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Q9NW81

- AT5SL_HUMAN

UniProt

Q9NW81 - AT5SL_HUMAN

Protein

ATP synthase subunit s-like protein

Gene

ATP5SL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP synthase subunit s-like protein
    Gene namesi
    Name:ATP5SL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:25496. ATP5SL.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162377263.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257ATP synthase subunit s-like proteinPRO_0000318695Add
    BLAST

    Proteomic databases

    MaxQBiQ9NW81.
    PaxDbiQ9NW81.
    PRIDEiQ9NW81.

    PTM databases

    PhosphoSiteiQ9NW81.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NW81.
    BgeeiQ9NW81.
    CleanExiHS_ATP5SL.
    GenevestigatoriQ9NW81.

    Organism-specific databases

    HPAiHPA041427.
    HPA042658.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NW81.
    SMRiQ9NW81. Positions 82-231.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP synthase subunit s family.Curated

    Phylogenomic databases

    eggNOGiNOG318773.
    HOVERGENiHBG056046.
    InParanoidiQ9NW81.
    OMAiGAVKFQG.
    PhylomeDBiQ9NW81.
    TreeFamiTF315274.

    Family and domain databases

    InterProiIPR026303. ATP5SL.
    [Graphical view]
    PANTHERiPTHR13318. PTHR13318. 1 hit.

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NW81-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAPWASLRL VAPMWNGRIR GIHRLGAAVA PEGNQKKKRT ILQFLTNYFY    50
    DVEALRDYLL QREMYKVHEK NRSYTWLEKQ HGPYGAGAFF ILKQGGAVKF 100
    RDKEWIRPDK YGHFSQEFWN FCEVPVEAVD AGDCDINYEG LDNLLRLKEL 150
    QSLSLQRCCH VDDWCLSRLY PLADSLQELS LAGCPRISER GLACLHHLQN 200
    LRRLDISDLP AVSNPGLTQI LVEEMLPNCE VVGVDWAEGL KSGPEEQPRD 250
    TASPVPA 257
    Length:257
    Mass (Da):29,267
    Last modified:May 18, 2010 - v3
    Checksum:i29CBFD02143DE806
    GO
    Isoform 2 (identifier: Q9NW81-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         73-99: Missing.
         145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA

    Note: No experimental confirmation available.

    Show »
    Length:158
    Mass (Da):18,602
    Checksum:i8387C635C5F26D39
    GO
    Isoform 3 (identifier: Q9NW81-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: MAAPWA → MWDLVLEDRRMN
         145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA

    Show »
    Length:191
    Mass (Da):22,471
    Checksum:i7F1EEBB93765A5EE
    GO
    Isoform 4 (identifier: Q9NW81-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-6: MAAPWA → MWDLVLEDRRMN

    Note: No experimental confirmation available.

    Show »
    Length:263
    Mass (Da):30,200
    Checksum:iB8A3EFDDE672C998
    GO
    Isoform 5 (identifier: Q9NW81-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         73-99: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:230
    Mass (Da):26,331
    Checksum:i430D9722498CE8E3
    GO
    Isoform 6 (identifier: Q9NW81-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA

    Note: No experimental confirmation available.

    Show »
    Length:185
    Mass (Da):21,539
    Checksum:i310CA9F8CAB2E26E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti128 – 1281A → S in BAG60467. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91R → C.
    Corresponds to variant rs2231938 [ dbSNP | Ensembl ].
    VAR_057798
    Natural varianti23 – 231H → R.1 Publication
    Corresponds to variant rs2231939 [ dbSNP | Ensembl ].
    VAR_057799
    Natural varianti34 – 341N → S.1 Publication
    Corresponds to variant rs2231940 [ dbSNP | Ensembl ].
    VAR_057800
    Natural varianti159 – 1591C → S.1 Publication
    Corresponds to variant rs1043413 [ dbSNP | Ensembl ].
    VAR_060165
    Natural varianti230 – 2301E → K.
    Corresponds to variant rs2231943 [ dbSNP | Ensembl ].
    VAR_057801

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 66MAAPWA → MWDLVLEDRRMN in isoform 3 and isoform 4. 1 PublicationVSP_043807
    Alternative sequencei73 – 9927Missing in isoform 2 and isoform 5. 2 PublicationsVSP_031270Add
    BLAST
    Alternative sequencei145 – 257113LRLKE…SPVPA → RTSAGWTSRTSLPCPTLASL RYWWRRCCPIARLWESTGLR A in isoform 2, isoform 3 and isoform 6. 2 PublicationsVSP_031271Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001103 mRNA. Translation: BAA91503.1.
    AK293132 mRNA. Translation: BAG56681.1.
    AK297698 mRNA. Translation: BAG60056.1.
    AK298197 mRNA. Translation: BAG60467.1.
    AK301940 mRNA. Translation: BAG63360.1.
    AC011526 Genomic DNA. No translation available.
    AC005795 Genomic DNA. No translation available.
    AC005945 Genomic DNA. No translation available.
    CH471126 Genomic DNA. Translation: EAW57042.1.
    CH471126 Genomic DNA. Translation: EAW57043.1.
    BC013323 mRNA. Translation: AAH13323.1.
    CCDSiCCDS33032.1. [Q9NW81-1]
    CCDS54269.1. [Q9NW81-3]
    CCDS54270.1. [Q9NW81-4]
    CCDS54271.1. [Q9NW81-5]
    CCDS59389.1. [Q9NW81-2]
    CCDS59390.1. [Q9NW81-6]
    RefSeqiNP_001161339.1. NM_001167867.1. [Q9NW81-4]
    NP_001161340.1. NM_001167868.1. [Q9NW81-3]
    NP_001161341.1. NM_001167869.1. [Q9NW81-6]
    NP_001161342.1. NM_001167870.1. [Q9NW81-2]
    NP_001161343.1. NM_001167871.1. [Q9NW81-5]
    NP_060505.2. NM_018035.2. [Q9NW81-1]
    UniGeneiHs.351099.

    Genome annotation databases

    GeneIDi55101.
    KEGGihsa:55101.
    UCSCiuc002oqw.2. human. [Q9NW81-1]
    uc002oqy.2. human. [Q9NW81-3]
    uc002oqz.2. human. [Q9NW81-2]

    Polymorphism databases

    DMDMi296439436.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001103 mRNA. Translation: BAA91503.1 .
    AK293132 mRNA. Translation: BAG56681.1 .
    AK297698 mRNA. Translation: BAG60056.1 .
    AK298197 mRNA. Translation: BAG60467.1 .
    AK301940 mRNA. Translation: BAG63360.1 .
    AC011526 Genomic DNA. No translation available.
    AC005795 Genomic DNA. No translation available.
    AC005945 Genomic DNA. No translation available.
    CH471126 Genomic DNA. Translation: EAW57042.1 .
    CH471126 Genomic DNA. Translation: EAW57043.1 .
    BC013323 mRNA. Translation: AAH13323.1 .
    CCDSi CCDS33032.1. [Q9NW81-1 ]
    CCDS54269.1. [Q9NW81-3 ]
    CCDS54270.1. [Q9NW81-4 ]
    CCDS54271.1. [Q9NW81-5 ]
    CCDS59389.1. [Q9NW81-2 ]
    CCDS59390.1. [Q9NW81-6 ]
    RefSeqi NP_001161339.1. NM_001167867.1. [Q9NW81-4 ]
    NP_001161340.1. NM_001167868.1. [Q9NW81-3 ]
    NP_001161341.1. NM_001167869.1. [Q9NW81-6 ]
    NP_001161342.1. NM_001167870.1. [Q9NW81-2 ]
    NP_001161343.1. NM_001167871.1. [Q9NW81-5 ]
    NP_060505.2. NM_018035.2. [Q9NW81-1 ]
    UniGenei Hs.351099.

    3D structure databases

    ProteinModelPortali Q9NW81.
    SMRi Q9NW81. Positions 82-231.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9NW81.

    Polymorphism databases

    DMDMi 296439436.

    Proteomic databases

    MaxQBi Q9NW81.
    PaxDbi Q9NW81.
    PRIDEi Q9NW81.

    Protocols and materials databases

    DNASUi 55101.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 55101.
    KEGGi hsa:55101.
    UCSCi uc002oqw.2. human. [Q9NW81-1 ]
    uc002oqy.2. human. [Q9NW81-3 ]
    uc002oqz.2. human. [Q9NW81-2 ]

    Organism-specific databases

    CTDi 55101.
    GeneCardsi GC19M041937.
    HGNCi HGNC:25496. ATP5SL.
    HPAi HPA041427.
    HPA042658.
    neXtProti NX_Q9NW81.
    PharmGKBi PA162377263.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG318773.
    HOVERGENi HBG056046.
    InParanoidi Q9NW81.
    OMAi GAVKFQG.
    PhylomeDBi Q9NW81.
    TreeFami TF315274.

    Miscellaneous databases

    ChiTaRSi ATP5SL. human.
    GeneWikii ATP5SL.
    GenomeRNAii 55101.
    NextBioi 58693.
    PROi Q9NW81.

    Gene expression databases

    ArrayExpressi Q9NW81.
    Bgeei Q9NW81.
    CleanExi HS_ATP5SL.
    Genevestigatori Q9NW81.

    Family and domain databases

    InterProi IPR026303. ATP5SL.
    [Graphical view ]
    PANTHERi PTHR13318. PTHR13318. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4; 5 AND 6), VARIANTS ARG-23; SER-34 AND SER-159.
      Tissue: Lung, Neuroblastoma and Testis.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Bone marrow.

    Entry informationi

    Entry nameiAT5SL_HUMAN
    AccessioniPrimary (citable) accession number: Q9NW81
    Secondary accession number(s): B4DDC0
    , B4DMZ4, B4DP55, B4DXE8, F5H4W7, K7EMF6, Q96D43
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3