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Protein

Transmembrane protein 45A

Gene

TMEM45A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181458-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 45A
Alternative name(s):
DNA polymerase-transactivated protein 4
Dermal papilla-derived protein 7
Gene namesi
Name:TMEM45A
Synonyms:DERP7, DNAPTP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25480. TMEM45A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55076.
OpenTargetsiENSG00000181458.
PharmGKBiPA134868262.

Polymorphism and mutation databases

BioMutaiTMEM45A.
DMDMi28380044.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725691 – 275Transmembrane protein 45AAdd BLAST275

Proteomic databases

MaxQBiQ9NWC5.
PaxDbiQ9NWC5.
PeptideAtlasiQ9NWC5.
PRIDEiQ9NWC5.

PTM databases

iPTMnetiQ9NWC5.
PhosphoSitePlusiQ9NWC5.

Expressioni

Gene expression databases

BgeeiENSG00000181458.
CleanExiHS_TMEM45A.
ExpressionAtlasiQ9NWC5. baseline and differential.
GenevisibleiQ9NWC5. HS.

Organism-specific databases

HPAiHPA024082.
HPA062101.

Interactioni

Protein-protein interaction databases

BioGridi120393. 1 interactor.
IntActiQ9NWC5. 2 interactors.
STRINGi9606.ENSP00000319009.

Structurei

3D structure databases

ProteinModelPortaliQ9NWC5.
SMRiQ9NWC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM45 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IG9I. Eukaryota.
ENOG410ZTA1. LUCA.
GeneTreeiENSGT00530000063088.
HOGENOMiHOG000136727.
HOVERGENiHBG008722.
InParanoidiQ9NWC5.
PhylomeDBiQ9NWC5.
TreeFamiTF328673.

Family and domain databases

InterProiIPR006904. DUF716_TMEM45.
[Graphical view]
PANTHERiPTHR16007. PTHR16007. 1 hit.
PfamiPF04819. DUF716. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NWC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNFRGHALP GTFFFIIGLW WCTKSILKYI CKKQKRTCYL GSKTLFYRLE
60 70 80 90 100
ILEGITIVGM ALTGMAGEQF IPGGPHLMLY DYKQGHWNQL LGWHHFTMYF
110 120 130 140 150
FFGLLGVADI LCFTISSLPV SLTKLMLSNA LFVEAFIFYN HTHGREMLDI
160 170 180 190 200
FVHQLLVLVV FLTGLVAFLE FLVRNNVLLE LLRSSLILLQ GSWFFQIGFV
210 220 230 240 250
LYPPSGGPAW DLMDHENILF LTICFCWHYA VTIVIVGMNY AFITWLVKSR
260 270
LKRLCSSEVG LLKNAEREQE SEEEM
Length:275
Mass (Da):31,680
Last modified:October 1, 2000 - v1
Checksum:iE005FF448116EC9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013911 mRNA. Translation: BAB87801.1.
AY450392 mRNA. Translation: AAR21085.1.
AK000996 mRNA. Translation: BAA91458.1.
BC040355 mRNA. Translation: AAH40355.1.
CCDSiCCDS2937.1.
RefSeqiNP_060474.1. NM_018004.2.
UniGeneiHs.658956.

Genome annotation databases

EnsembliENST00000323523; ENSP00000319009; ENSG00000181458.
GeneIDi55076.
KEGGihsa:55076.
UCSCiuc003dtz.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB013911 mRNA. Translation: BAB87801.1.
AY450392 mRNA. Translation: AAR21085.1.
AK000996 mRNA. Translation: BAA91458.1.
BC040355 mRNA. Translation: AAH40355.1.
CCDSiCCDS2937.1.
RefSeqiNP_060474.1. NM_018004.2.
UniGeneiHs.658956.

3D structure databases

ProteinModelPortaliQ9NWC5.
SMRiQ9NWC5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120393. 1 interactor.
IntActiQ9NWC5. 2 interactors.
STRINGi9606.ENSP00000319009.

PTM databases

iPTMnetiQ9NWC5.
PhosphoSitePlusiQ9NWC5.

Polymorphism and mutation databases

BioMutaiTMEM45A.
DMDMi28380044.

Proteomic databases

MaxQBiQ9NWC5.
PaxDbiQ9NWC5.
PeptideAtlasiQ9NWC5.
PRIDEiQ9NWC5.

Protocols and materials databases

DNASUi55076.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000323523; ENSP00000319009; ENSG00000181458.
GeneIDi55076.
KEGGihsa:55076.
UCSCiuc003dtz.2. human.

Organism-specific databases

CTDi55076.
DisGeNETi55076.
GeneCardsiTMEM45A.
HGNCiHGNC:25480. TMEM45A.
HPAiHPA024082.
HPA062101.
neXtProtiNX_Q9NWC5.
OpenTargetsiENSG00000181458.
PharmGKBiPA134868262.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG9I. Eukaryota.
ENOG410ZTA1. LUCA.
GeneTreeiENSGT00530000063088.
HOGENOMiHOG000136727.
HOVERGENiHBG008722.
InParanoidiQ9NWC5.
PhylomeDBiQ9NWC5.
TreeFamiTF328673.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181458-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM45A. human.
GenomeRNAii55076.
PROiQ9NWC5.

Gene expression databases

BgeeiENSG00000181458.
CleanExiHS_TMEM45A.
ExpressionAtlasiQ9NWC5. baseline and differential.
GenevisibleiQ9NWC5. HS.

Family and domain databases

InterProiIPR006904. DUF716_TMEM45.
[Graphical view]
PANTHERiPTHR16007. PTHR16007. 1 hit.
PfamiPF04819. DUF716. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM45A_HUMAN
AccessioniPrimary (citable) accession number: Q9NWC5
Secondary accession number(s): Q53YW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.