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Protein

Transmembrane protein 45A

Gene

TMEM45A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 45A
Alternative name(s):
DNA polymerase-transactivated protein 4
Dermal papilla-derived protein 7
Gene namesi
Name:TMEM45A
Synonyms:DERP7, DNAPTP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000181458.10
HGNCiHGNC:25480 TMEM45A
neXtProtiNX_Q9NWC5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55076
OpenTargetsiENSG00000181458
PharmGKBiPA134868262

Polymorphism and mutation databases

BioMutaiTMEM45A
DMDMi28380044

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725691 – 275Transmembrane protein 45AAdd BLAST275

Proteomic databases

MaxQBiQ9NWC5
PaxDbiQ9NWC5
PeptideAtlasiQ9NWC5
PRIDEiQ9NWC5

PTM databases

iPTMnetiQ9NWC5
PhosphoSitePlusiQ9NWC5

Expressioni

Gene expression databases

BgeeiENSG00000181458
CleanExiHS_TMEM45A
ExpressionAtlasiQ9NWC5 baseline and differential
GenevisibleiQ9NWC5 HS

Organism-specific databases

HPAiHPA024082
HPA062101

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PROP1O753604EBI-10823938,EBI-9027467

Protein-protein interaction databases

BioGridi120393, 1 interactor
IntActiQ9NWC5, 3 interactors
MINTiQ9NWC5
STRINGi9606.ENSP00000319009

Structurei

3D structure databases

ProteinModelPortaliQ9NWC5
SMRiQ9NWC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM45 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG9I Eukaryota
ENOG410ZTA1 LUCA
GeneTreeiENSGT00530000063088
HOGENOMiHOG000136727
HOVERGENiHBG008722
InParanoidiQ9NWC5
PhylomeDBiQ9NWC5
TreeFamiTF328673

Family and domain databases

InterProiView protein in InterPro
IPR006904 DUF716_TMEM45
PANTHERiPTHR16007 PTHR16007, 1 hit
PfamiView protein in Pfam
PF04819 DUF716, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NWC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNFRGHALP GTFFFIIGLW WCTKSILKYI CKKQKRTCYL GSKTLFYRLE
60 70 80 90 100
ILEGITIVGM ALTGMAGEQF IPGGPHLMLY DYKQGHWNQL LGWHHFTMYF
110 120 130 140 150
FFGLLGVADI LCFTISSLPV SLTKLMLSNA LFVEAFIFYN HTHGREMLDI
160 170 180 190 200
FVHQLLVLVV FLTGLVAFLE FLVRNNVLLE LLRSSLILLQ GSWFFQIGFV
210 220 230 240 250
LYPPSGGPAW DLMDHENILF LTICFCWHYA VTIVIVGMNY AFITWLVKSR
260 270
LKRLCSSEVG LLKNAEREQE SEEEM
Length:275
Mass (Da):31,680
Last modified:October 1, 2000 - v1
Checksum:iE005FF448116EC9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013911 mRNA Translation: BAB87801.1
AY450392 mRNA Translation: AAR21085.1
AK000996 mRNA Translation: BAA91458.1
BC040355 mRNA Translation: AAH40355.1
CCDSiCCDS2937.1
RefSeqiNP_060474.1, NM_018004.2
UniGeneiHs.658956

Genome annotation databases

EnsembliENST00000323523; ENSP00000319009; ENSG00000181458
GeneIDi55076
KEGGihsa:55076
UCSCiuc003dtz.2 human

Similar proteinsi

Entry informationi

Entry nameiTM45A_HUMAN
AccessioniPrimary (citable) accession number: Q9NWC5
Secondary accession number(s): Q53YW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health