AccessioniPrimary (citable) accession number: Q9NWL6
Secondary accession number(s): D3DPH6, Q3LIC3, Q4ZG45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 2, 2010
Last modified: September 7, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.