Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NWB6

- ARGL1_HUMAN

UniProt

Q9NWB6 - ARGL1_HUMAN

Protein

Arginine and glutamate-rich protein 1

Gene

ARGLU1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine and glutamate-rich protein 1
    Gene namesi
    Name:ARGLU1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:25482. ARGLU1.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters. Colocalizes with MED1.

    GO - Cellular componenti

    1. mitochondrion Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162376869.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273Arginine and glutamate-rich protein 1PRO_0000288438Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei58 – 581Phosphoserine1 Publication
    Modified residuei60 – 601Phosphoserine2 Publications
    Modified residuei61 – 611Phosphothreonine1 Publication
    Modified residuei77 – 771Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NWB6.
    PaxDbiQ9NWB6.
    PeptideAtlasiQ9NWB6.
    PRIDEiQ9NWB6.

    PTM databases

    PhosphoSiteiQ9NWB6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NWB6.
    BgeeiQ9NWB6.
    CleanExiHS_ARGLU1.
    GenevestigatoriQ9NWB6.

    Organism-specific databases

    HPAiHPA034962.
    HPA056792.

    Interactioni

    Subunit structurei

    Directly interacts with MED1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SRPK2P783622EBI-2808785,EBI-593303

    Protein-protein interaction databases

    BioGridi120397. 13 interactions.
    IntActiQ9NWB6. 9 interactions.
    MINTiMINT-7945105.
    STRINGi9606.ENSP00000383059.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NWB6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi3 – 7472Arg-richAdd
    BLAST
    Compositional biasi97 – 251155Glu-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UPF0430 family.Curated

    Phylogenomic databases

    eggNOGiNOG87986.
    HOGENOMiHOG000030700.
    HOVERGENiHBG096780.
    InParanoidiQ9NWB6.
    KOiK13173.
    OMAiISQVRIR.
    OrthoDBiEOG71CFQN.
    PhylomeDBiQ9NWB6.
    TreeFamiTF324123.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NWB6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGRSRSRSSS RSKHTKSSKH NKKRSRSRSR SRDKERVRKR SKSRESKRNR    50
    RRESRSRSRS TNTAVSRRER DRERASSPPD RIDIFGRTVS KRSSLDEKQK 100
    REEEEKKAEF ERQRKIRQQE IEEKLIEEET ARRVEELVAK RVEEELEKRK 150
    DEIEREVLRR VEEAKRIMEK QLLEELERQR QAELAAQKAR EEEERAKREE 200
    LERILEENNR KIAEAQAKLA EEQLRIVEEQ RKIHEERMKL EQERQRQQKE 250
    EQKIILGKGK SRPKLSFSLK TQD 273
    Length:273
    Mass (Da):33,216
    Last modified:October 1, 2000 - v1
    Checksum:i70B88496BF18AAE0
    GO
    Isoform 2 (identifier: Q9NWB6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         192-273: EEERAKREEL...KLSFSLKTQD → VTLGRLESRD...ILFDLMELAI

    Note: No experimental confirmation available.

    Show »
    Length:273
    Mass (Da):32,885
    Checksum:iB5940853C1085382
    GO
    Isoform 3 (identifier: Q9NWB6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         16-90: Missing.
         192-273: EEERAKREEL...KLSFSLKTQD → VTLGRLESRD...ILFDLMELAI

    Note: No experimental confirmation available.

    Show »
    Length:198
    Mass (Da):23,834
    Checksum:i1A015D05EC248B4E
    GO

    Sequence cautioni

    The sequence CAI13166.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei16 – 9075Missing in isoform 3. 1 PublicationVSP_053685Add
    BLAST
    Alternative sequencei192 – 27382EEERA…LKTQD → VTLGRLESRDSPWQNFQCWV LPPAQFRKRWNTDYLIPFSS KLNIAAKVNFLAYSEVLTDN LKVGSFYKTYSRILFDLMEL AI in isoform 2 and isoform 3. 2 PublicationsVSP_025674Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001016 mRNA. Translation: BAA91467.1.
    AK303575 mRNA. Translation: BAG64595.1.
    AL442127 Genomic DNA. Translation: CAI13166.1. Sequence problems.
    AL442127 Genomic DNA. Translation: CAI13168.1.
    BC050434 mRNA. Translation: AAH50434.1.
    BC071587 mRNA. Translation: AAH71587.1.
    CCDSiCCDS41906.1. [Q9NWB6-1]
    RefSeqiNP_060481.3. NM_018011.3. [Q9NWB6-1]
    UniGeneiHs.508644.

    Genome annotation databases

    EnsembliENST00000400198; ENSP00000383059; ENSG00000134884. [Q9NWB6-1]
    GeneIDi55082.
    KEGGihsa:55082.
    UCSCiuc001vqk.4. human. [Q9NWB6-1]

    Polymorphism databases

    DMDMi74753014.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001016 mRNA. Translation: BAA91467.1 .
    AK303575 mRNA. Translation: BAG64595.1 .
    AL442127 Genomic DNA. Translation: CAI13166.1 . Sequence problems.
    AL442127 Genomic DNA. Translation: CAI13168.1 .
    BC050434 mRNA. Translation: AAH50434.1 .
    BC071587 mRNA. Translation: AAH71587.1 .
    CCDSi CCDS41906.1. [Q9NWB6-1 ]
    RefSeqi NP_060481.3. NM_018011.3. [Q9NWB6-1 ]
    UniGenei Hs.508644.

    3D structure databases

    ProteinModelPortali Q9NWB6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120397. 13 interactions.
    IntActi Q9NWB6. 9 interactions.
    MINTi MINT-7945105.
    STRINGi 9606.ENSP00000383059.

    PTM databases

    PhosphoSitei Q9NWB6.

    Polymorphism databases

    DMDMi 74753014.

    Proteomic databases

    MaxQBi Q9NWB6.
    PaxDbi Q9NWB6.
    PeptideAtlasi Q9NWB6.
    PRIDEi Q9NWB6.

    Protocols and materials databases

    DNASUi 55082.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000400198 ; ENSP00000383059 ; ENSG00000134884 . [Q9NWB6-1 ]
    GeneIDi 55082.
    KEGGi hsa:55082.
    UCSCi uc001vqk.4. human. [Q9NWB6-1 ]

    Organism-specific databases

    CTDi 55082.
    GeneCardsi GC13M107194.
    HGNCi HGNC:25482. ARGLU1.
    HPAi HPA034962.
    HPA056792.
    MIMi 614046. gene.
    neXtProti NX_Q9NWB6.
    PharmGKBi PA162376869.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87986.
    HOGENOMi HOG000030700.
    HOVERGENi HBG096780.
    InParanoidi Q9NWB6.
    KOi K13173.
    OMAi ISQVRIR.
    OrthoDBi EOG71CFQN.
    PhylomeDBi Q9NWB6.
    TreeFami TF324123.

    Miscellaneous databases

    ChiTaRSi ARGLU1. human.
    GeneWikii ARGLU1.
    GenomeRNAii 55082.
    NextBioi 35476884.
    PROi Q9NWB6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NWB6.
    Bgeei Q9NWB6.
    CleanExi HS_ARGLU1.
    Genevestigatori Q9NWB6.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Embryo and Thymus.
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis.
    4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58; SER-60 AND SER-77, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth."
      Zhang D., Jiang P., Xu Q., Zhang X.
      J. Biol. Chem. 286:17746-17754(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MED1, SUBCELLULAR LOCATION.
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; THR-61 AND SER-77, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiARGL1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NWB6
    Secondary accession number(s): B4E0Y3, Q5T257, Q6IQ34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families
    4. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3