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Q9NWD9

- BEX4_HUMAN

UniProt

Q9NWD9 - BEX4_HUMAN

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Protein

Protein BEX4

Gene
BEX4, BEXL1, NADE3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX4
Alternative name(s):
BEX1-like protein 1
Brain-expressed X-linked protein 4
Nerve growth factor receptor-associated protein 3
Gene namesi
Name:BEX4
Synonyms:BEXL1, NADE3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:25475. BEX4.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377543.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 120120Protein BEX4PRO_0000229783Add
BLAST

Post-translational modificationi

Ubiquitinated. Degraded by the proteasome By similarity.

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9NWD9.
PRIDEiQ9NWD9.

PTM databases

PhosphoSiteiQ9NWD9.

Expressioni

Gene expression databases

BgeeiQ9NWD9.
CleanExiHS_BEX4.
GenevestigatoriQ9NWD9.

Organism-specific databases

HPAiHPA045105.

Interactioni

Protein-protein interaction databases

BioGridi121131. 1 interaction.
STRINGi9606.ENSP00000361776.

Structurei

3D structure databases

ProteinModelPortaliQ9NWD9.

Family & Domainsi

Sequence similaritiesi

Belongs to the BEX family.

Phylogenomic databases

eggNOGiNOG42267.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ9NWD9.
OMAiVGQMMEV.
OrthoDBiEOG7WHHD5.
PhylomeDBiQ9NWD9.
TreeFamiTF337909.

Family and domain databases

InterProiIPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view]
PfamiPF04538. BEX. 1 hit.
[Graphical view]
PIRSFiPIRSF008633. BEX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NWD9-1 [UniParc]FASTAAdd to Basket

« Hide

MESKEELAAN NLNGENAQQE NEGGEQAPTQ NEEESRHLGG GEGQKPGGNI    50
RRGRVRRLVP NFRWAIPNRH IEHNEARDDV ERFVGQMMEI KRKTREQQMR 100
HYMRFQTPEP DNHYDFCLIP 120
Length:120
Mass (Da):14,067
Last modified:October 1, 2000 - v1
Checksum:iAD9527B5587622D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000959 mRNA. Translation: BAA91443.1.
AY833563 mRNA. Translation: AAX40681.1.
AL035494 Genomic DNA. Translation: CAI42990.1.
CCDSiCCDS35355.1.
RefSeqiNP_001073894.1. NM_001080425.3.
NP_001121160.1. NM_001127688.2.
UniGeneiHs.184736.

Genome annotation databases

EnsembliENST00000372691; ENSP00000361776; ENSG00000102409.
ENST00000372695; ENSP00000361780; ENSG00000102409.
GeneIDi56271.
KEGGihsa:56271.
UCSCiuc004ejv.4. human.

Polymorphism databases

DMDMi74753015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000959 mRNA. Translation: BAA91443.1 .
AY833563 mRNA. Translation: AAX40681.1 .
AL035494 Genomic DNA. Translation: CAI42990.1 .
CCDSi CCDS35355.1.
RefSeqi NP_001073894.1. NM_001080425.3.
NP_001121160.1. NM_001127688.2.
UniGenei Hs.184736.

3D structure databases

ProteinModelPortali Q9NWD9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121131. 1 interaction.
STRINGi 9606.ENSP00000361776.

PTM databases

PhosphoSitei Q9NWD9.

Polymorphism databases

DMDMi 74753015.

Proteomic databases

PaxDbi Q9NWD9.
PRIDEi Q9NWD9.

Protocols and materials databases

DNASUi 56271.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372691 ; ENSP00000361776 ; ENSG00000102409 .
ENST00000372695 ; ENSP00000361780 ; ENSG00000102409 .
GeneIDi 56271.
KEGGi hsa:56271.
UCSCi uc004ejv.4. human.

Organism-specific databases

CTDi 56271.
GeneCardsi GC0XP102470.
HGNCi HGNC:25475. BEX4.
HPAi HPA045105.
MIMi 300692. gene.
neXtProti NX_Q9NWD9.
PharmGKBi PA162377543.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42267.
HOGENOMi HOG000236300.
HOVERGENi HBG080240.
InParanoidi Q9NWD9.
OMAi VGQMMEV.
OrthoDBi EOG7WHHD5.
PhylomeDBi Q9NWD9.
TreeFami TF337909.

Miscellaneous databases

GenomeRNAii 56271.
NextBioi 61945.
PROi Q9NWD9.
SOURCEi Search...

Gene expression databases

Bgeei Q9NWD9.
CleanExi HS_BEX4.
Genevestigatori Q9NWD9.

Family and domain databases

InterProi IPR007623. BEX.
IPR021156. TF_A-like/BEX-like.
[Graphical view ]
Pfami PF04538. BEX. 1 hit.
[Graphical view ]
PIRSFi PIRSF008633. BEX. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the Bex gene family in humans, mice, and rats."
    Alvarez E., Zhou W., Witta S.E., Freed C.R.
    Gene 357:18-28(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiBEX4_HUMAN
AccessioniPrimary (citable) accession number: Q9NWD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi