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Q9NWB6

- ARGL1_HUMAN

UniProt

Q9NWB6 - ARGL1_HUMAN

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Protein

Arginine and glutamate-rich protein 1

Gene

ARGLU1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.1 Publication

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine and glutamate-rich protein 1
Gene namesi
Name:ARGLU1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:25482. ARGLU1.

Subcellular locationi

Nucleus 1 Publication
Note: Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters. Colocalizes with MED1.

GO - Cellular componenti

  1. mitochondrion Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Arginine and glutamate-rich protein 1PRO_0000288438Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581Phosphoserine1 Publication
Modified residuei60 – 601Phosphoserine2 Publications
Modified residuei61 – 611Phosphothreonine1 Publication
Modified residuei77 – 771Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NWB6.
PaxDbiQ9NWB6.
PeptideAtlasiQ9NWB6.
PRIDEiQ9NWB6.

PTM databases

PhosphoSiteiQ9NWB6.

Expressioni

Gene expression databases

BgeeiQ9NWB6.
CleanExiHS_ARGLU1.
ExpressionAtlasiQ9NWB6. baseline and differential.
GenevestigatoriQ9NWB6.

Organism-specific databases

HPAiHPA034962.
HPA056792.

Interactioni

Subunit structurei

Directly interacts with MED1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SRPK2P783622EBI-2808785,EBI-593303

Protein-protein interaction databases

BioGridi120397. 15 interactions.
IntActiQ9NWB6. 9 interactions.
MINTiMINT-7945105.
STRINGi9606.ENSP00000383059.

Structurei

3D structure databases

ProteinModelPortaliQ9NWB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 7472Arg-richAdd
BLAST
Compositional biasi97 – 251155Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0430 family.Curated

Phylogenomic databases

eggNOGiNOG87986.
GeneTreeiENSGT00730000111249.
HOGENOMiHOG000030700.
HOVERGENiHBG096780.
InParanoidiQ9NWB6.
KOiK13173.
OMAiISQVRIR.
OrthoDBiEOG71CFQN.
PhylomeDBiQ9NWB6.
TreeFamiTF324123.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NWB6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRSRSRSSS RSKHTKSSKH NKKRSRSRSR SRDKERVRKR SKSRESKRNR
60 70 80 90 100
RRESRSRSRS TNTAVSRRER DRERASSPPD RIDIFGRTVS KRSSLDEKQK
110 120 130 140 150
REEEEKKAEF ERQRKIRQQE IEEKLIEEET ARRVEELVAK RVEEELEKRK
160 170 180 190 200
DEIEREVLRR VEEAKRIMEK QLLEELERQR QAELAAQKAR EEEERAKREE
210 220 230 240 250
LERILEENNR KIAEAQAKLA EEQLRIVEEQ RKIHEERMKL EQERQRQQKE
260 270
EQKIILGKGK SRPKLSFSLK TQD
Length:273
Mass (Da):33,216
Last modified:October 1, 2000 - v1
Checksum:i70B88496BF18AAE0
GO
Isoform 2 (identifier: Q9NWB6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-273: EEERAKREEL...KLSFSLKTQD → VTLGRLESRD...ILFDLMELAI

Note: No experimental confirmation available.

Show »
Length:273
Mass (Da):32,885
Checksum:iB5940853C1085382
GO
Isoform 3 (identifier: Q9NWB6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-90: Missing.
     192-273: EEERAKREEL...KLSFSLKTQD → VTLGRLESRD...ILFDLMELAI

Note: No experimental confirmation available.

Show »
Length:198
Mass (Da):23,834
Checksum:i1A015D05EC248B4E
GO

Sequence cautioni

The sequence CAI13166.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei16 – 9075Missing in isoform 3. 1 PublicationVSP_053685Add
BLAST
Alternative sequencei192 – 27382EEERA…LKTQD → VTLGRLESRDSPWQNFQCWV LPPAQFRKRWNTDYLIPFSS KLNIAAKVNFLAYSEVLTDN LKVGSFYKTYSRILFDLMEL AI in isoform 2 and isoform 3. 2 PublicationsVSP_025674Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001016 mRNA. Translation: BAA91467.1.
AK303575 mRNA. Translation: BAG64595.1.
AL442127 Genomic DNA. Translation: CAI13166.1. Sequence problems.
AL442127 Genomic DNA. Translation: CAI13168.1.
BC050434 mRNA. Translation: AAH50434.1.
BC071587 mRNA. Translation: AAH71587.1.
CCDSiCCDS41906.1. [Q9NWB6-1]
RefSeqiNP_060481.3. NM_018011.3. [Q9NWB6-1]
UniGeneiHs.508644.

Genome annotation databases

EnsembliENST00000400198; ENSP00000383059; ENSG00000134884. [Q9NWB6-1]
GeneIDi55082.
KEGGihsa:55082.
UCSCiuc001vqk.4. human. [Q9NWB6-1]

Polymorphism databases

DMDMi74753014.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001016 mRNA. Translation: BAA91467.1 .
AK303575 mRNA. Translation: BAG64595.1 .
AL442127 Genomic DNA. Translation: CAI13166.1 . Sequence problems.
AL442127 Genomic DNA. Translation: CAI13168.1 .
BC050434 mRNA. Translation: AAH50434.1 .
BC071587 mRNA. Translation: AAH71587.1 .
CCDSi CCDS41906.1. [Q9NWB6-1 ]
RefSeqi NP_060481.3. NM_018011.3. [Q9NWB6-1 ]
UniGenei Hs.508644.

3D structure databases

ProteinModelPortali Q9NWB6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120397. 15 interactions.
IntActi Q9NWB6. 9 interactions.
MINTi MINT-7945105.
STRINGi 9606.ENSP00000383059.

PTM databases

PhosphoSitei Q9NWB6.

Polymorphism databases

DMDMi 74753014.

Proteomic databases

MaxQBi Q9NWB6.
PaxDbi Q9NWB6.
PeptideAtlasi Q9NWB6.
PRIDEi Q9NWB6.

Protocols and materials databases

DNASUi 55082.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000400198 ; ENSP00000383059 ; ENSG00000134884 . [Q9NWB6-1 ]
GeneIDi 55082.
KEGGi hsa:55082.
UCSCi uc001vqk.4. human. [Q9NWB6-1 ]

Organism-specific databases

CTDi 55082.
GeneCardsi GC13M107194.
HGNCi HGNC:25482. ARGLU1.
HPAi HPA034962.
HPA056792.
MIMi 614046. gene.
neXtProti NX_Q9NWB6.
PharmGKBi PA162376869.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG87986.
GeneTreei ENSGT00730000111249.
HOGENOMi HOG000030700.
HOVERGENi HBG096780.
InParanoidi Q9NWB6.
KOi K13173.
OMAi ISQVRIR.
OrthoDBi EOG71CFQN.
PhylomeDBi Q9NWB6.
TreeFami TF324123.

Miscellaneous databases

ChiTaRSi ARGLU1. human.
GeneWikii ARGLU1.
GenomeRNAii 55082.
NextBioi 35476884.
PROi Q9NWB6.
SOURCEi Search...

Gene expression databases

Bgeei Q9NWB6.
CleanExi HS_ARGLU1.
ExpressionAtlasi Q9NWB6. baseline and differential.
Genevestigatori Q9NWB6.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Embryo and Thymus.
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58; SER-60 AND SER-77, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth."
    Zhang D., Jiang P., Xu Q., Zhang X.
    J. Biol. Chem. 286:17746-17754(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MED1, SUBCELLULAR LOCATION.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; THR-61 AND SER-77, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARGL1_HUMAN
AccessioniPrimary (citable) accession number: Q9NWB6
Secondary accession number(s): B4E0Y3, Q5T257, Q6IQ34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3