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Protein

Arginine and glutamate-rich protein 1

Gene

ARGLU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.1 Publication

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine and glutamate-rich protein 1
Gene namesi
Name:ARGLU1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:25482. ARGLU1.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters. Colocalizes with MED1.

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • mitochondrion Source: HPA
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376869.

Polymorphism and mutation databases

BioMutaiARGLU1.
DMDMi74753014.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Arginine and glutamate-rich protein 1PRO_0000288438Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581PhosphoserineCombined sources
Modified residuei60 – 601PhosphoserineCombined sources
Modified residuei61 – 611PhosphothreonineCombined sources
Modified residuei76 – 761PhosphoserineCombined sources
Modified residuei77 – 771PhosphoserineCombined sources
Modified residuei266 – 2661PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NWB6.
MaxQBiQ9NWB6.
PaxDbiQ9NWB6.
PeptideAtlasiQ9NWB6.
PRIDEiQ9NWB6.

PTM databases

iPTMnetiQ9NWB6.
PhosphoSiteiQ9NWB6.

Expressioni

Gene expression databases

BgeeiENSG00000134884.
CleanExiHS_ARGLU1.
ExpressionAtlasiQ9NWB6. baseline and differential.
GenevisibleiQ9NWB6. HS.

Organism-specific databases

HPAiHPA034962.
HPA056792.

Interactioni

Subunit structurei

Directly interacts with MED1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SRPK2P783622EBI-2808785,EBI-593303

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi120397. 27 interactions.
IntActiQ9NWB6. 12 interactions.
MINTiMINT-7945105.
STRINGi9606.ENSP00000383059.

Structurei

3D structure databases

ProteinModelPortaliQ9NWB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 7472Arg-richAdd
BLAST
Compositional biasi97 – 251155Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0430 family.Curated

Phylogenomic databases

eggNOGiENOG410IHEN. Eukaryota.
ENOG4111J08. LUCA.
GeneTreeiENSGT00730000111249.
HOGENOMiHOG000030700.
HOVERGENiHBG096780.
InParanoidiQ9NWB6.
KOiK13173.
OMAiQPAENTY.
PhylomeDBiQ9NWB6.
TreeFamiTF324123.

Family and domain databases

InterProiIPR033371. ARGLU1.
[Graphical view]
PANTHERiPTHR31711. PTHR31711. 1 hit.
PfamiPF15346. ARGLU. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NWB6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRSRSRSSS RSKHTKSSKH NKKRSRSRSR SRDKERVRKR SKSRESKRNR
60 70 80 90 100
RRESRSRSRS TNTAVSRRER DRERASSPPD RIDIFGRTVS KRSSLDEKQK
110 120 130 140 150
REEEEKKAEF ERQRKIRQQE IEEKLIEEET ARRVEELVAK RVEEELEKRK
160 170 180 190 200
DEIEREVLRR VEEAKRIMEK QLLEELERQR QAELAAQKAR EEEERAKREE
210 220 230 240 250
LERILEENNR KIAEAQAKLA EEQLRIVEEQ RKIHEERMKL EQERQRQQKE
260 270
EQKIILGKGK SRPKLSFSLK TQD
Length:273
Mass (Da):33,216
Last modified:October 1, 2000 - v1
Checksum:i70B88496BF18AAE0
GO
Isoform 2 (identifier: Q9NWB6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-273: EEERAKREEL...KLSFSLKTQD → VTLGRLESRD...ILFDLMELAI

Note: No experimental confirmation available.
Show »
Length:273
Mass (Da):32,885
Checksum:iB5940853C1085382
GO
Isoform 3 (identifier: Q9NWB6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-90: Missing.
     192-273: EEERAKREEL...KLSFSLKTQD → VTLGRLESRD...ILFDLMELAI

Note: No experimental confirmation available.
Show »
Length:198
Mass (Da):23,834
Checksum:i1A015D05EC248B4E
GO

Sequence cautioni

The sequence CAI13166 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei16 – 9075Missing in isoform 3. 1 PublicationVSP_053685Add
BLAST
Alternative sequencei192 – 27382EEERA…LKTQD → VTLGRLESRDSPWQNFQCWV LPPAQFRKRWNTDYLIPFSS KLNIAAKVNFLAYSEVLTDN LKVGSFYKTYSRILFDLMEL AI in isoform 2 and isoform 3. 2 PublicationsVSP_025674Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001016 mRNA. Translation: BAA91467.1.
AK303575 mRNA. Translation: BAG64595.1.
AL442127 Genomic DNA. Translation: CAI13166.1. Sequence problems.
AL442127 Genomic DNA. Translation: CAI13168.1.
BC050434 mRNA. Translation: AAH50434.1.
BC071587 mRNA. Translation: AAH71587.1.
CCDSiCCDS41906.1. [Q9NWB6-1]
RefSeqiNP_060481.3. NM_018011.3. [Q9NWB6-1]
UniGeneiHs.508644.

Genome annotation databases

EnsembliENST00000400198; ENSP00000383059; ENSG00000134884. [Q9NWB6-1]
GeneIDi55082.
KEGGihsa:55082.
UCSCiuc001vqk.5. human. [Q9NWB6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001016 mRNA. Translation: BAA91467.1.
AK303575 mRNA. Translation: BAG64595.1.
AL442127 Genomic DNA. Translation: CAI13166.1. Sequence problems.
AL442127 Genomic DNA. Translation: CAI13168.1.
BC050434 mRNA. Translation: AAH50434.1.
BC071587 mRNA. Translation: AAH71587.1.
CCDSiCCDS41906.1. [Q9NWB6-1]
RefSeqiNP_060481.3. NM_018011.3. [Q9NWB6-1]
UniGeneiHs.508644.

3D structure databases

ProteinModelPortaliQ9NWB6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120397. 27 interactions.
IntActiQ9NWB6. 12 interactions.
MINTiMINT-7945105.
STRINGi9606.ENSP00000383059.

PTM databases

iPTMnetiQ9NWB6.
PhosphoSiteiQ9NWB6.

Polymorphism and mutation databases

BioMutaiARGLU1.
DMDMi74753014.

Proteomic databases

EPDiQ9NWB6.
MaxQBiQ9NWB6.
PaxDbiQ9NWB6.
PeptideAtlasiQ9NWB6.
PRIDEiQ9NWB6.

Protocols and materials databases

DNASUi55082.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400198; ENSP00000383059; ENSG00000134884. [Q9NWB6-1]
GeneIDi55082.
KEGGihsa:55082.
UCSCiuc001vqk.5. human. [Q9NWB6-1]

Organism-specific databases

CTDi55082.
GeneCardsiARGLU1.
HGNCiHGNC:25482. ARGLU1.
HPAiHPA034962.
HPA056792.
MIMi614046. gene.
neXtProtiNX_Q9NWB6.
PharmGKBiPA162376869.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHEN. Eukaryota.
ENOG4111J08. LUCA.
GeneTreeiENSGT00730000111249.
HOGENOMiHOG000030700.
HOVERGENiHBG096780.
InParanoidiQ9NWB6.
KOiK13173.
OMAiQPAENTY.
PhylomeDBiQ9NWB6.
TreeFamiTF324123.

Miscellaneous databases

ChiTaRSiARGLU1. human.
GeneWikiiARGLU1.
GenomeRNAii55082.
PROiQ9NWB6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134884.
CleanExiHS_ARGLU1.
ExpressionAtlasiQ9NWB6. baseline and differential.
GenevisibleiQ9NWB6. HS.

Family and domain databases

InterProiIPR033371. ARGLU1.
[Graphical view]
PANTHERiPTHR31711. PTHR31711. 1 hit.
PfamiPF15346. ARGLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGL1_HUMAN
AccessioniPrimary (citable) accession number: Q9NWB6
Secondary accession number(s): B4E0Y3, Q5T257, Q6IQ34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.