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Q9NW81

- AT5SL_HUMAN

UniProt

Q9NW81 - AT5SL_HUMAN

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Protein

ATP synthase subunit s-like protein

Gene

ATP5SL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit s-like protein
Gene namesi
Name:ATP5SL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:25496. ATP5SL.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377263.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257ATP synthase subunit s-like proteinPRO_0000318695Add
BLAST

Proteomic databases

MaxQBiQ9NW81.
PaxDbiQ9NW81.
PRIDEiQ9NW81.

PTM databases

PhosphoSiteiQ9NW81.

Expressioni

Gene expression databases

BgeeiQ9NW81.
CleanExiHS_ATP5SL.
ExpressionAtlasiQ9NW81. baseline and differential.
GenevestigatoriQ9NW81.

Organism-specific databases

HPAiHPA041427.
HPA042658.

Structurei

3D structure databases

ProteinModelPortaliQ9NW81.
SMRiQ9NW81. Positions 82-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP synthase subunit s family.Curated

Phylogenomic databases

eggNOGiNOG318773.
GeneTreeiENSGT00530000063680.
HOVERGENiHBG056046.
InParanoidiQ9NW81.
OMAiGAVKFQG.
PhylomeDBiQ9NW81.
TreeFamiTF315274.

Family and domain databases

InterProiIPR026303. ATP5SL.
[Graphical view]
PANTHERiPTHR13318. PTHR13318. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NW81-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPWASLRL VAPMWNGRIR GIHRLGAAVA PEGNQKKKRT ILQFLTNYFY
60 70 80 90 100
DVEALRDYLL QREMYKVHEK NRSYTWLEKQ HGPYGAGAFF ILKQGGAVKF
110 120 130 140 150
RDKEWIRPDK YGHFSQEFWN FCEVPVEAVD AGDCDINYEG LDNLLRLKEL
160 170 180 190 200
QSLSLQRCCH VDDWCLSRLY PLADSLQELS LAGCPRISER GLACLHHLQN
210 220 230 240 250
LRRLDISDLP AVSNPGLTQI LVEEMLPNCE VVGVDWAEGL KSGPEEQPRD

TASPVPA
Length:257
Mass (Da):29,267
Last modified:May 18, 2010 - v3
Checksum:i29CBFD02143DE806
GO
Isoform 2 (identifier: Q9NW81-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-99: Missing.
     145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA

Note: No experimental confirmation available.

Show »
Length:158
Mass (Da):18,602
Checksum:i8387C635C5F26D39
GO
Isoform 3 (identifier: Q9NW81-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAAPWA → MWDLVLEDRRMN
     145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA

Show »
Length:191
Mass (Da):22,471
Checksum:i7F1EEBB93765A5EE
GO
Isoform 4 (identifier: Q9NW81-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAAPWA → MWDLVLEDRRMN

Note: No experimental confirmation available.

Show »
Length:263
Mass (Da):30,200
Checksum:iB8A3EFDDE672C998
GO
Isoform 5 (identifier: Q9NW81-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-99: Missing.

Note: No experimental confirmation available.

Show »
Length:230
Mass (Da):26,331
Checksum:i430D9722498CE8E3
GO
Isoform 6 (identifier: Q9NW81-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-257: LRLKELQSLS...PRDTASPVPA → RTSAGWTSRT...RLWESTGLRA

Note: No experimental confirmation available.

Show »
Length:185
Mass (Da):21,539
Checksum:i310CA9F8CAB2E26E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281A → S in BAG60467. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91R → C.
Corresponds to variant rs2231938 [ dbSNP | Ensembl ].
VAR_057798
Natural varianti23 – 231H → R.1 Publication
Corresponds to variant rs2231939 [ dbSNP | Ensembl ].
VAR_057799
Natural varianti34 – 341N → S.1 Publication
Corresponds to variant rs2231940 [ dbSNP | Ensembl ].
VAR_057800
Natural varianti159 – 1591C → S.1 Publication
Corresponds to variant rs1043413 [ dbSNP | Ensembl ].
VAR_060165
Natural varianti230 – 2301E → K.
Corresponds to variant rs2231943 [ dbSNP | Ensembl ].
VAR_057801

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 66MAAPWA → MWDLVLEDRRMN in isoform 3 and isoform 4. 1 PublicationVSP_043807
Alternative sequencei73 – 9927Missing in isoform 2 and isoform 5. 2 PublicationsVSP_031270Add
BLAST
Alternative sequencei145 – 257113LRLKE…SPVPA → RTSAGWTSRTSLPCPTLASL RYWWRRCCPIARLWESTGLR A in isoform 2, isoform 3 and isoform 6. 2 PublicationsVSP_031271Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001103 mRNA. Translation: BAA91503.1.
AK293132 mRNA. Translation: BAG56681.1.
AK297698 mRNA. Translation: BAG60056.1.
AK298197 mRNA. Translation: BAG60467.1.
AK301940 mRNA. Translation: BAG63360.1.
AC011526 Genomic DNA. No translation available.
AC005795 Genomic DNA. No translation available.
AC005945 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57042.1.
CH471126 Genomic DNA. Translation: EAW57043.1.
BC013323 mRNA. Translation: AAH13323.1.
CCDSiCCDS33032.1. [Q9NW81-1]
CCDS54269.1. [Q9NW81-3]
CCDS54270.1. [Q9NW81-4]
CCDS54271.1. [Q9NW81-5]
CCDS59389.1. [Q9NW81-2]
CCDS59390.1. [Q9NW81-6]
RefSeqiNP_001161339.1. NM_001167867.1. [Q9NW81-4]
NP_001161340.1. NM_001167868.1. [Q9NW81-3]
NP_001161341.1. NM_001167869.1. [Q9NW81-6]
NP_001161342.1. NM_001167870.1. [Q9NW81-2]
NP_001161343.1. NM_001167871.1. [Q9NW81-5]
NP_060505.2. NM_018035.2. [Q9NW81-1]
UniGeneiHs.351099.

Genome annotation databases

GeneIDi55101.
KEGGihsa:55101.
UCSCiuc002oqw.2. human. [Q9NW81-1]
uc002oqy.2. human. [Q9NW81-3]
uc002oqz.2. human. [Q9NW81-2]

Polymorphism databases

DMDMi296439436.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001103 mRNA. Translation: BAA91503.1 .
AK293132 mRNA. Translation: BAG56681.1 .
AK297698 mRNA. Translation: BAG60056.1 .
AK298197 mRNA. Translation: BAG60467.1 .
AK301940 mRNA. Translation: BAG63360.1 .
AC011526 Genomic DNA. No translation available.
AC005795 Genomic DNA. No translation available.
AC005945 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57042.1 .
CH471126 Genomic DNA. Translation: EAW57043.1 .
BC013323 mRNA. Translation: AAH13323.1 .
CCDSi CCDS33032.1. [Q9NW81-1 ]
CCDS54269.1. [Q9NW81-3 ]
CCDS54270.1. [Q9NW81-4 ]
CCDS54271.1. [Q9NW81-5 ]
CCDS59389.1. [Q9NW81-2 ]
CCDS59390.1. [Q9NW81-6 ]
RefSeqi NP_001161339.1. NM_001167867.1. [Q9NW81-4 ]
NP_001161340.1. NM_001167868.1. [Q9NW81-3 ]
NP_001161341.1. NM_001167869.1. [Q9NW81-6 ]
NP_001161342.1. NM_001167870.1. [Q9NW81-2 ]
NP_001161343.1. NM_001167871.1. [Q9NW81-5 ]
NP_060505.2. NM_018035.2. [Q9NW81-1 ]
UniGenei Hs.351099.

3D structure databases

ProteinModelPortali Q9NW81.
SMRi Q9NW81. Positions 82-231.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9NW81.

Polymorphism databases

DMDMi 296439436.

Proteomic databases

MaxQBi Q9NW81.
PaxDbi Q9NW81.
PRIDEi Q9NW81.

Protocols and materials databases

DNASUi 55101.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 55101.
KEGGi hsa:55101.
UCSCi uc002oqw.2. human. [Q9NW81-1 ]
uc002oqy.2. human. [Q9NW81-3 ]
uc002oqz.2. human. [Q9NW81-2 ]

Organism-specific databases

CTDi 55101.
GeneCardsi GC19M041937.
HGNCi HGNC:25496. ATP5SL.
HPAi HPA041427.
HPA042658.
neXtProti NX_Q9NW81.
PharmGKBi PA162377263.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG318773.
GeneTreei ENSGT00530000063680.
HOVERGENi HBG056046.
InParanoidi Q9NW81.
OMAi GAVKFQG.
PhylomeDBi Q9NW81.
TreeFami TF315274.

Miscellaneous databases

ChiTaRSi ATP5SL. human.
GeneWikii ATP5SL.
GenomeRNAii 55101.
NextBioi 58693.
PROi Q9NW81.

Gene expression databases

Bgeei Q9NW81.
CleanExi HS_ATP5SL.
ExpressionAtlasi Q9NW81. baseline and differential.
Genevestigatori Q9NW81.

Family and domain databases

InterProi IPR026303. ATP5SL.
[Graphical view ]
PANTHERi PTHR13318. PTHR13318. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4; 5 AND 6), VARIANTS ARG-23; SER-34 AND SER-159.
    Tissue: Lung, Neuroblastoma and Testis.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Bone marrow.

Entry informationi

Entry nameiAT5SL_HUMAN
AccessioniPrimary (citable) accession number: Q9NW81
Secondary accession number(s): B4DDC0
, B4DMZ4, B4DP55, B4DXE8, F5H4W7, K7EMF6, Q96D43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3