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Q9NWB1

- RFOX1_HUMAN

UniProt

Q9NWB1 - RFOX1_HUMAN

Protein

RNA binding protein fox-1 homolog 1

Gene

RBFOX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei118 – 1181Interaction with RNA
    Sitei126 – 1261Interaction with RNA
    Sitei127 – 1271Interaction with RNA
    Sitei151 – 1511Interaction with RNA
    Sitei156 – 1561Interaction with RNA
    Sitei160 – 1601Interaction with RNA
    Sitei184 – 1841Interaction with RNA
    Sitei194 – 1941Interaction with RNA

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. protein binding Source: IntAct
    3. protein C-terminus binding Source: UniProtKB
    4. RNA binding Source: UniProtKB

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. neuromuscular process controlling balance Source: Ensembl
    3. regulation of RNA splicing Source: InterPro
    4. RNA splicing Source: UniProtKB-KW
    5. RNA transport Source: UniProtKB

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA binding protein fox-1 homolog 1
    Alternative name(s):
    Ataxin-2-binding protein 1
    Fox-1 homolog A
    Hexaribonucleotide-binding protein 1
    Gene namesi
    Name:RBFOX1
    Synonyms:A2BP, A2BP1, FOX1, HRNBP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:18222. RBFOX1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB-SubCell
    3. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi120 – 1201H → A: Reduces RNA-binding affinity 160-fold. 1 Publication
    Mutagenesisi126 – 1261F → A, I or R: Reduces RNA-binding affinity 1500-fold. 1 Publication
    Mutagenesisi126 – 1261F → H or W: Reduces RNA-binding affinity 15-fold. 1 Publication
    Mutagenesisi126 – 1261F → Y: No effect on RNA-binding. 1 Publication
    Mutagenesisi158 – 1581F → A: Reduces RNA-binding affinity 700-fold. 1 Publication
    Mutagenesisi160 – 1601F → A: Reduces RNA-binding affinity 30'000-fold. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397RNA binding protein fox-1 homolog 1PRO_0000081480Add
    BLAST

    Proteomic databases

    PaxDbiQ9NWB1.
    PRIDEiQ9NWB1.

    PTM databases

    PhosphoSiteiQ9NWB1.

    Expressioni

    Tissue specificityi

    Predominantly expressed in muscle and brain.

    Gene expression databases

    ArrayExpressiQ9NWB1.
    BgeeiQ9NWB1.
    GenevestigatoriQ9NWB1.

    Organism-specific databases

    HPAiHPA040809.

    Interactioni

    Subunit structurei

    Binds to the C-terminus of ATXN2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATN1P542592EBI-945906,EBI-945980
    ATXN1P542532EBI-945906,EBI-930964
    NUMBLQ9Y6R02EBI-945906,EBI-945925
    PLEKHA5Q9HAU02EBI-945906,EBI-945934
    PSMF1Q925302EBI-945906,EBI-945916
    QKIQ96PU82EBI-945906,EBI-945792
    RBFOX2O432512EBI-945906,EBI-746056

    Protein-protein interaction databases

    BioGridi120107. 23 interactions.
    IntActiQ9NWB1. 22 interactions.
    MINTiMINT-2854938.
    STRINGi9606.ENSP00000309117.

    Structurei

    Secondary structure

    1
    397
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi118 – 1236
    Helixi130 – 1367
    Helixi137 – 1393
    Beta strandi146 – 1483
    Beta strandi158 – 1625
    Helixi167 – 17610
    Beta strandi187 – 1904

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ERRNMR-A109-196[»]
    ProteinModelPortaliQ9NWB1.
    SMRiQ9NWB1. Positions 75-196.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NWB1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini117 – 19377RRMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG258617.
    HOVERGENiHBG000044.
    KOiK14946.
    OMAiLVYTSTM.
    PhylomeDBiQ9NWB1.
    TreeFamiTF315942.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR025670. Fox-1_C_dom.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR017325. RNA-bd_Fox-1.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF12414. Fox-1_C. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037932. Ataxin_2_bd_A2BP. 1 hit.
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NWB1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNCEREQLRG NQEAAAAPDT MAQPYASAQF APPQNGIPAE YTAPHPHPAP    50
    EYTGQTTVPE HTLNLYPPAQ THSEQSPADT SAQTVSGTAT QTDDAAPTDG 100
    QPQTQPSENT ENKSQPKRLH VSNIPFRFRD PDLRQMFGQF GKILDVEIIF 150
    NERGSKGFGF VTFENSADAD RAREKLHGTV VEGRKIEVNN ATARVMTNKK 200
    TVNPYTNGWK LNPVVGAVYS PEFYAGTVLL CQANQEGSSM YSAPSSLVYT 250
    SAMPGFPYPA ATAAAAYRGA HLRGRGRTVY NTFRAAAPPP PIPAYGGVVY 300
    QDGFYGADIY GGYAAYRYAQ PTPATAAAYS DSYGRVYAAD PYHHALAPAP 350
    TYGVGAMNAF APLTDAKTRS HADDVGLVLS SLQASIYRGG YNRFAPY 397
    Length:397
    Mass (Da):42,784
    Last modified:February 5, 2008 - v2
    Checksum:iEA96AA7B6E144D80
    GO
    Isoform 2 (identifier: Q9NWB1-2) [UniParc]FASTAAdd to Basket

    Also known as: Gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: MNCEREQLR → MLASQGVLLHPYGVPMIVPAAPYLPGLIQ
         302-310: DGFYGADIY → EPVYGNKLLQ

    Show »
    Length:418
    Mass (Da):44,793
    Checksum:i47D6FC140F75D01A
    GO
    Isoform 3 (identifier: Q9NWB1-3) [UniParc]FASTAAdd to Basket

    Also known as: 1

    The sequence of this isoform differs from the canonical sequence as follows:
         226-253: GTVLLCQANQEGSSMYSAPSSLVYTSAM → V

    Show »
    Length:370
    Mass (Da):40,005
    Checksum:i26DBC3263B7E5EA9
    GO
    Isoform 4 (identifier: Q9NWB1-4) [UniParc]FASTAAdd to Basket

    Also known as: Alpha

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: MNCEREQLR → MLASQGVLLHPYGVPMIVPAAPYLPGLIQ
         302-310: DGFYGADIY → EPVYGNKLLQ
         358-383: Missing.

    Show »
    Length:392
    Mass (Da):42,084
    Checksum:i68F8CEFE2FC6D674
    GO
    Isoform 5 (identifier: Q9NWB1-5) [UniParc]FASTAAdd to Basket

    Also known as: Beta

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: MNCEREQLR → MLASQGVLLHPYGVPMIVPAAPYLPGLIQ
         302-310: DGFYGADIY → EPVYGNKLLQ
         332-397: SYGRVYAADP...RGGYNRFAPY → RNQFVFVAAD...LQPPPTALVP

    Show »
    Length:395
    Mass (Da):42,402
    Checksum:i2299F9127AA1DE39
    GO

    Sequence cautioni

    The sequence AAF78291.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 921T → A in BAA91472. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 99MNCEREQLR → MLASQGVLLHPYGVPMIVPA APYLPGLIQ in isoform 2, isoform 4 and isoform 5. 2 PublicationsVSP_030874
    Alternative sequencei226 – 25328GTVLL…YTSAM → V in isoform 3. 3 PublicationsVSP_030875Add
    BLAST
    Alternative sequencei302 – 3109DGFYGADIY → EPVYGNKLLQ in isoform 2, isoform 4 and isoform 5. 2 PublicationsVSP_030876
    Alternative sequencei332 – 39766SYGRV…RFAPY → RNQFVFVAADEISCNTSAVT DEFMLPTPTTTHLLQPPPTA LVP in isoform 5. 2 PublicationsVSP_030877Add
    BLAST
    Alternative sequencei358 – 38326Missing in isoform 4. 1 PublicationVSP_030878Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF107203 mRNA. Translation: AAF78291.1. Different initiation.
    AF229057 mRNA. Translation: AAL71904.1.
    AF094849 mRNA. Translation: AAL83405.1.
    AF109106 mRNA. Translation: AAL83406.1.
    AF109120
    , AF109107, AF109108, AF109109, AF109110, AF109111, AF109112, AF109113, AF109114, AF109115, AF109116, AF109117, AF109118, AF109119 Genomic DNA. Translation: AAL83407.1.
    AF109120
    , AF109107, AF109108, AF109109, AF109110, AF109111, AF109112, AF109113, AF109114, AF109115, AF109116, AF109117, AF109119 Genomic DNA. Translation: AAL83408.1.
    AF109120
    , AF109107, AF109108, AF109109, AF109110, AF109111, AF109112, AF109113, AF109114, AF109115, AF109116, AF109117, AF109119 Genomic DNA. Translation: AAL83409.1.
    AF448859 mRNA. Translation: AAP41925.1.
    AK001027 mRNA. Translation: BAA91472.1.
    AC005774 Genomic DNA. No translation available.
    AC006075 Genomic DNA. No translation available.
    AC006112 Genomic DNA. No translation available.
    AC007012 Genomic DNA. No translation available.
    AC007217 Genomic DNA. No translation available.
    AC007222 Genomic DNA. No translation available.
    AC007223 Genomic DNA. No translation available.
    AC009135 Genomic DNA. No translation available.
    AC022206 Genomic DNA. No translation available.
    AC023829 Genomic DNA. No translation available.
    AC027683 Genomic DNA. No translation available.
    AC079410 Genomic DNA. No translation available.
    AC125796 Genomic DNA. No translation available.
    AC131390 Genomic DNA. No translation available.
    BC113691 mRNA. Translation: AAI13692.1.
    CCDSiCCDS10531.1. [Q9NWB1-2]
    CCDS10532.1. [Q9NWB1-5]
    CCDS45405.1. [Q9NWB1-4]
    CCDS55983.1. [Q9NWB1-1]
    CCDS55984.1. [Q9NWB1-3]
    RefSeqiNP_001135805.1. NM_001142333.1. [Q9NWB1-3]
    NP_001135806.1. NM_001142334.1. [Q9NWB1-1]
    NP_061193.2. NM_018723.3. [Q9NWB1-1]
    NP_665898.1. NM_145891.2. [Q9NWB1-2]
    NP_665899.1. NM_145892.2. [Q9NWB1-4]
    NP_665900.1. NM_145893.2. [Q9NWB1-5]
    UniGeneiHs.459842.

    Genome annotation databases

    EnsembliENST00000311745; ENSP00000309117; ENSG00000078328. [Q9NWB1-2]
    ENST00000355637; ENSP00000347855; ENSG00000078328. [Q9NWB1-5]
    ENST00000436368; ENSP00000402745; ENSG00000078328. [Q9NWB1-4]
    ENST00000547338; ENSP00000447717; ENSG00000078328. [Q9NWB1-1]
    ENST00000550418; ENSP00000450031; ENSG00000078328. [Q9NWB1-1]
    ENST00000553186; ENSP00000447753; ENSG00000078328. [Q9NWB1-3]
    GeneIDi54715.
    KEGGihsa:54715.
    UCSCiuc002cys.2. human. [Q9NWB1-1]
    uc002cyt.2. human. [Q9NWB1-3]
    uc002cyw.2. human. [Q9NWB1-5]
    uc002cyx.2. human. [Q9NWB1-4]
    uc002cyy.2. human. [Q9NWB1-2]

    Polymorphism databases

    DMDMi166897979.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF107203 mRNA. Translation: AAF78291.1 . Different initiation.
    AF229057 mRNA. Translation: AAL71904.1 .
    AF094849 mRNA. Translation: AAL83405.1 .
    AF109106 mRNA. Translation: AAL83406.1 .
    AF109120
    , AF109107 , AF109108 , AF109109 , AF109110 , AF109111 , AF109112 , AF109113 , AF109114 , AF109115 , AF109116 , AF109117 , AF109118 , AF109119 Genomic DNA. Translation: AAL83407.1 .
    AF109120
    , AF109107 , AF109108 , AF109109 , AF109110 , AF109111 , AF109112 , AF109113 , AF109114 , AF109115 , AF109116 , AF109117 , AF109119 Genomic DNA. Translation: AAL83408.1 .
    AF109120
    , AF109107 , AF109108 , AF109109 , AF109110 , AF109111 , AF109112 , AF109113 , AF109114 , AF109115 , AF109116 , AF109117 , AF109119 Genomic DNA. Translation: AAL83409.1 .
    AF448859 mRNA. Translation: AAP41925.1 .
    AK001027 mRNA. Translation: BAA91472.1 .
    AC005774 Genomic DNA. No translation available.
    AC006075 Genomic DNA. No translation available.
    AC006112 Genomic DNA. No translation available.
    AC007012 Genomic DNA. No translation available.
    AC007217 Genomic DNA. No translation available.
    AC007222 Genomic DNA. No translation available.
    AC007223 Genomic DNA. No translation available.
    AC009135 Genomic DNA. No translation available.
    AC022206 Genomic DNA. No translation available.
    AC023829 Genomic DNA. No translation available.
    AC027683 Genomic DNA. No translation available.
    AC079410 Genomic DNA. No translation available.
    AC125796 Genomic DNA. No translation available.
    AC131390 Genomic DNA. No translation available.
    BC113691 mRNA. Translation: AAI13692.1 .
    CCDSi CCDS10531.1. [Q9NWB1-2 ]
    CCDS10532.1. [Q9NWB1-5 ]
    CCDS45405.1. [Q9NWB1-4 ]
    CCDS55983.1. [Q9NWB1-1 ]
    CCDS55984.1. [Q9NWB1-3 ]
    RefSeqi NP_001135805.1. NM_001142333.1. [Q9NWB1-3 ]
    NP_001135806.1. NM_001142334.1. [Q9NWB1-1 ]
    NP_061193.2. NM_018723.3. [Q9NWB1-1 ]
    NP_665898.1. NM_145891.2. [Q9NWB1-2 ]
    NP_665899.1. NM_145892.2. [Q9NWB1-4 ]
    NP_665900.1. NM_145893.2. [Q9NWB1-5 ]
    UniGenei Hs.459842.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ERR NMR - A 109-196 [» ]
    ProteinModelPortali Q9NWB1.
    SMRi Q9NWB1. Positions 75-196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120107. 23 interactions.
    IntActi Q9NWB1. 22 interactions.
    MINTi MINT-2854938.
    STRINGi 9606.ENSP00000309117.

    PTM databases

    PhosphoSitei Q9NWB1.

    Polymorphism databases

    DMDMi 166897979.

    Proteomic databases

    PaxDbi Q9NWB1.
    PRIDEi Q9NWB1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000311745 ; ENSP00000309117 ; ENSG00000078328 . [Q9NWB1-2 ]
    ENST00000355637 ; ENSP00000347855 ; ENSG00000078328 . [Q9NWB1-5 ]
    ENST00000436368 ; ENSP00000402745 ; ENSG00000078328 . [Q9NWB1-4 ]
    ENST00000547338 ; ENSP00000447717 ; ENSG00000078328 . [Q9NWB1-1 ]
    ENST00000550418 ; ENSP00000450031 ; ENSG00000078328 . [Q9NWB1-1 ]
    ENST00000553186 ; ENSP00000447753 ; ENSG00000078328 . [Q9NWB1-3 ]
    GeneIDi 54715.
    KEGGi hsa:54715.
    UCSCi uc002cys.2. human. [Q9NWB1-1 ]
    uc002cyt.2. human. [Q9NWB1-3 ]
    uc002cyw.2. human. [Q9NWB1-5 ]
    uc002cyx.2. human. [Q9NWB1-4 ]
    uc002cyy.2. human. [Q9NWB1-2 ]

    Organism-specific databases

    CTDi 54715.
    GeneCardsi GC16P006033.
    HGNCi HGNC:18222. RBFOX1.
    HPAi HPA040809.
    MIMi 605104. gene.
    neXtProti NX_Q9NWB1.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258617.
    HOVERGENi HBG000044.
    KOi K14946.
    OMAi LVYTSTM.
    PhylomeDBi Q9NWB1.
    TreeFami TF315942.

    Miscellaneous databases

    ChiTaRSi RBFOX1. human.
    EvolutionaryTracei Q9NWB1.
    GeneWikii RBFOX1.
    GenomeRNAii 54715.
    NextBioi 57277.
    PROi Q9NWB1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NWB1.
    Bgeei Q9NWB1.
    Genevestigatori Q9NWB1.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR025670. Fox-1_C_dom.
    IPR012677. Nucleotide-bd_a/b_plait.
    IPR017325. RNA-bd_Fox-1.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF12414. Fox-1_C. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037932. Ataxin_2_bd_A2BP. 1 hit.
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel protein with RNA-binding motifs interacts with ataxin-2."
      Shibata H., Huynh D.P., Pulst S.-M.
      Hum. Mol. Genet. 9:1303-1313(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH ATXN2.
    2. "Molecular cloning and chromosomal localization of a human brain, heart and skeletal muscle specific RNA binding protein gene homologous to fox-1 in Caenorhabditis elegans."
      Chen W., Chu Z.-L., Blough R.I., Liu L., Hoppes B., Winkelmann J.C.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2; 4 AND 5).
    3. "An alternative splicing of a novel protein with RNA-binding motifs interacts with ataxin-2."
      Yu L., Guo J., She X.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    7. "Fox-2 splicing factor binds to a conserved intron motif to promote inclusion of protein 4.1R alternative exon 16."
      Ponthier J.L., Schluepen C., Chen W., Lersch R.A., Gee S.L., Hou V.C., Lo A.J., Short S.A., Chasis J.A., Winkelmann J.C., Conboy J.G.
      J. Biol. Chem. 281:12468-12474(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Molecular basis of RNA recognition by the human alternative splicing factor Fox-1."
      Auweter S.D., Fasan R., Reymond L., Underwood J.G., Black D.L., Pitsch S., Allain F.H.-T.
      EMBO J. 25:163-173(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 109-196 IN COMPLEX WITH RNA, MUTAGENESIS OF HIS-120; PHE-126; PHE-158 AND PHE-160.

    Entry informationi

    Entry nameiRFOX1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NWB1
    Secondary accession number(s): Q7Z7I7
    , Q8TAE3, Q8TAF2, Q8WYB2, Q9NS20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3