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Protein

SAFB-like transcription modulator

Gene

SLTM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SAFB-like transcription modulator
Alternative name(s):
Modulator of estrogen-induced transcription
Gene namesi
Name:SLTM
Synonyms:MET
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:20709. SLTM.

Subcellular locationi

  • Nucleus By similarity

  • Note: Detected in punctate structures.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi79811.
OpenTargetsiENSG00000137776.
PharmGKBiPA142670898.

Polymorphism and mutation databases

BioMutaiSLTM.
DMDMi160185645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00003077982 – 1034SAFB-like transcription modulatorAdd BLAST1033

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei93PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei139PhosphoserineBy similarity1
Modified residuei144PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Modified residuei401N6-acetyllysineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Cross-linki500Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei550PhosphoserineCombined sources1
Modified residuei551PhosphoserineCombined sources1
Modified residuei553PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1
Modified residuei789PhosphoserineCombined sources1
Modified residuei800PhosphoserineCombined sources1
Modified residuei815PhosphoserineCombined sources1
Cross-linki884Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei909PhosphoserineCombined sources1
Modified residuei923PhosphoserineCombined sources1
Modified residuei929PhosphoserineCombined sources1
Modified residuei944PhosphoserineCombined sources1
Modified residuei998PhosphoserineCombined sources1
Modified residuei1002PhosphoserineCombined sources1
Modified residuei1014PhosphoserineCombined sources1
Modified residuei1017Omega-N-methylarginineCombined sources1
Modified residuei1019PhosphoserineCombined sources1
Modified residuei1021PhosphoserineCombined sources1
Modified residuei1024N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NWH9.
MaxQBiQ9NWH9.
PaxDbiQ9NWH9.
PeptideAtlasiQ9NWH9.
PRIDEiQ9NWH9.

PTM databases

iPTMnetiQ9NWH9.
PhosphoSitePlusiQ9NWH9.

Expressioni

Gene expression databases

BgeeiENSG00000137776.
CleanExiHS_MET.
HS_SLTM.
ExpressionAtlasiQ9NWH9. baseline and differential.
GenevisibleiQ9NWH9. HS.

Organism-specific databases

HPAiHPA040256.
HPA040381.

Interactioni

Protein-protein interaction databases

BioGridi122906. 28 interactors.
IntActiQ9NWH9. 11 interactors.
MINTiMINT-4540292.
STRINGi9606.ENSP00000369887.

Structurei

3D structure databases

ProteinModelPortaliQ9NWH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 56SAPPROSITE-ProRule annotationAdd BLAST35
Domaini384 – 462RRMPROSITE-ProRule annotationAdd BLAST79

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili609 – 728Sequence analysisAdd BLAST120

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 239Glu-richAdd BLAST132
Compositional biasi569 – 906Arg/Glu-richAdd BLAST338

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation
Contains 1 SAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4661. Eukaryota.
ENOG4111FBJ. LUCA.
GeneTreeiENSGT00730000110777.
HOVERGENiHBG096731.
InParanoidiQ9NWH9.
OMAiWKSEANM.
OrthoDBiEOG091G0GPT.
PhylomeDBiQ9NWH9.
TreeFamiTF325240.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00513. SAP. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS50800. SAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NWH9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAATGAVAA SAASGQAEGK KITDLRVIDL KSELKRRNLD ITGVKTVLIS
60 70 80 90 100
RLKQAIEEEG GDPDNIELTV STDTPNKKPT KGKGKKHEAD ELSGDASVED
110 120 130 140 150
DAFIKDCELE NQEAHEQDGN DELKDSEEFG ENEEENVHSK ELLSAEENKR
160 170 180 190 200
AHELIEAEGI EDIEKEDIES QEIEAQEGED DTFLTAQDGE EEENEKDIAG
210 220 230 240 250
SGDGTQEVSK PLPSEGSLAE ADHTAHEEME AHTTVKEAED DNISVTIQAE
260 270 280 290 300
DAITLDFDGD DLLETGKNVK ITDSEASKPK DGQDAIAQSP EKESKDYEMN
310 320 330 340 350
ANHKDGKKED CVKGDPVEKE ARESSKKAES GDKEKDTLKK GPSSTGASGQ
360 370 380 390 400
AKSSSKESKD SKTSSKDDKG STSSTSGSSG SSTKNIWVSG LSSNTKAADL
410 420 430 440 450
KNLFGKYGKV LSAKVVTNAR SPGAKCYGIV TMSSSTEVSR CIAHLHRTEL
460 470 480 490 500
HGQLISVEKV KGDPSKKEMK KENDEKSSSR SSGDKKNTSD RSSKTQASVK
510 520 530 540 550
KEEKRSSEKS EKKESKDTKK IEGKDEKNDN GASGQTSESI KKSEEKKRIS
560 570 580 590 600
SKSPGHMVIL DQTKGDHCRP SRRGRYEKIH GRSKEKERAS LDKKRDKDYR
610 620 630 640 650
RKEILPFEKM KEQRLREHLV RFERLRRAME LRRRREIAER ERRERERIRI
660 670 680 690 700
IREREERERL QRERERLEIE RQKLERERME RERLERERIR IEQERRKEAE
710 720 730 740 750
RIAREREELR RQQQQLRYEQ EKRNSLKRPR DVDHRRDDPY WSENKKLSLD
760 770 780 790 800
TDARFGHGSD YSRQQNRFND FDHRERGRFP ESSAVQSSSF ERRDRFVGQS
810 820 830 840 850
EGKKARPTAR REDPSFERYP KNFSDSRRNE PPPPRNELRE SDRREVRGER
860 870 880 890 900
DERRTVIIHD RPDITHPRHP REAGPNPSRP TSWKSEGSMS TDKRETRVER
910 920 930 940 950
PERSGREVSG HSVRGAPPGN RSSASGYGSR EGDRGVITDR GGGSQHYPEE
960 970 980 990 1000
RHVVERHGRD TSGPRKEWHG PPSQGPSYHD TRRMGDGRAG AGMITQHSSN
1010 1020 1030
ASPINRIVQI SGNSMPRGSG SGFKPFKGGP PRRF
Length:1,034
Mass (Da):117,148
Last modified:October 23, 2007 - v2
Checksum:iFF63F506929CFD6F
GO
Isoform 2 (identifier: Q9NWH9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-431: Missing.

Note: No experimental confirmation available.
Show »
Length:603
Mass (Da):71,067
Checksum:i853D368AF075F7E1
GO

Sequence cautioni

The sequence AAI08657 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB14502 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14971 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB14971 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126S → F in BAA91401 (PubMed:14702039).Curated1
Sequence conflicti511E → V in BAA91401 (PubMed:14702039).Curated1
Sequence conflicti606P → S in AAH14944 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037088235V → L.Corresponds to variant rs7175939dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560511 – 431Missing in isoform 2. 1 PublicationAdd BLAST431

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000867 mRNA. Translation: BAA91401.1.
AK023275 mRNA. Translation: BAB14502.1. Different initiation.
AK024710 mRNA. Translation: BAB14971.1. Sequence problems.
AK055195 mRNA. Translation: BAG51484.1.
AK291423 mRNA. Translation: BAF84112.1.
AC025918 Genomic DNA. No translation available.
AC090515 Genomic DNA. No translation available.
BC014944 mRNA. Translation: AAH14944.1.
BC046119 mRNA. Translation: AAH46119.3.
BC108656 mRNA. Translation: AAI08657.1. Sequence problems.
BC140851 mRNA. Translation: AAI40852.1.
AL834297 mRNA. Translation: CAH56362.1.
CCDSiCCDS10168.2. [Q9NWH9-1]
RefSeqiNP_001013865.1. NM_001013843.2.
NP_079031.2. NM_024755.3. [Q9NWH9-1]
XP_006720753.1. XM_006720690.1. [Q9NWH9-3]
XP_016878069.1. XM_017022580.1. [Q9NWH9-3]
UniGeneiHs.512932.

Genome annotation databases

EnsembliENST00000380516; ENSP00000369887; ENSG00000137776. [Q9NWH9-1]
GeneIDi79811.
KEGGihsa:79811.
UCSCiuc002afp.3. human. [Q9NWH9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000867 mRNA. Translation: BAA91401.1.
AK023275 mRNA. Translation: BAB14502.1. Different initiation.
AK024710 mRNA. Translation: BAB14971.1. Sequence problems.
AK055195 mRNA. Translation: BAG51484.1.
AK291423 mRNA. Translation: BAF84112.1.
AC025918 Genomic DNA. No translation available.
AC090515 Genomic DNA. No translation available.
BC014944 mRNA. Translation: AAH14944.1.
BC046119 mRNA. Translation: AAH46119.3.
BC108656 mRNA. Translation: AAI08657.1. Sequence problems.
BC140851 mRNA. Translation: AAI40852.1.
AL834297 mRNA. Translation: CAH56362.1.
CCDSiCCDS10168.2. [Q9NWH9-1]
RefSeqiNP_001013865.1. NM_001013843.2.
NP_079031.2. NM_024755.3. [Q9NWH9-1]
XP_006720753.1. XM_006720690.1. [Q9NWH9-3]
XP_016878069.1. XM_017022580.1. [Q9NWH9-3]
UniGeneiHs.512932.

3D structure databases

ProteinModelPortaliQ9NWH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122906. 28 interactors.
IntActiQ9NWH9. 11 interactors.
MINTiMINT-4540292.
STRINGi9606.ENSP00000369887.

PTM databases

iPTMnetiQ9NWH9.
PhosphoSitePlusiQ9NWH9.

Polymorphism and mutation databases

BioMutaiSLTM.
DMDMi160185645.

Proteomic databases

EPDiQ9NWH9.
MaxQBiQ9NWH9.
PaxDbiQ9NWH9.
PeptideAtlasiQ9NWH9.
PRIDEiQ9NWH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380516; ENSP00000369887; ENSG00000137776. [Q9NWH9-1]
GeneIDi79811.
KEGGihsa:79811.
UCSCiuc002afp.3. human. [Q9NWH9-1]

Organism-specific databases

CTDi79811.
DisGeNETi79811.
GeneCardsiSLTM.
H-InvDBHIX0012286.
HGNCiHGNC:20709. SLTM.
HPAiHPA040256.
HPA040381.
neXtProtiNX_Q9NWH9.
OpenTargetsiENSG00000137776.
PharmGKBiPA142670898.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4661. Eukaryota.
ENOG4111FBJ. LUCA.
GeneTreeiENSGT00730000110777.
HOVERGENiHBG096731.
InParanoidiQ9NWH9.
OMAiWKSEANM.
OrthoDBiEOG091G0GPT.
PhylomeDBiQ9NWH9.
TreeFamiTF325240.

Miscellaneous databases

ChiTaRSiSLTM. human.
GenomeRNAii79811.
PROiQ9NWH9.

Gene expression databases

BgeeiENSG00000137776.
CleanExiHS_MET.
HS_SLTM.
ExpressionAtlasiQ9NWH9. baseline and differential.
GenevisibleiQ9NWH9. HS.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF02037. SAP. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00513. SAP. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS50800. SAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLTM_HUMAN
AccessioniPrimary (citable) accession number: Q9NWH9
Secondary accession number(s): A8K5V8
, B2RTX3, Q2VPK7, Q52MB3, Q658J7, Q6ZNF2, Q86TK6, Q9H7C3, Q9H8U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.