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Q9NW81 (AT5SL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP synthase subunit s-like protein
Gene names
Name:ATP5SL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ATP synthase subunit s family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NW81-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NW81-2)

The sequence of this isoform differs from the canonical sequence as follows:
     73-99: Missing.
     145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9NW81-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAAPWA → MWDLVLEDRRMN
     145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA
Isoform 4 (identifier: Q9NW81-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAAPWA → MWDLVLEDRRMN
Note: No experimental confirmation available.
Isoform 5 (identifier: Q9NW81-5)

The sequence of this isoform differs from the canonical sequence as follows:
     73-99: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: Q9NW81-6)

The sequence of this isoform differs from the canonical sequence as follows:
     145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257ATP synthase subunit s-like protein
PRO_0000318695

Natural variations

Alternative sequence1 – 66MAAPWA → MWDLVLEDRRMN in isoform 3 and isoform 4.
VSP_043807
Alternative sequence73 – 9927Missing in isoform 2 and isoform 5.
VSP_031270
Alternative sequence145 – 257113LRLKE…SPVPA → RTSAGWTSRTSLPCPTLASL RYWWRRCCPIARLWESTGLR A in isoform 2, isoform 3 and isoform 6.
VSP_031271
Natural variant91R → C.
Corresponds to variant rs2231938 [ dbSNP | Ensembl ].
VAR_057798
Natural variant231H → R. Ref.1
Corresponds to variant rs2231939 [ dbSNP | Ensembl ].
VAR_057799
Natural variant341N → S. Ref.1
Corresponds to variant rs2231940 [ dbSNP | Ensembl ].
VAR_057800
Natural variant1591C → S. Ref.1
Corresponds to variant rs1043413 [ dbSNP | Ensembl ].
VAR_060165
Natural variant2301E → K.
Corresponds to variant rs2231943 [ dbSNP | Ensembl ].
VAR_057801

Experimental info

Sequence conflict1281A → S in BAG60467. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 29CBFD02143DE806

FASTA25729,267
        10         20         30         40         50         60 
MAAPWASLRL VAPMWNGRIR GIHRLGAAVA PEGNQKKKRT ILQFLTNYFY DVEALRDYLL 

        70         80         90        100        110        120 
QREMYKVHEK NRSYTWLEKQ HGPYGAGAFF ILKQGGAVKF RDKEWIRPDK YGHFSQEFWN 

       130        140        150        160        170        180 
FCEVPVEAVD AGDCDINYEG LDNLLRLKEL QSLSLQRCCH VDDWCLSRLY PLADSLQELS 

       190        200        210        220        230        240 
LAGCPRISER GLACLHHLQN LRRLDISDLP AVSNPGLTQI LVEEMLPNCE VVGVDWAEGL 

       250 
KSGPEEQPRD TASPVPA 

« Hide

Isoform 2 [UniParc].

Checksum: 8387C635C5F26D39
Show »

FASTA15818,602
Isoform 3 [UniParc].

Checksum: 7F1EEBB93765A5EE
Show »

FASTA19122,471
Isoform 4 [UniParc].

Checksum: B8A3EFDDE672C998
Show »

FASTA26330,200
Isoform 5 [UniParc].

Checksum: 430D9722498CE8E3
Show »

FASTA23026,331
Isoform 6 [UniParc].

Checksum: 310CA9F8CAB2E26E
Show »

FASTA18521,539

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4; 5 AND 6), VARIANTS ARG-23; SER-34 AND SER-159.
Tissue: Lung, Neuroblastoma and Testis.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Bone marrow.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK001103 mRNA. Translation: BAA91503.1.
AK293132 mRNA. Translation: BAG56681.1.
AK297698 mRNA. Translation: BAG60056.1.
AK298197 mRNA. Translation: BAG60467.1.
AK301940 mRNA. Translation: BAG63360.1.
AC011526 Genomic DNA. No translation available.
AC005795 Genomic DNA. No translation available.
AC005945 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57042.1.
CH471126 Genomic DNA. Translation: EAW57043.1.
BC013323 mRNA. Translation: AAH13323.1.
CCDSCCDS33032.1. [Q9NW81-1]
CCDS54269.1. [Q9NW81-3]
CCDS54270.1. [Q9NW81-4]
CCDS54271.1. [Q9NW81-5]
CCDS59389.1. [Q9NW81-2]
CCDS59390.1. [Q9NW81-6]
RefSeqNP_001161339.1. NM_001167867.1. [Q9NW81-4]
NP_001161340.1. NM_001167868.1. [Q9NW81-3]
NP_001161341.1. NM_001167869.1. [Q9NW81-6]
NP_001161342.1. NM_001167870.1. [Q9NW81-2]
NP_001161343.1. NM_001167871.1. [Q9NW81-5]
NP_060505.2. NM_018035.2. [Q9NW81-1]
UniGeneHs.351099.

3D structure databases

ProteinModelPortalQ9NW81.
SMRQ9NW81. Positions 82-231.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9NW81.

Polymorphism databases

DMDM296439436.

Proteomic databases

MaxQBQ9NW81.
PaxDbQ9NW81.
PRIDEQ9NW81.

Protocols and materials databases

DNASU55101.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000221943; ENSP00000221943; ENSG00000105341. [Q9NW81-1]
ENST00000301183; ENSP00000301183; ENSG00000105341. [Q9NW81-3]
ENST00000417807; ENSP00000403910; ENSG00000105341. [Q9NW81-4]
ENST00000438807; ENSP00000397413; ENSG00000105341. [Q9NW81-2]
ENST00000589970; ENSP00000466485; ENSG00000105341. [Q9NW81-6]
ENST00000592922; ENSP00000467205; ENSG00000105341. [Q9NW81-5]
ENST00000608186; ENSP00000477321; ENSG00000272997. [Q9NW81-4]
ENST00000608480; ENSP00000477071; ENSG00000272997. [Q9NW81-2]
ENST00000608528; ENSP00000477178; ENSG00000272997. [Q9NW81-1]
ENST00000608542; ENSP00000477151; ENSG00000272997. [Q9NW81-6]
ENST00000608638; ENSP00000477129; ENSG00000272997. [Q9NW81-5]
ENST00000609840; ENSP00000477274; ENSG00000272997. [Q9NW81-3]
GeneID55101.
KEGGhsa:55101.
UCSCuc002oqw.2. human. [Q9NW81-1]
uc002oqy.2. human. [Q9NW81-3]
uc002oqz.2. human. [Q9NW81-2]

Organism-specific databases

CTD55101.
GeneCardsGC19M041937.
HGNCHGNC:25496. ATP5SL.
HPAHPA041427.
HPA042658.
neXtProtNX_Q9NW81.
PharmGKBPA162377263.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG318773.
HOVERGENHBG056046.
InParanoidQ9NW81.
OMAGAVKFQG.
PhylomeDBQ9NW81.
TreeFamTF315274.

Gene expression databases

ArrayExpressQ9NW81.
BgeeQ9NW81.
CleanExHS_ATP5SL.
GenevestigatorQ9NW81.

Family and domain databases

InterProIPR026303. ATP5SL.
[Graphical view]
PANTHERPTHR13318. PTHR13318. 1 hit.
ProtoNetSearch...

Other

ChiTaRSATP5SL. human.
GeneWikiATP5SL.
GenomeRNAi55101.
NextBio58693.
PROQ9NW81.

Entry information

Entry nameAT5SL_HUMAN
AccessionPrimary (citable) accession number: Q9NW81
Secondary accession number(s): B4DDC0 expand/collapse secondary AC list , B4DMZ4, B4DP55, B4DXE8, F5H4W7, K7EMF6, Q96D43
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM