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Q9NWD9

- BEX4_HUMAN

UniProt

Q9NWD9 - BEX4_HUMAN

Protein

Protein BEX4

Gene

BEX4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein BEX4
    Alternative name(s):
    BEX1-like protein 1
    Brain-expressed X-linked protein 4
    Nerve growth factor receptor-associated protein 3
    Gene namesi
    Name:BEX4
    Synonyms:BEXL1, NADE3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:25475. BEX4.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162377543.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 120120Protein BEX4PRO_0000229783Add
    BLAST

    Post-translational modificationi

    Ubiquitinated. Degraded by the proteasome By similarity.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiQ9NWD9.
    PRIDEiQ9NWD9.

    PTM databases

    PhosphoSiteiQ9NWD9.

    Expressioni

    Gene expression databases

    BgeeiQ9NWD9.
    CleanExiHS_BEX4.
    GenevestigatoriQ9NWD9.

    Organism-specific databases

    HPAiHPA045105.

    Interactioni

    Protein-protein interaction databases

    BioGridi121131. 1 interaction.
    STRINGi9606.ENSP00000361776.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NWD9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BEX family.Curated

    Phylogenomic databases

    eggNOGiNOG42267.
    HOGENOMiHOG000236300.
    HOVERGENiHBG080240.
    InParanoidiQ9NWD9.
    OMAiVGQMMEV.
    OrthoDBiEOG7WHHD5.
    PhylomeDBiQ9NWD9.
    TreeFamiTF337909.

    Family and domain databases

    InterProiIPR007623. BEX.
    IPR021156. TF_A-like/BEX-like.
    [Graphical view]
    PfamiPF04538. BEX. 1 hit.
    [Graphical view]
    PIRSFiPIRSF008633. BEX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9NWD9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESKEELAAN NLNGENAQQE NEGGEQAPTQ NEEESRHLGG GEGQKPGGNI    50
    RRGRVRRLVP NFRWAIPNRH IEHNEARDDV ERFVGQMMEI KRKTREQQMR 100
    HYMRFQTPEP DNHYDFCLIP 120
    Length:120
    Mass (Da):14,067
    Last modified:October 1, 2000 - v1
    Checksum:iAD9527B5587622D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000959 mRNA. Translation: BAA91443.1.
    AY833563 mRNA. Translation: AAX40681.1.
    AL035494 Genomic DNA. Translation: CAI42990.1.
    CCDSiCCDS35355.1.
    RefSeqiNP_001073894.1. NM_001080425.3.
    NP_001121160.1. NM_001127688.2.
    UniGeneiHs.184736.

    Genome annotation databases

    EnsembliENST00000372691; ENSP00000361776; ENSG00000102409.
    ENST00000372695; ENSP00000361780; ENSG00000102409.
    GeneIDi56271.
    KEGGihsa:56271.
    UCSCiuc004ejv.4. human.

    Polymorphism databases

    DMDMi74753015.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000959 mRNA. Translation: BAA91443.1 .
    AY833563 mRNA. Translation: AAX40681.1 .
    AL035494 Genomic DNA. Translation: CAI42990.1 .
    CCDSi CCDS35355.1.
    RefSeqi NP_001073894.1. NM_001080425.3.
    NP_001121160.1. NM_001127688.2.
    UniGenei Hs.184736.

    3D structure databases

    ProteinModelPortali Q9NWD9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121131. 1 interaction.
    STRINGi 9606.ENSP00000361776.

    PTM databases

    PhosphoSitei Q9NWD9.

    Polymorphism databases

    DMDMi 74753015.

    Proteomic databases

    PaxDbi Q9NWD9.
    PRIDEi Q9NWD9.

    Protocols and materials databases

    DNASUi 56271.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372691 ; ENSP00000361776 ; ENSG00000102409 .
    ENST00000372695 ; ENSP00000361780 ; ENSG00000102409 .
    GeneIDi 56271.
    KEGGi hsa:56271.
    UCSCi uc004ejv.4. human.

    Organism-specific databases

    CTDi 56271.
    GeneCardsi GC0XP102470.
    HGNCi HGNC:25475. BEX4.
    HPAi HPA045105.
    MIMi 300692. gene.
    neXtProti NX_Q9NWD9.
    PharmGKBi PA162377543.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42267.
    HOGENOMi HOG000236300.
    HOVERGENi HBG080240.
    InParanoidi Q9NWD9.
    OMAi VGQMMEV.
    OrthoDBi EOG7WHHD5.
    PhylomeDBi Q9NWD9.
    TreeFami TF337909.

    Miscellaneous databases

    GenomeRNAii 56271.
    NextBioi 61945.
    PROi Q9NWD9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NWD9.
    CleanExi HS_BEX4.
    Genevestigatori Q9NWD9.

    Family and domain databases

    InterProi IPR007623. BEX.
    IPR021156. TF_A-like/BEX-like.
    [Graphical view ]
    Pfami PF04538. BEX. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF008633. BEX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the Bex gene family in humans, mice, and rats."
      Alvarez E., Zhou W., Witta S.E., Freed C.R.
      Gene 357:18-28(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiBEX4_HUMAN
    AccessioniPrimary (citable) accession number: Q9NWD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3