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Protein

G patch domain-containing protein 2

Gene

GPATCH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the ATPase activity of DHX15 in vitro.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G patch domain-containing protein 2
Gene namesi
Name:GPATCH2
Synonyms:GPATC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25499. GPATCH2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162390064.

Polymorphism and mutation databases

BioMutaiGPATCH2.
DMDMi48428171.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528G patch domain-containing protein 2PRO_0000087566Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei115 – 1151PhosphoserineCombined sources
Modified residuei117 – 1171PhosphoserineCombined sources
Modified residuei146 – 1461PhosphoserineCombined sources
Modified residuei195 – 1951PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NW75.
MaxQBiQ9NW75.
PaxDbiQ9NW75.
PeptideAtlasiQ9NW75.
PRIDEiQ9NW75.

PTM databases

iPTMnetiQ9NW75.
PhosphoSiteiQ9NW75.

Expressioni

Tissue specificityi

Testis.1 Publication

Gene expression databases

BgeeiQ9NW75.
CleanExiHS_GPATCH2.
GenevisibleiQ9NW75. HS.

Organism-specific databases

HPAiHPA027181.
HPA027322.

Interactioni

Subunit structurei

Interacts with DHX15.1 Publication

Protein-protein interaction databases

BioGridi120415. 4 interactions.
IntActiQ9NW75. 3 interactions.
STRINGi9606.ENSP00000355902.

Structurei

3D structure databases

ProteinModelPortaliQ9NW75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini467 – 51347G-patchPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 G-patch domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQDT. Eukaryota.
ENOG410ZH5F. LUCA.
GeneTreeiENSGT00410000025698.
HOGENOMiHOG000294060.
HOVERGENiHBG062801.
InParanoidiQ9NW75.
KOiK17569.
OMAiFPLMSHP.
OrthoDBiEOG7J446Q.
PhylomeDBiQ9NW75.
TreeFamiTF331954.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR026291. Gpatch2.
[Graphical view]
PANTHERiPTHR14195. PTHR14195. 1 hit.
PfamiPF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NW75-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGAAGRQPI GAPAAGNSWH FSRTMEELVH DLVSALEESS EQARGGFAET
60 70 80 90 100
GDHSRSISCP LKRQARKRRG RKRRSYNVHH PWETGHCLSE GSDSSLEEPS
110 120 130 140 150
KDYRENHNNN KKDHSDSDDQ MLVAKRRPSS NLNNNVRGKR PLWHESDFAV
160 170 180 190 200
DNVGNRTLRR RRKVKRMAVD LPQDISNKRT MTQPPEGCRD QDMDSDRAYQ
210 220 230 240 250
YQEFTKNKVK KRKLKIIRQG PKIQDEGVVL ESEETNQTNK DKMECEEQKV
260 270 280 290 300
SDELMSESDS SSLSSTDAGL FTNDEGRQGD DEQSDWFYEK ESGGACGITG
310 320 330 340 350
VVPWWEKEDP TELDKNVPDP VFESILTGSF PLMSHPSRRG FQARLSRLHG
360 370 380 390 400
MSSKNIKKSG GTPTSMVPIP GPVGNKRMVH FSPDSHHHDH WFSPGARTEH
410 420 430 440 450
DQHQLLRDNR AERGHKKNCS VRTASRQTSM HLGSLCTGDI KRRRKAAPLP
460 470 480 490 500
GPTTAGFVGE NAQPILENNI GNRMLQNMGW TPGSGLGRDG KGISEPIQAM
510 520
QRPKGLGLGF PLPKSTSATT TPNAGKSA
Length:528
Mass (Da):58,944
Last modified:October 1, 2000 - v1
Checksum:i472143144700DC26
GO
Isoform 2 (identifier: Q9NW75-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-376: VPIPGPVGNK → ATNWTSEIPL
     377-528: Missing.

Note: No experimental confirmation available.
Show »
Length:376
Mass (Da):42,599
Checksum:i42E7688983E717E5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti220 – 2201G → A in AAH63474 (PubMed:15489334).Curated
Sequence conflicti225 – 2251D → N in AAH42193 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei367 – 37610VPIPGPVGNK → ATNWTSEIPL in isoform 2. 1 PublicationVSP_010527
Alternative sequencei377 – 528152Missing in isoform 2. 1 PublicationVSP_010528Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001114 mRNA. Translation: BAA91509.1.
AL354659 Genomic DNA. Translation: CAH70663.1.
AL354659, AC096641 Genomic DNA. Translation: CAH70664.1.
CH471100 Genomic DNA. Translation: EAW93333.1.
BC042193 mRNA. Translation: AAH42193.1.
BC063474 mRNA. Translation: AAH63474.1.
CCDSiCCDS1518.1. [Q9NW75-1]
CCDS73031.1. [Q9NW75-2]
RefSeqiNP_001284683.1. NM_001297754.1. [Q9NW75-2]
NP_060510.1. NM_018040.3. [Q9NW75-1]
UniGeneiHs.362343.
Hs.420757.

Genome annotation databases

EnsembliENST00000366934; ENSP00000355901; ENSG00000092978. [Q9NW75-2]
ENST00000366935; ENSP00000355902; ENSG00000092978. [Q9NW75-1]
GeneIDi55105.
KEGGihsa:55105.
UCSCiuc001hlf.2. human. [Q9NW75-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001114 mRNA. Translation: BAA91509.1.
AL354659 Genomic DNA. Translation: CAH70663.1.
AL354659, AC096641 Genomic DNA. Translation: CAH70664.1.
CH471100 Genomic DNA. Translation: EAW93333.1.
BC042193 mRNA. Translation: AAH42193.1.
BC063474 mRNA. Translation: AAH63474.1.
CCDSiCCDS1518.1. [Q9NW75-1]
CCDS73031.1. [Q9NW75-2]
RefSeqiNP_001284683.1. NM_001297754.1. [Q9NW75-2]
NP_060510.1. NM_018040.3. [Q9NW75-1]
UniGeneiHs.362343.
Hs.420757.

3D structure databases

ProteinModelPortaliQ9NW75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120415. 4 interactions.
IntActiQ9NW75. 3 interactions.
STRINGi9606.ENSP00000355902.

PTM databases

iPTMnetiQ9NW75.
PhosphoSiteiQ9NW75.

Polymorphism and mutation databases

BioMutaiGPATCH2.
DMDMi48428171.

Proteomic databases

EPDiQ9NW75.
MaxQBiQ9NW75.
PaxDbiQ9NW75.
PeptideAtlasiQ9NW75.
PRIDEiQ9NW75.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366934; ENSP00000355901; ENSG00000092978. [Q9NW75-2]
ENST00000366935; ENSP00000355902; ENSG00000092978. [Q9NW75-1]
GeneIDi55105.
KEGGihsa:55105.
UCSCiuc001hlf.2. human. [Q9NW75-1]

Organism-specific databases

CTDi55105.
GeneCardsiGPATCH2.
HGNCiHGNC:25499. GPATCH2.
HPAiHPA027181.
HPA027322.
neXtProtiNX_Q9NW75.
PharmGKBiPA162390064.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQDT. Eukaryota.
ENOG410ZH5F. LUCA.
GeneTreeiENSGT00410000025698.
HOGENOMiHOG000294060.
HOVERGENiHBG062801.
InParanoidiQ9NW75.
KOiK17569.
OMAiFPLMSHP.
OrthoDBiEOG7J446Q.
PhylomeDBiQ9NW75.
TreeFamiTF331954.

Miscellaneous databases

ChiTaRSiGPATCH2. human.
GenomeRNAii55105.
PROiQ9NW75.

Gene expression databases

BgeeiQ9NW75.
CleanExiHS_GPATCH2.
GenevisibleiQ9NW75. HS.

Family and domain databases

InterProiIPR000467. G_patch_dom.
IPR026291. Gpatch2.
[Graphical view]
PANTHERiPTHR14195. PTHR14195. 1 hit.
PfamiPF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
[Graphical view]
PROSITEiPS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryo.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung and Uterus.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Involvement of G-patch domain containing 2 overexpression in breast carcinogenesis."
    Lin M.L., Fukukawa C., Park J.H., Naito K., Kijima K., Shimo A., Ajiro M., Nishidate T., Nakamura Y., Katagiri T.
    Cancer Sci. 100:1443-1450(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DHX15, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115 AND SER-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115 AND SER-117, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-115 AND SER-117, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146 AND SER-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiGPTC2_HUMAN
AccessioniPrimary (citable) accession number: Q9NW75
Secondary accession number(s): Q5VYK7, Q5VYK8, Q86YE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.