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Protein

Protein BEX4

Gene

BEX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate to the control of cell cycle progression and genomic stability.1 Publication

GO - Molecular functioni

  • alpha-tubulin binding Source: UniProtKB
  • histone deacetylase binding Source: UniProtKB

GO - Biological processi

  • chromosome segregation Source: UniProtKB
  • negative regulation of tubulin deacetylation Source: UniProtKB
  • regulation of cell migration Source: UniProtKB
  • regulation of cell proliferation Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BEX4Curated
Alternative name(s):
BEX1-like protein 1Imported
Brain-expressed X-linked protein 41 PublicationImported
Nerve growth factor receptor-associated protein 31 Publication
Gene namesi
Name:BEX41 PublicationImported
Synonyms:BEXL1Imported, NADE31 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102409.9.
HGNCiHGNC:25475. BEX4.
MIMi300692. gene.
neXtProtiNX_Q9NWD9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi56271.
OpenTargetsiENSG00000102409.
PharmGKBiPA162377543.

Polymorphism and mutation databases

BioMutaiBEX4.
DMDMi74753015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297831 – 120Protein BEX4Add BLAST120

Post-translational modificationi

Ubiquitinated and degraded by the proteasome.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9NWD9.
PeptideAtlasiQ9NWD9.
PRIDEiQ9NWD9.

PTM databases

iPTMnetiQ9NWD9.
PhosphoSitePlusiQ9NWD9.

Expressioni

Tissue specificityi

Very high expression in heart, skeletal muscle, liver, and kidney. The levels of expression are uniform throughout the brain.1 Publication

Gene expression databases

BgeeiENSG00000102409.
CleanExiHS_BEX4.
GenevisibleiQ9NWD9. HS.

Organism-specific databases

HPAiHPA045105.
HPA051935.

Interactioni

Subunit structurei

Interacts with alpha-tubulin (PubMed:27512957). Interacts with SIRT2 (PubMed:27512957).1 Publication

GO - Molecular functioni

  • alpha-tubulin binding Source: UniProtKB
  • histone deacetylase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121131. 1 interactor.
IntActiQ9NWD9. 1 interactor.
STRINGi9606.ENSP00000361776.

Structurei

3D structure databases

ProteinModelPortaliQ9NWD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni31 – 120Interaction with alpha-tubulin1 PublicationAdd BLAST90
Regioni31 – 90Interaction with SIRT21 PublicationAdd BLAST60

Sequence similaritiesi

Belongs to the BEX family.Curated

Phylogenomic databases

eggNOGiENOG410JD8K. Eukaryota.
ENOG411163E. LUCA.
GeneTreeiENSGT00810000125492.
HOGENOMiHOG000236300.
HOVERGENiHBG080240.
InParanoidiQ9NWD9.
OMAiMPNEEES.
OrthoDBiEOG091G12ZB.
PhylomeDBiQ9NWD9.
TreeFamiTF337909.

Family and domain databases

InterProiView protein in InterPro
IPR007623. BEX.
IPR021156. TF_A-like/BEX.
PfamiView protein in Pfam
PF04538. BEX. 1 hit.
PIRSFiPIRSF008633. BEX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NWD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESKEELAAN NLNGENAQQE NEGGEQAPTQ NEEESRHLGG GEGQKPGGNI
60 70 80 90 100
RRGRVRRLVP NFRWAIPNRH IEHNEARDDV ERFVGQMMEI KRKTREQQMR
110 120
HYMRFQTPEP DNHYDFCLIP
Length:120
Mass (Da):14,067
Last modified:October 1, 2000 - v1
Checksum:iAD9527B5587622D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000959 mRNA. Translation: BAA91443.1.
AY833563 mRNA. Translation: AAX40681.1.
AL035494 Genomic DNA. No translation available.
CCDSiCCDS35355.1.
RefSeqiNP_001073894.1. NM_001080425.3.
NP_001121160.1. NM_001127688.2.
UniGeneiHs.184736.

Genome annotation databases

EnsembliENST00000372691; ENSP00000361776; ENSG00000102409.
ENST00000372695; ENSP00000361780; ENSG00000102409.
GeneIDi56271.
KEGGihsa:56271.
UCSCiuc004ejv.5. human.

Similar proteinsi

Entry informationi

Entry nameiBEX4_HUMAN
AccessioniPrimary (citable) accession number: Q9NWD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families