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Protein

Transmembrane protein 242

Gene

TMEM242

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 242
Gene namesi
Name:TMEM242
Synonyms:C6orf35
ORF Names:BM-033, HSPC287
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:17206. TMEM242.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalSequence analysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25936.

Polymorphism and mutation databases

BioMutaiTMEM242.
DMDMi74753021.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141Transmembrane protein 242PRO_0000295848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NWH2.
MaxQBiQ9NWH2.
PaxDbiQ9NWH2.
PRIDEiQ9NWH2.
TopDownProteomicsiQ9NWH2.

PTM databases

PhosphoSiteiQ9NWH2.

Expressioni

Gene expression databases

BgeeiQ9NWH2.
CleanExiHS_C6orf35.
ExpressionAtlasiQ9NWH2. baseline and differential.
GenevisibleiQ9NWH2. HS.

Organism-specific databases

HPAiHPA025764.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GGT7Q9UJ143EBI-10315004,EBI-1058791
RNF5Q999423EBI-10315004,EBI-348482

Protein-protein interaction databases

BioGridi609914. 6 interactions.
IntActiQ9NWH2. 2 interactions.
STRINGi9606.ENSP00000383594.

Structurei

3D structure databases

ProteinModelPortaliQ9NWH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM242 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVW9. Eukaryota.
ENOG4111SBW. LUCA.
GeneTreeiENSGT00390000008642.
HOGENOMiHOG000047628.
HOVERGENiHBG057272.
InParanoidiQ9NWH2.
OMAiMKYLAAW.
OrthoDBiEOG7RZ5S5.
PhylomeDBiQ9NWH2.
TreeFamiTF323317.

Family and domain databases

InterProiIPR009792. TMEM242.
[Graphical view]
PANTHERiPTHR13141. PTHR13141. 1 hit.
PfamiPF07096. DUF1358. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NWH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METAGAATGQ PASGLEAPGS TNDRLFLVKG GIFLGTVAAA GMLAGFITTL
60 70 80 90 100
SLAKKKSPEW FNKGSMATAA LPESGSSLAL RALGWGSLYA WCGVGVISFA
110 120 130 140
VWKALGVHSM NDFRSKMQSI FPTIPKNSES AVEWEETLKS K
Length:141
Mass (Da):14,758
Last modified:October 1, 2000 - v1
Checksum:i448CDA01809A2B37
GO

Sequence cautioni

The sequence AAF28965.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAF67621.1 differs from that shown. Reason: Frameshift at position 130. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161405 mRNA. Translation: AAF28965.1. Different initiation.
AF217510 mRNA. Translation: AAF67621.1. Frameshift.
AK000891 mRNA. Translation: BAA91409.1.
AL607068, AL390955 Genomic DNA. Translation: CAI17123.1.
AL390955, AL607068 Genomic DNA. Translation: CAI23394.1.
CH471051 Genomic DNA. Translation: EAW47677.1.
BC029130 mRNA. Translation: AAH29130.1.
BC146893 mRNA. Translation: AAI46894.1.
BC146895 mRNA. Translation: AAI46896.1.
CCDSiCCDS43519.1.
RefSeqiNP_060922.2. NM_018452.5.
UniGeneiHs.157212.

Genome annotation databases

EnsembliENST00000400788; ENSP00000383594; ENSG00000215712.
GeneIDi729515.
KEGGihsa:729515.
UCSCiuc003sih.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161405 mRNA. Translation: AAF28965.1. Different initiation.
AF217510 mRNA. Translation: AAF67621.1. Frameshift.
AK000891 mRNA. Translation: BAA91409.1.
AL607068, AL390955 Genomic DNA. Translation: CAI17123.1.
AL390955, AL607068 Genomic DNA. Translation: CAI23394.1.
CH471051 Genomic DNA. Translation: EAW47677.1.
BC029130 mRNA. Translation: AAH29130.1.
BC146893 mRNA. Translation: AAI46894.1.
BC146895 mRNA. Translation: AAI46896.1.
CCDSiCCDS43519.1.
RefSeqiNP_060922.2. NM_018452.5.
UniGeneiHs.157212.

3D structure databases

ProteinModelPortaliQ9NWH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi609914. 6 interactions.
IntActiQ9NWH2. 2 interactions.
STRINGi9606.ENSP00000383594.

PTM databases

PhosphoSiteiQ9NWH2.

Polymorphism and mutation databases

BioMutaiTMEM242.
DMDMi74753021.

Proteomic databases

EPDiQ9NWH2.
MaxQBiQ9NWH2.
PaxDbiQ9NWH2.
PRIDEiQ9NWH2.
TopDownProteomicsiQ9NWH2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400788; ENSP00000383594; ENSG00000215712.
GeneIDi729515.
KEGGihsa:729515.
UCSCiuc003sih.5. human.

Organism-specific databases

CTDi729515.
GeneCardsiTMEM242.
HGNCiHGNC:17206. TMEM242.
HPAiHPA025764.
neXtProtiNX_Q9NWH2.
PharmGKBiPA25936.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVW9. Eukaryota.
ENOG4111SBW. LUCA.
GeneTreeiENSGT00390000008642.
HOGENOMiHOG000047628.
HOVERGENiHBG057272.
InParanoidiQ9NWH2.
OMAiMKYLAAW.
OrthoDBiEOG7RZ5S5.
PhylomeDBiQ9NWH2.
TreeFamiTF323317.

Miscellaneous databases

GeneWikiiC6orf35.
GenomeRNAii729515.
NextBioi130516.
PROiQ9NWH2.

Gene expression databases

BgeeiQ9NWH2.
CleanExiHS_C6orf35.
ExpressionAtlasiQ9NWH2. baseline and differential.
GenevisibleiQ9NWH2. HS.

Family and domain databases

InterProiIPR009792. TMEM242.
[Graphical view]
PANTHERiPTHR13141. PTHR13141. 1 hit.
PfamiPF07096. DUF1358. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Human partial CDS from CD34+ stem cells."
    Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  2. "A novel gene expressed in human bone marrow."
    Zhao M., Gu J., Li N., Peng Y., Han Z., Chen Z.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM242_HUMAN
AccessioniPrimary (citable) accession number: Q9NWH2
Secondary accession number(s): B9EJD0, Q9NZ88, Q9P094
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 1, 2000
Last modified: March 16, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.