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Protein

Transmembrane protein 51

Gene

TMEM51

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 51
Gene namesi
Name:TMEM51
Synonyms:C1orf72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25488. TMEM51.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55092.
OpenTargetsiENSG00000171729.
PharmGKBiPA142670767.

Polymorphism and mutation databases

BioMutaiTMEM51.
DMDMi68053240.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725771 – 253Transmembrane protein 51Add BLAST253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115PhosphoserineCombined sources1
Modified residuei182PhosphoserineCombined sources1
Modified residuei192PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NW97.
MaxQBiQ9NW97.
PaxDbiQ9NW97.
PeptideAtlasiQ9NW97.
PRIDEiQ9NW97.

PTM databases

iPTMnetiQ9NW97.
PhosphoSitePlusiQ9NW97.

Expressioni

Gene expression databases

BgeeiENSG00000171729.
CleanExiHS_TMEM51.
ExpressionAtlasiQ9NW97. baseline and differential.
GenevisibleiQ9NW97. HS.

Organism-specific databases

HPAiHPA014547.
HPA019441.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPN5P548293EBI-726044,EBI-1220572

Protein-protein interaction databases

BioGridi120404. 25 interactors.
IntActiQ9NW97. 6 interactors.
MINTiMINT-1419433.
STRINGi9606.ENSP00000365176.

Structurei

3D structure databases

ProteinModelPortaliQ9NW97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJTH. Eukaryota.
ENOG4111TGG. LUCA.
GeneTreeiENSGT00390000009278.
HOGENOMiHOG000233553.
HOVERGENiHBG061167.
InParanoidiQ9NW97.
OMAiQGEEMAH.
OrthoDBiEOG091G0LPK.
PhylomeDBiQ9NW97.
TreeFamiTF332361.

Family and domain databases

InterProiIPR029265. TMEM51.
[Graphical view]
PfamiPF15345. TMEM51. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NW97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAQSKANGS HYALTAIGLG MLVLGVIMAM WNLVPGFSAA EKPTAQGSNK
60 70 80 90 100
TEVGGGILKS KTFSVAYVLV GAGVMLLLLS ICLSIRDKRK QRQGEDLAHV
110 120 130 140 150
QHPTGAGPHA QEEDSQEEEE EDEEAASRYY VPSYEEVMNT NYSEARGEEQ
160 170 180 190 200
NPRLSISLPS YESLTGLDET TPTSTRADVE ASPGNPPDRQ NSKLAKRLKP
210 220 230 240 250
LKVRRIKSEK LHLKDFRINL PDKNVPPPSI EPLTPPPQYD EVQEKAPDTR

PPD
Length:253
Mass (Da):27,759
Last modified:October 1, 2000 - v1
Checksum:iC0CC36D41C57157C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05144634V → A.Corresponds to variant rs17405421dbSNPEnsembl.1
Natural variantiVAR_05144792R → Q.Corresponds to variant rs3766158dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001061 mRNA. Translation: BAA91486.1.
AK292184 mRNA. Translation: BAF84873.1.
CR457120 mRNA. Translation: CAG33401.1.
AL391094 Genomic DNA. Translation: CAI23267.1.
CH471167 Genomic DNA. Translation: EAW51711.1.
BC000202 mRNA. Translation: AAH00202.1.
BC000593 mRNA. Translation: AAH00593.1.
CCDSiCCDS154.1.
RefSeqiNP_001129688.1. NM_001136216.1.
NP_001129689.1. NM_001136217.1.
NP_001129690.1. NM_001136218.1.
NP_001306594.1. NM_001319665.1.
NP_060492.1. NM_018022.2.
XP_005245976.1. XM_005245919.1.
XP_011539978.1. XM_011541676.1.
XP_016857079.1. XM_017001590.1.
UniGeneiHs.465305.

Genome annotation databases

EnsembliENST00000376008; ENSP00000365176; ENSG00000171729.
ENST00000376014; ENSP00000365182; ENSG00000171729.
ENST00000400796; ENSP00000383600; ENSG00000171729.
ENST00000428417; ENSP00000394899; ENSG00000171729.
GeneIDi55092.
KEGGihsa:55092.
UCSCiuc001avw.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001061 mRNA. Translation: BAA91486.1.
AK292184 mRNA. Translation: BAF84873.1.
CR457120 mRNA. Translation: CAG33401.1.
AL391094 Genomic DNA. Translation: CAI23267.1.
CH471167 Genomic DNA. Translation: EAW51711.1.
BC000202 mRNA. Translation: AAH00202.1.
BC000593 mRNA. Translation: AAH00593.1.
CCDSiCCDS154.1.
RefSeqiNP_001129688.1. NM_001136216.1.
NP_001129689.1. NM_001136217.1.
NP_001129690.1. NM_001136218.1.
NP_001306594.1. NM_001319665.1.
NP_060492.1. NM_018022.2.
XP_005245976.1. XM_005245919.1.
XP_011539978.1. XM_011541676.1.
XP_016857079.1. XM_017001590.1.
UniGeneiHs.465305.

3D structure databases

ProteinModelPortaliQ9NW97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120404. 25 interactors.
IntActiQ9NW97. 6 interactors.
MINTiMINT-1419433.
STRINGi9606.ENSP00000365176.

PTM databases

iPTMnetiQ9NW97.
PhosphoSitePlusiQ9NW97.

Polymorphism and mutation databases

BioMutaiTMEM51.
DMDMi68053240.

Proteomic databases

EPDiQ9NW97.
MaxQBiQ9NW97.
PaxDbiQ9NW97.
PeptideAtlasiQ9NW97.
PRIDEiQ9NW97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376008; ENSP00000365176; ENSG00000171729.
ENST00000376014; ENSP00000365182; ENSG00000171729.
ENST00000400796; ENSP00000383600; ENSG00000171729.
ENST00000428417; ENSP00000394899; ENSG00000171729.
GeneIDi55092.
KEGGihsa:55092.
UCSCiuc001avw.5. human.

Organism-specific databases

CTDi55092.
DisGeNETi55092.
GeneCardsiTMEM51.
HGNCiHGNC:25488. TMEM51.
HPAiHPA014547.
HPA019441.
neXtProtiNX_Q9NW97.
OpenTargetsiENSG00000171729.
PharmGKBiPA142670767.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJTH. Eukaryota.
ENOG4111TGG. LUCA.
GeneTreeiENSGT00390000009278.
HOGENOMiHOG000233553.
HOVERGENiHBG061167.
InParanoidiQ9NW97.
OMAiQGEEMAH.
OrthoDBiEOG091G0LPK.
PhylomeDBiQ9NW97.
TreeFamiTF332361.

Miscellaneous databases

ChiTaRSiTMEM51. human.
GeneWikiiTMEM51_(gene).
GenomeRNAii55092.
PROiQ9NW97.

Gene expression databases

BgeeiENSG00000171729.
CleanExiHS_TMEM51.
ExpressionAtlasiQ9NW97. baseline and differential.
GenevisibleiQ9NW97. HS.

Family and domain databases

InterProiIPR029265. TMEM51.
[Graphical view]
PfamiPF15345. TMEM51. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM51_HUMAN
AccessioniPrimary (citable) accession number: Q9NW97
Secondary accession number(s): A8K819
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.