Q9NW81 (AT5SL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP synthase subunit s-like protein

Gene names

Name:

ATP5SL

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ATP synthase subunit s family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NW81-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NW81-2)

The sequence of this isoform differs from the canonical sequence as follows:
     73-99: Missing.
     145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	ATP synthase subunit s-like protein		PRO_0000318695
Natural variations
	Alternative sequence	73 – 99	27	Missing in isoform 2.		VSP_031270
	Alternative sequence	145 – 257	113	LRLKE…SPVPA → RTSAGWTSRTSLPCPTLASL RYWWRRCCPIARLWESTGLR A in isoform 2.		VSP_031271
	Natural variant	9	1	R → C. Corresponds to variant rs2231938 [ dbSNP | Ensembl ].		VAR_057798
	Natural variant	23	1	H → R. Corresponds to variant rs2231939 [ dbSNP | Ensembl ].		VAR_057799
	Natural variant	34	1	N → S. Ref.1 Corresponds to variant rs2231940 [ dbSNP | Ensembl ].		VAR_057800
	Natural variant	159	1	C → S. Ref.1 Corresponds to variant rs1043413 [ dbSNP | Ensembl ].		VAR_060165
	Natural variant	230	1	E → K. Corresponds to variant rs2231943 [ dbSNP | Ensembl ].		VAR_057801

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 29CBFD02143DE806	FASTA	257	29,267
	10 20 30 40 50 60 MAAPWASLRL VAPMWNGRIR GIHRLGAAVA PEGNQKKKRT ILQFLTNYFY DVEALRDYLL 70 80 90 100 110 120 QREMYKVHEK NRSYTWLEKQ HGPYGAGAFF ILKQGGAVKF RDKEWIRPDK YGHFSQEFWN 130 140 150 160 170 180 FCEVPVEAVD AGDCDINYEG LDNLLRLKEL QSLSLQRCCH VDDWCLSRLY PLADSLQELS 190 200 210 220 230 240 LAGCPRISER GLACLHHLQN LRRLDISDLP AVSNPGLTQI LVEEMLPNCE VVGVDWAEGL 250 KSGPEEQPRD TASPVPA
	Isoform 2 [UniParc]. Checksum: 8387C635C5F26D39	FASTA	158	18,602
	10 20 30 40 50 60 MAAPWASLRL VAPMWNGRIR GIHRLGAAVA PEGNQKKKRT ILQFLTNYFY DVEALRDYLL 70 80 90 100 110 120 QREMYKVHEK NRFRDKEWIR PDKYGHFSQE FWNFCEVPVE AVDAGDCDIN YEGLDNLRTS 130 140 150 AGWTSRTSLP CPTLASLRYW WRRCCPIARL WESTGLRA

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-34 AND SER-159.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Bone marrow.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001103 mRNA. Translation: BAA91503.1. AC011526 Genomic DNA. No translation available. CH471126 Genomic DNA. Translation: EAW57043.1. BC013323 mRNA. Translation: AAH13323.1.
IPI	IPI00060651. IPI00942215.
RefSeq	NP_001161339.1. NM_001167867.1. NP_001161340.1. NM_001167868.1. NP_001161341.1. NM_001167869.1. NP_001161342.1. NM_001167870.1. NP_001161343.1. NM_001167871.1. NP_060505.2. NM_018035.2.
UniGene	Hs.728825.
3D structure databases
ProteinModelPortal	Q9NW81.
SMR	Q9NW81. Positions 63-232.
ModBase	Search...
PTM databases
PhosphoSite	Q9NW81.
Polymorphism databases
DMDM	296439436.
Proteomic databases
PRIDE	Q9NW81.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000221943; ENSP00000221943; ENSG00000105341.
GeneID	55101.
KEGG	hsa:55101.
UCSC	uc002oqv.1. human. uc002oqy.1. human.
Organism-specific databases
CTD	55101.
GeneCards	GC19M041937.
HGNC	HGNC:25496. ATP5SL.
neXtProt	NX_Q9NW81.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15528.
GeneTree	ENSGT00530000063680.
HOVERGEN	HBG056046.
InParanoid	Q9NW81.
PhylomeDB	Q9NW81.
Gene expression databases
ArrayExpress	Q9NW81.
Bgee	Q9NW81.
CleanEx	HS_ATP5SL.
Genevestigator	Q9NW81.
Family and domain databases
ProtoNet	Search...
Other
NextBio	58693.

Entry information

Entry name

AT5SL_HUMAN

Accession

Primary (citable) accession number: Q9NW81
Secondary accession number(s): Q96D43

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 62 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.