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Protein

Transmembrane protein 242

Gene

TMEM242

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 242
Gene namesi
Name:TMEM242
Synonyms:C6orf35
ORF Names:BM-033, HSPC287
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000215712.10.
HGNCiHGNC:17206. TMEM242.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 50HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000215712.
PharmGKBiPA25936.

Polymorphism and mutation databases

BioMutaiTMEM242.
DMDMi74753021.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002958481 – 141Transmembrane protein 242Add BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NWH2.
MaxQBiQ9NWH2.
PaxDbiQ9NWH2.
PeptideAtlasiQ9NWH2.
PRIDEiQ9NWH2.
TopDownProteomicsiQ9NWH2.

PTM databases

iPTMnetiQ9NWH2.
PhosphoSitePlusiQ9NWH2.

Expressioni

Gene expression databases

BgeeiENSG00000215712.
CleanExiHS_C6orf35.
ExpressionAtlasiQ9NWH2. baseline and differential.
GenevisibleiQ9NWH2. HS.

Organism-specific databases

HPAiHPA025764.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi609914. 9 interactors.
IntActiQ9NWH2. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9NWH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM242 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVW9. Eukaryota.
ENOG4111SBW. LUCA.
GeneTreeiENSGT00390000008642.
HOGENOMiHOG000047628.
HOVERGENiHBG057272.
InParanoidiQ9NWH2.
OMAiHSMKDFR.
OrthoDBiEOG091G0YBU.
PhylomeDBiQ9NWH2.
TreeFamiTF323317.

Family and domain databases

InterProiView protein in InterPro
IPR009792. TMEM242.
PANTHERiPTHR13141. PTHR13141. 1 hit.
PfamiView protein in Pfam
PF07096. DUF1358. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NWH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METAGAATGQ PASGLEAPGS TNDRLFLVKG GIFLGTVAAA GMLAGFITTL
60 70 80 90 100
SLAKKKSPEW FNKGSMATAA LPESGSSLAL RALGWGSLYA WCGVGVISFA
110 120 130 140
VWKALGVHSM NDFRSKMQSI FPTIPKNSES AVEWEETLKS K
Length:141
Mass (Da):14,758
Last modified:October 1, 2000 - v1
Checksum:i448CDA01809A2B37
GO

Sequence cautioni

Q9NWH2: The sequence AAF28965 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Q9NWH2: The sequence AAF67621 differs from that shown. Reason: Frameshift at position 130.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161405 mRNA. Translation: AAF28965.1. Different initiation.
AF217510 mRNA. Translation: AAF67621.1. Frameshift.
AK000891 mRNA. Translation: BAA91409.1.
AL607068, AL390955 Genomic DNA. Translation: CAI17123.1.
AL390955, AL607068 Genomic DNA. Translation: CAI23394.1.
CH471051 Genomic DNA. Translation: EAW47677.1.
BC029130 mRNA. Translation: AAH29130.1.
BC146893 mRNA. Translation: AAI46894.1.
BC146895 mRNA. Translation: AAI46896.1.
CCDSiCCDS43519.1.
RefSeqiNP_060922.2. NM_018452.5.
UniGeneiHs.157212.

Genome annotation databases

EnsembliENST00000400788; ENSP00000383594; ENSG00000215712.
GeneIDi729515.
KEGGihsa:729515.
UCSCiuc003sih.5. human.

Similar proteinsi

Entry informationi

Entry nameiTM242_HUMAN
AccessioniPrimary (citable) accession number: Q9NWH2
Secondary accession number(s): B9EJD0, Q9NZ88, Q9P094
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries