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Q9NWB1

- RFOX1_HUMAN

UniProt

Q9NWB1 - RFOX1_HUMAN

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Protein

RNA binding protein fox-1 homolog 1

Gene

RBFOX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei118 – 1181Interaction with RNA
Sitei126 – 1261Interaction with RNA
Sitei127 – 1271Interaction with RNA
Sitei151 – 1511Interaction with RNA
Sitei156 – 1561Interaction with RNA
Sitei160 – 1601Interaction with RNA
Sitei184 – 1841Interaction with RNA
Sitei194 – 1941Interaction with RNA

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. protein C-terminus binding Source: UniProtKB
  3. RNA binding Source: UniProtKB

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
  2. neuromuscular process controlling balance Source: Ensembl
  3. regulation of RNA splicing Source: InterPro
  4. RNA splicing Source: UniProtKB-KW
  5. RNA transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA binding protein fox-1 homolog 1
Alternative name(s):
Ataxin-2-binding protein 1
Fox-1 homolog A
Hexaribonucleotide-binding protein 1
Gene namesi
Name:RBFOX1
Synonyms:A2BP, A2BP1, FOX1, HRNBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:18222. RBFOX1.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB-KW
  3. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi120 – 1201H → A: Reduces RNA-binding affinity 160-fold. 1 Publication
Mutagenesisi126 – 1261F → A, I or R: Reduces RNA-binding affinity 1500-fold. 1 Publication
Mutagenesisi126 – 1261F → H or W: Reduces RNA-binding affinity 15-fold. 1 Publication
Mutagenesisi126 – 1261F → Y: No effect on RNA-binding. 1 Publication
Mutagenesisi158 – 1581F → A: Reduces RNA-binding affinity 700-fold. 1 Publication
Mutagenesisi160 – 1601F → A: Reduces RNA-binding affinity 30'000-fold. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397RNA binding protein fox-1 homolog 1PRO_0000081480Add
BLAST

Proteomic databases

MaxQBiQ9NWB1.
PaxDbiQ9NWB1.
PRIDEiQ9NWB1.

PTM databases

PhosphoSiteiQ9NWB1.

Expressioni

Tissue specificityi

Predominantly expressed in muscle and brain.

Gene expression databases

BgeeiQ9NWB1.
ExpressionAtlasiQ9NWB1. baseline and differential.
GenevestigatoriQ9NWB1.

Organism-specific databases

HPAiHPA040809.

Interactioni

Subunit structurei

Binds to the C-terminus of ATXN2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATN1P542592EBI-945906,EBI-945980
ATXN1P542532EBI-945906,EBI-930964
NUMBLQ9Y6R02EBI-945906,EBI-945925
PLEKHA5Q9HAU02EBI-945906,EBI-945934
PSMF1Q925302EBI-945906,EBI-945916
QKIQ96PU82EBI-945906,EBI-945792
RBFOX2O432512EBI-945906,EBI-746056

Protein-protein interaction databases

BioGridi120107. 35 interactions.
IntActiQ9NWB1. 22 interactions.
MINTiMINT-2854938.
STRINGi9606.ENSP00000309117.

Structurei

Secondary structure

1
397
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi118 – 1236Combined sources
Helixi130 – 1367Combined sources
Helixi137 – 1393Combined sources
Beta strandi146 – 1483Combined sources
Beta strandi158 – 1625Combined sources
Helixi167 – 17610Combined sources
Beta strandi187 – 1904Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ERRNMR-A109-196[»]
ProteinModelPortaliQ9NWB1.
SMRiQ9NWB1. Positions 75-196.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NWB1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 19377RRMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG258617.
GeneTreeiENSGT00390000013767.
HOVERGENiHBG000044.
InParanoidiQ9NWB1.
KOiK14946.
OMAiLVYTSTM.
PhylomeDBiQ9NWB1.
TreeFamiTF315942.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR025670. Fox-1_C_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR017325. RNA-bd_Fox-1.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF12414. Fox-1_C. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037932. Ataxin_2_bd_A2BP. 1 hit.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NWB1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNCEREQLRG NQEAAAAPDT MAQPYASAQF APPQNGIPAE YTAPHPHPAP
60 70 80 90 100
EYTGQTTVPE HTLNLYPPAQ THSEQSPADT SAQTVSGTAT QTDDAAPTDG
110 120 130 140 150
QPQTQPSENT ENKSQPKRLH VSNIPFRFRD PDLRQMFGQF GKILDVEIIF
160 170 180 190 200
NERGSKGFGF VTFENSADAD RAREKLHGTV VEGRKIEVNN ATARVMTNKK
210 220 230 240 250
TVNPYTNGWK LNPVVGAVYS PEFYAGTVLL CQANQEGSSM YSAPSSLVYT
260 270 280 290 300
SAMPGFPYPA ATAAAAYRGA HLRGRGRTVY NTFRAAAPPP PIPAYGGVVY
310 320 330 340 350
QDGFYGADIY GGYAAYRYAQ PTPATAAAYS DSYGRVYAAD PYHHALAPAP
360 370 380 390
TYGVGAMNAF APLTDAKTRS HADDVGLVLS SLQASIYRGG YNRFAPY
Length:397
Mass (Da):42,784
Last modified:February 5, 2008 - v2
Checksum:iEA96AA7B6E144D80
GO
Isoform 2 (identifier: Q9NWB1-2) [UniParc]FASTAAdd to Basket

Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MNCEREQLR → MLASQGVLLHPYGVPMIVPAAPYLPGLIQ
     302-310: DGFYGADIY → EPVYGNKLLQ

Show »
Length:418
Mass (Da):44,793
Checksum:i47D6FC140F75D01A
GO
Isoform 3 (identifier: Q9NWB1-3) [UniParc]FASTAAdd to Basket

Also known as: 1

The sequence of this isoform differs from the canonical sequence as follows:
     226-253: GTVLLCQANQEGSSMYSAPSSLVYTSAM → V

Show »
Length:370
Mass (Da):40,005
Checksum:i26DBC3263B7E5EA9
GO
Isoform 4 (identifier: Q9NWB1-4) [UniParc]FASTAAdd to Basket

Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MNCEREQLR → MLASQGVLLHPYGVPMIVPAAPYLPGLIQ
     302-310: DGFYGADIY → EPVYGNKLLQ
     358-383: Missing.

Show »
Length:392
Mass (Da):42,084
Checksum:i68F8CEFE2FC6D674
GO
Isoform 5 (identifier: Q9NWB1-5) [UniParc]FASTAAdd to Basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MNCEREQLR → MLASQGVLLHPYGVPMIVPAAPYLPGLIQ
     302-310: DGFYGADIY → EPVYGNKLLQ
     332-397: SYGRVYAADP...RGGYNRFAPY → RNQFVFVAAD...LQPPPTALVP

Show »
Length:395
Mass (Da):42,402
Checksum:i2299F9127AA1DE39
GO

Sequence cautioni

The sequence AAF78291.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921T → A in BAA91472. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 99MNCEREQLR → MLASQGVLLHPYGVPMIVPA APYLPGLIQ in isoform 2, isoform 4 and isoform 5. 2 PublicationsVSP_030874
Alternative sequencei226 – 25328GTVLL…YTSAM → V in isoform 3. 3 PublicationsVSP_030875Add
BLAST
Alternative sequencei302 – 3109DGFYGADIY → EPVYGNKLLQ in isoform 2, isoform 4 and isoform 5. 2 PublicationsVSP_030876
Alternative sequencei332 – 39766SYGRV…RFAPY → RNQFVFVAADEISCNTSAVT DEFMLPTPTTTHLLQPPPTA LVP in isoform 5. 2 PublicationsVSP_030877Add
BLAST
Alternative sequencei358 – 38326Missing in isoform 4. 1 PublicationVSP_030878Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107203 mRNA. Translation: AAF78291.1. Different initiation.
AF229057 mRNA. Translation: AAL71904.1.
AF094849 mRNA. Translation: AAL83405.1.
AF109106 mRNA. Translation: AAL83406.1.
AF109120
, AF109107, AF109108, AF109109, AF109110, AF109111, AF109112, AF109113, AF109114, AF109115, AF109116, AF109117, AF109118, AF109119 Genomic DNA. Translation: AAL83407.1.
AF109120
, AF109107, AF109108, AF109109, AF109110, AF109111, AF109112, AF109113, AF109114, AF109115, AF109116, AF109117, AF109119 Genomic DNA. Translation: AAL83408.1.
AF109120
, AF109107, AF109108, AF109109, AF109110, AF109111, AF109112, AF109113, AF109114, AF109115, AF109116, AF109117, AF109119 Genomic DNA. Translation: AAL83409.1.
AF448859 mRNA. Translation: AAP41925.1.
AK001027 mRNA. Translation: BAA91472.1.
AC005774 Genomic DNA. No translation available.
AC006075 Genomic DNA. No translation available.
AC006112 Genomic DNA. No translation available.
AC007012 Genomic DNA. No translation available.
AC007217 Genomic DNA. No translation available.
AC007222 Genomic DNA. No translation available.
AC007223 Genomic DNA. No translation available.
AC009135 Genomic DNA. No translation available.
AC022206 Genomic DNA. No translation available.
AC023829 Genomic DNA. No translation available.
AC027683 Genomic DNA. No translation available.
AC079410 Genomic DNA. No translation available.
AC125796 Genomic DNA. No translation available.
AC131390 Genomic DNA. No translation available.
BC113691 mRNA. Translation: AAI13692.1.
CCDSiCCDS10531.1. [Q9NWB1-2]
CCDS10532.1. [Q9NWB1-5]
CCDS45405.1. [Q9NWB1-4]
CCDS55983.1. [Q9NWB1-1]
CCDS55984.1. [Q9NWB1-3]
RefSeqiNP_001135805.1. NM_001142333.1. [Q9NWB1-3]
NP_001135806.1. NM_001142334.1. [Q9NWB1-1]
NP_061193.2. NM_018723.3. [Q9NWB1-1]
NP_665898.1. NM_145891.2. [Q9NWB1-2]
NP_665899.1. NM_145892.2. [Q9NWB1-4]
NP_665900.1. NM_145893.2. [Q9NWB1-5]
UniGeneiHs.459842.

Genome annotation databases

EnsembliENST00000311745; ENSP00000309117; ENSG00000078328. [Q9NWB1-2]
ENST00000355637; ENSP00000347855; ENSG00000078328. [Q9NWB1-5]
ENST00000436368; ENSP00000402745; ENSG00000078328. [Q9NWB1-4]
ENST00000547338; ENSP00000447717; ENSG00000078328. [Q9NWB1-1]
ENST00000550418; ENSP00000450031; ENSG00000078328. [Q9NWB1-1]
ENST00000553186; ENSP00000447753; ENSG00000078328. [Q9NWB1-3]
GeneIDi54715.
KEGGihsa:54715.
UCSCiuc002cys.2. human. [Q9NWB1-1]
uc002cyt.2. human. [Q9NWB1-3]
uc002cyw.2. human. [Q9NWB1-5]
uc002cyx.2. human. [Q9NWB1-4]
uc002cyy.2. human. [Q9NWB1-2]

Polymorphism databases

DMDMi166897979.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107203 mRNA. Translation: AAF78291.1 . Different initiation.
AF229057 mRNA. Translation: AAL71904.1 .
AF094849 mRNA. Translation: AAL83405.1 .
AF109106 mRNA. Translation: AAL83406.1 .
AF109120
, AF109107 , AF109108 , AF109109 , AF109110 , AF109111 , AF109112 , AF109113 , AF109114 , AF109115 , AF109116 , AF109117 , AF109118 , AF109119 Genomic DNA. Translation: AAL83407.1 .
AF109120
, AF109107 , AF109108 , AF109109 , AF109110 , AF109111 , AF109112 , AF109113 , AF109114 , AF109115 , AF109116 , AF109117 , AF109119 Genomic DNA. Translation: AAL83408.1 .
AF109120
, AF109107 , AF109108 , AF109109 , AF109110 , AF109111 , AF109112 , AF109113 , AF109114 , AF109115 , AF109116 , AF109117 , AF109119 Genomic DNA. Translation: AAL83409.1 .
AF448859 mRNA. Translation: AAP41925.1 .
AK001027 mRNA. Translation: BAA91472.1 .
AC005774 Genomic DNA. No translation available.
AC006075 Genomic DNA. No translation available.
AC006112 Genomic DNA. No translation available.
AC007012 Genomic DNA. No translation available.
AC007217 Genomic DNA. No translation available.
AC007222 Genomic DNA. No translation available.
AC007223 Genomic DNA. No translation available.
AC009135 Genomic DNA. No translation available.
AC022206 Genomic DNA. No translation available.
AC023829 Genomic DNA. No translation available.
AC027683 Genomic DNA. No translation available.
AC079410 Genomic DNA. No translation available.
AC125796 Genomic DNA. No translation available.
AC131390 Genomic DNA. No translation available.
BC113691 mRNA. Translation: AAI13692.1 .
CCDSi CCDS10531.1. [Q9NWB1-2 ]
CCDS10532.1. [Q9NWB1-5 ]
CCDS45405.1. [Q9NWB1-4 ]
CCDS55983.1. [Q9NWB1-1 ]
CCDS55984.1. [Q9NWB1-3 ]
RefSeqi NP_001135805.1. NM_001142333.1. [Q9NWB1-3 ]
NP_001135806.1. NM_001142334.1. [Q9NWB1-1 ]
NP_061193.2. NM_018723.3. [Q9NWB1-1 ]
NP_665898.1. NM_145891.2. [Q9NWB1-2 ]
NP_665899.1. NM_145892.2. [Q9NWB1-4 ]
NP_665900.1. NM_145893.2. [Q9NWB1-5 ]
UniGenei Hs.459842.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ERR NMR - A 109-196 [» ]
ProteinModelPortali Q9NWB1.
SMRi Q9NWB1. Positions 75-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120107. 35 interactions.
IntActi Q9NWB1. 22 interactions.
MINTi MINT-2854938.
STRINGi 9606.ENSP00000309117.

PTM databases

PhosphoSitei Q9NWB1.

Polymorphism databases

DMDMi 166897979.

Proteomic databases

MaxQBi Q9NWB1.
PaxDbi Q9NWB1.
PRIDEi Q9NWB1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311745 ; ENSP00000309117 ; ENSG00000078328 . [Q9NWB1-2 ]
ENST00000355637 ; ENSP00000347855 ; ENSG00000078328 . [Q9NWB1-5 ]
ENST00000436368 ; ENSP00000402745 ; ENSG00000078328 . [Q9NWB1-4 ]
ENST00000547338 ; ENSP00000447717 ; ENSG00000078328 . [Q9NWB1-1 ]
ENST00000550418 ; ENSP00000450031 ; ENSG00000078328 . [Q9NWB1-1 ]
ENST00000553186 ; ENSP00000447753 ; ENSG00000078328 . [Q9NWB1-3 ]
GeneIDi 54715.
KEGGi hsa:54715.
UCSCi uc002cys.2. human. [Q9NWB1-1 ]
uc002cyt.2. human. [Q9NWB1-3 ]
uc002cyw.2. human. [Q9NWB1-5 ]
uc002cyx.2. human. [Q9NWB1-4 ]
uc002cyy.2. human. [Q9NWB1-2 ]

Organism-specific databases

CTDi 54715.
GeneCardsi GC16P006033.
HGNCi HGNC:18222. RBFOX1.
HPAi HPA040809.
MIMi 605104. gene.
neXtProti NX_Q9NWB1.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG258617.
GeneTreei ENSGT00390000013767.
HOVERGENi HBG000044.
InParanoidi Q9NWB1.
KOi K14946.
OMAi LVYTSTM.
PhylomeDBi Q9NWB1.
TreeFami TF315942.

Miscellaneous databases

ChiTaRSi RBFOX1. human.
EvolutionaryTracei Q9NWB1.
GeneWikii RBFOX1.
GenomeRNAii 54715.
NextBioi 57277.
PROi Q9NWB1.
SOURCEi Search...

Gene expression databases

Bgeei Q9NWB1.
ExpressionAtlasi Q9NWB1. baseline and differential.
Genevestigatori Q9NWB1.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR025670. Fox-1_C_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR017325. RNA-bd_Fox-1.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF12414. Fox-1_C. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037932. Ataxin_2_bd_A2BP. 1 hit.
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel protein with RNA-binding motifs interacts with ataxin-2."
    Shibata H., Huynh D.P., Pulst S.-M.
    Hum. Mol. Genet. 9:1303-1313(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH ATXN2.
  2. "Molecular cloning and chromosomal localization of a human brain, heart and skeletal muscle specific RNA binding protein gene homologous to fox-1 in Caenorhabditis elegans."
    Chen W., Chu Z.-L., Blough R.I., Liu L., Hoppes B., Winkelmann J.C.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2; 4 AND 5).
  3. "An alternative splicing of a novel protein with RNA-binding motifs interacts with ataxin-2."
    Yu L., Guo J., She X.
    Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  7. "Fox-2 splicing factor binds to a conserved intron motif to promote inclusion of protein 4.1R alternative exon 16."
    Ponthier J.L., Schluepen C., Chen W., Lersch R.A., Gee S.L., Hou V.C., Lo A.J., Short S.A., Chasis J.A., Winkelmann J.C., Conboy J.G.
    J. Biol. Chem. 281:12468-12474(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Molecular basis of RNA recognition by the human alternative splicing factor Fox-1."
    Auweter S.D., Fasan R., Reymond L., Underwood J.G., Black D.L., Pitsch S., Allain F.H.-T.
    EMBO J. 25:163-173(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 109-196 IN COMPLEX WITH RNA, MUTAGENESIS OF HIS-120; PHE-126; PHE-158 AND PHE-160.

Entry informationi

Entry nameiRFOX1_HUMAN
AccessioniPrimary (citable) accession number: Q9NWB1
Secondary accession number(s): Q7Z7I7
, Q8TAE3, Q8TAF2, Q8WYB2, Q9NS20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3