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Protein

Arginine and glutamate-rich protein 1

Gene

ARGLU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine and glutamate-rich protein 1
Gene namesi
Name:ARGLU1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000134884.13
HGNCiHGNC:25482 ARGLU1
MIMi614046 gene
neXtProtiNX_Q9NWB6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55082
OpenTargetsiENSG00000134884
PharmGKBiPA162376869

Polymorphism and mutation databases

BioMutaiARGLU1
DMDMi74753014

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002884381 – 273Arginine and glutamate-rich protein 1Add BLAST273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei61PhosphothreonineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei266PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NWB6
MaxQBiQ9NWB6
PaxDbiQ9NWB6
PeptideAtlasiQ9NWB6
PRIDEiQ9NWB6

PTM databases

iPTMnetiQ9NWB6
PhosphoSitePlusiQ9NWB6

Expressioni

Gene expression databases

BgeeiENSG00000134884
CleanExiHS_ARGLU1
ExpressionAtlasiQ9NWB6 baseline and differential
GenevisibleiQ9NWB6 HS

Organism-specific databases

HPAiHPA034962
HPA056792

Interactioni

Subunit structurei

Directly interacts with MED1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SRPK2P783622EBI-2808785,EBI-593303

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120397, 46 interactors
IntActiQ9NWB6, 13 interactors
MINTiQ9NWB6
STRINGi9606.ENSP00000383059

Structurei

3D structure databases

ProteinModelPortaliQ9NWB6
SMRiQ9NWB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 74Arg-richAdd BLAST72
Compositional biasi97 – 251Glu-richAdd BLAST155

Sequence similaritiesi

Belongs to the UPF0430 family.Curated

Phylogenomic databases

eggNOGiENOG410IHEN Eukaryota
ENOG4111J08 LUCA
GeneTreeiENSGT00730000111249
HOGENOMiHOG000030700
HOVERGENiHBG096780
InParanoidiQ9NWB6
KOiK13173
OMAiTHTERDY
OrthoDBiEOG09370GQ2
PhylomeDBiQ9NWB6
TreeFamiTF324123

Family and domain databases

InterProiView protein in InterPro
IPR033371 ARGLU1
PANTHERiPTHR31711 PTHR31711, 1 hit
PfamiView protein in Pfam
PF15346 ARGLU, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NWB6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRSRSRSSS RSKHTKSSKH NKKRSRSRSR SRDKERVRKR SKSRESKRNR
60 70 80 90 100
RRESRSRSRS TNTAVSRRER DRERASSPPD RIDIFGRTVS KRSSLDEKQK
110 120 130 140 150
REEEEKKAEF ERQRKIRQQE IEEKLIEEET ARRVEELVAK RVEEELEKRK
160 170 180 190 200
DEIEREVLRR VEEAKRIMEK QLLEELERQR QAELAAQKAR EEEERAKREE
210 220 230 240 250
LERILEENNR KIAEAQAKLA EEQLRIVEEQ RKIHEERMKL EQERQRQQKE
260 270
EQKIILGKGK SRPKLSFSLK TQD
Length:273
Mass (Da):33,216
Last modified:October 1, 2000 - v1
Checksum:i70B88496BF18AAE0
GO
Isoform 2 (identifier: Q9NWB6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-273: EEERAKREEL...KLSFSLKTQD → VTLGRLESRD...ILFDLMELAI

Note: No experimental confirmation available.
Show »
Length:273
Mass (Da):32,885
Checksum:iB5940853C1085382
GO
Isoform 3 (identifier: Q9NWB6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-90: Missing.
     192-273: EEERAKREEL...KLSFSLKTQD → VTLGRLESRD...ILFDLMELAI

Note: No experimental confirmation available.
Show »
Length:198
Mass (Da):23,834
Checksum:i1A015D05EC248B4E
GO

Sequence cautioni

The sequence CAI13166 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05368516 – 90Missing in isoform 3. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_025674192 – 273EEERA…LKTQD → VTLGRLESRDSPWQNFQCWV LPPAQFRKRWNTDYLIPFSS KLNIAAKVNFLAYSEVLTDN LKVGSFYKTYSRILFDLMEL AI in isoform 2 and isoform 3. 2 PublicationsAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001016 mRNA Translation: BAA91467.1
AK303575 mRNA Translation: BAG64595.1
AL442127 Genomic DNA Translation: CAI13166.1 Sequence problems.
AL442127 Genomic DNA Translation: CAI13168.1
BC050434 mRNA Translation: AAH50434.1
BC071587 mRNA Translation: AAH71587.1
CCDSiCCDS41906.1 [Q9NWB6-1]
RefSeqiNP_060481.3, NM_018011.3 [Q9NWB6-1]
UniGeneiHs.508644

Genome annotation databases

EnsembliENST00000400198; ENSP00000383059; ENSG00000134884 [Q9NWB6-1]
GeneIDi55082
KEGGihsa:55082
UCSCiuc001vqk.5 human [Q9NWB6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARGL1_HUMAN
AccessioniPrimary (citable) accession number: Q9NWB6
Secondary accession number(s): B4E0Y3, Q5T257, Q6IQ34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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