Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

WD repeat-containing protein 70

Gene

WDR70

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Enzyme and pathway databases

SignaLinkiQ9NW82

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 70
Gene namesi
Name:WDR70
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000082068.8
HGNCiHGNC:25495 WDR70
neXtProtiNX_Q9NW82

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000082068
PharmGKBiPA142670603

Polymorphism and mutation databases

BioMutaiWDR70
DMDMi74761752

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003051441 – 654WD repeat-containing protein 70Add BLAST654

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki296Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei452N6-acetyllysineCombined sources1
Modified residuei579PhosphothreonineCombined sources1
Cross-linki590Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki596Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei621PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NW82
MaxQBiQ9NW82
PaxDbiQ9NW82
PeptideAtlasiQ9NW82
PRIDEiQ9NW82

PTM databases

iPTMnetiQ9NW82
PhosphoSitePlusiQ9NW82

Expressioni

Gene expression databases

BgeeiENSG00000082068
CleanExiHS_WDR70
ExpressionAtlasiQ9NW82 baseline and differential
GenevisibleiQ9NW82 HS

Organism-specific databases

HPAiHPA043064
HPA048149

Interactioni

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi12041023 interactors.
IntActiQ9NW82 9 interactors.
MINTiQ9NW82
STRINGi9606.ENSP00000265107

Structurei

3D structure databases

ProteinModelPortaliQ9NW82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati180 – 219WD 1Add BLAST40
Repeati227 – 268WD 2Add BLAST42
Repeati281 – 321WD 3Add BLAST41
Repeati330 – 369WD 4Add BLAST40
Repeati376 – 415WD 5Add BLAST40
Repeati421 – 466WD 6Add BLAST46
Repeati469 – 508WD 7Add BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi84 – 113Ser-richAdd BLAST30
Compositional biasi148 – 164Glu-richAdd BLAST17

Sequence similaritiesi

Belongs to the WD repeat GAD-1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0772 Eukaryota
ENOG410XP76 LUCA
GeneTreeiENSGT00390000015433
HOGENOMiHOG000172867
HOVERGENiHBG108671
InParanoidiQ9NW82
OMAiATVRTWE
OrthoDBiEOG091G043W
PhylomeDBiQ9NW82
TreeFamiTF105809

Family and domain databases

Gene3Di2.130.10.102 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NW82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERSGPSEVT GSDASGPDPQ LAVTMGFTGF GKKARTFDLE AMFEQTRRTA
60 70 80 90 100
VERSRKTLEA REKEEEMNRE KELRRQNEDI EPTSSRSNVV RDCSKSSSRD
110 120 130 140 150
TSSSESEQSS DSSDDELIGP PLPPKMVGKP VNFMEEDILG PLPPPLNEEE
160 170 180 190 200
EEAEEEEEEE EEEENPVHKI PDSHEITLKH GTKTVSALGL DPSGARLVTG
210 220 230 240 250
GYDYDVKFWD FAGMDASFKA FRSLQPCECH QIKSLQYSNT GDMILVVSGS
260 270 280 290 300
SQAKVIDRDG FEVMECIKGD QYIVDMANTK GHTAMLHTGS WHPKIKGEFM
310 320 330 340 350
TCSNDATVRT WEVENPKKQK SVFKPRTMQG KKVIPTTCTY SRDGNLIAAA
360 370 380 390 400
CQNGSIQIWD RNLTVHPKFH YKQAHDSGTD TSCVTFSYDG NVLASRGGDD
410 420 430 440 450
SLKLWDIRQF NKPLFSASGL PTMFPMTDCC FSPDDKLIVT GTSIQRGCGS
460 470 480 490 500
GKLVFFERRT FQRVYEIDIT DASVVRCLWH PKLNQIMVGT GNGLAKVYYD
510 520 530 540 550
PNKSQRGAKL CVVKTQRKAK QAETLTQDYI ITPHALPMFR EPRQRSTRKQ
560 570 580 590 600
LEKDRLDPLK SHKPEPPVAG PGRGGRVGTH GGTLSSYIVK NIALDKTDDS
610 620 630 640 650
NPREAILRHA KAAEDSPYWV SPAYSKTQPK TMFAQVESDD EEAKNEPEWK

KRKI
Length:654
Mass (Da):73,201
Last modified:October 1, 2000 - v1
Checksum:i5AE0E1B43A5B8E18
GO

Sequence cautioni

The sequence CAC21644 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001095 mRNA Translation: BAA91502.1
AL512685 mRNA Translation: CAC21644.1 Different initiation.
BC009648 mRNA Translation: AAH09648.1
BC025315 mRNA Translation: AAH25315.1
CCDSiCCDS34147.1
RefSeqiNP_060504.1, NM_018034.3
UniGeneiHs.213690

Genome annotation databases

EnsembliENST00000265107; ENSP00000265107; ENSG00000082068
GeneIDi55100
KEGGihsa:55100
UCSCiuc003jkv.4 human

Similar proteinsi

Entry informationi

Entry nameiWDR70_HUMAN
AccessioniPrimary (citable) accession number: Q9NW82
Secondary accession number(s): Q9H053
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome