Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP synthase subunit s-like protein

Gene

ATP5SL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit s-like protein
Gene namesi
Name:ATP5SL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25496. ATP5SL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377263.

Polymorphism and mutation databases

BioMutaiATP5SL.
DMDMi296439436.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257ATP synthase subunit s-like proteinPRO_0000318695Add
BLAST

Proteomic databases

MaxQBiQ9NW81.
PaxDbiQ9NW81.
PRIDEiQ9NW81.

PTM databases

PhosphoSiteiQ9NW81.

Expressioni

Gene expression databases

BgeeiQ9NW81.
CleanExiHS_ATP5SL.
ExpressionAtlasiQ9NW81. baseline and differential.
GenevisibleiQ9NW81. HS.

Organism-specific databases

HPAiHPA041427.
HPA042658.

Interactioni

Protein-protein interaction databases

BioGridi120411. 2 interactions.
STRINGi9606.ENSP00000403910.

Structurei

3D structure databases

ProteinModelPortaliQ9NW81.
SMRiQ9NW81. Positions 82-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP synthase subunit s family.Curated

Phylogenomic databases

eggNOGiNOG318773.
GeneTreeiENSGT00530000063680.
HOGENOMiHOG000034116.
HOVERGENiHBG056046.
InParanoidiQ9NW81.
OMAiGAVKFRD.
PhylomeDBiQ9NW81.
TreeFamiTF315274.

Family and domain databases

InterProiIPR026303. ATP5SL.
[Graphical view]
PANTHERiPTHR13318. PTHR13318. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NW81-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPWASLRL VAPMWNGRIR GIHRLGAAVA PEGNQKKKRT ILQFLTNYFY
60 70 80 90 100
DVEALRDYLL QREMYKVHEK NRSYTWLEKQ HGPYGAGAFF ILKQGGAVKF
110 120 130 140 150
RDKEWIRPDK YGHFSQEFWN FCEVPVEAVD AGDCDINYEG LDNLLRLKEL
160 170 180 190 200
QSLSLQRCCH VDDWCLSRLY PLADSLQELS LAGCPRISER GLACLHHLQN
210 220 230 240 250
LRRLDISDLP AVSNPGLTQI LVEEMLPNCE VVGVDWAEGL KSGPEEQPRD

TASPVPA
Length:257
Mass (Da):29,267
Last modified:May 18, 2010 - v3
Checksum:i29CBFD02143DE806
GO
Isoform 2 (identifier: Q9NW81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-99: Missing.
     145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):18,602
Checksum:i8387C635C5F26D39
GO
Isoform 3 (identifier: Q9NW81-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAAPWA → MWDLVLEDRRMN
     145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA

Show »
Length:191
Mass (Da):22,471
Checksum:i7F1EEBB93765A5EE
GO
Isoform 4 (identifier: Q9NW81-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAAPWA → MWDLVLEDRRMN

Note: No experimental confirmation available.
Show »
Length:263
Mass (Da):30,200
Checksum:iB8A3EFDDE672C998
GO
Isoform 5 (identifier: Q9NW81-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-99: Missing.

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):26,331
Checksum:i430D9722498CE8E3
GO
Isoform 6 (identifier: Q9NW81-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA

Note: No experimental confirmation available.
Show »
Length:185
Mass (Da):21,539
Checksum:i310CA9F8CAB2E26E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281A → S in BAG60467 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91R → C.
Corresponds to variant rs2231938 [ dbSNP | Ensembl ].
VAR_057798
Natural varianti23 – 231H → R.1 Publication
Corresponds to variant rs2231939 [ dbSNP | Ensembl ].
VAR_057799
Natural varianti34 – 341N → S.1 Publication
Corresponds to variant rs2231940 [ dbSNP | Ensembl ].
VAR_057800
Natural varianti159 – 1591C → S.1 Publication
Corresponds to variant rs1043413 [ dbSNP | Ensembl ].
VAR_060165
Natural varianti230 – 2301E → K.
Corresponds to variant rs2231943 [ dbSNP | Ensembl ].
VAR_057801

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 66MAAPWA → MWDLVLEDRRMN in isoform 3 and isoform 4. 1 PublicationVSP_043807
Alternative sequencei73 – 9927Missing in isoform 2 and isoform 5. 2 PublicationsVSP_031270Add
BLAST
Alternative sequencei145 – 257113LRLKE…SPVPA → RTSAGWTSRTSLPCPTLASL RYWWRRCCPIARLWESTGLR A in isoform 2, isoform 3 and isoform 6. 2 PublicationsVSP_031271Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001103 mRNA. Translation: BAA91503.1.
AK293132 mRNA. Translation: BAG56681.1.
AK297698 mRNA. Translation: BAG60056.1.
AK298197 mRNA. Translation: BAG60467.1.
AK301940 mRNA. Translation: BAG63360.1.
AC011526 Genomic DNA. No translation available.
AC005795 Genomic DNA. No translation available.
AC005945 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57042.1.
CH471126 Genomic DNA. Translation: EAW57043.1.
BC013323 mRNA. Translation: AAH13323.1.
CCDSiCCDS33032.1. [Q9NW81-1]
CCDS54269.1. [Q9NW81-3]
CCDS54270.1. [Q9NW81-4]
CCDS54271.1. [Q9NW81-5]
CCDS59389.1. [Q9NW81-2]
CCDS59390.1. [Q9NW81-6]
RefSeqiNP_001161339.1. NM_001167867.1. [Q9NW81-4]
NP_001161340.1. NM_001167868.1. [Q9NW81-3]
NP_001161341.1. NM_001167869.1. [Q9NW81-6]
NP_001161342.1. NM_001167870.1. [Q9NW81-2]
NP_001161343.1. NM_001167871.1. [Q9NW81-5]
NP_060505.2. NM_018035.2. [Q9NW81-1]
UniGeneiHs.351099.

Genome annotation databases

EnsembliENST00000221943; ENSP00000221943; ENSG00000105341.
ENST00000301183; ENSP00000301183; ENSG00000105341. [Q9NW81-3]
ENST00000417807; ENSP00000403910; ENSG00000105341. [Q9NW81-4]
ENST00000438807; ENSP00000397413; ENSG00000105341. [Q9NW81-2]
ENST00000589970; ENSP00000466485; ENSG00000105341. [Q9NW81-6]
ENST00000592922; ENSP00000467205; ENSG00000105341. [Q9NW81-5]
GeneIDi55101.
KEGGihsa:55101.
UCSCiuc002oqw.2. human. [Q9NW81-1]
uc002oqy.2. human. [Q9NW81-3]
uc002oqz.2. human. [Q9NW81-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001103 mRNA. Translation: BAA91503.1.
AK293132 mRNA. Translation: BAG56681.1.
AK297698 mRNA. Translation: BAG60056.1.
AK298197 mRNA. Translation: BAG60467.1.
AK301940 mRNA. Translation: BAG63360.1.
AC011526 Genomic DNA. No translation available.
AC005795 Genomic DNA. No translation available.
AC005945 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57042.1.
CH471126 Genomic DNA. Translation: EAW57043.1.
BC013323 mRNA. Translation: AAH13323.1.
CCDSiCCDS33032.1. [Q9NW81-1]
CCDS54269.1. [Q9NW81-3]
CCDS54270.1. [Q9NW81-4]
CCDS54271.1. [Q9NW81-5]
CCDS59389.1. [Q9NW81-2]
CCDS59390.1. [Q9NW81-6]
RefSeqiNP_001161339.1. NM_001167867.1. [Q9NW81-4]
NP_001161340.1. NM_001167868.1. [Q9NW81-3]
NP_001161341.1. NM_001167869.1. [Q9NW81-6]
NP_001161342.1. NM_001167870.1. [Q9NW81-2]
NP_001161343.1. NM_001167871.1. [Q9NW81-5]
NP_060505.2. NM_018035.2. [Q9NW81-1]
UniGeneiHs.351099.

3D structure databases

ProteinModelPortaliQ9NW81.
SMRiQ9NW81. Positions 82-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120411. 2 interactions.
STRINGi9606.ENSP00000403910.

PTM databases

PhosphoSiteiQ9NW81.

Polymorphism and mutation databases

BioMutaiATP5SL.
DMDMi296439436.

Proteomic databases

MaxQBiQ9NW81.
PaxDbiQ9NW81.
PRIDEiQ9NW81.

Protocols and materials databases

DNASUi55101.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221943; ENSP00000221943; ENSG00000105341.
ENST00000301183; ENSP00000301183; ENSG00000105341. [Q9NW81-3]
ENST00000417807; ENSP00000403910; ENSG00000105341. [Q9NW81-4]
ENST00000438807; ENSP00000397413; ENSG00000105341. [Q9NW81-2]
ENST00000589970; ENSP00000466485; ENSG00000105341. [Q9NW81-6]
ENST00000592922; ENSP00000467205; ENSG00000105341. [Q9NW81-5]
GeneIDi55101.
KEGGihsa:55101.
UCSCiuc002oqw.2. human. [Q9NW81-1]
uc002oqy.2. human. [Q9NW81-3]
uc002oqz.2. human. [Q9NW81-2]

Organism-specific databases

CTDi55101.
GeneCardsiGC19M041937.
HGNCiHGNC:25496. ATP5SL.
HPAiHPA041427.
HPA042658.
neXtProtiNX_Q9NW81.
PharmGKBiPA162377263.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG318773.
GeneTreeiENSGT00530000063680.
HOGENOMiHOG000034116.
HOVERGENiHBG056046.
InParanoidiQ9NW81.
OMAiGAVKFRD.
PhylomeDBiQ9NW81.
TreeFamiTF315274.

Miscellaneous databases

GeneWikiiATP5SL.
GenomeRNAii55101.
NextBioi58693.
PROiQ9NW81.

Gene expression databases

BgeeiQ9NW81.
CleanExiHS_ATP5SL.
ExpressionAtlasiQ9NW81. baseline and differential.
GenevisibleiQ9NW81. HS.

Family and domain databases

InterProiIPR026303. ATP5SL.
[Graphical view]
PANTHERiPTHR13318. PTHR13318. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4; 5 AND 6), VARIANTS ARG-23; SER-34 AND SER-159.
    Tissue: Lung, Neuroblastoma and Testis.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Bone marrow.

Entry informationi

Entry nameiAT5SL_HUMAN
AccessioniPrimary (citable) accession number: Q9NW81
Secondary accession number(s): B4DDC0
, B4DMZ4, B4DP55, B4DXE8, F5H4W7, K7EMF6, Q96D43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: July 22, 2015
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.